J W Funder

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi request reprint Aldosterone and mineralocorticoid receptors: orphan questions
    J W Funder
    Baker Medical Research Institute, Melbourne, Australia
    Kidney Int 57:1358-63. 2000
  2. ncbi request reprint Aldosterone action: fact, failure and the future
    J W Funder
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Clin Exp Pharmacol Physiol Suppl 25:S47-50. 1998
  3. ncbi request reprint cAMP modulates glucocorticoid-induced protein accumulation and glucocorticoid receptor in cardiomyocytes
    A Sato
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Am J Physiol 271:E827-33. 1996
  4. ncbi request reprint Serum 5-androstene-3 beta,17 beta-diol sulphate, sex hormone binding globulin and free androgen index in girls with premature adrenarche
    J Montalto
    Department of Clinical Biochemistry, Royal Children s Hospital, Melbourne, Australia
    J Steroid Biochem 33:1149-54. 1989
  5. ncbi request reprint Rapid and specific lowering of pituitary FSH beta mRNA levels by inhibin
    J E Mercer
    Medical Research Centre, Prince Henry s Hospital, Melbourne, Australia
    Mol Cell Endocrinol 53:251-4. 1987
  6. ncbi request reprint Experimental cardiac fibrosis: differential time course of responses to mineralocorticoid-salt administration
    G Fujisawa
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Endocrinology 142:3625-31. 2001
  7. ncbi request reprint The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action
    A Bhargava
    Baker Medical Research Institute, Melbourne 8008, Australia
    Endocrinology 142:1587-94. 2001
  8. ncbi request reprint The forced swimming test: effects of glucose administration on the response to food deprivation and adrenalectomy
    D Jefferys
    Baker Medical Research Institute, Prahran, Australia
    Eur J Pharmacol 205:267-9. 1991
  9. ncbi request reprint Luteinizing hormone-beta mRNA levels are regulated primarily by gonadotropin-releasing hormone and not by negative estrogen feedback on the pituitary
    J E Mercer
    Medical Research Centre, Prince Henry s Hospital, Melbourne, Australia
    Neuroendocrinology 47:563-6. 1988
  10. ncbi request reprint Non-genomic actions of aldosterone: role in hypertension
    J W Funder
    Baker Medical Research Institute, Melbourne, Australia
    Curr Opin Nephrol Hypertens 10:227-30. 2001

Collaborators

  • I J Clarke
  • H Li
  • K E Sheppard
  • A I Smith
  • D I Godfrey
  • Y Cao
  • P Ferrari
  • CEDRIC HOWARD SHACKLETON
  • R Smith
  • T J Cole
  • M J Fullerton
  • A Bhargava
  • M J Young
  • G Fujisawa
  • Z Yang
  • K Myles
  • Z S Krozowski
  • R C Wilson
  • S Dave-Sharma
  • J Q Wei
  • M I New
  • M D Harbison
  • K Sudhir
  • K X Li
  • A Sato
  • T M Purdy
  • J P Liu
  • P S Brereton
  • C D Clyne
  • N M Solomon
  • R Dilley
  • J F Purton
  • B H Toh
  • Z Chai
  • D Pearce
  • A Fattah
  • C De Santis
  • R Newfield
  • A Moran
  • H L Bradlow
  • M R Azar
  • J W Balfe
  • J Hertecant
  • R E Neiberger
  • D Daneman
  • H I Akkurt
  • G L Jennings
  • D E Jefferys
  • P A Komesaroff
  • M Razzaghy-Azar
  • V R Obeyesekere
  • K Li
  • J E Mercer
  • J A Clements
  • J Montalto
  • G F Christian
  • J F Connelly
  • A B Yong
  • D Jefferys
  • H Y How
  • J Jamison
  • B A Matheson
  • B Alder
  • R J MacDonald
  • G J Stanton
  • M Fullerton
  • D Sissons
  • H E Davies

Detail Information

Publications25

  1. ncbi request reprint Aldosterone and mineralocorticoid receptors: orphan questions
    J W Funder
    Baker Medical Research Institute, Melbourne, Australia
    Kidney Int 57:1358-63. 2000
    ....
  2. ncbi request reprint Aldosterone action: fact, failure and the future
    J W Funder
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Clin Exp Pharmacol Physiol Suppl 25:S47-50. 1998
    ..4. Possible avenues for consideration of the last two of these questions are briefly proposed...
  3. ncbi request reprint cAMP modulates glucocorticoid-induced protein accumulation and glucocorticoid receptor in cardiomyocytes
    A Sato
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Am J Physiol 271:E827-33. 1996
    ..These results suggest that glucocorticoid effects on cardiomyocytes may be modulated by cAMP-mediated mechanisms, which may produce the complex effects of glucocorticoids on cardiomyocyte growth in vivo...
  4. ncbi request reprint Serum 5-androstene-3 beta,17 beta-diol sulphate, sex hormone binding globulin and free androgen index in girls with premature adrenarche
    J Montalto
    Department of Clinical Biochemistry, Royal Children s Hospital, Melbourne, Australia
    J Steroid Biochem 33:1149-54. 1989
    ..This may be compounded by the elevated levels of 5-ADIOL-S in girls with PA since its role may be as a prohormone for more potent androgens (testosterone, 5 alpha-dihydrotestosterone) in target tissues such as pubic skin...
  5. ncbi request reprint Rapid and specific lowering of pituitary FSH beta mRNA levels by inhibin
    J E Mercer
    Medical Research Centre, Prince Henry s Hospital, Melbourne, Australia
    Mol Cell Endocrinol 53:251-4. 1987
    ..These data show that inhibin has a very rapid and specific effect on FSH beta mRNA levels directly at the level of the pituitary gland...
  6. ncbi request reprint Experimental cardiac fibrosis: differential time course of responses to mineralocorticoid-salt administration
    G Fujisawa
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Endocrinology 142:3625-31. 2001
    ..When mineralocorticoid levels are elevated acutely by bolus injection, changes are discernible after 2 d, in contrast with previous infusion studies in which 3-4 wk were required for measurable changes...
  7. ncbi request reprint The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action
    A Bhargava
    Baker Medical Research Institute, Melbourne 8008, Australia
    Endocrinology 142:1587-94. 2001
    ....
  8. ncbi request reprint The forced swimming test: effects of glucose administration on the response to food deprivation and adrenalectomy
    D Jefferys
    Baker Medical Research Institute, Prahran, Australia
    Eur J Pharmacol 205:267-9. 1991
    ..We interpret these findings as suggesting a complex interplay of endocrine and metabolic factors are necessary for retention of the behavioural response...
  9. ncbi request reprint Luteinizing hormone-beta mRNA levels are regulated primarily by gonadotropin-releasing hormone and not by negative estrogen feedback on the pituitary
    J E Mercer
    Medical Research Centre, Prince Henry s Hospital, Melbourne, Australia
    Neuroendocrinology 47:563-6. 1988
    ..Long-term regulation of LH-beta mRNA is thus primarily regulated by GnRH...
  10. ncbi request reprint Non-genomic actions of aldosterone: role in hypertension
    J W Funder
    Baker Medical Research Institute, Melbourne, Australia
    Curr Opin Nephrol Hypertens 10:227-30. 2001
    ....
  11. ncbi request reprint Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
    J W Funder
    Medical Research Centre, Prince Henry s Hospital, Melbourne, Australia
    Science 242:583-5. 1988
    ..These analogs cannot bind to mineralocorticoid receptors...
  12. ncbi request reprint Differential regulation of MAP kinase activity by corticotropin-releasing hormone in normal and neoplastic corticotropes
    H Li
    Baker Medical Research Institute, Prahran, Vic, Australia
    Int J Biochem Cell Biol 30:1389-401. 1998
    ..Thus, CRH may differentially regulate cell growth in sheep normal anterior pituitary and mouse tumor corticotropes by modulating MAP kinase activity through a mechanism dependent on cAMP production and subject to regulation by ANP...
  13. ncbi request reprint GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant
    T J Cole
    Baker Medical Research Institute, Commercial Road, Prahran, 3181, Victoria, Australia
    Mol Cell Endocrinol 173:193-202. 2001
    ..Thus although the surviving adult homozygous GRKO mice express a dexamethasone-binding GR fragment, their classic target tissues remain profoundly glucocorticoid insensitive...
  14. ncbi request reprint Rat 11 beta-hydroxysteroid dehydrogenase type 2 enzyme is expressed at low levels in the placenta and is modulated by adrenal steroids in the kidney
    K X Li
    Laboratory of Molecular Hypertension, Baker Institute of Medical Research, Prahran, Vic, Australia
    Mol Cell Endocrinol 120:67-75. 1996
    ....
  15. doi request reprint Primary aldosteronism: are we missing the wood for the trees?
    J W Funder
    Prince Henry s Institute, Clayton, Victoria, Australia
    Horm Metab Res 44:251-3. 2012
    ..We do not have the resources to diagnose PA, but we do have the wherewithal to treat it...
  16. ncbi request reprint Oestrogen administration and the expression of the kallikrein gene family in the rat submandibular gland
    J A Clements
    Medical Research Centre, Prince Henry s Hospital, Melbourne, Australia
    J Steroid Biochem 35:55-60. 1990
    ....
  17. ncbi request reprint Cardiac steroidogenesis in the normal and failing heart
    M J Young
    Baker Medical Research Institute, Prahran, Victoria 3181, Australia
    J Clin Endocrinol Metab 86:5121-6. 2001
    ..The exact cellular location of steroid synthesis in the failing human heart remains to be established...
  18. ncbi request reprint Dynamin II regulates hormone secretion in neuroendocrine cells
    Z Yang
    Baker Medical Research Institute, Department of Pathology and Immunology, Monash University Medical School, Commercial Road, Prahran, Victoria 3181, Australia
    J Biol Chem 276:4251-60. 2001
    ..Thus, dynamin II regulates secretory vesicle formation from the Golgi apparatus and hormone release from mammalian neuroendocrine cells...
  19. ncbi request reprint The thyroadrenal axis, food deprivation and retention of a behavioural response
    D E Jefferys
    Baker Medical Research Institute, Melbourne, Australia
    Eur J Pharmacol 239:189-93. 1993
    ..These counterintuitive findings suggest hitherto unrecognized commonalities and/or interactions in the metabolic effects of the thyroid and adrenal glands...
  20. ncbi request reprint Immunoreactive ACTH, beta-endorphin, and cortisol levels in plasma following spinal manipulative therapy
    G F Christian
    School of Chiropractic, Phillip Institute of Technology, Victoria, Australia
    Spine (Phila Pa 1976) 13:1411-7. 1988
    ....
  21. ncbi request reprint Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women
    K Sudhir
    Alfred and Baker Medical Unit, Baker Medical Research Institute, Melbourne, Australia
    Hypertension 28:330-4. 1996
    ..Thus, in perimenopausal women, estrogen supplementation reduces blood pressure and enhances basal but not acetylcholine-induced nitric oxide release in fore-arm resistance arteries...
  22. ncbi request reprint Serum 5-androstene-3 beta,17 beta-diol sulphate and 5 alpha-androstane-3 alpha,17 beta-diol sulphate in hirsute females with polycystic ovarian disease
    J Montalto
    Department of Clinical Biochemistry, Royal Children s Hospital, Melbourne, Australia
    J Steroid Biochem 36:67-74. 1990
    ..A comprehensive biochemical profile of PCO should thus include the analysis of these sulphoconjugates as well as unconjugated steroids...
  23. ncbi request reprint Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro
    H Li
    Molecular Signaling Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    Oncogene 18:6785-94. 1999
    ....
  24. ncbi request reprint Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess
    S Dave-Sharma
    Department of Pediatrics, New York Hospital Cornell Medical Center, New York 10021, USA
    J Clin Endocrinol Metab 83:2244-54. 1998
    ..The outcome of treatment in more patients may establish the efficacy of treatment...
  25. ncbi request reprint A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess
    R C Wilson
    Department of Pediatrics, New York Hospital Cornell Medical Center, New York 10021, USA
    J Clin Endocrinol Metab 80:2263-6. 1995
    ..A mutation in the HSD11B2 gene has been discovered in a consanguineous Iranian family with three sibs suffering from Apparent Mineralocorticoid Excess (AME). Sequence data demonstrate a C to T transition resulting in an R337C mutation...