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Genomes and Genes | Dianne C WebbSummaryAffiliation: Australian National University Country: Australia Publications
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Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell functionDianne C Webb
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
J Immunol 178:219-27. 2007..The affinity of IL-4Ralpha also appears to be a determinant in the balance between Th2 and IFN-gamma responses and thus the severity of allergic disease...- Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13-/- miceDianne C Webb
Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia 2601
J Immunol 172:1092-8. 2004..Collectively, these data show that polymorphisms in IL-4Ralpha, which have been shown to affect the interaction with IL-4, correlate with the ability of IL-4 to regulate allergic responses in IL-13(-/-) mice... - A method for the purification and refolding of a recombinant form of the nontypeable Haemophilus influenzae P5 outer membrane protein fused to polyhistidineD C Webb
Research Centre for Human and Biomedical Science, Faculty of Applied Science, University of Canberra, Canberra City, ACT 2601, Australia
Protein Expr Purif 15:1-7. 1999..Circular dichroism of the refolded rP5 demonstrated 55% beta-strand content, which is consistent with the beta-strand content of native P5 and the homologous E. coli protein OmpA... 
Immunization with recombinant transferrin binding protein B enhances clearance of nontypeable Haemophilus influenzae from the rat lungD C Webb
Gadi Research Centre, Faculty of Applied Science, University of Canberra, Canberra City, ACT 2601, Australia
Infect Immun 67:2138-44. 1999....- A P5 peptide that is homologous to peptide 10 of OprF from Pseudomonas aeruginosa enhances clearance of nontypeable Haemophilus influenzae from acutely infected rat lung in the absence of detectable peptide-specific antibodyD C Webb
The Gadi Research Center, Faculty of Applied Science and Design, University of Canberra, Canberra City, Australian Capital Territory 2601, Australia
Infect Immun 68:377-81. 2000.... - Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivityDianne C Webb
Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
Eur J Immunol 33:3377-85. 2003..Collectively, these results demonstrate that IL-13-dependent processes regulating the development of AHR and T helper bias persist in the in the lungs of allergic IL-4Ralpha(-/-) mice... - Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthmaJoerg Mattes
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Exp Med 195:1433-44. 2002.... 
Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammationYeping Cai
John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 182:5393-9. 2009..In summary, our results suggest that production of Ym1/2 in response to IL-13 promotes Th2 cytokine production and allergic airways inflammation by inhibiting the production of 12(S)-HETE by 12/15-LOX...- Estrogen stimulates Th2 cytokine production and regulates the compartmentalisation of eosinophils during allergen challenge in a mouse model of asthmaYeping Cai
Immunology Department, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
Int Arch Allergy Immunol 158:252-60. 2012..However, most studies examining the role of estrogen in rodent models of asthma are complicated by their reliance on ovariectomised mice in which hormones other than estrogen are also attenuated... - Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsivenessMing Yang
Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 177:5595-603. 2006.... - Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthmaJiansheng Zhou
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Am J Respir Crit Care Med 178:1202-10. 2008.... - Investigation of the potential of a 48 kDa protein as a vaccine candidate for infection against nontypable Haemophilus influenzaeDianne C Webb
Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, P O Box 334, Canberra City, ACT 2601, Australia
Vaccine 25:4012-9. 2007..These antibodies were not bactericidal against NTHi. The results suggest that P48 warrants further investigation as a vaccine component for NTHi disease... - Interleukin-5 and eosinophils as therapeutic targets for asthmaPaul S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
Trends Mol Med 8:162-7. 2002..The contribution of these IL-5-independent pathways should be considered when assessing the role of eosinophils in disease processes... - Treatment of mice with fenbendazole attenuates allergic airways inflammation and Th2 cytokine production in a model of asthmaYeping Cai
Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 87:623-9. 2009..In addition, eosinophilia and Th2 responses remained attenuated after a 4-week withholding period in allergic mice treated preweaning with FBZ. Thus, FBZ modulates the amplitude of Th2 responses both in vivo and in vitro... - Distinct spatial requirement for eosinophil-induced airways hyperreactivityD C Webb
Leukocyte Signalling and Regulation Laboratory, Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Australia
Immunol Cell Biol 79:165-9. 2001.... - IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lungJ Mattes
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Immunol 167:1683-92. 2001..We show that this novel pathway for IL-13 signaling is dependent on T cell activation in the lung and is critically linked to downstream effector pathways regulated by eotaxin and STAT6... - Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivityD C Webb
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra
J Immunol 165:108-13. 2000..Taken together, our data suggest both a modulatory role for IL-13 during sensitization and a proinflammatory role during aeroallergen challenge. The latter process appears redundant with respect to IL-4... - Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthmaP S Foster
Division of Molecular Biosciences, John Curtin School of Medical Research, Australian National University, Canberra Australia
Clin Exp Allergy 33:688-95. 2003..Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the pathogenesis of asthma... - Characterization of PitA and PitB from Escherichia coliR M Harris
School of Biochemistry and Molecular Biology, The Faculties, The Australian National University, ACT, 0200, Australia
J Bacteriol 183:5008-14. 2001..This mutation greatly decreased the amount of PitA protein present in cell membranes, indicating that the aspartic acid substitution disrupts protein structure... - Elemental signals regulating eosinophil accumulation in the lungP S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Acton, Canberra ACT
Immunol Rev 179:173-81. 2001..These data highlight the importance of targeting both IL-5 and CCR3 signalling systems for the resolution of inflammation and AHR associated with asthma... - Mutational analysis of the Escherichia coli phosphate-specific transport system, a member of the traffic ATPase (or ABC) family of membrane transporters. A role for proline residues in transmembrane helicesD C Webb
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra
J Biol Chem 267:24661-8. 1992..The double mutation in the PstA protein resulted in a permanently "closed" system, whereas the double mutation in the PstC protein resulted in a permanently "open" transport system... - Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated proteinD C Webb
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia
J Biol Chem 276:41969-76. 2001.... - Structural model of human IL-13 defines the spatial interactions with the IL-13Ralpha/IL-4Ralpha receptorJ Zuegg
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research and Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 79:332-9. 2001..From these studies we predict that helices A and C of HuIL-13 interact with the IL-4 receptor alpha (IL-4Ralpha) region and helix D is responsible for the interaction with the IL-13 receptor alpha 1 (IL-13Ralpha1) receptor... - Effects of anticytokine therapy in a mouse model of chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Am J Respir Crit Care Med 170:1043-8. 2004.... - Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
J Pharmacol Exp Ther 307:349-55. 2003..Roflumilast did not diminish accumulation of transforming growth factor-beta1, suggesting that it might affect remodeling by mechanisms distinct from glucocorticoids... - Interferon-gamma as a possible target in chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Inflamm Allergy Drug Targets 5:253-6. 2006..This may be particularly relevant to acute exacerbations of asthma, in which setting there may be justification for therapeutic inhibition of IFN-gamma...