Dianne C Webb

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. ncbi Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function
    Dianne C Webb
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 178:219-27. 2007
  2. ncbi Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13-/- mice
    Dianne C Webb
    Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia 2601
    J Immunol 172:1092-8. 2004
  3. ncbi A method for the purification and refolding of a recombinant form of the nontypeable Haemophilus influenzae P5 outer membrane protein fused to polyhistidine
    D C Webb
    Research Centre for Human and Biomedical Science, Faculty of Applied Science, University of Canberra, Canberra City, ACT 2601, Australia
    Protein Expr Purif 15:1-7. 1999
  4. pmc Immunization with recombinant transferrin binding protein B enhances clearance of nontypeable Haemophilus influenzae from the rat lung
    D C Webb
    Gadi Research Centre, Faculty of Applied Science, University of Canberra, Canberra City, ACT 2601, Australia
    Infect Immun 67:2138-44. 1999
  5. pmc A P5 peptide that is homologous to peptide 10 of OprF from Pseudomonas aeruginosa enhances clearance of nontypeable Haemophilus influenzae from acutely infected rat lung in the absence of detectable peptide-specific antibody
    D C Webb
    The Gadi Research Center, Faculty of Applied Science and Design, University of Canberra, Canberra City, Australian Capital Territory 2601, Australia
    Infect Immun 68:377-81. 2000
  6. ncbi Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity
    Dianne C Webb
    Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Eur J Immunol 33:3377-85. 2003
  7. pmc Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
    Joerg Mattes
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Exp Med 195:1433-44. 2002
  8. doi Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation
    Yeping Cai
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 182:5393-9. 2009
  9. doi Estrogen stimulates Th2 cytokine production and regulates the compartmentalisation of eosinophils during allergen challenge in a mouse model of asthma
    Yeping Cai
    Immunology Department, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Int Arch Allergy Immunol 158:252-60. 2012
  10. ncbi Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness
    Ming Yang
    Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 177:5595-603. 2006

Detail Information

Publications26

  1. ncbi Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function
    Dianne C Webb
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 178:219-27. 2007
    ..The affinity of IL-4Ralpha also appears to be a determinant in the balance between Th2 and IFN-gamma responses and thus the severity of allergic disease...
  2. ncbi Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13-/- mice
    Dianne C Webb
    Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia 2601
    J Immunol 172:1092-8. 2004
    ..Collectively, these data show that polymorphisms in IL-4Ralpha, which have been shown to affect the interaction with IL-4, correlate with the ability of IL-4 to regulate allergic responses in IL-13(-/-) mice...
  3. ncbi A method for the purification and refolding of a recombinant form of the nontypeable Haemophilus influenzae P5 outer membrane protein fused to polyhistidine
    D C Webb
    Research Centre for Human and Biomedical Science, Faculty of Applied Science, University of Canberra, Canberra City, ACT 2601, Australia
    Protein Expr Purif 15:1-7. 1999
    ..Circular dichroism of the refolded rP5 demonstrated 55% beta-strand content, which is consistent with the beta-strand content of native P5 and the homologous E. coli protein OmpA...
  4. pmc Immunization with recombinant transferrin binding protein B enhances clearance of nontypeable Haemophilus influenzae from the rat lung
    D C Webb
    Gadi Research Centre, Faculty of Applied Science, University of Canberra, Canberra City, ACT 2601, Australia
    Infect Immun 67:2138-44. 1999
    ....
  5. pmc A P5 peptide that is homologous to peptide 10 of OprF from Pseudomonas aeruginosa enhances clearance of nontypeable Haemophilus influenzae from acutely infected rat lung in the absence of detectable peptide-specific antibody
    D C Webb
    The Gadi Research Center, Faculty of Applied Science and Design, University of Canberra, Canberra City, Australian Capital Territory 2601, Australia
    Infect Immun 68:377-81. 2000
    ....
  6. ncbi Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity
    Dianne C Webb
    Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Eur J Immunol 33:3377-85. 2003
    ..Collectively, these results demonstrate that IL-13-dependent processes regulating the development of AHR and T helper bias persist in the in the lungs of allergic IL-4Ralpha(-/-) mice...
  7. pmc Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
    Joerg Mattes
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Exp Med 195:1433-44. 2002
    ....
  8. doi Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation
    Yeping Cai
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 182:5393-9. 2009
    ..In summary, our results suggest that production of Ym1/2 in response to IL-13 promotes Th2 cytokine production and allergic airways inflammation by inhibiting the production of 12(S)-HETE by 12/15-LOX...
  9. doi Estrogen stimulates Th2 cytokine production and regulates the compartmentalisation of eosinophils during allergen challenge in a mouse model of asthma
    Yeping Cai
    Immunology Department, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Int Arch Allergy Immunol 158:252-60. 2012
    ..However, most studies examining the role of estrogen in rodent models of asthma are complicated by their reliance on ovariectomised mice in which hormones other than estrogen are also attenuated...
  10. ncbi Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness
    Ming Yang
    Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 177:5595-603. 2006
    ....
  11. doi Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma
    Jiansheng Zhou
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Am J Respir Crit Care Med 178:1202-10. 2008
    ....
  12. ncbi Investigation of the potential of a 48 kDa protein as a vaccine candidate for infection against nontypable Haemophilus influenzae
    Dianne C Webb
    Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, P O Box 334, Canberra City, ACT 2601, Australia
    Vaccine 25:4012-9. 2007
    ..These antibodies were not bactericidal against NTHi. The results suggest that P48 warrants further investigation as a vaccine component for NTHi disease...
  13. ncbi Interleukin-5 and eosinophils as therapeutic targets for asthma
    Paul S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
    Trends Mol Med 8:162-7. 2002
    ..The contribution of these IL-5-independent pathways should be considered when assessing the role of eosinophils in disease processes...
  14. doi Treatment of mice with fenbendazole attenuates allergic airways inflammation and Th2 cytokine production in a model of asthma
    Yeping Cai
    Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 87:623-9. 2009
    ..In addition, eosinophilia and Th2 responses remained attenuated after a 4-week withholding period in allergic mice treated preweaning with FBZ. Thus, FBZ modulates the amplitude of Th2 responses both in vivo and in vitro...
  15. ncbi Distinct spatial requirement for eosinophil-induced airways hyperreactivity
    D C Webb
    Leukocyte Signalling and Regulation Laboratory, Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Australia
    Immunol Cell Biol 79:165-9. 2001
    ....
  16. ncbi IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung
    J Mattes
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Immunol 167:1683-92. 2001
    ..We show that this novel pathway for IL-13 signaling is dependent on T cell activation in the lung and is critically linked to downstream effector pathways regulated by eotaxin and STAT6...
  17. ncbi Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity
    D C Webb
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra
    J Immunol 165:108-13. 2000
    ..Taken together, our data suggest both a modulatory role for IL-13 during sensitization and a proinflammatory role during aeroallergen challenge. The latter process appears redundant with respect to IL-4...
  18. ncbi Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma
    P S Foster
    Division of Molecular Biosciences, John Curtin School of Medical Research, Australian National University, Canberra Australia
    Clin Exp Allergy 33:688-95. 2003
    ..Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the pathogenesis of asthma...
  19. pmc Characterization of PitA and PitB from Escherichia coli
    R M Harris
    School of Biochemistry and Molecular Biology, The Faculties, The Australian National University, ACT, 0200, Australia
    J Bacteriol 183:5008-14. 2001
    ..This mutation greatly decreased the amount of PitA protein present in cell membranes, indicating that the aspartic acid substitution disrupts protein structure...
  20. ncbi Elemental signals regulating eosinophil accumulation in the lung
    P S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Acton, Canberra ACT
    Immunol Rev 179:173-81. 2001
    ..These data highlight the importance of targeting both IL-5 and CCR3 signalling systems for the resolution of inflammation and AHR associated with asthma...
  21. ncbi Mutational analysis of the Escherichia coli phosphate-specific transport system, a member of the traffic ATPase (or ABC) family of membrane transporters. A role for proline residues in transmembrane helices
    D C Webb
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra
    J Biol Chem 267:24661-8. 1992
    ..The double mutation in the PstA protein resulted in a permanently "closed" system, whereas the double mutation in the PstC protein resulted in a permanently "open" transport system...
  22. ncbi Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated protein
    D C Webb
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia
    J Biol Chem 276:41969-76. 2001
    ....
  23. ncbi Structural model of human IL-13 defines the spatial interactions with the IL-13Ralpha/IL-4Ralpha receptor
    J Zuegg
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research and Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 79:332-9. 2001
    ..From these studies we predict that helices A and C of HuIL-13 interact with the IL-4 receptor alpha (IL-4Ralpha) region and helix D is responsible for the interaction with the IL-13 receptor alpha 1 (IL-13Ralpha1) receptor...
  24. ncbi Effects of anticytokine therapy in a mouse model of chronic asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    Am J Respir Crit Care Med 170:1043-8. 2004
    ....
  25. ncbi Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    J Pharmacol Exp Ther 307:349-55. 2003
    ..Roflumilast did not diminish accumulation of transforming growth factor-beta1, suggesting that it might affect remodeling by mechanisms distinct from glucocorticoids...
  26. ncbi Interferon-gamma as a possible target in chronic asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    Inflamm Allergy Drug Targets 5:253-6. 2006
    ..This may be particularly relevant to acute exacerbations of asthma, in which setting there may be justification for therapeutic inhibition of IFN-gamma...