Tye Dawood

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi request reprint Glucocorticoid responses to stress in castrate and testosterone-replaced rams
    Tye Dawood
    Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Regul Pept 125:47-53. 2005
  2. ncbi request reprint Specific serotonin reuptake inhibition in major depressive disorder adversely affects novel markers of cardiac risk
    Tye Dawood
    Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 30:285-93. 2007
  3. pmc Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:1126-32. 2009
  4. doi request reprint The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components
    Nora E Straznicky
    Laboratories of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 96:E503-8. 2011
  5. doi request reprint Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
  6. pmc Single-unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover
    Elisabeth A Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Physiol 589:2597-605. 2011
  7. pmc Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 59:71-9. 2010
  8. doi request reprint Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals
    Nora E Straznicky
    Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Hypertens 29:553-64. 2011
  9. doi request reprint Blunted sympathetic neural response to oral glucose in obese subjects with the insulin-resistant metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters and Heart Failure Division, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Am J Clin Nutr 89:27-36. 2009
  10. doi request reprint Baseline sympathetic nervous system activity predicts dietary weight loss in obese metabolic syndrome subjects
    Nora E Straznicky
    Laboratory of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 97:605-13. 2012

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Glucocorticoid responses to stress in castrate and testosterone-replaced rams
    Tye Dawood
    Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Regul Pept 125:47-53. 2005
    ..While the implications of these results for human physiology require further studies, they suggest that male hypogonadism may play a role in determining the risk of cardiovascular disease and diabetes...
  2. ncbi request reprint Specific serotonin reuptake inhibition in major depressive disorder adversely affects novel markers of cardiac risk
    Tye Dawood
    Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 30:285-93. 2007
    ..Mechanisms potentially responsible for generating cardiac risk in patients treated with selective serotonin reuptake inhibitors may need to be therapeutically targeted to reduce the incidence of coronary heart disease in this population...
  3. pmc Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:1126-32. 2009
    ..The purpose of this study was to examine the effects of weight loss on sympathetic nervous system responsiveness to glucose ingestion in obese subjects with metabolic syndrome, in whom such responses are reportedly blunted...
  4. doi request reprint The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components
    Nora E Straznicky
    Laboratories of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 96:E503-8. 2011
    ..Sympathetic nervous system (SNS) overactivity participates in both the pathogenesis and adverse clinical complications of metabolic syndrome (MetS) obesity...
  5. doi request reprint Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
    ....
  6. pmc Single-unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover
    Elisabeth A Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Physiol 589:2597-605. 2011
    ..05). This study indicates that multiple within-burst firing and increased single-unit firing rates of the sympathetic outflow to the skeletal muscle vasculature is associated with high cardiac noradrenaline spillover...
  7. pmc Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 59:71-9. 2010
    ..This study was conducted to examine the effects of lifestyle interventions (weight loss alone or together with exercise) on SNS function...
  8. doi request reprint Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals
    Nora E Straznicky
    Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Hypertens 29:553-64. 2011
    ..This study was conducted to examine the effects of lifestyle interventions on renal parameters and putative metabolic, neuroadrenergic and hemodynamic mediators of renal injury...
  9. doi request reprint Blunted sympathetic neural response to oral glucose in obese subjects with the insulin-resistant metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters and Heart Failure Division, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Am J Clin Nutr 89:27-36. 2009
    ..Glucose ingestion stimulates sympathetic nervous system (SNS) activity in lean subjects, whereas blunted responses have been reported in the obese...
  10. doi request reprint Baseline sympathetic nervous system activity predicts dietary weight loss in obese metabolic syndrome subjects
    Nora E Straznicky
    Laboratory of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 97:605-13. 2012
    ..The sympathetic nervous system is an important physiological modulator of basal and postprandial energy expenditure...
  11. doi request reprint Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy
    David A Barton
    Department of Psychological Medicine, Alfred Hospital, Monash University, Melbourne, Victoria, Australia
    Arch Gen Psychiatry 65:38-46. 2008
    ..The biological basis for the development of major depressive disorder (MDD) remains incompletely understood...
  12. doi request reprint Chronic mental stress is a cause of essential hypertension: presence of biological markers of stress
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:498-502. 2008
    ..This judgement was reached after consideration of the epidemiological evidence, but in particular after review of the specific elements of the neural pathophysiology of essential hypertension, described above...
  13. ncbi request reprint Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertension 50:862-8. 2007
    ..The underlying central nervous system mechanism and the adverse consequences of the 2 modes of sympathetic activation may differ...
  14. doi request reprint Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 58:43-50. 2011
    ..These responses may represent a combination of peripheral (baroreflex-mediated) and central effects of ghrelin...
  15. doi request reprint Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 56:351-8. 2010
    ..Sympathetic activity is closely associated with cardiovascular and renal alterations observed in these subjects...
  16. doi request reprint Association between the sympathetic firing pattern and anxiety level in patients with the metabolic syndrome and elevated blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    J Hypertens 28:543-50. 2010
    ....
  17. doi request reprint Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 1:103-9. 2008
    ..Clinical observations in patients with postural tachycardia syndrome (POTS) suggest abnormal sympathetic nervous system activity and a dysfunction of the norepinephrine (NE) transporter (NET)...
  18. ncbi request reprint The effects of dietary weight loss on indices of norepinephrine turnover: modulatory influence of hyperinsulinemia
    Nora E Straznicky
    Laboratories of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Obesity (Silver Spring) 22:652-62. 2014
    ..This study was conducted to examine (1) the effects of dietary weight loss on indices of norepinephrine (NE) turnover and (2) whether baseline hyperinsulinemia modulates sympathetic neural adaptations...
  19. doi request reprint Renal denervation: a potential new treatment modality for polycystic ovary syndrome?
    Markus P Schlaich
    Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Hypertens 29:991-6. 2011
    ..Here we report on the effects of renal denervation on hemodynamic, metabolic, and renal parameters in two obese PCOS patients with hypertension...
  20. doi request reprint Single-unit sympathetic discharge pattern in pathological conditions associated with elevated cardiovascular risk
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:503-7. 2008
    ..4. Single-unit methodology may represent a major step forward in the understanding of the link between disturbed sympathetic nerve firing and associated cardiovascular risk...
  21. doi request reprint Persistence of muscle sympathetic nerve activity during vasovagal syncope
    Gautam Vaddadi
    Human Neurotransmitter Laboratory, BakerIDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia
    Eur Heart J 31:2027-33. 2010
    ..To determine whether sympathetic nerve firing to skeletal muscle vasculature is withdrawn during vasovagal syncope (VVS) precipitated by passive graded head-up tilt (HUT) table testing...
  22. pmc Effects of selective serotonin reuptake inhibitor treatment on plasma oxytocin and cortisol in major depressive disorder
    Charlotte Keating
    Monash Alfred Psychiatry Research Centre, Central Clinical School, Monash University and the Alfred, Melbourne, Australia
    BMC Psychiatry 13:124. 2013
    ..g., oxytocin and cortisol) and MDD. Our objective was to measure oxytocin and cortisol in patients with MDD before and following treatment with selective serotonin reuptake inhibitors, SSRI...
  23. ncbi request reprint Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs
    Maro R I Williams
    Baker Medical Research Institute and Alfred Hospital, Melbourne, Victoria 3181, Australia
    J Clin Endocrinol Metab 87:176-81. 2002
    ..DHEA inhibits human VSMC proliferation by a mechanism independent of either ARs or ERs, presumably via a DHEA-specific receptor that involves ERK1 signaling pathways...
  24. ncbi request reprint Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor
    Murray Esler
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Stress 10:295-304. 2007
    ....
  25. pmc Single-unit analysis of sympathetic nervous discharges in patients with panic disorder
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria, Australia
    J Physiol 570:637-43. 2006
    ..Quantification from single vasoconstrictor unit recording provides evidence of a disturbed sympathetic firing pattern in patients with panic disorder...
  26. ncbi request reprint Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?
    David A Barton
    Human Neurotransmitter Laboratory, Australia
    J Hypertens 25:2117-24. 2007
    ..Evidence exists linking major depressive disorder (MDD) with clinical cardiovascular events. The importance of the sympathetic nervous system in the generation of cardiac risk in other contexts is established...
  27. doi request reprint Raised CRP levels in obese patients: symptoms of depression have an independent positive association
    John B Dixon
    Centre for Obesity Research and Education, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Obesity (Silver Spring) 16:2010-5. 2008
    ..Are the effects of depression and obesity related or do they influence CRP levels independently?..
  28. ncbi request reprint Gender differences in sympathetic nervous activity: influence of body mass and blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 25:1411-9. 2007
    ..We tested whether the sympathetic nervous system was differently affected in men and women by the body mass index (BMI), BP, leptin and weight loss...
  29. doi request reprint Elevated cardiac risk in patients with major depressive disorder
    Richard G Bayles
    Am J Psychiatry 165:137; author reply 137-8. 2008
  30. ncbi request reprint Is "cardiovascular protection" by estrogens due to inhibition of the sympathetic nervous system?
    Murray Esler
    Clin Auton Res 15:186-8. 2005
  31. doi request reprint QT interval variability and cardiac norepinephrine spillover in patients with depression and panic disorder
    Mathias Baumert
    School of Electrical and Electronic Engineering, Centre for Biomedical Engineering, University of Adelaide, Adelaide, Australia
    Am J Physiol Heart Circ Physiol 295:H962-H968. 2008
    ..We conclude that in depression/panic disorder patients with near-normal cardiac norepinephrine levels QT variability is not correlated with cardiac norepinephrine spillover and is not affected by treatment with SSRI...
  32. ncbi request reprint Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors
    Maro R I Williams
    Department of Medicine, Monash University, Alfred Hospital, Commercial Road, Prahran, Victoria 3181, Australia
    J Clin Endocrinol Metab 89:4708-15. 2004
    ..Thus, DHEA increases EC proliferation in vitro by mechanism(s) independently of either androgen receptor or estrogen receptor and in vivo enhances large and small vessel EC function in postmenopausal women...
  33. ncbi request reprint Hormone therapy impairs endothelial function in postmenopausal women with type 2 diabetes mellitus treated with rosiglitazone
    Suzy Y Honisett
    Department of Medicine, Monash University, The Alfred Hospital, Commercial Road, Prahran, Victoria, Australia 3181
    J Clin Endocrinol Metab 89:4615-9. 2004
    ..Caution should, therefore, be exercised when considering combined treatment with thiazolidinedione and HT...
  34. ncbi request reprint Endogenous estrogens influence endothelial function in young men
    Robert Lew
    Baker Medical Research Institute and Alfred Hospital, Prahran, Victoria, Australia
    Circ Res 93:1127-33. 2003
    ..Our results suggest that endogenous estrogens play a direct regulatory role in endothelial function in young healthy men...
  35. ncbi request reprint Rosiglitazone lowers blood pressure and increases arterial compliance in postmenopausal women with type 2 diabetes
    Suzy Y Honisett
    Diabetes Care 26:3194-5. 2003