Charani Ranasinghe

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. doi IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants
    Charani Ranasinghe
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia Electronic address
    Cytokine Growth Factor Rev 25:437-42. 2014
  2. doi New advances in mucosal vaccination
    Charani Ranasinghe
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia Electronic address
    Immunol Lett 161:204-6. 2014
  3. doi Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8(+) CTL avidity
    Charani Ranasinghe
    The Australian National University, Canberra, Australia
    Eur J Immunol 39:1819-30. 2009
  4. ncbi Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1
    Charani Ranasinghe
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Vaccine 24:5881-95. 2006
  5. ncbi Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles
    Charani Ranasinghe
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 178:2370-9. 2007
  6. pmc A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations
    Charani Ranasinghe
    The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Vaccine 29:3008-20. 2011
  7. doi Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity
    Charani Ranasinghe
    The Emerging Pathogens and Vaccines Program, The John Curtin School of Medical Research, The Australian National University, ACT, Australia
    Expert Rev Vaccines 8:1171-81. 2009
  8. ncbi 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine
    Jodie M Harrison
    Department of Immunology and Genetics, The John Curtin School of Medical Research, Canberra City, Australia
    Vaccine 24:6867-74. 2006
  9. pmc Role of novel type I interferon epsilon in viral infection and mucosal immunity
    Yang Xi
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Mucosal Immunol 5:610-22. 2012
  10. ncbi Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy
    Stephanie L Day
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 180:7158-66. 2008

Collaborators

Detail Information

Publications25

  1. doi IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants
    Charani Ranasinghe
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia Electronic address
    Cytokine Growth Factor Rev 25:437-42. 2014
    ....
  2. doi New advances in mucosal vaccination
    Charani Ranasinghe
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia Electronic address
    Immunol Lett 161:204-6. 2014
    ..Collectively, the workshop provided insights into recent developments in the mucosal vaccine research field, highlighting the complexities associated with designing safe and effective mucosal vaccines. ..
  3. doi Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8(+) CTL avidity
    Charani Ranasinghe
    The Australian National University, Canberra, Australia
    Eur J Immunol 39:1819-30. 2009
    ..STAT6(-/-) mice also showed memory CTL of higher avidity. Furthermore, CCL5 expression in K(d)Gag(197-205)-specific CTL was also regulated by IL-4/IL-13...
  4. ncbi Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1
    Charani Ranasinghe
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Vaccine 24:5881-95. 2006
    ....
  5. ncbi Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles
    Charani Ranasinghe
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 178:2370-9. 2007
    ..A greater understanding of these factors will be crucial for the development of effective vaccines in the future...
  6. pmc A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations
    Charani Ranasinghe
    The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Vaccine 29:3008-20. 2011
    ..Our findings further substantiate the importance of vector selection/combination, order and route of delivery when designing effective vaccines for HIV-1...
  7. doi Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity
    Charani Ranasinghe
    The Emerging Pathogens and Vaccines Program, The John Curtin School of Medical Research, The Australian National University, ACT, Australia
    Expert Rev Vaccines 8:1171-81. 2009
    ....
  8. ncbi 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine
    Jodie M Harrison
    Department of Immunology and Genetics, The John Curtin School of Medical Research, Canberra City, Australia
    Vaccine 24:6867-74. 2006
    ..This data is the first to show modulation of the immune response to a viral vaccine by coexpression of 4-1BBL and supports this strategy as an exciting approach for enhancement of T cell memory in prime-boost vaccines...
  9. pmc Role of novel type I interferon epsilon in viral infection and mucosal immunity
    Yang Xi
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Mucosal Immunol 5:610-22. 2012
    ..Our results indicate that IFN-ε has a unique role in the mucosae and most likely can be used to control local lung and/or gut infections (i.e., microbicide) such as tuberculosis, HIV-1, or sexually transmitted diseases...
  10. ncbi Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy
    Stephanie L Day
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 180:7158-66. 2008
    ..Our data also indicate that while IFN-epsilon exhibits certain biological traits similar to other type I IFNs, it may also have a specific role in mucosal immune regulation that is quite distinct...
  11. doi Fluorescent target array T helper assay: a multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Immunol Methods 387:181-90. 2013
    ....
  12. doi Evaluating vaccinia virus cytokine co-expression in TLR GKO mice
    Duncan B Sutherland
    Emerging Pathogens and Vaccines Program, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 89:706-15. 2011
    ....
  13. pmc Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity
    Danushka K Wijesundara
    The Molecular Mucosal Vaccine Immunology Group, The Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Acton, Canberra, Australia
    PLoS ONE 8:e55788. 2013
    ..This can improve the quality of anti-viral CD8(+) T cell immunity. Our findings have important implications in understanding anti-viral CD8(+) T cell immunity and designing effective vaccines against chronic viral infections...
  14. doi Human immunodeficiency virus-1 vaccine design: where do we go now?
    Danushka K Wijesundara
    Department Emerging Pathogens and Vaccines, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 89:367-74. 2011
    ....
  15. ncbi Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use
    Scott A Thomson
    Division of Immunology and Genetics, John Curtin School of Medical Research JCSMR, Australian National University, P O Box 334, Canberra, ACT 2601, Australia
    Vaccine 23:4647-57. 2005
    ..This platform strategy could be used for other infections and cancers where T cell responses are important for protection...
  16. pmc Use of an in vivo FTA assay to assess the magnitude, functional avidity and epitope variant cross-reactivity of T cell responses following HIV-1 recombinant poxvirus vaccination
    Danushka K Wijesundara
    Molecular Mucosal Vaccine Immunology Group, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    PLoS ONE 9:e105366. 2014
    ....
  17. doi IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination
    Danushka K Wijesundara
    The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia Electronic address
    Vaccine 31:4548-55. 2013
    ..These findings can be exploited to, design more efficacious vaccines not only against HIV-1, but many chronic infections where high, avidity CD8(+) T cells help protection. ..
  18. doi Fluorescent target array killing assay: a multiplex cytotoxic T-cell assay to measure detailed T-cell antigen specificity and avidity in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia
    Cytometry A 81:679-90. 2012
    ..This fluorescent target array killing assay can be used to measure the fine antigen specificity and avidity of polyclonal cytotoxic T-cell responses in vivo, immunological parameters that were previously impossible to monitor...
  19. pmc The use of fluorescent target arrays for assessment of T cell responses in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University
    J Vis Exp . 2014
    ..Herein, we describe how these FTAs are constructed and give an example of how they can be applied to assess T cell responses induced by a recombinant pox virus vaccine...
  20. doi Novel HIV IL-4R antagonist vaccine strategy can induce both high avidity CD8 T and B cell immunity with greater protective efficacy
    Ronald J Jackson
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia
    Vaccine 32:5703-14. 2014
    ....
  21. doi Different HIV pox viral vector-based vaccines and adjuvants can induce unique antigen presenting cells that modulate CD8 T cell avidity
    Shubhanshi Trivedi
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia Electronic address
    Virology 468:479-89. 2014
    ..Collectively; our observations revealed that rFPV vector prime and transient inhibition of IL-4/IL-13 at the vaccination site favoured the recruitment of unique LDCs, associated with the induction of high quality immunity. ..
  22. pmc IL-17A expression in HIV-specific CD8 T cells is regulated by IL-4/IL-13 following HIV-1 prime-boost immunization
    Jayashree Ravichandran
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    J Interferon Cytokine Res 35:176-85. 2015
    ....
  23. doi Progresses in DNA-based heterologous prime-boost immunization strategies
    Ronald J Jackson
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia
    Methods Mol Biol 1143:61-90. 2014
    ....
  24. ncbi Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3
    Stephen J Kent
    Department of Microbiology and Immunology, University of Melbourne, VIC 3010, Australia
    Vaccine 23:5009-21. 2005
    ..Our data suggest strategies for effective priming of partial immunity to mucosal HIV-1 exposure utilizing systemic prime and mucosal boost vaccination strategies...
  25. ncbi Prime-boost strategies in DNA vaccines
    C Jane Dale
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Methods Mol Med 127:171-97. 2006
    ..Methods for the construction of the vaccines, the use of animal models, and the detection of immune responses are described...