Charani Ranasinghe

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. pmc Role of novel type I interferon epsilon in viral infection and mucosal immunity
    Yang Xi
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Mucosal Immunol 5:610-22. 2012
  2. pmc A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations
    Charani Ranasinghe
    The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Vaccine 29:3008-20. 2011
  3. ncbi request reprint Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1
    Charani Ranasinghe
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Vaccine 24:5881-95. 2006
  4. doi request reprint Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity
    Charani Ranasinghe
    The Emerging Pathogens and Vaccines Program, The John Curtin School of Medical Research, The Australian National University, ACT, Australia
    Expert Rev Vaccines 8:1171-81. 2009
  5. ncbi request reprint Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles
    Charani Ranasinghe
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 178:2370-9. 2007
  6. doi request reprint Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8(+) CTL avidity
    Charani Ranasinghe
    The Australian National University, Canberra, Australia
    Eur J Immunol 39:1819-30. 2009
  7. ncbi request reprint 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine
    Jodie M Harrison
    Department of Immunology and Genetics, The John Curtin School of Medical Research, Canberra City, Australia
    Vaccine 24:6867-74. 2006
  8. ncbi request reprint Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy
    Stephanie L Day
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 180:7158-66. 2008
  9. doi request reprint Fluorescent target array T helper assay: a multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Immunol Methods 387:181-90. 2013
  10. doi request reprint Evaluating vaccinia virus cytokine co-expression in TLR GKO mice
    Duncan B Sutherland
    Emerging Pathogens and Vaccines Program, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 89:706-15. 2011

Collaborators

Detail Information

Publications18

  1. pmc Role of novel type I interferon epsilon in viral infection and mucosal immunity
    Yang Xi
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Mucosal Immunol 5:610-22. 2012
    ..Our results indicate that IFN-ε has a unique role in the mucosae and most likely can be used to control local lung and/or gut infections (i.e., microbicide) such as tuberculosis, HIV-1, or sexually transmitted diseases...
  2. pmc A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations
    Charani Ranasinghe
    The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Vaccine 29:3008-20. 2011
    ..Our findings further substantiate the importance of vector selection/combination, order and route of delivery when designing effective vaccines for HIV-1...
  3. ncbi request reprint Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1
    Charani Ranasinghe
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Vaccine 24:5881-95. 2006
    ....
  4. doi request reprint Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity
    Charani Ranasinghe
    The Emerging Pathogens and Vaccines Program, The John Curtin School of Medical Research, The Australian National University, ACT, Australia
    Expert Rev Vaccines 8:1171-81. 2009
    ....
  5. ncbi request reprint Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles
    Charani Ranasinghe
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 178:2370-9. 2007
    ..A greater understanding of these factors will be crucial for the development of effective vaccines in the future...
  6. doi request reprint Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8(+) CTL avidity
    Charani Ranasinghe
    The Australian National University, Canberra, Australia
    Eur J Immunol 39:1819-30. 2009
    ..STAT6(-/-) mice also showed memory CTL of higher avidity. Furthermore, CCL5 expression in K(d)Gag(197-205)-specific CTL was also regulated by IL-4/IL-13...
  7. ncbi request reprint 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine
    Jodie M Harrison
    Department of Immunology and Genetics, The John Curtin School of Medical Research, Canberra City, Australia
    Vaccine 24:6867-74. 2006
    ..This data is the first to show modulation of the immune response to a viral vaccine by coexpression of 4-1BBL and supports this strategy as an exciting approach for enhancement of T cell memory in prime-boost vaccines...
  8. ncbi request reprint Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy
    Stephanie L Day
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 180:7158-66. 2008
    ..Our data also indicate that while IFN-epsilon exhibits certain biological traits similar to other type I IFNs, it may also have a specific role in mucosal immune regulation that is quite distinct...
  9. doi request reprint Fluorescent target array T helper assay: a multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Immunol Methods 387:181-90. 2013
    ....
  10. doi request reprint Evaluating vaccinia virus cytokine co-expression in TLR GKO mice
    Duncan B Sutherland
    Emerging Pathogens and Vaccines Program, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 89:706-15. 2011
    ....
  11. pmc Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity
    Danushka K Wijesundara
    The Molecular Mucosal Vaccine Immunology Group, The Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Acton, Canberra, Australia
    PLoS ONE 8:e55788. 2013
    ..This can improve the quality of anti-viral CD8(+) T cell immunity. Our findings have important implications in understanding anti-viral CD8(+) T cell immunity and designing effective vaccines against chronic viral infections...
  12. ncbi request reprint Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use
    Scott A Thomson
    Division of Immunology and Genetics, John Curtin School of Medical Research JCSMR, Australian National University, P O Box 334, Canberra, ACT 2601, Australia
    Vaccine 23:4647-57. 2005
    ..This platform strategy could be used for other infections and cancers where T cell responses are important for protection...
  13. doi request reprint IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination
    Danushka K Wijesundara
    The John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia Electronic address
    Vaccine 31:4548-55. 2013
    ..These findings can be exploited to, design more efficacious vaccines not only against HIV-1, but many chronic infections where high, avidity CD8(+) T cells help protection. ..
  14. doi request reprint Fluorescent target array killing assay: a multiplex cytotoxic T-cell assay to measure detailed T-cell antigen specificity and avidity in vivo
    Benjamin J C Quah
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia
    Cytometry A 81:679-90. 2012
    ..This fluorescent target array killing assay can be used to measure the fine antigen specificity and avidity of polyclonal cytotoxic T-cell responses in vivo, immunological parameters that were previously impossible to monitor...
  15. doi request reprint Human immunodeficiency virus-1 vaccine design: where do we go now?
    Danushka K Wijesundara
    Department Emerging Pathogens and Vaccines, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 89:367-74. 2011
    ....
  16. doi request reprint Progresses in DNA-Based Heterologous Prime-Boost Immunization Strategies
    Ronald J Jackson
    Molecular Mucosal Vaccine Immunology Group, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia
    Methods Mol Biol 1143:61-90. 2014
    ....
  17. ncbi request reprint Prime-boost strategies in DNA vaccines
    C Jane Dale
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Methods Mol Med 127:171-97. 2006
    ..Methods for the construction of the vaccines, the use of animal models, and the detection of immune responses are described...
  18. ncbi request reprint Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3
    Stephen J Kent
    Department of Microbiology and Immunology, University of Melbourne, VIC 3010, Australia
    Vaccine 23:5009-21. 2005
    ..Our data suggest strategies for effective priming of partial immunity to mucosal HIV-1 exposure utilizing systemic prime and mucosal boost vaccination strategies...