Julie R McMullen
Affiliation: Baker Heart Research Institute
Bernardo B, Weeks K, Pongsukwechkul T, Gao X, Kiriazis H, Cemerlang N, et al
. Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling. Clin Sci (Lond). 2018;132:381-397 pubmed publisher
..In summary, MCAD induced physiological cardiac hypertrophy in healthy adult mice and attenuated features of pathological remodelling in a cardiac disease model. ..
Tham Y, Bernardo B, Huynh K, Ooi J, Gao X, Kiriazis H, et al
. Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets. Cell Rep. 2018;24:2757-2772 pubmed publisher
..This study highlights the adaptations that occur to lipid profiles in response to endurance training versus pathology and provides a resource to investigate potential therapeutic targets and biomarkers. ..
Bass Stringer S, Bernardo B, May C, Thomas C, Weeks K, McMullen J. Adeno-Associated Virus Gene Therapy: Translational Progress and Future Prospects in the Treatment of Heart Failure. Heart Lung Circ. 2018;27:1285-1300 pubmed publisher
Howden E, La Gerche A, Arthur J, McMullen J, Jennings G, Dunstan D, et al
. Standing up to the cardiometabolic consequences of hematological cancers. Blood Rev. 2018;32:349-360 pubmed publisher
..In this context, we focus particularly on strategies targeting reducing and breaking up sedentary time and provide recommendations for future research. ..
McMullen J, Amirahmadi F, Woodcock E, Schinke Braun M, Bouwman R, Hewitt K, et al
. Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2007;104:612-7 pubmed
..Identification of genes important for hypertrophy in the athlete's heart could offer new strategies for treating heart failure. ..
Weeks K, Bernardo B, Ooi J, Patterson N, McMullen J. The IGF1-PI3K-Akt Signaling Pathway in Mediating Exercise-Induced Cardiac Hypertrophy and Protection. Adv Exp Med Biol. 2017;1000:187-210 pubmed publisher
..Finally we summarize therapeutic approaches that target the IGF1-PI3K-Akt signaling pathway which are showing promise in preclinical models of heart disease. ..
Tham Y, Huynh K, Mellett N, Henstridge D, Kiriazis H, Ooi J, et al
. Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:219-234 pubmed publisher
..Here we show that lipid species are differentially regulated in settings of physiological and pathological remodeling. Restoration of lipid species in the failing heart warrants further examination. ..