G A Head


Affiliation: Baker Heart Research Institute
Country: Australia


  1. Gueguen C, Jackson K, Marques F, Eikelis N, Phillips S, Stevenson E, et al. Renal nerves contribute to hypertension in Schlager BPH/2J mice. Hypertens Res. 2019;42:306-318 pubmed publisher
    ..The lack of inhibition of the depressor effects of pentolinium and enalaprilat by RD suggests that vasoconstrictor effects of the SNS or RAS are not involved. ..
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    Head G, Mayorov D. Central angiotensin and baroreceptor control of circulation. Ann N Y Acad Sci. 2001;940:361-79 pubmed
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    Head G, Mayorov D. Imidazoline receptors, novel agents and therapeutic potential. Cardiovasc Hematol Agents Med Chem. 2006;4:17-32 pubmed
    ..We are therefore only at the threshold of an exciting new era as we begin to understand the diverse and complex nature of their function. ..
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    Saigusa T, Granger N, Godwin S, Head G. The rostral ventrolateral medulla mediates sympathetic baroreflex responses to intraventricular angiotensin II in rabbits. Auton Neurosci. 2003;107:20-31 pubmed
    ..These studies suggest that the major medullary pressor site of action of Ang II when injected into the hindbrain cerebro-spinal fluid of anaesthetized rabbits is the RVLM where it facilitates baroreflex control of RSNA. ..
  5. Head G, Mihailidou A, Duggan K, Beilin L, Berry N, Brown M, et al. Definition of ambulatory blood pressure targets for diagnosis and treatment of hypertension in relation to clinic blood pressure: prospective cohort study. BMJ. 2010;340:c1104 pubmed publisher
    ..These results provide a framework for the diagnosis and management of hypertension using ambulatory blood pressure values. ..
  6. Jackson K, Marques F, Watson A, Palma Rigo K, Nguyen Huu T, Morris B, et al. A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice. Hypertension. 2013;62:775-81 pubmed publisher
    ..We suggest that renal hyperinnervation and enhanced sympathetically induced renin synthesis mediated by lower micro-RNA-181a contributes to hypertension in BPH/2J mice. ..
  7. Burke S, Lim K, Moretti J, Head G. Comparison of sympathetic nerve activity normalization procedures in conscious rabbits. Am J Physiol Heart Circ Physiol. 2016;310:H1222-32 pubmed publisher
    ..We conclude that the nasopharyngeal reflex is the superior method for normalizing sympathetic recordings in conscious rabbits. ..
  8. Jackson K, Dampney B, Moretti J, Stevenson E, Davern P, Carrive P, et al. Contribution of Orexin to the Neurogenic Hypertension in BPH/2J Mice. Hypertension. 2016;67:959-69 pubmed publisher
    ..The results suggest that enhanced orexinergic signaling contributes to sympathetic overactivity and hypertension during the dark period in BPH/2J mice. ..
  9. Lim K, Jackson K, Sata Y, Head G. Factors Responsible for Obesity-Related Hypertension. Curr Hypertens Rep. 2017;19:53 pubmed publisher
    ..This review describes the evidence to support the contribution of the SNS to obesity related hypertension and the major metabolic and adipokine signals. ..

More Information


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    Head G, Gundlach A, Musgrave I. Recent advances in imidazoline receptor research: ligands--localization and isolation--signaling--functional and clinical studies. J Auton Nerv Syst. 1998;72:74-9 pubmed
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    Head G, Chan C, Burke S. Relationship between imidazoline and alpha2-adrenoceptors involved in the sympatho-inhibitory actions of centrally acting antihypertensive agents. J Auton Nerv Syst. 1998;72:163-9 pubmed
    ..Our hypothesis brings together opposing points of view that the mechanism for hypotension must involve either the imidazoline receptor or the alpha2-adrenoceptor. Clearly both are important...
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    Head G, Burke S. Comparison of renal sympathetic baroreflex effects of rilmenidine and alpha-methylnoradrenaline in the ventrolateral medulla of the rabbit. J Hypertens. 2000;18:1263-76 pubmed
    ..To determine the influence of imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla (RVLM) on the renal sympathetic baroreflex...
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    Head G, Obeyesekere V, Jones M, Simpson E, Krozowski Z. Aromatase-deficient (ArKO) mice have reduced blood pressure and baroreflex sensitivity. Endocrinology. 2004;145:4286-91 pubmed
    ..Thus, aromatase activity is critical for normal autonomic control of the heart and, hence, for reducing the deleterious effects of high BP variability. ..