Danushka K Wijesundara

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. pmc Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity
    Danushka K Wijesundara
    The Molecular Mucosal Vaccine Immunology Group, The Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Acton, Canberra, Australia
    PLoS ONE 8:e55788. 2013
  2. doi request reprint Antigen-specific activation thresholds of CD8+ T cells are independent of IFN-I-mediated partial lymphocyte activation
    Danushka K Wijesundara
    Viral Immunology, Emerging Pathogens and Vaccines Program, John Curtin School of Medical Research, Acton, ACT 0200, Canberra, Australia
    Int Immunol 22:757-67. 2010
  3. doi request reprint Human immunodeficiency virus-1 vaccine design: where do we go now?
    Danushka K Wijesundara
    Department Emerging Pathogens and Vaccines, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 89:367-74. 2011
  4. doi request reprint Fluorescent target array T helper assay: a multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Immunol Methods 387:181-90. 2013
  5. doi request reprint IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8(+) T cell avidity following HIV-1 recombinant pox viral vaccination
    Danushka K Wijesundara
    The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia Electronic address
    Vaccine 31:4548-55. 2013
  6. pmc MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies
    Mohammed Alsharifi
    Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 8:e68458. 2013
  7. doi request reprint Fluorescent target array killing assay: a multiplex cytotoxic T-cell assay to measure detailed T-cell antigen specificity and avidity in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia
    Cytometry A 81:679-90. 2012

Collaborators

Detail Information

Publications7

  1. pmc Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity
    Danushka K Wijesundara
    The Molecular Mucosal Vaccine Immunology Group, The Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Acton, Canberra, Australia
    PLoS ONE 8:e55788. 2013
    ..This can improve the quality of anti-viral CD8(+) T cell immunity. Our findings have important implications in understanding anti-viral CD8(+) T cell immunity and designing effective vaccines against chronic viral infections...
  2. doi request reprint Antigen-specific activation thresholds of CD8+ T cells are independent of IFN-I-mediated partial lymphocyte activation
    Danushka K Wijesundara
    Viral Immunology, Emerging Pathogens and Vaccines Program, John Curtin School of Medical Research, Acton, ACT 0200, Canberra, Australia
    Int Immunol 22:757-67. 2010
    ....
  3. doi request reprint Human immunodeficiency virus-1 vaccine design: where do we go now?
    Danushka K Wijesundara
    Department Emerging Pathogens and Vaccines, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 89:367-74. 2011
    ....
  4. doi request reprint Fluorescent target array T helper assay: a multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Immunol Methods 387:181-90. 2013
    ....
  5. doi request reprint IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8(+) T cell avidity following HIV-1 recombinant pox viral vaccination
    Danushka K Wijesundara
    The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia Electronic address
    Vaccine 31:4548-55. 2013
    ..These findings can be exploited to, design more efficacious vaccines not only against HIV-1, but many chronic infections where high, avidity CD8(+) T cells help protection. ..
  6. pmc MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies
    Mohammed Alsharifi
    Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 8:e68458. 2013
    ..Detailed genetic analysis will be carried out to characterise the underlining genetic defects responsible for the observed phenomenon. ..
  7. doi request reprint Fluorescent target array killing assay: a multiplex cytotoxic T-cell assay to measure detailed T-cell antigen specificity and avidity in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia
    Cytometry A 81:679-90. 2012
    ..This fluorescent target array killing assay can be used to measure the fine antigen specificity and avidity of polyclonal cytotoxic T-cell responses in vivo, immunological parameters that were previously impossible to monitor...