M Esler

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi Sympathetic neuronal regulation of the heart in aging and heart failure
    David Kaye
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, VIC 8008, Australia
    Cardiovasc Res 66:256-64. 2005
  2. ncbi Is "cardiovascular protection" by estrogens due to inhibition of the sympathetic nervous system?
    Murray Esler
    Clin Auton Res 15:186-8. 2005
  3. ncbi Effect of angiotensin II receptor blockade on autonomic nervous system function in patients with essential hypertension
    Henry Krum
    National Health and Medical Research Council of Australia, Centre of Clinical Research Excellence in Therapeutics, Monash University, Melbourne, VIC 3004, Australia
    Am J Physiol Heart Circ Physiol 290:H1706-12. 2006
  4. ncbi Sympathetic nervous system and insulin resistance: from obesity to diabetes
    M Esler
    Baker Medical Research Institute, Melbourne, Australia
    Am J Hypertens 14:304S-309S. 2001
  5. ncbi Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
  6. ncbi Differentiation in the effects of the angiotensin II receptor blocker class on autonomic function
    Murray Esler
    Baker Medical Research Institute, Commercial Road, Prahran 3181, Melbourne, Australia
    J Hypertens Suppl 20:S13-9. 2002
  7. ncbi Chronic mental stress is a cause of essential hypertension: presence of biological markers of stress
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:498-502. 2008
  8. ncbi Management of hypertension complicated by psychiatric comorbidity
    Murray Esler
    Baker Heart Research Institute, Royal Women's Hospital, Melbourne, Australia
    J Clin Hypertens (Greenwich) 9:708-13. 2007
  9. ncbi Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor
    Murray Esler
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Stress 10:295-304. 2007
  10. ncbi [Rilmenidine sympatholytic activity preserves mental and orthostatic sympathetic response and epinephrine secretion]
    M Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australie
    Arch Mal Coeur Vaiss 97:786-92. 2004

Detail Information

Publications56

  1. ncbi Sympathetic neuronal regulation of the heart in aging and heart failure
    David Kaye
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, VIC 8008, Australia
    Cardiovasc Res 66:256-64. 2005
    ..Our conclusion is, on balance, that this proposition is not supported by the available evidence...
  2. ncbi Is "cardiovascular protection" by estrogens due to inhibition of the sympathetic nervous system?
    Murray Esler
    Clin Auton Res 15:186-8. 2005
  3. ncbi Effect of angiotensin II receptor blockade on autonomic nervous system function in patients with essential hypertension
    Henry Krum
    National Health and Medical Research Council of Australia, Centre of Clinical Research Excellence in Therapeutics, Monash University, Melbourne, VIC 3004, Australia
    Am J Physiol Heart Circ Physiol 290:H1706-12. 2006
    ..We conclude that sympathetic nervous inhibition is not a major component of the blood pressure-lowering action of ARBs in essential hypertension...
  4. ncbi Sympathetic nervous system and insulin resistance: from obesity to diabetes
    M Esler
    Baker Medical Research Institute, Melbourne, Australia
    Am J Hypertens 14:304S-309S. 2001
    ....
  5. ncbi Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
    ....
  6. ncbi Differentiation in the effects of the angiotensin II receptor blocker class on autonomic function
    Murray Esler
    Baker Medical Research Institute, Commercial Road, Prahran 3181, Melbourne, Australia
    J Hypertens Suppl 20:S13-9. 2002
    ..A reduction in noradrenaline spillover disproportionate to any possible fall in nerve firing would document the presence of presynaptic antagonism of noradrenaline release...
  7. ncbi Chronic mental stress is a cause of essential hypertension: presence of biological markers of stress
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:498-502. 2008
    ..This judgement was reached after consideration of the epidemiological evidence, but in particular after review of the specific elements of the neural pathophysiology of essential hypertension, described above...
  8. ncbi Management of hypertension complicated by psychiatric comorbidity
    Murray Esler
    Baker Heart Research Institute, Royal Women's Hospital, Melbourne, Australia
    J Clin Hypertens (Greenwich) 9:708-13. 2007
  9. ncbi Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor
    Murray Esler
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Stress 10:295-304. 2007
    ....
  10. ncbi [Rilmenidine sympatholytic activity preserves mental and orthostatic sympathetic response and epinephrine secretion]
    M Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australie
    Arch Mal Coeur Vaiss 97:786-92. 2004
    ..Acute sympathetic nervous activation is a proven trigger for adverse cardiovascular events. Accordingly, antihypertensive drugs inhibiting sympathetic outflow represent a theoretically attractive therapeutic option...
  11. ncbi Mechanisms of sympathetic activation in obesity-related hypertension
    Murray Esler
    Baker Heart Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Hypertension 48:787-96. 2006
  12. ncbi Cardiac sympathetic nerve biology and brain monoamine turnover in panic disorder
    Murray Esler
    Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Ann N Y Acad Sci 1018:505-14. 2004
    ....
  13. ncbi Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 22:1529-34. 2004
    ..Acute sympathetic nervous activation is a proven trigger for adverse cardiovascular events. Accordingly, antihypertensive drugs inhibiting sympathetic outflow represent a theoretically attractive therapeutic option...
  14. ncbi Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress
    Murray Esler
    Baker Medical Research Institute, Melbourne, Australia
    Biogerontology 3:45-9. 2002
    ..Sympathetic nervous responses with stressors were augmented. Conversely, adrenal medullary release of epinephrine was subnormal in the elderly, at rest and during stress...
  15. ncbi Sympathetic nerve biology in essential hypertension
    M Esler
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Clin Exp Pharmacol Physiol 28:986-9. 2001
    ....
  16. ncbi The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover
    Murray Esler
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Am J Physiol Regul Integr Comp Physiol 282:R909-16. 2002
    ....
  17. ncbi The sympathetic neurobiology of essential hypertension: disparate influences of obesity, stress, and noradrenaline transporter dysfunction?
    M Esler
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Am J Hypertens 14:139S-146S. 2001
    ..High renal sympathetic tone in the latter, of course, may well still contribute to elevation of their pressure level, although not on such a scale as to cause clinical hypertension...
  18. ncbi Postprandial sympatho-adrenal activity: its relation to metabolic and cardiovascular events and to changes in meal frequency
    M Vaz
    Human Autonomic Function Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    Clin Sci (Lond) 89:349-57. 1995
    ..Thus, no close relation was demonstrated between postprandial sympathetic nervous activation and either insulin secretion or thermogenesis...
  19. ncbi Leptin is released from the human brain: influence of adiposity and gender
    G Wiesner
    Baker Medical Research Institute and the Alfred Baker Medical Unit, Alfred Hospital, Melbourne, Victoria, Australia
    J Clin Endocrinol Metab 84:2270-4. 1999
    ..In addition, the higher level of brain release observed in females may contribute to the well documented gender differences in overall plasma leptin levels...
  20. ncbi Sympathetic nerve activity and neurotransmitter release in humans: translation from pathophysiology into clinical practice
    M Esler
    Baker Heart Research Institute, Prahran, Melbourne, Australia
    Acta Physiol Scand 177:275-84. 2003
    ..These observations provide the theoretical foundation for the very successful introduction of beta-adrenergic blockers for treatment of heart failure...
  21. ncbi Interactions between leptin and the human sympathetic nervous system
    Nina Eikelis
    Baker Heart Research Institute and Alfred Baker Medical Unit, Alfred Hospital, Melbourne, Australia
    Hypertension 41:1072-9. 2003
    ....
  22. ncbi Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function
    Nina Eikelis
    Baker Heart Research Institute, Melbourne University, Melbourne, Victoria 8008, Australia
    Am J Physiol Endocrinol Metab 286:E744-52. 2004
    ..9 +/- 1.4 vs. 5.3 +/- 2.2 ng/min (P = 0.042). These results suggest that leptin is released within the brain and at an increased rate in obese humans, in whom activation of brain serotonergic and NPY mechanisms also exists...
  23. ncbi The sympathetic system and hypertension
    M Esler
    Baker Medical Research Institute, Prahran, Melbourne, Australia
    Am J Hypertens 13:99S-105S. 2000
    ....
  24. ncbi Measurement of sympathetic nervous system activity in heart failure: the role of norepinephrine kinetics
    M Esler
    Baker Medical Research Institute, Alfred Lane, Prahran, 3181, Melbourne, Australia
    Heart Fail Rev 5:17-25. 2000
    ....
  25. ncbi Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 56:351-8. 2010
    ..Sympathetic activity is closely associated with cardiovascular and renal alterations observed in these subjects...
  26. ncbi Noradrenaline release and the pathophysiology of primary human hypertension
    M Esler
    Baker Medical Research Institute, Melbourne, Australia
    Am J Hypertens 2:140S-146S. 1989
    ..These measurements of regional norepinephrine overflow suggest that sympathetic nervous outflow to the kidneys and heart is selectively activated in early hypertension...
  27. ncbi Increased sympathetic nervous system activity and its therapeutic reduction in arterial hypertension, portal hypertension and heart failure
    M Esler
    Baker Medical Research Institute, Prahran, Melbourne, Australia
    J Auton Nerv Syst 72:210-9. 1998
    ....
  28. ncbi Brain leptin resistance in human obesity revisited
    N Eikelis
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Alfred Hospital, Melbourne, Australia
    Regul Pept 139:45-51. 2007
    ....
  29. ncbi Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 1:103-9. 2008
    ..Clinical observations in patients with postural tachycardia syndrome (POTS) suggest abnormal sympathetic nervous system activity and a dysfunction of the norepinephrine (NE) transporter (NET)...
  30. ncbi Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertension 50:862-8. 2007
    ..The underlying central nervous system mechanism and the adverse consequences of the 2 modes of sympathetic activation may differ...
  31. ncbi Gender differences in sympathetic nervous activity: influence of body mass and blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 25:1411-9. 2007
    ..We tested whether the sympathetic nervous system was differently affected in men and women by the body mass index (BMI), BP, leptin and weight loss...
  32. ncbi Single-unit sympathetic discharge pattern in pathological conditions associated with elevated cardiovascular risk
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:503-7. 2008
    ..4. Single-unit methodology may represent a major step forward in the understanding of the link between disturbed sympathetic nerve firing and associated cardiovascular risk...
  33. ncbi The neurobiology of human obesity
    Nina Eikelis
    Baker Heart Research Institute, Melbourne, Australia
    Exp Physiol 90:673-82. 2005
    ..Brain leptin release has the potential to override the peripheral, adipocyte leptin system...
  34. ncbi Influence of leptin on neurotransmitter overflow from the rat brain in vitro
    Jacqueline A Hastings
    Baker Medical Research Institute, Human Neurotransmitter Laboratory, P O Box 6492, Victoria 8008, Melbourne, Australia
    Regul Pept 103:67-74. 2002
    ..This study lends support to the notion of a complex interaction of the leptinergic and brain neurotransmitters involved in the control of feeding and energy metabolism...
  35. ncbi Single-unit analysis of sympathetic nervous discharges in patients with panic disorder
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria, Australia
    J Physiol 570:637-43. 2006
    ..Quantification from single vasoconstrictor unit recording provides evidence of a disturbed sympathetic firing pattern in patients with panic disorder...
  36. ncbi Increased suicide rate in the middle-aged and its association with hours of sunlight
    Gavin Lambert
    Human Neurotransmitter Laboratory, Baker Medical Research Institute, Australia
    Am J Psychiatry 160:793-5. 2003
    ....
  37. ncbi NPY and NPY Y1 receptor effects on noradrenaline overflow from the rat brain in vitro
    Jacqueline A Hastings
    Baker Heart Research Institute, Human Neurotransmitter Laboratory, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Regul Pept 120:107-12. 2004
    ....
  38. ncbi Modulation of vascular function by diet and exercise
    G L Jennings
    Alfred Hospital, Melbourne, Australia
    Clin Exp Hypertens 19:727-37. 1997
    ..In both cases there is regulation both at a local and systemic level. Habitual, and recent, lifestyle can exert important cardiovascular effects which must be taken into account in clinical and epidemiological research...
  39. ncbi The 2009 Carl Ludwig Lecture: Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management
    Murray Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Appl Physiol 108:227-37. 2010
    ..With psychogenic heart disease and postural syncope syndromes, knowledge of the neural pathophysiology is emerging, but clinical translation remains for the future...
  40. ncbi The neuronal noradrenaline transporter, anxiety and cardiovascular disease
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    J Psychopharmacol 20:60-6. 2006
    ....
  41. ncbi Management strategies for recurrent vasovagal syncope
    G Vaddadi
    Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Intern Med J 40:554-60. 2010
    ..Permanent cardiac pacing is rarely needed and randomized trials do not support its use...
  42. ncbi Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
    Henry Krum
    Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic, Australia
    Lancet 373:1275-81. 2009
    ....
  43. ncbi Association between the sympathetic firing pattern and anxiety level in patients with the metabolic syndrome and elevated blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    J Hypertens 28:543-50. 2010
    ....
  44. ncbi Beta-adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure
    David M Kaye
    Heart Centre, Alfred Hospital and Baker Medical Reserach Insititute, Melbourne, Victoria, Australia
    Pharmacogenetics 13:379-82. 2003
    ..These data demonstrate a significant influence of beta2AR genotype in the response to carvedilol in CHF patients. Accordingly, determination of beta2AR status may be of value in the tailoring of individual therapy in patients with CHF...
  45. ncbi Dysautonomias: clinical disorders of the autonomic nervous system
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 6N252, 10 Center Drive MSC-1620, Bethesda, MD 20892-1620, USA
    Ann Intern Med 137:753-63. 2002
    ..Dysautonomias are an important subject in clinical neurocardiology...
  46. ncbi Is very high sympathetic tone in heart failure a result of keeping bad company?
    Murray Esler
    Hypertension 42:870-2. 2003
  47. ncbi Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia
    Philip W Gold
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 102:8303-8. 2005
    ..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
  48. ncbi Development of the metabolic syndrome along the female biological life-path
    Murray Esler
    J Hypertens 24:43-5. 2006
  49. ncbi Is obstructive sleep apnea the cause of sympathetic nervous activation in human obesity?
    Murray Esler
    J Appl Physiol 100:11-2. 2006
  50. ncbi The sympathetic nervous system in renovascular hypertension: lead actor or 'bit' player?
    Guido Grassi
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, , Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Istituto Auxologico Italiano, Milan, Italy
    J Hypertens 20:1071-3. 2002
  51. ncbi Is essential hypertension sometimes a psychosomatic disorder?
    Murray Esler
    J Hypertens 22:873-6. 2004
  52. ncbi On a low calorie diet, are there separate and discrete effects of negative energy balance and weight loss on blood pressure?
    Murray Esler
    J Hypertens 21:261-2. 2003
  53. ncbi The sympathetic nervous system and the metabolic syndrome
    Giuseppe Mancia
    Ospedale San Gerardo dei Tintori, Universita Milano Bicocca, Monza, Milan, Italy
    J Hypertens 25:909-20. 2007
    ..This will be followed by an analysis of the role played by neuroadrenergic factors in disease progression as well as in the pathogenesis of its complications. Finally, the therapeutic implications of these findings will be highlighted...
  54. ncbi Reduced HRV and baroreflex sensitivity as universally applicable cardiovascular "risk factors"; waiting for the bubble to burst
    Murray Esler
    Clin Auton Res 13:170-2. 2003
  55. ncbi Cardiovascular trophic effects from the sympathetic nerve cotransmitter neuropeptide Y in end-stage renal disease?
    Murray Esler
    J Hypertens 21:1263-4. 2003
  56. ncbi Sympathetic nervous system neuroplasticity
    Murray Esler
    Hypertension 47:143-4. 2006