Mario Lobigs

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. pmc Feasibility of cross-protective vaccination against flaviviruses of the Japanese encephalitis serocomplex
    Mario Lobigs
    Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, 2600, ACT, Australia
    Expert Rev Vaccines 11:177-87. 2012
  2. ncbi Cross-protective and infection-enhancing immunity in mice vaccinated against flaviviruses belonging to the Japanese encephalitis virus serocomplex
    Mario Lobigs
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, P O Box 334, ACT 2601, Canberra, Australia
    Vaccine 21:1572-9. 2003
  3. pmc An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses
    Mario Lobigs
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    J Gen Virol 91:1407-17. 2010
  4. ncbi MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 81:217-23. 2003
  5. doi A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis
    Mario Lobigs
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Virology 401:80-9. 2010
  6. pmc Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, P O Box 334, Canberra, A C T 2601, Australia
    J Virol 83:2436-45. 2009
  7. pmc Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranes
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    J Virol 78:178-86. 2004
  8. ncbi Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class I
    M Lobigs
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    Eur J Immunol 30:1496-506. 2000
  9. ncbi Antigen presentation in syrian hamster cells: substrate selectivity of TAP controlled by polymorphic residues in TAP1 and differential requirements for loading of H2 class I molecules
    M Lobigs
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, P O Box 334, A C T 2601, Australia
    Immunogenetics 49:931-41. 1999
  10. ncbi Evidence that a mechanism for efficient flavivirus budding upregulates MHC class I
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Immunol Cell Biol 82:184-8. 2004

Collaborators

Detail Information

Publications50

  1. pmc Feasibility of cross-protective vaccination against flaviviruses of the Japanese encephalitis serocomplex
    Mario Lobigs
    Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, 2600, ACT, Australia
    Expert Rev Vaccines 11:177-87. 2012
    ..The review will also focus on the structural and mechanistic basis for cross-protective immunity among this group of flaviviruses, which is predominantly mediated by antibodies against a single viral surface protein...
  2. ncbi Cross-protective and infection-enhancing immunity in mice vaccinated against flaviviruses belonging to the Japanese encephalitis virus serocomplex
    Mario Lobigs
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, P O Box 334, ACT 2601, Canberra, Australia
    Vaccine 21:1572-9. 2003
    ..Immunepotentiation of heterologous flavivirus disease was apparent in animals immunized with a 'killed' virus preparation when humoral antiviral immunity of low magnitude was elicited...
  3. pmc An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses
    Mario Lobigs
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    J Gen Virol 91:1407-17. 2010
    ..There is also an ongoing lack of human vaccines against other JEV serocomplex flaviviruses, such as MVEV, making this adjuvanted, cell culture-grown JEV vaccine a promising candidate to address both needs with one vaccine...
  4. ncbi MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 81:217-23. 2003
    ....
  5. doi A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis
    Mario Lobigs
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Virology 401:80-9. 2010
    ....
  6. pmc Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, P O Box 334, Canberra, A C T 2601, Australia
    J Virol 83:2436-45. 2009
    ..Our results suggest that the live chimeric JEV vaccine will protect against other viruses belonging to the JEV serocomplex, consistent with the observation of cross-protection following live virus infections...
  7. pmc Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranes
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    J Virol 78:178-86. 2004
    ..Our results support a model for flavivirus morphogenesis involving temporal and spatial coordination of NC assembly and envelopment by regulated cleavages of an ER membrane-spanning capsid-prM intermediate...
  8. ncbi Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class I
    M Lobigs
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    Eur J Immunol 30:1496-506. 2000
    ..Finally, we conclusively show that an aminopeptidase in the endoplasmic reticulum is also involved in antigen presentation in cells with a functional peptide transporter...
  9. ncbi Antigen presentation in syrian hamster cells: substrate selectivity of TAP controlled by polymorphic residues in TAP1 and differential requirements for loading of H2 class I molecules
    M Lobigs
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, P O Box 334, A C T 2601, Australia
    Immunogenetics 49:931-41. 1999
    ..Thus, polymorphic residues in TAP1 can influence the substrate selectivity of the Syrian hamster peptide transporter...
  10. ncbi Evidence that a mechanism for efficient flavivirus budding upregulates MHC class I
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Immunol Cell Biol 82:184-8. 2004
    ....
  11. ncbi Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus
    Mario Lobigs
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    J Gen Virol 84:567-72. 2003
    ..In contrast, mice deficient in IFN-gamma or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus...
  12. ncbi NK cell-mediated immunopathology during an acute viral infection of the CNS
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Eur J Immunol 36:887-96. 2006
    ..This is the first study illustrating an NK cell-mediated immunopathological outcome to an acute viral infection...
  13. pmc Cytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A viruses
    Yoichi Furuya
    Viral Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Virol 84:4212-21. 2010
    ..Therefore, cross-protective immunity induced by vaccination with gamma-irradiated influenza A virus is mediated mainly by Tc-cell responses...
  14. ncbi CD8(+) T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon
    Yang Wang
    Division of Immunology and Genetics, The John Curtin School of Medical Research, The Australian National University ANU, PO Box 334, Canberra, ACT 2601, Australia
    J Gen Virol 87:3599-609. 2006
    ....
  15. pmc Common E protein determinants for attenuation of glycosaminoglycan-binding variants of Japanese encephalitis and West Nile viruses
    Eva Lee
    John Curtin School of Medical Research, Australian National University, Australia
    J Virol 78:8271-80. 2004
    ....
  16. ncbi Exhaustion of type I interferon response following an acute viral infection
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Immunol 177:3235-41. 2006
    ..Thus, transient immunosuppression through exhaustion of IFN-I production during an acute viral infection creates a time period of enhanced susceptibility to secondary infection...
  17. doi Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations
    Yoichi Furuya
    Viral Immunology and Molecular Virology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Gen Virol 91:1450-60. 2010
    ..Finally, freeze-drying of gamma-A/PC did not affect the ability to induce cross-protective immunity...
  18. ncbi Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice
    Yang Wang
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Immunol Cell Biol 82:170-3. 2004
    ..Virus-host immune interactions have to be assessed individually and cannot be generalized...
  19. ncbi Type I interferons trigger systemic, partial lymphocyte activation in response to viral infection
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 175:4635-40. 2005
    ..We conclude that virus-induced IFN-I release systemically affects most of the hosts T and B cells by triggering them rapidly and independently of Ag-reactivity into a semiactivated state...
  20. ncbi Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis
    Arno Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 169:145-50. 2002
    ..The results are discussed as to the possible relevance of the phenomenon in efficiency and regulation of the Tc cell response to infections by viruses...
  21. pmc The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responses
    Carolina R Melo-Silva
    Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, Australian National University, Canberra ACT, Australia
    J Virol 85:11170-82. 2011
    ..Consequently, SPI-2 renders mousepox lethal in susceptible strains by preventing protective NK cell defenses...
  22. doi Restricted Semliki Forest virus replication in perforin and Fas-ligand double-deficient mice
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Gen Virol 89:1942-4. 2008
    ..Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated...
  23. pmc Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus
    Eva Lee
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Virol 76:4901-11. 2002
    ..The close spatial proximity of amino acids 306 and 390 in the predicted E protein structure strongly suggests that the two residues define a receptor-binding domain involved in virus attachment to sulfated proteoglycans...
  24. ncbi Can we really learn from model pathogens?
    Arno Mullbacher
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Trends Immunol 25:524-8. 2004
    ..Thus, virus-host immune interactions have to be assessed individually and cannot be generalized...
  25. ncbi Virulence attenuation of Dengue virus due to augmented glycosaminoglycan-binding affinity and restriction in extraneural dissemination
    Eva Lee
    John Curtin School of Medical Research, Division of Immunology and Genetics, Australian National University, PO Box 334, Canberra, ACT 2600, Australia
    J Gen Virol 87:2791-801. 2006
    ..This discrepancy of attenuated neuroinvasiveness and augmented neurovirulence may be reconciled by the existence of different mechanisms of virus dissemination in the brain and in extraneural tissues...
  26. pmc Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 4:e5336. 2009
    ..We have previously reported that gamma-ray inactivated flu virus can induce cross-reactive Tc cell responses...
  27. pmc Pivotal role of antibody and subsidiary contribution of CD8+ T cells to recovery from infection in a murine model of Japanese encephalitis
    Maximilian Larena
    Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University Australia
    J Virol 85:5446-55. 2011
    ..This finding highlights the conflicting role that CD8(+) T cells play in the pathogenesis of JEV and closely related encephalitic flaviviruses such as West Nile virus...
  28. ncbi Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses
    Eva Lee
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, P O Box 334, Canberra, ACT 2601, Australia
    Antiviral Res 69:31-8. 2006
    ..In mouse models for DEN and flaviviral encephalitis, only PI-88 demonstrated a significant beneficial effect in disease outcome...
  29. pmc E protein domain III determinants of yellow fever virus 17D vaccine strain enhance binding to glycosaminoglycans, impede virus spread, and attenuate virulence
    Eva Lee
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University P O Box 334, Canberra, ACT 2600, Australia
    J Virol 82:6024-33. 2008
    ....
  30. doi Cytolytic effector pathways and IFN-γ help protect against Japanese encephalitis
    Maximilian Larena
    Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    Eur J Immunol 43:1789-98. 2013
    ..Accordingly, cell contact-dependent cytolytic and IFN-γ-dependent noncytolytic clearance of virus mediated by T cells trafficking into the CNS help in recovery from lethal infection in a mouse model of Japanese encephalitis. ..
  31. pmc CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitis
    Yang Wang
    Division of Immunology and Genetics, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia
    J Virol 77:13323-34. 2003
    ..Using high doses of virus in CD8-deficient mice leads to increased survival. These results provide evidence that CD8(+) T cells are involved in both recovery and immunopathology in WNV infection...
  32. ncbi Immunobiology of mosquito-borne encephalitic flaviviruses
    Arno Mullbacher
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra City, A C T 2601, Australia
    Adv Virus Res 60:87-120. 2003
  33. pmc JE-ADVAX vaccine protection against Japanese encephalitis virus mediated by memory B cells in the absence of CD8(+) T cells and pre-exposure neutralizing antibody
    Maximilian Larena
    Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    J Virol 87:4395-402. 2013
    ..Our investigation also established the suitability of a novel flavivirus challenge model (β(2)-microglobulin-knockout mice) for studies of the role of B-cell memory responses in vaccine protection...
  34. pmc The chemokine receptor CCR5, a therapeutic target for HIV/AIDS antagonists, is critical for recovery in a mouse model of Japanese encephalitis
    Maximilian Larena
    Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    PLoS ONE 7:e44834. 2012
    ..This result is consistent with a mechanism by which CCR5 expression enhances lymphocyte activation and thereby promotes host survival in Japanese encephalitis...
  35. pmc Both E protein glycans adversely affect dengue virus infectivity but are beneficial for virion release
    Eva Lee
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
    J Virol 84:5171-80. 2010
    ..The dueling influences of infectivity and release on virus growth affected by the glycans may explain the plasticity in E protein glycosylation among the flaviviruses...
  36. pmc Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice
    Rosa M Licon Luna
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia
    J Virol 76:3202-11. 2002
    ..Mice deficient in both cytotoxic effector functions were resistant to a low-dose peripheral infection with the neurotropic virus...
  37. ncbi Spontaneous mutation at position 114 in H-2Kd affects cytotoxic T cell responses to influenza virus infection
    A Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra City, ACT
    Eur J Immunol 29:1228-34. 1999
    ..Kdw presented NPP147-155 encoded by the full-length NP gene, but Kdw-NPP147-155 complexes were at least 100-fold less abundant than after translation from a minigene...
  38. ncbi Interferon-inducible chemokines and immunity to poxvirus infections
    S Mahalingam
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra ACT
    Immunol Rev 177:127-33. 2000
    ..The results of these investigations demonstrate that the mechanisms of Mig- and Crg-2-induced viral clearance involve natural killer cells and interferons...
  39. ncbi Nonobese diabetic mice display elevated levels of class II-associated invariant chain peptide associated with I-Ag7 on the cell surface
    A Bhatnagar
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 166:4490-7. 2001
    ..These results indicated that an intrinsic property of I-A(g7) would affect both the quantity and the repertoire of self-peptides presented during thymic selection...
  40. ncbi Antiviral cytotoxic T cells cross-reactively recognize disparate peptide determinants from related viruses but ignore more similar self- and foreign determinants
    M Regner
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 166:3820-8. 2001
    ..These results raise the paradox that virus-immune Tc cell responses, which are mostly directed against only a few "immunodominant" viral determinants, are remarkably peptide cross-reactive...
  41. ncbi Effector cytolotic function but not IFN-gamma production in cytotoxic T cells triggered by virus-infected target cells in vitro
    M Regner
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, PO Box334, Canberra, ACT 2601, Australia
    Scand J Immunol 54:366-74. 2001
    ..This result raises the possibility that the levels of presentation of cognate antigen on virus-infected cells in vivo may be below the threshold required for the IFN-gamma production...
  42. ncbi The flavivirus nonstructural protein NS3 is a dominant source of cytotoxic T cell peptide determinants
    M Lobigs
    Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra
    Virology 202:195-201. 1994
    ..Processing of the MVE polyprotein by the viral proteinase did not markedly influence the availability of this peptide determinant...
  43. ncbi Immunogenicity of two peptide determinants in the cytolytic T-cell response to flavivirus infection: inverse correlation between peptide affinity for MHC class I and T-cell precursor frequency
    M Regner
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT
    Viral Immunol 14:135-49. 2001
    ....
  44. ncbi DNA-based and alphavirus-vectored immunisation with prM and E proteins elicits long-lived and protective immunity against the flavivirus, Murray Valley encephalitis virus
    G Colombage
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia
    Virology 250:151-63. 1998
    ..Single-cycle infections in mice vaccinated with packaged recombinant replicon particles elicited durable, MVE-specific, and virus-neutralising antibody responses...
  45. ncbi Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing
    Anne Halenius
    Division of Viral Infections, Robert Koch Institute, Nordurfer 20, 13353 Berlin, Germany
    J Biol Chem 281:5383-90. 2006
    ..By forming multimeric complexes, gpUS6 reaches the distant target domains to arrest peptide transport. The data revealed a nonanalogous multipolar bridging of the TAP TMDs by gpUS6...
  46. pmc The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice
    Julian Pardo
    Metschnikoff Laboratory, Max Planck Institut fur Immunbiologie, D 79108 Freiburg, Germany
    J Cell Biol 174:509-19. 2006
    ..The elucidation of the molecular basis opens new strategies for the development of therapeutic regimens to combat A. fumigatus and related fungal infections...
  47. ncbi In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein
    David C Clark
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Australia
    J Gen Virol 88:1175-83. 2007
    ..The inability to detect dimeric NS1 in supernatant or cell monolayers of cultures productively infected with mutant virus also suggests that dimerization of the protein may not be essential for virus replication...
  48. pmc A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in mice
    Wen Jun Liu
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Australia
    J Virol 80:2396-404. 2006
    ....
  49. ncbi Biological, antigenic and phylogenetic characterization of the flavivirus Alfuy
    Fiona J May
    Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, The University of Queensland, Building 76, Cooper Road, St Lucia, QLD 4072, Australia
    J Gen Virol 87:329-37. 2006
    ..Accordingly, the data suggest that ALFV is a distinct species within the serogroup Japanese encephalitis virus...
  50. ncbi Cytotoxic T-cell immunity as a target for influenza vaccines
    Arno Mullbacher
    Lancet Infect Dis 6:255-6. 2006