Xiao Ming Gao

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. doi request reprint Infarct size and post-infarct inflammation determine the risk of cardiac rupture in mice
    Xiao Ming Gao
    Experimental Cardiology Laboratory, Baker IDI Heart Diabetes Institute, and Alfred Heart Centre, The Alfred Hospital, Monash University, 75 Commercial Road, Prahran, Melbourne, Victoria 3004, Australia
    Int J Cardiol 143:20-8. 2010
  2. ncbi request reprint Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis
    Xiao Ming Gao
    Experimental Cardiology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 24:1663-70. 2006
  3. ncbi request reprint Transgenic alpha1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival
    Xiao Jun Du
    Experimental Cardiology Laboratory, Baker Heart Research Institute, and Alfred Heart Centre, Alfred Hospital, Melbourne, Australia
    Cardiovasc Res 71:735-43. 2006
  4. ncbi request reprint Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis
    Qi Xu
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Endocrinology 149:476-82. 2008
  5. ncbi request reprint Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression
    Xiao Ming Gao
    Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, Victoria 8008, Australia
    Endocrinology 144:4097-105. 2003
  6. ncbi request reprint Regression of pressure overload-induced left ventricular hypertrophy in mice
    Xiao Ming Gao
    Baker Heart Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Am J Physiol Heart Circ Physiol 288:H2702-7. 2005
  7. ncbi request reprint Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype
    Xiao Jun Du
    Experimental Cardiology Laboratory, Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    Cardiovasc Res 57:395-404. 2003
  8. ncbi request reprint Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction
    Xiao Jun Du
    Baker Heart Research Institute, Commercial Road, Victoria 3004, Melbourne, Australia
    J Mol Cell Cardiol 37:979-87. 2004
  9. doi request reprint Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction
    Yang Liu
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 31:834-41. 2011
  10. ncbi request reprint Lower risk of postinfarct rupture in mouse heart overexpressing beta 2-adrenergic receptors: importance of collagen content
    Xiao Ming Gao
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    J Cardiovasc Pharmacol 40:632-40. 2002

Collaborators

Detail Information

Publications34

  1. doi request reprint Infarct size and post-infarct inflammation determine the risk of cardiac rupture in mice
    Xiao Ming Gao
    Experimental Cardiology Laboratory, Baker IDI Heart Diabetes Institute, and Alfred Heart Centre, The Alfred Hospital, Monash University, 75 Commercial Road, Prahran, Melbourne, Victoria 3004, Australia
    Int J Cardiol 143:20-8. 2010
    ..Infarct size (IS) is a determinant of pathophysiological events after myocardial infarction (MI), but its relation to the risk of cardiac rupture remains undefined...
  2. ncbi request reprint Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis
    Xiao Ming Gao
    Experimental Cardiology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 24:1663-70. 2006
    ..The mammalian target of rapamycin, mTOR, is known to play a critical role in determining cell and organ size. We investigated whether mTOR inhibition can inhibit the chronic pressure-overload-induced LVH and fibrosis...
  3. ncbi request reprint Transgenic alpha1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival
    Xiao Jun Du
    Experimental Cardiology Laboratory, Baker Heart Research Institute, and Alfred Heart Centre, Alfred Hospital, Melbourne, Australia
    Cardiovasc Res 71:735-43. 2006
    ..We tested the hypothesis that this enhanced inotropy protects against dysfunction and remodeling after myocardial infarction (MI)...
  4. ncbi request reprint Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis
    Qi Xu
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Endocrinology 149:476-82. 2008
    ..Thus, although up-regulated in its expression, endogenous relaxin had no significant effect on the progression of cardiac maladaptation and dysfunction in the setting of chronic pressure overload...
  5. ncbi request reprint Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression
    Xiao Ming Gao
    Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, Victoria 8008, Australia
    Endocrinology 144:4097-105. 2003
    ..TG males showed benefit from orchiectomy, suggesting a contribution by testicular hormones to the progression of the cardiomyopathic phenotype...
  6. ncbi request reprint Regression of pressure overload-induced left ventricular hypertrophy in mice
    Xiao Ming Gao
    Baker Heart Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Am J Physiol Heart Circ Physiol 288:H2702-7. 2005
    ..In conclusion, LVH regression comprises a variety of morphological, functional, and genetic components that show distinct time courses. A longer period of pressure overload is associated with a slower rate of LVH regression...
  7. ncbi request reprint Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype
    Xiao Jun Du
    Experimental Cardiology Laboratory, Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    Cardiovasc Res 57:395-404. 2003
    ..To investigate cardiac phenotypes in mice deficient in the peptide hormone relaxin by gene targeting...
  8. ncbi request reprint Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction
    Xiao Jun Du
    Baker Heart Research Institute, Commercial Road, Victoria 3004, Melbourne, Australia
    J Mol Cell Cardiol 37:979-87. 2004
    ....
  9. doi request reprint Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction
    Yang Liu
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 31:834-41. 2011
    ..The goal of this study was to investigate the role of platelets in systemic and cardiac inflammatory responses and the development of postinfarct ventricular complications, as well as the efficacy of antiplatelet interventions...
  10. ncbi request reprint Lower risk of postinfarct rupture in mouse heart overexpressing beta 2-adrenergic receptors: importance of collagen content
    Xiao Ming Gao
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    J Cardiovasc Pharmacol 40:632-40. 2002
    ....
  11. ncbi request reprint Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction
    Lu Fang
    Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, Australia
    J Mol Cell Cardiol 43:535-44. 2007
    ..Our study illustrates the breakdown of fibril collagen as a central mechanism of cardiac rupture...
  12. doi request reprint Relaxin remodels fibrotic healing following myocardial infarction
    Chrishan S Samuel
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    Lab Invest 91:675-90. 2011
    ....
  13. pmc Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice
    Xiao Jun Du
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Mol Cell Biol 22:2821-9. 2002
    ..The data demonstrate that high S100A1 protein levels are essential for the cardiac reserve and adaptation to acute and chronic hemodynamic stress in vivo...
  14. doi request reprint Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansion
    William Chan
    Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    JACC Cardiovasc Imaging 5:884-93. 2012
    ..This prospective study aimed to assess regional and temporal patterns of extracellular matrix (ECM) changes post-myocardial infarction (MI)...
  15. doi request reprint Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation
    Xiao Ming Gao
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Mol Cell Cardiol 50:991-9. 2011
    ..We have identified a critical role of MIF in mediating severe I/R injury. Thus, MIF inhibitory therapy may be a novel strategy to protect the heart against severe I/R injury...
  16. pmc I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities
    Xiao Jun Du
    Experimental Cardiology Laboratory, Baker Heart Research Institute, Commercial Road, Melbourne, Victoria 3004, Australia
    Br J Pharmacol 142:107-12. 2004
    ..This specific HR-reducing action of ivabradine is well preserved under conditions that are associated with significant activation of the sympathoadrenergic system...
  17. ncbi request reprint Assessment of cardiac function by echocardiography in conscious and anesthetized mice: importance of the autonomic nervous system and disease state
    Tze Ping Tan
    Experimental Cardiology Laboratory, Baker Heart Research Institute, St Kilda Road Centrral, Melbourne, Victoria 8008, Australia
    J Cardiovasc Pharmacol 42:182-90. 2003
    ..The results indicate that the autonomic nervous system plays a critical role in the observed differences in cardiac structure and function between anesthetized and conscious mice...
  18. ncbi request reprint Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF
    Yves Brandenburger
    Molecular Cardiology, Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Vic, 8008, Australia
    FEBS Lett 548:79-84. 2003
    ..5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice...
  19. ncbi request reprint Down-regulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivo
    Lu Fang
    Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, Australia
    Life Sci 80:2154-60. 2007
    ..Further study is required to examine the causal relationship between Mfn2 and cardiac hypertrophy...
  20. doi request reprint Reversal of cardiac fibrosis and related dysfunction by relaxin
    Xiao Jun Du
    Experimental Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, University of Melbourne, Melbourne, Australia
    Ann N Y Acad Sci 1160:278-84. 2009
    ..Future research needs to explore functional improvement following fibrosis reversal by relaxin and the usefulness of relaxin in antiarrhythmic or stem cell-based therapy...
  21. ncbi request reprint Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes
    Xiao Lei Moore
    Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Endocrinology 148:1582-9. 2007
    ..In conclusion, these results extend our current knowledge of the cardiac actions of relaxin by demonstrating that H2-relaxin indirectly inhibits CM hypertrophy and directly protects CM from apoptosis...
  22. ncbi request reprint Preserved left ventricular structure and function in mice with cardiac sympathetic hyperinnervation
    Helen Kiriazis
    Experimental Cardiology Laboratory, Baker Heart Research Institute, P O Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Am J Physiol Heart Circ Physiol 289:H1359-65. 2005
    ..In conclusion, overexpression of NGF in heart leads to sympathetic hyperinnervation that is not associated with detrimental effects on LV performance and is likely due to concomitantly enhanced norepinephrine neuronal uptake...
  23. doi request reprint Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction
    Lu Fang
    Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, VIC 3004, Australia
    Clin Sci (Lond) 115:99-106. 2008
    ..We conclude that a higher collagen level is associated with facilitated fibrotic healing of an infarct and preserves the tensile strength of infarcted myocardium, thereby preventing cardiac rupture and acute ventricular remodelling...
  24. doi request reprint Chronic activation of the low affinity site of β1 -adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling
    Helen Kiriazis
    Experimental Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Vic, Australia
    Br J Pharmacol 170:352-65. 2013
    ..Hence, it is important to determine the potential significance of β1L -adrenoceptors in vivo, particularly in pathological situations...
  25. doi request reprint Post-infarct cardiac rupture: recent insights on pathogenesis and therapeutic interventions
    Xiao Ming Gao
    Experimental Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Pharmacol Ther 134:156-79. 2012
    ..Studies using the mouse model have also identified novel molecular mechanisms and therapeutic targets as well as suitable interventional regimens providing useful clues for clinical translation...
  26. doi request reprint Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction
    Xiao Jun Du
    Baker IDI Heart and Diabetes Institute, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Thromb Haemost 105:356-64. 2011
    ..IMT could be either triggered by a wall tear or act as initiator of rupture. IMT may propagate towards the ventricular chamber to trigger LVT...
  27. ncbi request reprint Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities
    Lisa Chang
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Epigenetics 6:760-8. 2011
    ..We hypothesize that cardiac hypertrophy and the fetal gene expression program are associated with distinguishable binding of Brm and Brg1 on genes present in distinct complexes, suggesting possible independent-regulatory roles...
  28. pmc Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
    Bianca C Bernardo
    Baker IDI Heart and Diabetes Institute, Melbourne, VIC 8008, Australia
    Proc Natl Acad Sci U S A 109:17615-20. 2012
    ..Furthermore, these data underscore the utility of seed-targeting 8-mer LNA-antimiRs in the development of new therapeutic approaches for pharmacologic inhibition of disease-implicated miRNA seed families...
  29. ncbi request reprint Mouse model of post-infarct ventricular rupture: time course, strain- and gender-dependency, tensile strength, and histopathology
    Xiao Ming Gao
    Experimental Cardiology Laboratory, Wynn Domain, Baker Medical Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Commercial Road, P O Box 6492, Melbourne, Victoria 3004, Australia
    Cardiovasc Res 65:469-77. 2005
    ..We have examined the natural history, histopathology and myocardial mechanical strength in mice with AMI...
  30. doi request reprint Age-related differences in postinfarct left ventricular rupture and remodeling
    Yining Yang
    Cardiovascular Research Institute, Xinjiang Medical University, Xinjinag, China
    Am J Physiol Heart Circ Physiol 294:H1815-22. 2008
    ....
  31. pmc Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells
    Xiao Yu Zhang
    Department of Immunology, Peking University Health Science Center, Peking University, Beijing, China
    Immunology 108:465-73. 2003
    ..Implications of this observation for our understanding of the immunoregulation and peripheral tolerance are discussed...
  32. ncbi request reprint Immune receptors for polysaccharides from Ganoderma lucidum
    Bao Mei Shao
    Department of Immunology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    Biochem Biophys Res Commun 323:133-41. 2004
    ..Our results may have important implications for our understanding on the molecular mechanisms of immunopotentiating polysaccharides from traditional Chinese medicine...
  33. ncbi request reprint Immunopotentiating effect of a 'Yang'-promoting formula of traditional Chinese medicine on aged female BALB/c mice
    Ling Zhang
    Department of Immunology, Peking University Health Science Center, Beijing, China
    Phytother Res 18:857-61. 2004
    ..These results have important implications for our understanding of the mechanisms of the immunoboosting effect of TCM...
  34. pmc Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus
    Jincun Zhao
    Department of Immunology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, China
    J Virol 81:6079-88. 2007
    ..These data provide useful insights regarding immunity against SARS-CoV and have the potential to help guide the design of peptide-based vaccines...