C G Vinuesa

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. pmc IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    Michelle A Linterman
    John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Exp Med 207:353-63. 2010
  2. pmc Follicular helper T cells are required for systemic autoimmunity
    Michelle A Linterman
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Exp Med 206:561-76. 2009
  3. pmc Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells
    Diego G Silva
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Diabetes 60:2102-11. 2011
  4. pmc B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
    Sau K Lee
    Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia
    J Exp Med 208:1377-88. 2011
  5. pmc Foxp3+ follicular regulatory T cells control the germinal center response
    Michelle A Linterman
    Cambridge Institute for Medical Research and the Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Nat Med 17:975-82. 2011
  6. doi request reprint Innate B cell helpers reveal novel types of antibody responses
    Carola G Vinuesa
    Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Nat Immunol 14:119-26. 2013
  7. pmc HIV and T follicular helper cells: a dangerous relationship
    Carola G Vinuesa
    Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Clin Invest 122:3059-62. 2012
  8. ncbi request reprint Analysis of B cell memory formation using DNA microarrays
    Carola G Vinuesa
    Medical Genome Centre, John Curtin School of Medical Research, Australian National University, ACT, Australia
    Ann N Y Acad Sci 975:33-45. 2002
  9. ncbi request reprint A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    Carola G Vinuesa
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Nature 435:452-8. 2005
  10. doi request reprint T cells and follicular dendritic cells in germinal center B-cell formation and selection
    Carola G Vinuesa
    John Curtin School of Medical Research and Australian Phenomics Facility, Australian National University, Canberra, ACT, Australia
    Immunol Rev 237:72-89. 2010

Collaborators

Detail Information

Publications37

  1. pmc IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    Michelle A Linterman
    John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Exp Med 207:353-63. 2010
    ..In contrast to the requirement for IL-21 in the follicular response to sheep red blood cells, a purely extrafollicular antibody response to Salmonella dominated by IgG2a was intact in the absence of IL-21...
  2. pmc Follicular helper T cells are required for systemic autoimmunity
    Michelle A Linterman
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Exp Med 206:561-76. 2009
    ..In contrast, adoptive transfer of sanroque T(FH) cells led to spontaneous GC formation. These findings identify T(FH) dysfunction within GCs and aberrant positive selection as a pathway to systemic autoimmunity...
  3. pmc Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells
    Diego G Silva
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Diabetes 60:2102-11. 2011
    ..To define cellular mechanisms by which B cells promote type 1 diabetes...
  4. pmc B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
    Sau K Lee
    Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia
    J Exp Med 208:1377-88. 2011
    ..In conclusion, Bcl-6(+) T cells are necessary at B cell priming to form extrafollicular antibody responses, and these pre-GC Tfh cells can be distinguished phenotypically from GC Tfh cells...
  5. pmc Foxp3+ follicular regulatory T cells control the germinal center response
    Michelle A Linterman
    Cambridge Institute for Medical Research and the Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Nat Med 17:975-82. 2011
    ..Thus, the T(FH) differentiation pathway is co-opted by T(reg) cells to control the germinal center response...
  6. doi request reprint Innate B cell helpers reveal novel types of antibody responses
    Carola G Vinuesa
    Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Nat Immunol 14:119-26. 2013
    ..Here we update the classification of antibody responses to take into account these emerging types of B cell helpers...
  7. pmc HIV and T follicular helper cells: a dangerous relationship
    Carola G Vinuesa
    Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Clin Invest 122:3059-62. 2012
    ..Their discoveries suggest that HIV harnesses TFH cells to evade the antibody response...
  8. ncbi request reprint Analysis of B cell memory formation using DNA microarrays
    Carola G Vinuesa
    Medical Genome Centre, John Curtin School of Medical Research, Australian National University, ACT, Australia
    Ann N Y Acad Sci 975:33-45. 2002
    ..This model demonstrates how genome-scale technology can be adapted to investigate specific aspects of B cell biology...
  9. ncbi request reprint A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    Carola G Vinuesa
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Nature 435:452-8. 2005
    ..The Roquin protein is distinguished by the presence of a CCCH zinc-finger found in RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating messenger RNA translation and stability...
  10. doi request reprint T cells and follicular dendritic cells in germinal center B-cell formation and selection
    Carola G Vinuesa
    John Curtin School of Medical Research and Australian Phenomics Facility, Australian National University, Canberra, ACT, Australia
    Immunol Rev 237:72-89. 2010
    ..This emerges as a powerful mechanism to ensure death of B cells that bind self-reactive antigen, which would not normally be presented on FDCs...
  11. ncbi request reprint The molecular basis of lymphoid architecture and B cell responses: implications for immunodeficiency and immunopathology
    C G Vinuesa
    Medical Genome Center, John Curtin School of Medical Research, Australian National University, Canberra, ACT
    Curr Mol Med 1:689-725. 2001
    ....
  12. ncbi request reprint Dysregulation of germinal centres in autoimmune disease
    Carola G Vinuesa
    John Curtin School of Medical Research, Australian National University, GPO Box 334, Canberra, ACT 2601, Australia
    Nat Rev Immunol 9:845-57. 2009
    ..Elucidation of crucial molecular signals in germinal centres has led to the identification of novel therapeutic targets...
  13. ncbi request reprint Logic and extent of miRNA-mediated control of autoimmune gene expression
    Carola G Vinuesa
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Int Rev Immunol 28:112-38. 2009
    ..In the light of this vast and promiscuous miRNA-mediated regulation of autoimmune genes it is anticipated that changes in miRNA levels or their target sequences will help explain susceptibility to complex autoimmune diseases...
  14. doi request reprint How T cells earn the follicular rite of passage
    Carola G Vinuesa
    Department of Pathogens and Immunity, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Immunity 35:671-80. 2011
    ..This review will focus on recent insights into the early events that determine Tfh cell differentiation...
  15. ncbi request reprint Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS
    Michelle A Linterman
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Immunity 30:228-41. 2009
    ..Mechanisms to functionally compartmentalize ICOS and CD28 signals are thus critical for two-signal control of normal immune reactions...
  16. doi request reprint Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    Nicholas Simpson
    Australian National University, Canberra, ACT, Australia
    Arthritis Rheum 62:234-44. 2010
    ..The purpose of this study was to examine the hypothesis that this pathway could account for a subset of patients with systemic lupus erythematosus (SLE)...
  17. ncbi request reprint Axon growth and guidance genes identify T-dependent germinal centre B cells
    Di Yu
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    Immunol Cell Biol 86:3-14. 2008
    ..Finally we show some of the axon growth genes upregulated in TD-GC B cells including Basp1, Shh, Sult4alpha, Sc4mol are also preferentially expressed in post-GC B cell neoplasms...
  18. ncbi request reprint Blood relatives of follicular helper T cells
    Carola G Vinuesa
    John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Immunity 34:10-2. 2011
    ..In this issue of Immunity, Morita et al. (2011) describe a heterogeneous circulating CXCR5(+)CD4(+) B cell helper population overrepresented in juvenile dermatomyositis patients...
  19. doi request reprint Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
    Di Yu
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
    Nature 450:299-303. 2007
    ..These findings illuminate a critical post-transcriptional pathway within T cells that regulates lymphocyte accumulation and autoimmunity, and highlights the therapeutic potential of partially antagonising the ICOS pathway...
  20. ncbi request reprint Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
    Lixin Rui
    ACRF Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Nat Immunol 4:594-600. 2003
    ....
  21. ncbi request reprint Control systems and decision making for antibody production
    Christopher C Goodnow
    John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Nat Immunol 11:681-8. 2010
    ..Understanding the engineering of these control systems represents a challenging future step for treating disorders of antibody production in autoimmunity, allergy and immunodeficiency...
  22. ncbi request reprint Cellular and genetic mechanisms of self tolerance and autoimmunity
    Christopher C Goodnow
    John Curtin School of Medical Research, Canberra ACT 2601
    Nature 435:590-7. 2005
    ..This provides the bridge between clinical studies and mechanisms defined in experimental animals to understand how sets of gene products coordinate self-tolerance mechanisms and how defects in these controls lead to autoimmune disease...
  23. ncbi request reprint Follicular B helper T cells in antibody responses and autoimmunity
    Carola G Vinuesa
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra 2601, Australia
    Nat Rev Immunol 5:853-65. 2005
    ..Here, we outline the central role of this subset in normal and pathological immune responses...
  24. ncbi request reprint Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis
    Todor Arsov
    John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia
    Mol Endocrinol 20:1610-22. 2006
    ....
  25. pmc Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
    Katrina L Randall
    John Curtin School of Medical Research and Australian Phenomics Facility, Australian National University, Australia
    Nat Immunol 10:1283-91. 2009
    ..Humoral immunodeficiency due to Dock8 mutation provides evidence that organization of the immunological synapse is critical for signaling the survival of B cell subsets required for long-lasting immunity...
  26. ncbi request reprint Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis
    Jesse E Jun
    Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, ACT 2601, Canberra, Australia
    Immunity 18:751-62. 2003
    ..These results define Carma-1 as a key regulator of the plasticity in antigen receptor signaling that underpins opposing mechanisms of immunity and tolerance...
  27. ncbi request reprint SiLEncing SLE: the power and promise of small noncoding RNAs
    Robert J Rigby
    Division of Immunity and Infection, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Curr Opin Rheumatol 20:526-31. 2008
    ....
  28. ncbi request reprint Tolerance mechanisms in the late phase of the antibody response
    Christopher C Goodnow
    John Curtin School of Medical Research, The Australian National University, Mills Rd, Canberra, ACT, Australia 0200
    Adv Exp Med Biol 596:163-8. 2007
  29. ncbi request reprint Genetic analysis of systemic autoimmunity
    Carola G Vinuesa
    John Curtin School of Medical Research and Medical School, Australian National University, Canberra, Australia
    Novartis Found Symp 281:103-20; discussion 120-8, 208-9. 2007
    ....
  30. ncbi request reprint Illuminating autoimmune regulators through controlled variation of the mouse genome sequence
    Carola G Vinuesa
    John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Mills Road, Canberra, ACT 2601, Australia
    Immunity 20:669-79. 2004
    ....
  31. doi request reprint The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs
    Vicki Athanasopoulos
    The Australian National University, Canberra, Australia
    FEBS J 277:2109-27. 2010
    ....
  32. ncbi request reprint ENU-mutagenesis: insight into immune function and pathology
    Matthew C Cook
    Frank Fenner Building, Australian National University, Canberra ACT 0200, Australia
    Curr Opin Immunol 18:627-33. 2006
    ..More than 20 of the phenotypes that exhibit a simple (Mendelian) pattern of inheritance have been mapped. Novel alleles have revealed new pathways of host defense, allergy and autoimmunity...
  33. ncbi request reprint Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens
    Carola G Vinuesa
    University of Birmingham, MRC Centre for Immune Regulation, Birmingham, GB
    Eur J Immunol 33:297-305. 2003
    ..The differentiation of B cells both from germinal centers and the recirculating pool to the MZ phenotype is likely to make an important contribution to the repertoire of B cells that respond to polysaccharide antigens...
  34. pmc Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers
    Kai Michael Toellner
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
    J Exp Med 195:383-9. 2002
    ..It is concluded that efficient activation of hypermutation depends on interaction with T cells, but some hypermutation may be induced without such signals, even outside germinal centers...
  35. ncbi request reprint Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice
    Jerome P Jayasekera
    Department of Pathology, Bosch Institute, School of Biomedical Sciences, Blackburn Building D06, University of Sydney, NSW 2006, Australia
    J Gen Virol 87:3361-71. 2006
    ..The relationship between viral load and the development of immunopathology is discussed...
  36. pmc B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular antibody responses
    Mei Chi Hsu
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 103:5905-10. 2006
    ..The absence of B2 and T cells confirms that hemopoietic cell chimerism leading to primary lymphopoiesis had not been established...
  37. ncbi request reprint Immunology: DNA drives autoimmunity
    Carola G Vinuesa
    Nature 416:595-8. 2002