N Petrovsky

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. pmc Identification of "pathologs" (disease-related genes) from the RIKEN mouse cDNA dataset using human curation plus FACTS, a new biological information extraction system
    Diego G Silva
    Medical Informatics Centre, University of Canberra, ACT 2601 Australia
    BMC Genomics 5:28. 2004
  2. ncbi Virtual models of the HLA class I antigen processing pathway
    Nikolai Petrovsky
    Autoimmunity Research Unit, The Canberra Hospital, ACT 2606, Australia
    Methods 34:429-35. 2004
  3. ncbi Vaccine adjuvants: current state and future trends
    Nikolai Petrovsky
    Autoimmunity Research Unit, ANU Medical School, Australian National University, Canberra, ACT 2061, Australia
    Immunol Cell Biol 82:488-96. 2004
  4. ncbi Vaccine therapies for the prevention of type 1 diabetes mellitus
    Nikolai Petrovsky
    Autoimmunity Research Unit, The Canberra Hospital, Canberra, Australian Capital Territory, Australia and John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Paediatr Drugs 5:575-82. 2003
  5. ncbi Bioinformatic strategies for better understanding of immune function
    Nikolai Petrovsky
    Centre for Medical Informatics, Division of Science and Design, University of Canberra, Bruce ACT 2617, Australia
    In Silico Biol 3:411-6. 2003
  6. ncbi The power of an integrated informatic and molecular approach to type 1 diabetes research
    Nikolai Petrovsky
    Director, Diabetes and Endocrinology, Flinders Medical Centre, Bedford Park, South Australia, Australia
    Ann N Y Acad Sci 1037:216-24. 2004
  7. ncbi Towards a unified model of neuroendocrine-immune interaction
    N Petrovsky
    Autoimmunity Research Unit, Canberra Clinical School, University of Sydney and Division of Science and Design, University of Canberra, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 79:350-7. 2001
  8. ncbi Prospects for the prevention and reversal of type 1 diabetes mellitus
    Nikolai Petrovsky
    Autoimmunity Research Unit, Canberra Hospital and Medical Informatics Centre, University of Canberra, ACT, Australia
    Drugs 62:2617-35. 2002
  9. ncbi The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice
    N Petrovsky
    Autoimmunity Research Unit, Canberra Clinical School, University of Sydney, Canberra ACT 2606, Australia
    Ann N Y Acad Sci 958:204-8. 2002
  10. ncbi Computational immunology: The coming of age
    Nikolai Petrovsky
    National BioinformaticsCentre, University of Canberra and National Health Sciences Centre, Canberra Clinical School, Woden, Australian Capital Territory, Australia
    Immunol Cell Biol 80:248-54. 2002

Detail Information

Publications44

  1. pmc Identification of "pathologs" (disease-related genes) from the RIKEN mouse cDNA dataset using human curation plus FACTS, a new biological information extraction system
    Diego G Silva
    Medical Informatics Centre, University of Canberra, ACT 2601 Australia
    BMC Genomics 5:28. 2004
    ..Rather than just focus on Mendelian inheritance, we applied the analysis to all potential pathologs regardless of their inheritance pattern...
  2. ncbi Virtual models of the HLA class I antigen processing pathway
    Nikolai Petrovsky
    Autoimmunity Research Unit, The Canberra Hospital, ACT 2606, Australia
    Methods 34:429-35. 2004
    ..Accurate models of antigen processing have implications for the study of basic immunology as well as for the design of peptide-based vaccines and other immunotherapies...
  3. ncbi Vaccine adjuvants: current state and future trends
    Nikolai Petrovsky
    Autoimmunity Research Unit, ANU Medical School, Australian National University, Canberra, ACT 2061, Australia
    Immunol Cell Biol 82:488-96. 2004
    ..This paper reviews the state of the art in the adjuvant field, explores future directions of adjuvant development and finally examines some of the impediments and barriers to development and registration of new human adjuvants...
  4. ncbi Vaccine therapies for the prevention of type 1 diabetes mellitus
    Nikolai Petrovsky
    Autoimmunity Research Unit, The Canberra Hospital, Canberra, Australian Capital Territory, Australia and John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Paediatr Drugs 5:575-82. 2003
    ..However, despite the significant hurdles that remain, vaccines remain one of the most promising strategies to prevent type 1 diabetes, with major advantages including convenience, safety, and long-lasting protection...
  5. ncbi Bioinformatic strategies for better understanding of immune function
    Nikolai Petrovsky
    Centre for Medical Informatics, Division of Science and Design, University of Canberra, Bruce ACT 2617, Australia
    In Silico Biol 3:411-6. 2003
    ..A main conclusion of the meeting is the critical role played by immunoinformatics in current immunology research. In particular, immunoinformatics provides a foundation for the emerging fields of systems immunology and immunogenomics...
  6. ncbi The power of an integrated informatic and molecular approach to type 1 diabetes research
    Nikolai Petrovsky
    Director, Diabetes and Endocrinology, Flinders Medical Centre, Bedford Park, South Australia, Australia
    Ann N Y Acad Sci 1037:216-24. 2004
    ....
  7. ncbi Towards a unified model of neuroendocrine-immune interaction
    N Petrovsky
    Autoimmunity Research Unit, Canberra Clinical School, University of Sydney and Division of Science and Design, University of Canberra, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 79:350-7. 2001
    ....
  8. ncbi Prospects for the prevention and reversal of type 1 diabetes mellitus
    Nikolai Petrovsky
    Autoimmunity Research Unit, Canberra Hospital and Medical Informatics Centre, University of Canberra, ACT, Australia
    Drugs 62:2617-35. 2002
    ..This review describes recent advances in each of these research areas and aims to provide clinicians with an idea of where and when an effective strategy to prevent or reverse diabetes development will become available...
  9. ncbi The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice
    N Petrovsky
    Autoimmunity Research Unit, Canberra Clinical School, University of Sydney, Canberra ACT 2606, Australia
    Ann N Y Acad Sci 958:204-8. 2002
    ..Interventions that block the Fas-FasL pathway may be useful, therefore, in the prevention or treatment of type 1 diabetes...
  10. ncbi Computational immunology: The coming of age
    Nikolai Petrovsky
    National BioinformaticsCentre, University of Canberra and National Health Sciences Centre, Canberra Clinical School, Woden, Australian Capital Territory, Australia
    Immunol Cell Biol 80:248-54. 2002
    ....
  11. ncbi The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.k iHEL, a novel model of beta cell death
    L Socha
    Autoimmunity Research Unit, The Canberra Hospital, Canberra, Australia
    Ann N Y Acad Sci 1005:178-83. 2003
    ..The observation that only male NOD.k iHEL mice develop diabetes and exhibit ER abnormalities is intriguing and suggests these mice may be useful in deciphering the link between hyperandrogenism, insulin resistance, and diabetes...
  12. ncbi Bioinformatics for study of autoimmunity
    Nikolai Petrovsky
    Flinders Medical Centre Flinders University, Bedford Park, Adelaide, SA, 5042, Australia
    Autoimmunity 39:635-43. 2006
    ..This paper reviews advances in the field of immunoinformatics pertinent to autoimmunity research including databases, tools in genomics and proteomics, tools for study of B- and T-cell epitopes, integrative approaches, and web servers...
  13. ncbi Prevention of autoimmune diabetes through immunostimulation with Q fever complement-fixing antigen
    D G Silva
    Autoimmunity Research Unit, The Canberra Hospital, Canberra, Australia
    Ann N Y Acad Sci 1005:423-30. 2003
    ..The elucidation of the mechanism should help identify the optimal way in which to administer QFA to provide diabetes protection. It may also assist the development of even more potent immunostimulatory vaccines...
  14. ncbi Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator
    Nikolai Petrovsky
    Autoimmunity Research Unit, The Canberra Hospital, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Immunol Cell Biol 81:137-43. 2003
    ..These observations explain the beneficial role of macrophage migration inhibitory factor neutralization in models of inflammatory arthritis...
  15. ncbi The future for computational modelling and prediction systems in clinical immunology
    Nikolai Petrovsky
    Medical Informatics Centre, University of Canberra, Bruce ACT 2601, Australia
    Novartis Found Symp 254:23-32; discussion 33-42, 98-101, 250-2. 2003
    ..This strategy will enable immunoinformatics to achieve its full potential to advance and shape clinical immunology in the future...
  16. pmc An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses
    Mario Lobigs
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    J Gen Virol 91:1407-17. 2010
    ..There is also an ongoing lack of human vaccines against other JEV serocomplex flaviviruses, such as MVEV, making this adjuvanted, cell culture-grown JEV vaccine a promising candidate to address both needs with one vaccine...
  17. ncbi Assessment of cardiovascular disease risk factors and diabetes mellitus in Australian prisons: is the prisoner population unhealthier than the rest of the Australian population?
    Rennie M D'Souza
    National Centre for Epidemiology and Population Health, Australian National University, Australian Capital Territory
    Aust N Z J Public Health 29:318-23. 2005
    ....
  18. ncbi Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis
    Todor Arsov
    John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia
    Mol Endocrinol 20:1610-22. 2006
    ....
  19. ncbi Mechanisms of accelerated immune-mediated diabetes resulting from islet beta cell expression of a Fas ligand transgene
    Diego G Silva
    Autoimmunity Research Unit, The Canberra Hospital, Medical School, Australian National University, Medical Informatics Center, University of Canberra, and The John Curtin School of Medical Research, Canberra, Australia
    J Immunol 170:4996-5002. 2003
    ..The data support a mechanism by which cytokines produced by the insulitis lesion mediate up-regulation of beta cell Fas expression, resulting in suicide or fratricide of HIPFasL beta cells that overexpress FasL...
  20. ncbi Inulin-derived adjuvants efficiently promote both Th1 and Th2 immune responses
    Diego G Silva
    Autoimmunity Research Unit, Australian National University Medical School, The Canberra Hospital, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 82:611-6. 2004
    ..If such trials are successful, then it is possible that inulin-derived adjuvants will one day replace alum as the adjuvant of choice in most human prophylactic vaccines...
  21. pmc Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity
    Nikolai Petrovsky
    Flinders Medical Centre, Flinders University, Bedford Park SA 4052, Australia
    Vaccine 24:S2-26-9. 2006
    ..Thus, adjuvants based on inulin have enormous potential for use in vaccines against both pathogens and cancer...
  22. doi Immunomodulation with microbial vaccines to prevent type 1 diabetes mellitus
    Nikolai Petrovsky
    Department of Endocrinology, Flinders Medical Centre, Flinders Drive, Bedford Park, Adelaide, SA 5042, Australia
    Nat Rev Endocrinol 6:131-8. 2010
    ....
  23. ncbi Macrophage migration inhibitory factor: a critical neurohumoral mediator
    Nikolai Petrovsky
    Cytokine and Autoimmunity Research Unit, Department of Endocrinology, Canberra Hospital, Canberra, Australia
    Front Horm Res 29:83-90. 2002
  24. ncbi The vaccines development forum
    Nikolai Petrovsky
    Flinders Medical Centre, Department of Diabetes and Endocrinology, Flinders Drive, Bedford Park, South Australia 5042, Australia
    IDrugs 11:478-81. 2008
  25. ncbi Identification of key beta cell gene signaling pathways involved in type 1 diabetes
    Diego Silva
    Director, Diabetes and Endocrinology, Flinders Medical Centre, Bedford Park, South Australia, Australia
    Ann N Y Acad Sci 1037:203-7. 2004
    ..Hence, any results obtained using beta cell lines should be interpreted with great caution when extrapolating to the behavior of real beta cells...
  26. ncbi Elevated lymphocyte expression of CLIP is associated with type 1 diabetes and may be a useful marker of autoimmune susceptibility
    Diego G Silva
    Director, Diabetes and Endocrinology, Flinders Medical Centre, Bedford Park, South Australia, Australia
    Ann N Y Acad Sci 1037:65-8. 2004
    ..This confirms that elevated CLIP expression is a feature of T1D and may be a useful marker for T1D susceptibility...
  27. ncbi Autoimmune diabetes in the NOD mouse: an essential role of Fas-FasL signaling in beta cell apoptosis
    Diego G Silva
    Autoimmunity Research Unit, The Canberra Hospital, Canberra, Australia
    Ann N Y Acad Sci 1005:161-5. 2003
    ..This points to a highly important role of Fas-FasL interaction in autoimmune beta cell death...
  28. ncbi Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice
    Todor Arsov
    John Curtin School of Medical Research, The Australian National University ANU, Canberra, ACT, Australia
    Biochem Biophys Res Commun 342:1152-9. 2006
    ..In this model of metabolic syndrome, transition of steatosis to steatohepatitis was associated with hypoadiponectinemia, a mediator of hepatic fatty acid disposal pathways...
  29. pmc Diabetic retinopathy is associated with elevated serum asymmetric and symmetric dimethylarginines
    Sotoodeh Abhary
    Department of Ophthalmology, Flinders Medical Centre and Flinders University, Bedford Park, Australia
    Diabetes Care 32:2084-6. 2009
    ..Our objective was to test whether serum ADMA, SDMA, or l-arginine levels correlate with diabetic retinopathy subtype or severity...
  30. pmc Evidence from twins for acquired cellular immune hyperactivity in type 1 diabetes
    Nikolai Petrovsky
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Immunology 106:584-9. 2002
    ..These findings suggest that T-cell hyperactivity in type 1 diabetes is an acquired trait and could reflect persisting virus expression...
  31. doi Initiation of insulin glargine therapy in type 2 diabetes subjects suboptimally controlled on oral antidiabetic agents: results from the AT.LANTUS trial
    M Davies
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Diabetes Obes Metab 10:387-99. 2008
    ..This subgroup analysis investigated the initiation of once-daily glargine therapy in patients suboptimally controlled on multiple OADs...
  32. pmc Cytokine-related genes identified from the RIKEN full-length mouse cDNA data set
    Vladimir Brusic
    Institute for Infocomm Research, Singapore 119613
    Genome Res 13:1307-17. 2003
    ..We performed a detailed sequence analysis of the candidate novel genes to elucidate their likely functional properties...
  33. ncbi Immunoinformatics--the new kid in town
    Vladimir Brusic
    Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613
    Novartis Found Symp 254:3-13; discussion 13-22, 98-101, 250-2. 2003
    ....
  34. pmc Inferring higher functional information for RIKEN mouse full-length cDNA clones with FACTS
    Takeshi Nagashima
    Biomedical Knowledge Discovery Team, Bioinformatics Group, RIKEN Genomic Sciences Center GSC, Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    Genome Res 13:1520-33. 2003
    ..The FACTS database will be a critical tool for investigating the functional complexity of the mouse transcriptome, cDNA-inferred interactome (molecular interactions), and pathome (pathologies)...
  35. ncbi Computational methods for prediction of T-cell epitopes--a framework for modelling, testing, and applications
    Vladimir Brusic
    Laboratories for Information Technology, 21 Heng Mui Keng Terrace, 119613, Singapore
    Methods 34:436-43. 2004
    ..In this article, we present and discuss a framework for modelling, testing, and applications of computational methods used in predictions of T-cell epitopes...
  36. pmc FREP: a database of functional repeats in mouse cDNAs
    Takeshi Nagashima
    Biomedical Knowledge Discovery Team, Bioinformatics Group, RIKEN Genomic Sciences Center GSC, RIKEN Yokohama Institute, Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nucleic Acids Res 32:D471-5. 2004
    ....
  37. ncbi PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse
    Menaka Rajapakse
    Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore, Singapore, 119613
    Autoimmunity 39:645-50. 2006
    ..We have developed a prediction system, PREDNOD, for accurate identification of peptides that bind the MHC molecules constituting the H-2g7 haplotype. PREDNOD is accessible at http://antigen.i2r.a-star.edu.sg/Ag7...
  38. pmc Methods for prediction of peptide binding to MHC molecules: a comparative study
    Kun Yu
    BIC KRDL, Kent Ridge Digital Labs, Singapore
    Mol Med 8:137-48. 2002
    ..These methods are based on binding motifs, binding matrices, hidden Markov models (HMM), or artificial neural networks (ANN). There has been little prior work on the comparative analysis of these methods...
  39. ncbi Prediction of promiscuous peptides that bind HLA class I molecules
    Vladimir Brusic
    Kent Ridge Digital Labs, Singapore
    Immunol Cell Biol 80:280-5. 2002
    ..Preliminary testing indicates that MULTIPRED can predict peptide binding to HLA-A2 supertype molecules with high accuracy, including those allelic variants for which no experimental binding data are currently available...
  40. ncbi Bioinformatics for characterisation of allergens, allergenicity and allergic crossreactivity
    Vladimir Brusic
    Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613
    Trends Immunol 24:225-8. 2003
  41. ncbi Information technologies for vaccine research
    Vladimir Brusic
    Institute for Infocomm Research, 21 Heng Mui Keng Terrace, 119613, Singapore
    Expert Rev Vaccines 4:407-17. 2005
    ..Immunomics, the large-scale screening of immune processes which includes powerful immunoinformatic tools, offers great promise for future translation of basic immunology research advances into successful vaccines...
  42. ncbi Dexamethasone infusion testing in the diagnosis of Cushing's syndrome
    Huy Anh Tran
    Department of Clinical Chemistry, Hunter Area Pathology Service, John Hunter Hospital, New South Wales, Australia
    Endocr J 52:103-9. 2005
    ..This test is much simpler and more convenient than the oral dexamethasone suppression test in confirming clinical suspicion of pituitary Cushing's disease...
  43. ncbi Addison's disease presenting in four adolescents with type 1 diabetes
    James B Thomas
    Institute of Diabetes and Endocrinology, The Children s Hospital at Westmead, Westmead, Australia
    Pediatr Diabetes 5:207-11. 2004
    ..The addition of specific HLA DRB1 subtyping has been proposed to improve predictive value...
  44. doi Freeing vaccine adjuvants from dangerous immunological dogma
    Nikolai Petrovsky
    Expert Rev Vaccines 7:7-10. 2008