Research Topics
Genomes and Genes | Xiao Ming GaoSummaryAffiliation: Baker Heart Research Institute Country: Australia Publications
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Publications
Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosisXiao Ming Gao
Experimental Cardiology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
J Hypertens 24:1663-70. 2006..The mammalian target of rapamycin, mTOR, is known to play a critical role in determining cell and organ size. We investigated whether mTOR inhibition can inhibit the chronic pressure-overload-induced LVH and fibrosis...- Transgenic alpha1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survivalXiao Jun Du
Experimental Cardiology Laboratory, Baker Heart Research Institute, and Alfred Heart Centre, Alfred Hospital, Melbourne, Australia
Cardiovasc Res 71:735-43. 2006..We tested the hypothesis that this enhanced inotropy protects against dysfunction and remodeling after myocardial infarction (MI)... - Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosisQi Xu
Baker Heart Research Institute, Melbourne, Vic, Australia
Endocrinology 149:476-82. 2008..Thus, although up-regulated in its expression, endogenous relaxin had no significant effect on the progression of cardiac maladaptation and dysfunction in the setting of chronic pressure overload... 
Infarct size and post-infarct inflammation determine the risk of cardiac rupture in miceXiao Ming Gao
Experimental Cardiology Laboratory, Baker IDI Heart Diabetes Institute, and Alfred Heart Centre, The Alfred Hospital, Monash University, 75 Commercial Road, Prahran, Melbourne, Victoria 3004, Australia
Int J Cardiol 143:20-8. 2010..Infarct size (IS) is a determinant of pathophysiological events after myocardial infarction (MI), but its relation to the risk of cardiac rupture remains undefined...- Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpressionXiao Ming Gao
Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, Victoria 8008, Australia
Endocrinology 144:4097-105. 2003..TG males showed benefit from orchiectomy, suggesting a contribution by testicular hormones to the progression of the cardiomyopathic phenotype... - Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotypeXiao Jun Du
Experimental Cardiology Laboratory, Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
Cardiovasc Res 57:395-404. 2003..To investigate cardiac phenotypes in mice deficient in the peptide hormone relaxin by gene targeting... - Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunctionXiao Jun Du
Baker Heart Research Institute, Commercial Road, Victoria 3004, Melbourne, Australia
J Mol Cell Cardiol 37:979-87. 2004.... - Lower risk of postinfarct rupture in mouse heart overexpressing beta 2-adrenergic receptors: importance of collagen contentXiao Ming Gao
Baker Medical Research Institute, Melbourne, Victoria, Australia
J Cardiovasc Pharmacol 40:632-40. 2002.... - Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarctionYang Liu
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
Arterioscler Thromb Vasc Biol 31:834-41. 2011..The goal of this study was to investigate the role of platelets in systemic and cardiac inflammatory responses and the development of postinfarct ventricular complications, as well as the efficacy of antiplatelet interventions... - Relaxin remodels fibrotic healing following myocardial infarctionChrishan S Samuel
Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
Lab Invest 91:675-90. 2011.... - Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarctionLu Fang
Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, Australia
J Mol Cell Cardiol 43:535-44. 2007..Our study illustrates the breakdown of fibril collagen as a central mechanism of cardiac rupture... 
Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient miceXiao Jun Du
Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
Mol Cell Biol 22:2821-9. 2002..The data demonstrate that high S100A1 protein levels are essential for the cardiac reserve and adaptation to acute and chronic hemodynamic stress in vivo...- Down-regulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivoLu Fang
Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, Australia
Life Sci 80:2154-60. 2007..Further study is required to examine the causal relationship between Mfn2 and cardiac hypertrophy... - I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activitiesXiao Jun Du
Experimental Cardiology Laboratory, Baker Heart Research Institute, Commercial Road, Melbourne, Victoria 3004, Australia
Br J Pharmacol 142:107-12. 2004..This specific HR-reducing action of ivabradine is well preserved under conditions that are associated with significant activation of the sympathoadrenergic system... - Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBFYves Brandenburger
Molecular Cardiology, Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Vic, 8008, Australia
FEBS Lett 548:79-84. 2003..5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice... - Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammationXiao Ming Gao
Baker IDI Heart and Diabetes Institute, Melbourne, Australia
J Mol Cell Cardiol 50:991-9. 2011..We have identified a critical role of MIF in mediating severe I/R injury. Thus, MIF inhibitory therapy may be a novel strategy to protect the heart against severe I/R injury... - Preserved left ventricular structure and function in mice with cardiac sympathetic hyperinnervationHelen Kiriazis
Experimental Cardiology Laboratory, Baker Heart Research Institute, P O Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia
Am J Physiol Heart Circ Physiol 289:H1359-65. 2005..In conclusion, overexpression of NGF in heart leads to sympathetic hyperinnervation that is not associated with detrimental effects on LV performance and is likely due to concomitantly enhanced norepinephrine neuronal uptake... - Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytesXiao Lei Moore
Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
Endocrinology 148:1582-9. 2007..In conclusion, these results extend our current knowledge of the cardiac actions of relaxin by demonstrating that H2-relaxin indirectly inhibits CM hypertrophy and directly protects CM from apoptosis... - Post-infarct cardiac rupture: recent insights on pathogenesis and therapeutic interventionsXiao Ming Gao
Experimental Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
Pharmacol Ther 134:156-79. 2012..Studies using the mouse model have also identified novel molecular mechanisms and therapeutic targets as well as suitable interventional regimens providing useful clues for clinical translation... - Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarctionLu Fang
Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, VIC 3004, Australia
Clin Sci (Lond) 115:99-106. 2008..We conclude that a higher collagen level is associated with facilitated fibrotic healing of an infarct and preserves the tensile strength of infarcted myocardium, thereby preventing cardiac rupture and acute ventricular remodelling... - Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarctionXiao Jun Du
Baker IDI Heart and Diabetes Institute, St Kilda Road Central, Melbourne, Victoria 8008, Australia
Thromb Haemost 105:356-64. 2011..IMT could be either triggered by a wall tear or act as initiator of rupture. IMT may propagate towards the ventricular chamber to trigger LVT... - Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activitiesLisa Chang
Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
Epigenetics 6:760-8. 2011..We hypothesize that cardiac hypertrophy and the fetal gene expression program are associated with distinguishable binding of Brm and Brg1 on genes present in distinct complexes, suggesting possible independent-regulatory roles... - Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansionWilliam Chan
Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia
JACC Cardiovasc Imaging 5:884-93. 2012..This prospective study aimed to assess regional and temporal patterns of extracellular matrix (ECM) changes post-myocardial infarction (MI)... - Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart functionBianca C Bernardo
Baker IDI Heart and Diabetes Institute, Melbourne, VIC 8008, Australia
Proc Natl Acad Sci U S A 109:17615-20. 2012..Furthermore, these data underscore the utility of seed-targeting 8-mer LNA-antimiRs in the development of new therapeutic approaches for pharmacologic inhibition of disease-implicated miRNA seed families... - Reversal of cardiac fibrosis and related dysfunction by relaxinXiao Jun Du
Experimental Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, University of Melbourne, Melbourne, Australia
Ann N Y Acad Sci 1160:278-84. 2009..Future research needs to explore functional improvement following fibrosis reversal by relaxin and the usefulness of relaxin in antiarrhythmic or stem cell-based therapy... - Age-related differences in postinfarct left ventricular rupture and remodelingYining Yang
Cardiovascular Research Institute, Xinjiang Medical University, Xinjinag, China
Am J Physiol Heart Circ Physiol 294:H1815-22. 2008.... - Regression of pressure overload-induced left ventricular hypertrophy in miceXiao-Ming Gao
Baker Heart Research Institute, PO Box 6492, St. Kilda Rd. Central, Melbourne, Victoria 8008, Australia
Am J Physiol Heart Circ Physiol 288:H2702-7. 2005..In conclusion, LVH regression comprises a variety of morphological, functional, and genetic components that show distinct time courses. A longer period of pressure overload is associated with a slower rate of LVH regression... - Immunopotentiating effect of a 'Yang'-promoting formula of traditional Chinese medicine on aged female BALB/c miceLing Zhang
Department of Immunology, Peking University Health Science Center, Beijing, China
Phytother Res 18:857-61. 2004..These results have important implications for our understanding of the mechanisms of the immunoboosting effect of TCM... - Immune receptors for polysaccharides from Ganoderma lucidumBao-Mei Shao
Department of Immunology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
Biochem Biophys Res Commun 323:133-41. 2004..Our results may have important implications for our understanding on the molecular mechanisms of immunopotentiating polysaccharides from traditional Chinese medicine... - Assessment of cardiac function by echocardiography in conscious and anesthetized mice: importance of the autonomic nervous system and disease stateTze Ping Tan
Experimental Cardiology Laboratory, Baker Heart Research Institute, St. Kilda Road Centrral, Melbourne, Victoria 8008, Australia
J Cardiovasc Pharmacol 42:182-90. 2003..The results indicate that the autonomic nervous system plays a critical role in the observed differences in cardiac structure and function between anesthetized and conscious mice... - Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cellsXiao-yu Zhang
Department of Immunology, Peking University Health Science Center, Peking University, Beijing, China
Immunology 108:465-73. 2003..Implications of this observation for our understanding of the immunoregulation and peripheral tolerance are discussed... - Mouse model of post-infarct ventricular rupture: time course, strain- and gender-dependency, tensile strength, and histopathologyXiao-Ming Gao
Experimental Cardiology Laboratory, Wynn Domain, Baker Medical Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Commercial Road, P.O. Box 6492, Melbourne, Victoria 3004, Australia
Cardiovasc Res 65:469-77. 2005..Infarct expansion, regional hemorrhage with formation of hematoma and leuocyte accumulation are important pathological changes leading to reduced myocardial tensile strength... - Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirusJincun Zhao
Department of Immunology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, China
J Virol 81:6079-88. 2007..These data provide useful insights regarding immunity against SARS-CoV and have the potential to help guide the design of peptide-based vaccines...