G A Head

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi request reprint Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine
    C K S Chan
    Neuropharmacology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Neuroscience 132:991-1007. 2005
  2. ncbi request reprint Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording
    Geoffrey A Head
    Baker IDI Heart and Diabetes Institute, Melbourne and Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia
    PLoS ONE 9:e93186. 2014
  3. ncbi request reprint Major contribution of the medial amygdala to hypertension in BPH/2J genetically hypertensive mice
    Kristy L Jackson
    Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Research Institute, 75 Commercial Rd, Melbourne, Vic, 3004, Australia
    Hypertension 63:811-8. 2014
  4. doi request reprint A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice
    Kristy L Jackson
    Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Research Institute, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Hypertension 62:775-81. 2013
  5. doi request reprint Obesity-related hypertension and the role of insulin and leptin in high-fat-fed rabbits
    Kyungjoon Lim
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Hypertension 61:628-34. 2013
  6. doi request reprint Comparison of blood pressure and sympathetic activity of rabbits in their home cage and the laboratory environment
    Kyungjoon Lim
    Department of Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Exp Physiol 97:1263-71. 2012
  7. doi request reprint Rapid onset of renal sympathetic nerve activation in rabbits fed a high-fat diet
    James A Armitage
    Departments of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    Hypertension 60:163-71. 2012
  8. doi request reprint Ambulatory blood pressure monitoring in Australia: 2011 consensus position statement
    Geoffrey A Head
    Baker IDI Heart and Diabetes Institute bSouthern Health, Melbourne, Victoria, Australia
    J Hypertens 30:253-66. 2012
  9. ncbi request reprint Nonsymmetrical double logistic analysis of ambulatory blood pressure recordings
    Geoffrey A Head
    Baker Heart Research Institute, Commercial Road Prahran, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria, 8008, Australia
    J Appl Physiol (1985) 98:1511-8. 2005
  10. ncbi request reprint Renal and cardiac sympathetic baroreflexes in hypertensive rabbits
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 28:972-5. 2001

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine
    C K S Chan
    Neuropharmacology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Neuroscience 132:991-1007. 2005
    ..Furthermore, the noradrenergic innervation may be associated with a 42 kDa imidazoline receptor protein...
  2. ncbi request reprint Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording
    Geoffrey A Head
    Baker IDI Heart and Diabetes Institute, Melbourne and Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia
    PLoS ONE 9:e93186. 2014
    ..We determined clinical predictors of the rate of rise (RoR) in blood pressure in the morning as well as a novel measure of the power of the BP surge (BP(power)) derived from ambulatory blood pressure recordings...
  3. ncbi request reprint Major contribution of the medial amygdala to hypertension in BPH/2J genetically hypertensive mice
    Kristy L Jackson
    Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Research Institute, 75 Commercial Rd, Melbourne, Vic, 3004, Australia
    Hypertension 63:811-8. 2014
    ..001; n=3). These findings indicate that the MeAm provides a tonic contribution to hypertension in BPH/2J mice, which is independent of its role in stress reactivity or circadian BP influences. ..
  4. doi request reprint A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice
    Kristy L Jackson
    Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Research Institute, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Hypertension 62:775-81. 2013
    ..We suggest that renal hyperinnervation and enhanced sympathetically induced renin synthesis mediated by lower micro-RNA-181a contributes to hypertension in BPH/2J mice...
  5. doi request reprint Obesity-related hypertension and the role of insulin and leptin in high-fat-fed rabbits
    Kyungjoon Lim
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Hypertension 61:628-34. 2013
    ..The elevation of blood pressure and RSNA induced by a HFD is predominantly mediated by central actions of leptin. Central actions of insulin contribute a smaller proportion of the hypertension but independently of RSNA...
  6. doi request reprint Comparison of blood pressure and sympathetic activity of rabbits in their home cage and the laboratory environment
    Kyungjoon Lim
    Department of Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Exp Physiol 97:1263-71. 2012
    ..We conclude that while HR is generally lower in the laboratory, a valid representation of MAP and RSNA can be given by laboratory measurements...
  7. doi request reprint Rapid onset of renal sympathetic nerve activation in rabbits fed a high-fat diet
    James A Armitage
    Departments of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    Hypertension 60:163-71. 2012
    ..Increased plasma leptin and insulin may contribute to the initiation of hypertension but are not required for maintenance of mean arterial pressure, which likely lies in alterations in the response of neurons in the hypothalamus...
  8. doi request reprint Ambulatory blood pressure monitoring in Australia: 2011 consensus position statement
    Geoffrey A Head
    Baker IDI Heart and Diabetes Institute bSouthern Health, Melbourne, Victoria, Australia
    J Hypertens 30:253-66. 2012
    ..The objective of this initiative is to provide ABP equivalents for BP cut-points for treatment initiation and targets to be included into guidelines...
  9. ncbi request reprint Nonsymmetrical double logistic analysis of ambulatory blood pressure recordings
    Geoffrey A Head
    Baker Heart Research Institute, Commercial Road Prahran, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria, 8008, Australia
    J Appl Physiol (1985) 98:1511-8. 2005
    ..The ability of the double logistic method to determine the diurnal blood pressure rates of change independently is key to determining new markers for cardiovascular risk...
  10. ncbi request reprint Renal and cardiac sympathetic baroreflexes in hypertensive rabbits
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 28:972-5. 2001
    ....
  11. ncbi request reprint Rate of morning increase in blood pressure is elevated in hypertensives
    Geoffrey A Head
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Am J Hypertens 19:1010-7. 2006
    ....
  12. ncbi request reprint Agmatine and imidazoline systems--fourth international symposium: 9-11 April 2003, San Diego, CA, USA
    Geoffrey A Head
    Baker Heart Research Institute, Central Melbourne, Vic, Australia
    IDrugs 6:544-7. 2003
  13. doi request reprint Understanding the morning rise in blood pressure
    Geoffrey A Head
    Neuropharmacology Laboratory, Baker Heart Research Institute and Monash University Department of Pharmacology, Melbourne, Australia
    Clin Exp Pharmacol Physiol 35:516-21. 2008
    ..7. Antihypertensive drugs and dosing regimes are being developed which may be useful adjuncts to standard therapy for preventing morning hypertension and hopefully also reducing cardiovascular damage or events...
  14. pmc Definition of ambulatory blood pressure targets for diagnosis and treatment of hypertension in relation to clinic blood pressure: prospective cohort study
    Geoffrey A Head
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    BMJ 340:c1104. 2010
    ..We aimed to derive age and sex related ambulatory blood pressure equivalents to clinic blood pressure thresholds for diagnosis and treatment of hypertension...
  15. ncbi request reprint Imidazoline receptors, novel agents and therapeutic potential
    G A Head
    P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Cardiovasc Hematol Agents Med Chem 4:17-32. 2006
    ..We are therefore only at the threshold of an exciting new era as we begin to understand the diverse and complex nature of their function...
  16. doi request reprint A novel measure of the power of the morning blood pressure surge from ambulatory blood pressure recordings
    Geoffrey A Head
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Am J Hypertens 23:1074-81. 2010
    ..We applied this method to determine whether morning BP(Power) is different in hypertensives compared to normotensives, males compared to females or altered by antihypertensive treatment...
  17. ncbi request reprint Non-symmetrical double-logistic analysis of 24-h blood pressure recordings in normotensive and hypertensive rats
    Geoffrey A Head
    Neuropharmacology Laboratory, Baker Heart Research Institute, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria, 8008, Australia
    J Hypertens 22:2075-85. 2004
    ..To determine the suitability of a new logistic curve fitting procedure to measure the diurnal rates of transition from the active to the asleep periods separately...
  18. ncbi request reprint Aromatase-deficient (ArKO) mice have reduced blood pressure and baroreflex sensitivity
    Geoffrey A Head
    Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Endocrinology 145:4286-91. 2004
    ..Thus, aromatase activity is critical for normal autonomic control of the heart and, hence, for reducing the deleterious effects of high BP variability...
  19. ncbi request reprint Are centrally acting imidazoline agents appropriate therapy for renovascular hypertension?
    Geoffrey A Head
    Neuropharmacology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Ann N Y Acad Sci 1009:234-43. 2003
    ..These studies suggest that the contribution of the sympathetic nervous system is greater in 2K1C hypertension and that imidazoline agents may be beneficial in treating renovascular hypertension...
  20. ncbi request reprint Sympathetic responses to stress and rilmenidine in 2K1C rabbits: evidence of enhanced nonvascular effector mechanism
    Geoffrey A Head
    Baker Heart Research Institute, Commercial Road Prahran, St Kilda Road Central, Melbourne, Victoria, 8008, Australia
    Hypertension 43:636-42. 2004
    ..As such, sympathoinhibitory agents such as rilmenidine are very suitable and very effective agents for the treatment of renovascular hypertension...
  21. ncbi request reprint The rostral ventrolateral medulla mediates sympathetic baroreflex responses to intraventricular angiotensin II in rabbits
    Takeshi Saigusa
    Department of Physiology, Faculty of Medicine, University of Yamanashi, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
    Auton Neurosci 107:20-31. 2003
    ..These studies suggest that the major medullary pressor site of action of Ang II when injected into the hindbrain cerebro-spinal fluid of anaesthetized rabbits is the RVLM where it facilitates baroreflex control of RSNA...
  22. ncbi request reprint Involvement of imidazoline receptors in the baroreflex effects of rilmenidine in conscious rabbits
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, PO Box 6492 Melbourne, Victoria 8008, Australia
    J Hypertens 19:1615-24. 2001
    ....
  23. ncbi request reprint Central angiotensin and baroreceptor control of circulation
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, 8008, Australia
    Ann N Y Acad Sci 940:361-79. 2001
    ....
  24. ncbi request reprint Relative importance of medullary brain nuclei for the sympatho-inhibitory actions of rilmenidine in the anaesthetized rabbit
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    J Hypertens 16:503-17. 1998
    ....
  25. ncbi request reprint Relationship between imidazoline and alpha2-adrenoceptors involved in the sympatho-inhibitory actions of centrally acting antihypertensive agents
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    J Auton Nerv Syst 72:163-9. 1998
    ..Our hypothesis brings together opposing points of view that the mechanism for hypotension must involve either the imidazoline receptor or the alpha2-adrenoceptor. Clearly both are important...
  26. ncbi request reprint Central imidazoline- and alpha 2-receptors involved in the cardiovascular actions of centrally acting antihypertensive agents
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    Ann N Y Acad Sci 881:279-86. 1999
    ..In conclusion, our studies suggest that imidazoline receptors and alpha 2-adrenoceptors within the RVLM are important for the antihypertensive actions of clonidine-like drugs...
  27. ncbi request reprint Site and receptors involved in the sympathoinhibitory actions of rilmenidine
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    J Hypertens Suppl 16:S7-12. 1998
    ..The central receptor involved, be it a central imidazoline receptor or an alpha2-adrenoceptor and its location, is less certain...
  28. ncbi request reprint Comparison of renal sympathetic baroreflex effects of rilmenidine and alpha-methylnoradrenaline in the ventrolateral medulla of the rabbit
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    J Hypertens 18:1263-76. 2000
    ..To determine the influence of imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla (RVLM) on the renal sympathetic baroreflex...
  29. ncbi request reprint I1 imidazoline receptors in cardiovascular regulation: the place of rilmenidine
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    Am J Hypertens 13:89S-98S. 2000
    ....
  30. ncbi request reprint Recent advances in imidazoline receptor research: ligands--localization and isolation--signaling--functional and clinical studies
    G A Head
    Baker Medical Research Institute, Prahran, Victoria, Australia
    J Auton Nerv Syst 72:74-9. 1998
    ....
  31. ncbi request reprint Role of brain amine transmitters and some neuromodulators in blood pressure, heart rate, and baroreflex control
    P I Korner
    Baker Medical Research Institute, Melbourne, Australia
    J Cardiovasc Pharmacol 10:S26-32. 1987
    ..This provides one model of the mechanisms by which central peptide transmitters may alter the action of other transmitters...
  32. ncbi request reprint Cardiovascular functions of central noradrenergic neurons in rabbits
    G A Head
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Clin Exp Pharmacol Physiol 18:51-4. 1991
    ..This provides a number of targets for future development of useful pharmacological agents...
  33. ncbi request reprint Cardiovascular role of the major noradrenergic cell groups in the rabbit: analysis based on 6-hydroxydopamine-induced transmitter release
    P I Korner
    Baker Medical Research Institute, Melbourne, Australia
    Brain Res 435:258-72. 1987
    ..We conclude that the various components of the MAP and HR responses are mediated through distinctive NA pathways; the deficits of a given lesion could be due to either to loss of NA cell bodies or of NA fibers of passage...
  34. ncbi request reprint Interaction of the dopamine D2 receptor agonist quinpirole with sympathetic vasomotor tone and the central action of rilmenidine in conscious rabbits
    M van den Buuse
    Neuropharmacology Laboratory, Baker Medical Research Institute, Melbourne, Victoria, Australia
    J Auton Nerv Syst 72:187-94. 1998
    ..However, the previously described apparent desensitisation to the antihypertensive effect of rilmenidine could not be observed in rabbits, suggesting marked species differences in the mechanism and site of action of rilmenidine...
  35. ncbi request reprint Relative importance of rostral ventrolateral medulla in sympathoinhibitory action of rilmenidine in conscious and anesthetized rabbits
    D N Mayorov
    Baker Medical Research Institute, Prahran, Melbourne, Australia
    J Cardiovasc Pharmacol 37:252-61. 2001
    ..A relatively moderate effect of rilmenidine on arterial pressure in conscious, chronically instrumented rabbits may relate to a lower level of sympathetic drive compared with anesthetized animals...
  36. ncbi request reprint Influence of rostral ventrolateral medulla on renal sympathetic baroreflex in conscious rabbits
    D N Mayorov
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Am J Physiol Regul Integr Comp Physiol 280:R577-87. 2001
    ..We conclude that the RVLM plays a key role in circulatory control in conscious rabbits. However, we find no evidence for the role of ANG II receptors in the RVLM in the moment-to-moment regulation of AP and RSNA...
  37. ncbi request reprint Importance of spinal noradrenergic pathways in cardiovascular reflexes and central actions of clonidine and alpha-methyldopa in the rabbit
    J L Elghozi
    Baker Medical Research Institute, Prahran, VIC Australia
    Brain Res 499:39-52. 1989
    ....
  38. ncbi request reprint Effects of central infusion of ANG II and losartan on the cardiac baroreflex in rabbits
    E Gaudet
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Am J Physiol Heart Circ Physiol 278:H558-66. 2000
    ..These data demonstrate a novel long-term modulation of cardiac baroreflexes by endogenous ANG II that is independent of blood pressure level...
  39. pmc Effects of chronic sympatho-inhibition on reflex control of renal blood flow and plasma renin activity in renovascular hypertension
    S L Burke
    Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Br J Pharmacol 159:438-48. 2010
    ....
  40. ncbi request reprint Angiotensin and baroreflex control of the circulation
    G A Head
    Neuropharmacology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Braz J Med Biol Res 35:1047-59. 2002
    ..The sympathoexcitatory AT1 receptors appear to be activated during stress, surgery and anesthesia...
  41. ncbi request reprint Contribution of forebrain noradrenaline innervation to the central circulatory effects of alpha-methyldopa and 6-hydroxydopamine
    M van den Buuse
    Baker Medical Research Institute, Melbourne, Australia
    Brain Res 541:300-8. 1991
    ..In SAD rabbits, almost all the changes to HR are mediated through the cardiac sympathetic and the lesions have little effect on HR...
  42. ncbi request reprint Spinal noradrenergic pathways and pressor responses to central angiotensin II
    J L Elghozi
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Am J Physiol 258:H240-6. 1990
    ..Under normal baroreceptor input the former pressor pathway is completely inhibited. Thus the role of the central renin-angiotensin system may be of greater physiological importance in conditions where the baroreflex is suppressed...
  43. ncbi request reprint Tempol in the dorsomedial hypothalamus attenuates the hypertensive response to stress in rabbits
    Robert De Matteo
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Am J Hypertens 19:396-402. 2006
    ..In the present study, we examined the influence of tempol on the blood pressure (BP) and heart rate (HR) responses to stress in the key region of the hypothalamic defense area, the dorsomedial hypothalamus (DMH)...
  44. ncbi request reprint Renal sympathetic neuroeffector function in renovascular and angiotensin II-dependent hypertension in rabbits
    Sandra L Burke
    Baker Heart Research Institute, Melbourne, Australia
    Hypertension 49:932-8. 2007
    ..This effect appears to be mediated postjunctionally, not through enhanced neural norepinephrine release, and may contribute to the development and/or maintenance of hypertension in these models...
  45. ncbi request reprint Cardiac vagal responsiveness during development in spontaneously hypertensive rats
    N Minami
    Neuropharmacology Laboratory, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Auton Neurosci 82:115-22. 2000
    ..Furthermore, the enhanced vagal bradycardia observed in very young SHR which was due primarily to the earlier establishment of the adult vagal response pattern may indicate accelerated vagal development in this strain compared to WKY...
  46. ncbi request reprint Contribution of imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla to sympathetic baroreflex inhibition by systemic rilmenidine
    Candy K S Chan
    Neuropharmacology Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Hypertens 25:147-55. 2007
    ..To determine whether the hypotensive and sympathetic baroreflex inhibition by rilmenidine administered systemically are mediated via imidazoline receptors in the rostral ventrolateral medulla (RVLM)...
  47. ncbi request reprint Reduced cardiovascular reactivity to stress but not feeding in renin enhancer knockout mice
    Kristy Jackson
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Am J Hypertens 20:893-9. 2007
    ..In this study, we examined whether the renin enhancer deficit alters the acute pressor response to emotional stress in mice...
  48. ncbi request reprint Glutamate receptors in RVLM modulate sympathetic baroreflex in conscious rabbits
    Dmitry N Mayorov
    Baker Heart Research Institute, Melbourne, Victoria 8008, Australia
    Am J Physiol Regul Integr Comp Physiol 284:R511-9. 2003
    ....
  49. ncbi request reprint Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits
    Monique L Parkin
    Neuropharmacology Laboratory, Baker Heart Research Institute, Commercial Road Prahran, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Hypertens 21:167-78. 2003
    ..To determine the involvement of central imidazoline receptors in the cardiovascular actions of the chronically administered antihypertensive agents moxonidine, rilmenidine and clonidine...
  50. doi request reprint Cardiovascular reactivity and neuronal activation to stress in Schlager genetically hypertensive mice
    P J Davern
    Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria, 3004, Australia
    Neuroscience 170:551-8. 2010
    ....
  51. doi request reprint Role of the sympathetic nervous system in Schlager genetically hypertensive mice
    Pamela J Davern
    Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Research Institute, 75 Commercial Road, Melbourne, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 54:852-9. 2009
    ..98). These findings indicate that the hypertension is largely attributable to sympathetic nervous system activity, possibly generated through greater levels of arousal regulated by neurons located in the medial amygdala...
  52. ncbi request reprint Baroreflex control of heart rate and cardiac hypertrophy in angiotensin II-induced hypertension in rabbits
    S C Malpas
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Hypertension 29:1284-90. 1997
    ..Furthermore, although cardiac hypertrophy developed, its presence did not appear to be sufficient to produce a decrease in barosensitivity independent of raised arterial pressure...
  53. doi request reprint Altered responsiveness of the kidney to activation of the renal nerves in fat-fed rabbits
    Sylvia Michaels
    Department of Physiology, Monash University, Melbourne, Victoria 3800, Australia
    Am J Physiol Regul Integr Comp Physiol 296:R1889-96. 2009
    ..Thus, sodium retention in obesity might be driven not only by increased RSNA, but also by increased responsiveness of the kidney to RSNA...
  54. doi request reprint Role of angiotensin II Type 1A receptors in cardiovascular reactivity and neuronal activation after aversive stress in mice
    Pamela J Davern
    Baker IDI Heart and Diabetes Institute, Commercial Rd, Prahran, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 54:1262-8. 2009
    ....
  55. ncbi request reprint Renal responses to acute reflex activation of renal sympathetic nerve activity and renal denervation in secondary hypertension
    Roger G Evans
    Department of Physiology, Monash University, Victoria 3800, Australia
    Am J Physiol Regul Integr Comp Physiol 293:R1247-56. 2007
    ..These findings do not support the hypothesis that enhanced neural control of renal function contributes to maintenance of hypertension associated with activation of the renin-angiotensin system...
  56. doi request reprint Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits
    Larissa J Prior
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Hypertension 55:862-8. 2010
    ..The paradoxical reduction in hypothalamic neuronal activation by leptin suggests a marked "selective leptin resistance" in these animals...
  57. doi request reprint Levels of renal and extrarenal sympathetic drive in angiotensin II-induced hypertension
    Sandra L Burke
    Neuropharmacology Laboratory, Baker Heart Research Institute, Melbourne, Australia
    Hypertension 51:878-83. 2008
    ..The greater depressor effect of acute ganglion blockade in hypertensive rabbits suggests that the sympathetic nervous system exerts increased vasoconstriction in the peripheral vasculature in Ang II-induced hypertension...
  58. ncbi request reprint Angiotensin II in dorsomedial hypothalamus modulates cardiovascular arousal caused by stress but not feeding in rabbits
    Robert De Matteo
    Baker Heart Research Institute, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Am J Physiol Regul Integr Comp Physiol 290:R257-64. 2006
    ..Conversely, angiotensin II, acting via AT1 receptors, may selectively modulate, in the DMH, cardiovascular response to stress, but not feeding...
  59. ncbi request reprint Quinpirole treatment increases renal sympathetic nerve activity and baroreflex gain in conscious rabbits: a spectral study
    M van den Buuse
    Neuropharmacology Laboratory, Baker Medical Research Institute, Commercial Road, Prahran, Melbourne, Australia
    Eur J Pharmacol 388:85-8. 2000
    ..7-fold). These results show that administration of the dopamine D(2)/D(3) receptor agonist quinpirole causes profound and long-lasting changes in the central integration of the sympathetic baroreceptor-vasomotor reflex...
  60. doi request reprint Enhanced responses to ganglion blockade do not reflect sympathetic nervous system contribution to angiotensin II-induced hypertension
    John Luis Moretti
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Hypertens 27:1838-48. 2009
    ....
  61. doi request reprint Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile
    Ngan N Huynh
    Vascular Pharmacology, Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Rd Central, Victoria, 8008 Australia
    Hypertension 54:294-301. 2009
    ..In conclusion, our data suggest that global loss of arginase II activity results in hypertension. We suggest that this strain of mouse warrants further investigation as a potentially novel model of hypertension...
  62. ncbi request reprint Impaired central stress-induced release of noradrenaline in rats with heart failure: a microdialysis study
    A M Arabia
    Inflammation and Nervous System Disease Laboratory, Istituto di Ricerche Farmacologiche Mario Negri, Milan 20157, Italy
    Neuroscience 114:591-9. 2002
    ..We have shown that heart failure causes an impairment of the central noradrenergic system's response to acute sympatho-excitation but does not affect the hypothalamo-pituitary-adrenocortical response...
  63. doi request reprint New approaches to quantifying sympathetic nerve activity
    Sandra L Burke
    Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Curr Hypertens Rep 13:249-57. 2011
    ..These have led to a better understanding of sympathoactivation in hypertension and its underlying mechanisms...
  64. doi request reprint Cardiovascular responses to aversive and nonaversive stressors in Schlager genetically hypertensive mice
    Pamela J Davern
    Baker IDI Heart and Diabetes Research Institute, Melbourne, Australia
    Am J Hypertens 23:838-44. 2010
    ..Therefore, in the present study, we hypothesize that an increased contribution of the SNS in BPH/2J mice may culminate in a greater pressor response to stressful stimuli in these hypertensive mice than normotensive (BPN/3J) mice...
  65. doi request reprint Angiotensin II and neurohumoral control of the renal medullary circulation
    Roger G Evans
    Department of Physiology, Monash University, Victoria, Australia
    Clin Exp Pharmacol Physiol 37:e58-69. 2010
    ....
  66. ncbi request reprint AT1 receptors in the RVLM mediate pressor responses to emotional stress in rabbits
    Dmitry N Mayorov
    Baker Heart Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Hypertension 41:1168-73. 2003
    ..These results suggest that AT1 receptors in the RVLM are important in mediating the pressor effects of emotional stress in conscious rabbits...
  67. ncbi request reprint Tempol attenuates excitatory actions of angiotensin II in the rostral ventrolateral medulla during emotional stress
    Dmitry N Mayorov
    Baker Heart Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Hypertension 44:101-6. 2004
    ..Together with our previous studies, these results also indicate that superoxide is a key mediator of excitatory actions of angiotensin II in RVLM during acute stress...
  68. ncbi request reprint Endothelial dysfunction and arterial pressure regulation during early diabetes in mice: roles for nitric oxide and endothelium-derived hyperpolarizing factor
    Sharyn M Fitzgerald
    Department of Physiology, Monash University, Victoria 3800, Australia
    Am J Physiol Regul Integr Comp Physiol 293:R707-13. 2007
    ..Thus, prior inhibition of NOS results in endothelial dysfunction in early diabetes, since the diabetes-induced reduction in EDHF function cannot be compensated by increases in NO production...
  69. ncbi request reprint Fos-related antigen immunoreactivity after acute and chronic angiotensin II-induced hypertension in the rabbit brain
    Pamela J Davern
    Neuropharmacology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertension 49:1170-7. 2007
    ..These findings suggest that there is desensitization of circumventricular organs but sensitization of neurons in hypothalamic regions to long-term angiotensin II infusion...
  70. doi request reprint Blood pressure reactivity to emotional stress is reduced in AT1A-receptor knockout mice on normal, but not high salt intake
    Daian Chen
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertens Res 32:559-64. 2009
    ..HSD can selectively reinforce the cardiovascular response to negative stress in AT(1A)(-/-) mice. However, there is little interaction between AT(1A) receptors, excess dietary sodium and feeding-induced cardiovascular arousal...
  71. ncbi request reprint Ionotropic glutamate receptors in the rostral ventrolateral medulla mediate sympathetic responses to acute stress in conscious rabbits
    Dmitry N Mayorov
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Auton Neurosci 98:20-3. 2002
    ..The EAA receptors are critically important in initiating the pressor and sympathoexcitatory responses to acute emotional stress, but play relatively little role in the maintenance of these responses...
  72. doi request reprint The morning blood pressure surge is related to serum cholesterol
    C A Martin
    Monash University, Clayton, Victoria, Australia
    J Hum Hypertens 27:315-20. 2013
    ..The novel finding of a significant relationship between measures of MBPS and LDL-cholesterol is an intriguing link between two major cardiovascular risk factors...
  73. ncbi request reprint Central monoamine neurons and cardiovascular control
    G A Head
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Kidney Int Suppl 37:S8-13. 1992
    ..By activating this forebrain pathway methyldopa minimises the baroreflex compensation that might normally be expected following a reduction in blood pressure...
  74. doi request reprint The day-night difference of blood pressure is increased in AT(1A)-receptor knockout mice on a high-sodium diet
    Daian Chen
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Am J Hypertens 23:481-7. 2010
    ..In this study, we examined the influence of angiotensin AT(1A) receptors on circadian BP variation, and specifically on its behavioral activity-related and -unrelated components...
  75. doi request reprint Development of cardiovascular disease due to renal insufficiency in male sheep following fetal unilateral nephrectomy
    Reetu R Singh
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    J Hypertens 27:386-96. 2009
    ..Renal insufficiency is associated with the development of cardiovascular disease...
  76. ncbi request reprint Method for in vivo calibration of renal sympathetic nerve activity in rabbits
    Sandra L Burke
    Neuropharmacology Laboratory, Baker Heart Research Institute, Commercial Road Prahran, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Neurosci Methods 127:63-74. 2003
    ....
  77. doi request reprint Endothelial cationic amino acid transporter-1 overexpression can prevent oxidative stress and increases in arterial pressure in response to superoxide dismutase inhibition in mice
    G Konstantinidis
    Baker IDI Heart and Diabetes Institute, Melbourne, Vic, Australia Department of Physiology, Monash University, Melbourne, Vic, Australia
    Acta Physiol (Oxf) 210:845-53. 2014
    ..The aim of our study is to examine whether increased expression of the predominant endothelial l-arginine transporter, cationic amino acid transporter-1 (CAT1), can prevent oxidative stress-induced hypertension...
  78. doi request reprint Genetic Ace2 deficiency accentuates vascular inflammation and atherosclerosis in the ApoE knockout mouse
    Merlin C Thomas
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Circ Res 107:888-97. 2010
    ..Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7...
  79. pmc Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation
    Lynette Pretorius
    Baker IDI Heart and Diabetes Institute, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Am J Pathol 175:998-1009. 2009
    ..Finally, in atrial appendages from patients with AF, PI3K activation was lower compared with tissue from patients in sinus rhythm. These results suggest a link between PI3K(p110alpha) and AF...
  80. ncbi request reprint A real-time algorithm for the quantification of blood pressure waveforms
    Michael A Navakatikyan
    Department of Physiology, University of Auckland, New Zealand
    IEEE Trans Biomed Eng 49:662-70. 2002
    ..The algorithm proved to be superior against three commercially available heartbeat detectors yielding an error rate of 0.09%...
  81. ncbi request reprint Spontaneous baroreflex sensitivity: towards an ideal index of cardiovascular risk
    Geoffrey A Head
    J Hypertens 20:829-31. 2002
  82. ncbi request reprint Sympathetic modulation of renal blood flow by rilmenidine and captopril: central vs. peripheral effects
    Ben J A Janssen
    Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, 6200 MD Maastricht, The Netherlands
    Am J Physiol Renal Physiol 282:F113-23. 2002
    ..In contrast, the renal vasodilator effect of captopril is not modulated by ongoing RSNA and is associated with impairment of autoregulation of RBF...
  83. ncbi request reprint Renin enhancer is critical for control of renin gene expression and cardiovascular function
    David J Adams
    School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia
    J Biol Chem 281:31753-61. 2006
    ..In conclusion, the renin enhancer is critical for renin gene expression and physiological sequelae, including response to alteration in salt intake. The REKO mouse may be useful as a low renin expression model...
  84. ncbi request reprint Therapeutic effects of evening administration of guanabenz and clonidine on morning hypertension
    Geoffrey A Head
    J Hypertens 21:701-3. 2003
  85. ncbi request reprint The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade
    Geoffrey A Head
    J Hypertens 21:1619-21. 2003