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Genomes and Genes | C R ParishSummaryAffiliation: Australian National University Country: Australia Publications
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Publications
Fluorescent dyes for lymphocyte migration and proliferation studiesC R Parish
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 77:499-508. 1999..In the future it is highly likely that additional fluorescent dyes, with different spectral properties to CFSE, will become available, as well as membrane inserting fluorescent dyes that more homogeneously label lymphocytes than PKH26...- The role of heparan sulphate in inflammationChristopher R Parish
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
Nat Rev Immunol 6:633-43. 2006.... - Dependence of the adaptive immune response on innate immunity: some questions answered but new paradoxes emergeC R Parish
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory
Immunol Cell Biol 75:523-7. 1997..Finally, we argue that the two paradoxes, rather than undermining the new model of immunity, highlight our lack of understanding of key elements of the vertebrate immune system... - Treatment of central nervous system inflammation with inhibitors of basement membrane degradationC R Parish
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 76:104-13. 1998..It is hoped that future work will result in the development of a totally new class of highly effective, subtle and non-toxic anti-inflammatory drugs for the treatment of MS and other inflammatory diseases... - Cancer immunotherapy: the past, the present and the futureChristopher R Parish
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Immunol Cell Biol 81:106-13. 2003..Alternative strategies include recruiting tumouricidal myeloid cells into tumours, generating antiangiogenic immune responses and directing innate immunity to hypoxia-induced ligands on tumour cells... - Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activityC R Parish
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra
Cancer Res 59:3433-41. 1999..Acute hematogenous metastasis assays also demonstrated that PI-88 was a potent (>90%) inhibitor of blood-borne metastasis. Thus, by the use of novel in vitro screening procedures, we have identified a promising antitumor agent... - Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytesN N Gorgani
Division of Immunology and Cell Biology, The John Curtin School of Medical Research, Faculty of Science, Australian National University, Canberra, ACT 0200, Australia
Int Immunol 11:1275-82. 1999..Thus HRG can interact with FcgammaRI on monocytes and block monomeric IgG binding, whereas when incorporated in IgG containing IC, HRG can enhance the uptake of IC by monocytes, probably via its heparan sulfate binding domain... - Identification of active-site residues of the pro-metastatic endoglycosidase heparanaseM D Hulett
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, P O Box 334, Canberra ACT 2601, Australia
Biochemistry 39:15659-67. 2000..These data suggest that heparanase is a member of the clan A glycosyl hydrolases and has a common catalytic mechanism that involves two conserved acidic residues, a putative proton donor at Glu(225) and a nucleophile at Glu(343)... - Isolation, tissue distribution, and chromosomal localization of a novel testis-specific human four-transmembrane gene related to CD20 and FcepsilonRI-betaM D Hulett
Division of Immunology and Cell Biology, John Curtin School of Medical Research, ANU, P O Box 344, Canberra, ACT 2601, Australia
Biochem Biophys Res Commun 280:374-9. 2001..TETM4 is the first nonhematopoietic member of the CD20/FcepsilonRIbeta family, and like its hematopoietic-specific relatives, it may be involved in signal transduction as a component of a multimeric receptor complex... - Cell surface expression of the 300 kDa mannose-6-phosphate receptor by activated T lymphocytesE J Hindmarsh
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 79:436-43. 2001..Such findings are consistent with the hypothesis that cell surface MPR-300 is required for the entry of T cells into inflammatory sites... - Human platelet heparanase: purification, characterization and catalytic activityC Freeman
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT2601, Australia
Biochem J 330:1341-50. 1998.... - Murine histidine-rich glycoprotein: cloning, characterization and cellular originM D Hulett
Division of Immunology and Cell Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 78:280-7. 2000..These data suggest that HRG expression by immune cells is due to the acquisition of plasma HRG derived from the liver. Finally, genomic Southern blot analysis of the mouse HRG gene suggests that it is a single copy gene... - Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factorK J Brown
Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra
Biochemistry 33:13918-27. 1994..Alternatively, they could act as negative regulators by masking HSPGs on responsive cells and preventing FGF receptor activation... - Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chainsN N Gorgani
Division of Immunology, The John Curtin School of Medical Research, Faculty of Science, Canberra, Australia
J Biol Chem 274:29633-40. 1999.... - Evidence that platelet and tumour heparanases are similar enzymesC Freeman
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia
Biochem J 342:361-8. 1999.... - Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasisM D Hulett
Division of Immunology and Cell Biology, John Curtin School of Medical Research, ANU, Canberra, ACT, Australia
Nat Med 5:803-9. 1999..Exhaustive studies have shown only one heparanase sequence, consistent with the idea that this enzyme is the dominant endoglucuronidase in mammalian tissues... - Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelationAllison L Jones
Cancer and Vascular Biology Group, Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia
J Biol Chem 279:30114-22. 2004..Based on these data, we propose that the N1N2 domain binds to cell-surface heparan sulfate and that the interaction of Zn2+ with the HRR can indirectly enhance cell-surface binding... - Detection of low-affinity adhesion ligands by linking recombinant cell adhesion molecules in uniform orientation to a fluorescently labelled dextran molecule by means of hexahistidine tagging: the case of multimeric CD40G Vassiliou
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT
J Immunol Methods 215:9-15. 1998..The uniform orientation of the molecules on the dextran is an advantage over previous systems and permits the preparation of heterogeneous, multimeric ligands which more closely mimic the conditions at the cell surface... - Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritisRachel W Li
Australian National University, and Canberra Hospital, Canberra, ACT, Australia
Arthritis Rheum 58:1590-600. 2008..In this study, we assessed heparanase activity in synovial fluid (SF) and synovial tissue (ST) from patients with RA or osteoarthritis (OA), and analyzed the expression of angiogenic pathway-focused genes in ST from RA and OA patients... - Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycanHilary S Warren
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
J Immunol 175:207-12. 2005..From these results we conclude that HS GAG are not ligands for NKp30, leaving open the question as to the nature of the cellular ligand for this important NK cell activation receptor... - C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic propertiesMartin G Banwell
Research School of Chemistry, The Australian National University, Canberra ACT 0200, Australia
Bioorg Med Chem Lett 16:181-5. 2006..These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents... - Liposomal vaccines--targeting the delivery of antigenJoseph G Altin
School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia
Methods 40:39-52. 2006.... - Targeting dendritic cells with antigen-containing liposomes: antitumour immunityJoseph G Altin
The Australian National University, School of Biochemistry and Molecular Biology, Faculty of Science, Canberra, ACT 0200, Australia
Expert Opin Biol Ther 4:1735-47. 2004..Liposomal targeting of antigen and maturation signals directly to DCs in vivo, therefore, represents a much simpler strategy for cancer immunotherapy than antigen loading DCs ex vivo... - Convergent synthesis and preliminary biological evaluations of the stilbenolignan (+/-)-aiphanol and various congenersMartin G Banwell
Research School of Chemistry, Institute of Advanced Studies, Australian National University, Canberra, ACT 0200, Australia
Org Biomol Chem 1:2427-9. 2003..2:1:2:1 mixture of the stilbenolignan (+/-)-aiphanol (1) and congeners 2-4 each of which show significant anti-angiogenic and COX-2 inhibitory properties... - Th2-mediated anti-tumour immunity: friend or foe?J I Ellyard
Cancer and Vascular Biology Group, Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra City, ACT 2601, Australia
Tissue Antigens 70:1-11. 2007..Collectively, from this analysis, we conclude that there is a great potential for the development of Th2-mediated immunotherapies that harness the cytotoxic activity of eosinophils... - Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expressionTorsten Juelich
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 183:7063-72. 2009..These data suggest that for high levels of transcription to occur a distinct set of histone modifications needs to be established in addition to histone loss at the proximal promoter of gzmB... - Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapyChristina L van Broekhoven
School of Biochemistry and Molecular Biology, Faculty of Science, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
Cancer Res 64:4357-65. 2004..The results show that the targeting of antigen to DCs in this way is highly effective at inducing immunity and protection against the tumor, with protection being at least partially dependent on the eosinophil chemokine eotaxin... - Molecular mechanisms of late apoptotic/necrotic cell clearanceI K H Poon
John Curtin School of Medical Research, Australian National University, Canberra, 2601, Australia
Cell Death Differ 17:381-97. 2010..This review provides an overview of the molecular mechanisms and the immunological outcomes of late apoptotic/necrotic cell removal and highlights the striking similarities between late apoptotic/necrotic cell and pathogen clearance... - Histidine-rich glycoprotein: A novel adaptor protein in plasma that modulates the immune, vascular and coagulation systemsAllison L Jones
Cancer and Vascular Biology Group, Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 83:106-18. 2005..This review outlines the molecular, structural, biological and clinical properties of HRG as well as describing the role of HRG in various physiological processes... - Continual low-level activation of the classical complement pathwayA P Manderson
Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia
J Exp Med 194:747-56. 2001..This antigen-independent mechanism for classical pathway activation may augment activation of the complement system at sites of inflammation and infarction... - Histidine-rich glycoprotein binds to human IgG and C1q and inhibits the formation of insoluble immune complexesN N Gorgani
Division of Immunology and Cell Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT
Biochemistry 36:6653-62. 1997..The results show that human HRG binds to C1q and to IgG in a Zn2+-modulated fashion, and that HRG can regulate the formation of IIC in vitro, thus indicating a new functional role for HRG in vivo... - Use of the intracellular fluorescent dye CFSE to monitor lymphocyte migration and proliferationChristopher R Parish
Australian National University, Canberra, Australia
Curr Protoc Immunol . 2009.... - Dynamic histone variant exchange accompanies gene induction in T cellsElissa L Sutcliffe
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
Mol Cell Biol 29:1972-86. 2009..From these observations, we propose that H3.3 deposition may both facilitate chromatin accessibility increases by destabilizing nucleosomes and compete with recruited histone modifiers to alter PTM patterns upon gene induction... - Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavageIvan K H Poon
The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
Biochem J 424:27-37. 2009..Thus proteolytic cleavage of HRG by plasmin may provide a feedback mechanism to regulate the effects of HRG on the plasminogen/plasmin system and other functions of HRG... - Histidine-rich glycoprotein functions cooperatively with cell surface heparan sulfate on phagocytes to promote necrotic cell uptakeIvan K H Poon
Department of Immunology, The John Curtain School of Medical Research, Australian National University, Bldg 131, Garran Rd, Acton, Canberra, ACT 0200 Australia
J Leukoc Biol 88:559-69. 2010..Thus, these data suggest that HRG can aid the phagocytosis of necrotic cells via a HS-dependent pathway, and this process can be regulated by the presence of certain HRG ligands, such as heparin... - Eotaxin selectively binds heparin. An interaction that protects eotaxin from proteolysis and potentiates chemotactic activity in vivoJulia I Ellyard
Cancer and Vascular Biology Group, Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Building 54, Garran Road, Acton, Australian Capital Territory 0200, Australia
J Biol Chem 282:15238-47. 2007..These results suggest a role for mast cell-derived heparin in the recruitment of eosinophils, reinforcing Th2 polarization of inflammatory responses... - Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillanceLjubov Simson
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Mills Road Acton, Canberra, Australian Capital Territory, Australia
J Immunol 178:4222-9. 2007..In addition, subsequent in vitro studies found that eosinophils could directly kill MCA-induced fibrosarcoma cells. Collectively, our data support a potential role for the eosinophil as an effector cell in tumor immune surveillance... - Histidine-rich glycoprotein is a novel plasma pattern recognition molecule that recruits IgG to facilitate necrotic cell clearance via FcgammaRI on phagocytesIvan K H Poon
The John Curtin School of Medical Research, Australian National University, Canberra, Australia
Blood 115:2473-82. 2010..Thus, HRG has the unique property of complexing with IgG and facilitating a proinflammatory innate immune response to promote the clearance of necrotic cells... - Heparanase in primary human osteoblastsPaul N Smith
Medical School, The Australian National University, Canberra, Australia
J Orthop Res 28:1315-22. 2010..HPSE upregulation may be a novel therapeutic approach in the prevention and treatment of OP... - Use of sulfated linked cyclitols as heparan sulfate mimetics to probe the heparin/heparan sulfate binding specificity of proteinsCraig Freeman
Division of Immunology and Genetics, John Curtin School of Medical Research and Research School of Chemistry, PO Box 334, Australian National University, Canberra 2601, Australian Capital Territory
J Biol Chem 280:8842-9. 2005..These data indicate that a simple panel of HS mimetics can be used to probe the HS binding specificity of proteins, with the position of anionic groups in the HS mimetics being critical... - Alternatively activated macrophage possess antitumor cytotoxicity that is induced by IL-4 and mediated by arginase-1Julia I Ellyard
Cancer and Vascular Biology Group, Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University daggerCancer Immunotherapy Group, Biomedical Sciences, Faculty of Applied Science, University of Canberra, Canberra, Australia
J Immunother 33:443-52. 2010..This highlights the fine balance between stimulating the antitumorigenic and protumorigenic properties of aaMacs in tumor immunotherapy protocols... - Histidine-rich glycoprotein specifically binds to necrotic cells via its amino-terminal domain and facilitates necrotic cell phagocytosisAllison L Jones
Cancer and Vascular Biology Group, Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, 0200, Australia
J Biol Chem 280:35733-41. 2005..Thus, HRG has the unique property of selectively recognizing necrotic cells and may play an important physiological role in vivo by facilitating the uptake and clearance of necrotic, but not apoptotic, cells by phagocytes... - Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl esterBen J C Quah
Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
Nat Protoc 2:2049-56. 2007..An important feature of the technique is that division-dependent changes in the expression of cell-surface markers and intracellular proteins are easily quantified by flow cytometry... - Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivoRamon C Sun
Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, P O Box 334, Canberra, 2601, Australia
Breast Cancer Res Treat 120:253-60. 2010..These results demonstrate that DCA has anti-proliferative properties in addition to pro-apoptotic properties, and can be effective against highly metastatic disease in vivo, highlighting its potential for clinical use... - Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transferBen J C Quah
Divisions of Immunology and Genetics and Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
Proc Natl Acad Sci U S A 105:4259-64. 2008..This results in a dramatic expansion in the number of antigen-binding B cells in vivo, with the transferred BCR endowing recipient B cells with the ability to present a specific antigen to antigen-specific CD4(+) T cells... - Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferationDouglas J Francis
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Circ Res 92:e70-7. 2003..As such, this study demonstrates a new role for PI-88 as an inhibitor of intimal thickening after balloon angioplasty. The full text of this article is available online at http://www.circresaha.org... - Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharidesYvonne Adams
Hygiene-Institut, Abteilung Parasigologie, , Germany
Antimicrob Agents Chemother 50:2850-2. 2006..4 microM) and demonstrated modest adhesion inhibition to cell surface CSA... - Heparan sulfate and inflammationChristopher R Parish
Nat Immunol 6:861-2. 2005 - A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancerJohanna A Joyce
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0534, USA
Oncogene 24:4037-51. 2005..These data encourage clinical applications of inhibitors such as PI-88 for the many human cancers where heparanase expression is elevated or mobilization of HS-binding regulatory factors is implicated... - The low molecular weight heparan sulfate-mimetic, PI-88, inhibits cell-to-cell spread of herpes simplex virusKicki Nyberg
Department of Clinical Virology, , Guldhedsgatan 10B, , Sweden
Antiviral Res 63:15-24. 2004..The latter was efficiently inhibited by a relatively small but densely sulfated PI-88 oligosaccharide, very likely due to the capability of the compound to access the narrow intercellular space... - Phosphomannopentaose sulfate (PI-88): heparan sulfate mimetic with clinical potential in multiple vascular pathologiesLevon M Khachigian
Centre for Vascular Research, Department of Pathology, University of New South Wales, Sydney NSW 2052, Australia
Cardiovasc Drug Rev 22:1-6. 2004..This heparan sulfate mimetic has, therefore, multiple functions and therapeutic potential in a variety of vascular disorders...