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Genomes and Genes | Mario LobigsSummaryAffiliation: Australian National University Country: Australia Publications
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Feasibility of cross-protective vaccination against flaviviruses of the Japanese encephalitis serocomplexMario Lobigs
Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, 2600, ACT, Australia
Expert Rev Vaccines 11:177-87. 2012..The review will also focus on the structural and mechanistic basis for cross-protective immunity among this group of flaviviruses, which is predominantly mediated by antibodies against a single viral surface protein...
Cross-protective and infection-enhancing immunity in mice vaccinated against flaviviruses belonging to the Japanese encephalitis virus serocomplexMario Lobigs
Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, P O Box 334, ACT 2601, Canberra, Australia
Vaccine 21:1572-9. 2003..Immunepotentiation of heterologous flavivirus disease was apparent in animals immunized with a 'killed' virus preparation when humoral antiviral immunity of low magnitude was elicited...- Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirusMario Lobigs
Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, ACT 2601, Australia
J Gen Virol 84:567-72. 2003..In contrast, mice deficient in IFN-gamma or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus... - An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flavivirusesMario Lobigs
John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
J Gen Virol 91:1407-17. 2010..There is also an ongoing lack of human vaccines against other JEV serocomplex flaviviruses, such as MVEV, making this adjuvanted, cell culture-grown JEV vaccine a promising candidate to address both needs with one vaccine... - MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogenMario Lobigs
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 81:217-23. 2003.... 
A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesisMario Lobigs
John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
Virology 401:80-9. 2010....- Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranesMario Lobigs
Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
J Virol 78:178-86. 2004..Our results support a model for flavivirus morphogenesis involving temporal and spatial coordination of NC assembly and envelopment by regulated cleavages of an ER membrane-spanning capsid-prM intermediate... - Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class IM Lobigs
Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
Eur J Immunol 30:1496-506. 2000..Finally, we conclusively show that an aminopeptidase in the endoplasmic reticulum is also involved in antigen presentation in cells with a functional peptide transporter... - Antigen presentation in syrian hamster cells: substrate selectivity of TAP controlled by polymorphic residues in TAP1 and differential requirements for loading of H2 class I moleculesM Lobigs
Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, P O Box 334, A C T 2601, Australia
Immunogenetics 49:931-41. 1999..Thus, polymorphic residues in TAP1 can influence the substrate selectivity of the Syrian hamster peptide transporter... - Evidence that a mechanism for efficient flavivirus budding upregulates MHC class IMario Lobigs
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
Immunol Cell Biol 82:184-8. 2004.... - Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virusMario Lobigs
Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, P O Box 334, Canberra, A C T 2601, Australia
J Virol 83:2436-45. 2009..Our results suggest that the live chimeric JEV vaccine will protect against other viruses belonging to the JEV serocomplex, consistent with the observation of cross-protection following live virus infections... - NK cell-mediated immunopathology during an acute viral infection of the CNSMohammed Alsharifi
Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
Eur J Immunol 36:887-96. 2006..This is the first study illustrating an NK cell-mediated immunopathological outcome to an acute viral infection... - Cytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A virusesYoichi Furuya
Viral Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
J Virol 84:4212-21. 2010..Therefore, cross-protective immunity induced by vaccination with gamma-irradiated influenza A virus is mediated mainly by Tc-cell responses... - CD8(+) T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferonYang Wang
Division of Immunology and Genetics, The John Curtin School of Medical Research, The Australian National University ANU, PO Box 334, Canberra, ACT 2601, Australia
J Gen Virol 87:3599-609. 2006.... - Common E protein determinants for attenuation of glycosaminoglycan-binding variants of Japanese encephalitis and West Nile virusesEva Lee
John Curtin School of Medical Research, Australian National University, Australia
J Virol 78:8271-80. 2004.... - Exhaustion of type I interferon response following an acute viral infectionMohammed Alsharifi
Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Immunol 177:3235-41. 2006..Thus, transient immunosuppression through exhaustion of IFN-I production during an acute viral infection creates a time period of enhanced susceptibility to secondary infection... - Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparationsYoichi Furuya
Viral Immunology and Molecular Virology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
J Gen Virol 91:1450-60. 2010..Finally, freeze-drying of gamma-A/PC did not affect the ability to induce cross-protective immunity... - Type I interferons trigger systemic, partial lymphocyte activation in response to viral infectionMohammed Alsharifi
Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 175:4635-40. 2005..We conclude that virus-induced IFN-I release systemically affects most of the hosts T and B cells by triggering them rapidly and independently of Ag-reactivity into a semiactivated state... - Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in miceYang Wang
Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, ACT 2601, Australia
Immunol Cell Biol 82:170-3. 2004..Virus-host immune interactions have to be assessed individually and cannot be generalized... - Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virusEva Lee
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Virol 76:4901-11. 2002..The close spatial proximity of amino acids 306 and 390 in the predicted E protein structure strongly suggests that the two residues define a receptor-binding domain involved in virus attachment to sulfated proteoglycans... - The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responsesCarolina R Melo-Silva
Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, Australian National University, Canberra ACT, Australia
J Virol 85:11170-82. 2011..Consequently, SPI-2 renders mousepox lethal in susceptible strains by preventing protective NK cell defenses... - Restricted Semliki Forest virus replication in perforin and Fas-ligand double-deficient miceMohammed Alsharifi
Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Gen Virol 89:1942-4. 2008..Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated... - Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysisArno Mullbacher
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 169:145-50. 2002..The results are discussed as to the possible relevance of the phenomenon in efficiency and regulation of the Tc cell response to infections by viruses... - Can we really learn from model pathogens?Arno Mullbacher
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
Trends Immunol 25:524-8. 2004..Thus, virus-host immune interactions have to be assessed individually and cannot be generalized... - Virulence attenuation of Dengue virus due to augmented glycosaminoglycan-binding affinity and restriction in extraneural disseminationEva Lee
John Curtin School of Medical Research, Division of Immunology and Genetics, Australian National University, PO Box 334, Canberra, ACT 2600, Australia
J Gen Virol 87:2791-801. 2006..This discrepancy of attenuated neuroinvasiveness and augmented neurovirulence may be reconciled by the existence of different mechanisms of virus dissemination in the brain and in extraneural tissues... - Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infectionsMohammed Alsharifi
Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
PLoS ONE 4:e5336. 2009..We have previously reported that gamma-ray inactivated flu virus can induce cross-reactive Tc cell responses... - Immunobiology of mosquito-borne encephalitic flavivirusesArno Mullbacher
Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra City, A C T 2601, Australia
Adv Virus Res 60:87-120. 2003 - Pivotal role of antibody and subsidiary contribution of CD8+ T cells to recovery from infection in a murine model of Japanese encephalitisMaximilian Larena
Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University Australia
J Virol 85:5446-55. 2011..This finding highlights the conflicting role that CD8(+) T cells play in the pathogenesis of JEV and closely related encephalitic flaviviruses such as West Nile virus... - E protein domain III determinants of yellow fever virus 17D vaccine strain enhance binding to glycosaminoglycans, impede virus spread, and attenuate virulenceEva Lee
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University P O Box 334, Canberra, ACT 2600, Australia
J Virol 82:6024-33. 2008.... - Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flavivirusesEva Lee
Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, P O Box 334, Canberra, ACT 2601, Australia
Antiviral Res 69:31-8. 2006..In mouse models for DEN and flaviviral encephalitis, only PI-88 demonstrated a significant beneficial effect in disease outcome... - The chemokine receptor CCR5, a therapeutic target for HIV/AIDS antagonists, is critical for recovery in a mouse model of Japanese encephalitisMaximilian Larena
Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
PLoS ONE 7:e44834. 2012..This result is consistent with a mechanism by which CCR5 expression enhances lymphocyte activation and thereby promotes host survival in Japanese encephalitis... - Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in miceRosa M Licon Luna
Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia
J Virol 76:3202-11. 2002..Mice deficient in both cytotoxic effector functions were resistant to a low-dose peripheral infection with the neurotropic virus... - Both E protein glycans adversely affect dengue virus infectivity but are beneficial for virion releaseEva Lee
John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
J Virol 84:5171-80. 2010..The dueling influences of infectivity and release on virus growth affected by the glycans may explain the plasticity in E protein glycosylation among the flaviviruses... - CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitisYang Wang
Division of Immunology and Genetics, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia
J Virol 77:13323-34. 2003..Using high doses of virus in CD8-deficient mice leads to increased survival. These results provide evidence that CD8(+) T cells are involved in both recovery and immunopathology in WNV infection... - Spontaneous mutation at position 114 in H-2Kd affects cytotoxic T cell responses to influenza virus infectionA Mullbacher
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra City, ACT
Eur J Immunol 29:1228-34. 1999..Kdw presented NPP147-155 encoded by the full-length NP gene, but Kdw-NPP147-155 complexes were at least 100-fold less abundant than after translation from a minigene... - Interferon-inducible chemokines and immunity to poxvirus infectionsS Mahalingam
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra ACT
Immunol Rev 177:127-33. 2000..The results of these investigations demonstrate that the mechanisms of Mig- and Crg-2-induced viral clearance involve natural killer cells and interferons... - JE-ADVAX vaccine protection against Japanese encephalitis virus mediated by memory B cells in the absence of CD8(+) T cells and pre-exposure neutralizing antibodyMaximilian Larena
Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
J Virol 87:4395-402. 2013..Our investigation also established the suitability of a novel flavivirus challenge model (β(2)-microglobulin-knockout mice) for studies of the role of B-cell memory responses in vaccine protection... - Nonobese diabetic mice display elevated levels of class II-associated invariant chain peptide associated with I-Ag7 on the cell surfaceA Bhatnagar
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 166:4490-7. 2001..These results indicated that an intrinsic property of I-A(g7) would affect both the quantity and the repertoire of self-peptides presented during thymic selection... - Antiviral cytotoxic T cells cross-reactively recognize disparate peptide determinants from related viruses but ignore more similar self- and foreign determinantsM Regner
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 166:3820-8. 2001..These results raise the paradox that virus-immune Tc cell responses, which are mostly directed against only a few "immunodominant" viral determinants, are remarkably peptide cross-reactive... - Effector cytolotic function but not IFN-gamma production in cytotoxic T cells triggered by virus-infected target cells in vitroM Regner
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, PO Box334, Canberra, ACT 2601, Australia
Scand J Immunol 54:366-74. 2001..This result raises the possibility that the levels of presentation of cognate antigen on virus-infected cells in vivo may be below the threshold required for the IFN-gamma production... - The flavivirus nonstructural protein NS3 is a dominant source of cytotoxic T cell peptide determinantsM Lobigs
Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra
Virology 202:195-201. 1994..Processing of the MVE polyprotein by the viral proteinase did not markedly influence the availability of this peptide determinant... - Immunogenicity of two peptide determinants in the cytolytic T-cell response to flavivirus infection: inverse correlation between peptide affinity for MHC class I and T-cell precursor frequencyM Regner
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT
Viral Immunol 14:135-49. 2001.... - DNA-based and alphavirus-vectored immunisation with prM and E proteins elicits long-lived and protective immunity against the flavivirus, Murray Valley encephalitis virusG Colombage
John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia
Virology 250:151-63. 1998..Single-cycle infections in mice vaccinated with packaged recombinant replicon particles elicited durable, MVE-specific, and virus-neutralising antibody responses... - In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 proteinDavid C Clark
School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Australia
J Gen Virol 88:1175-83. 2007..The inability to detect dimeric NS1 in supernatant or cell monolayers of cultures productively infected with mutant virus also suggests that dimerization of the protein may not be essential for virus replication... - Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processingAnne Halenius
Division of Viral Infections, Robert Koch Institute, Nordurfer 20, 13353 Berlin, Germany
J Biol Chem 281:5383-90. 2006..By forming multimeric complexes, gpUS6 reaches the distant target domains to arrest peptide transport. The data revealed a nonanalogous multipolar bridging of the TAP TMDs by gpUS6... - Biological, antigenic and phylogenetic characterization of the flavivirus AlfuyFiona J May
Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, The University of Queensland, Building 76, Cooper Road, St Lucia, QLD 4072, Australia
J Gen Virol 87:329-37. 2006..Accordingly, the data suggest that ALFV is a distinct species within the serogroup Japanese encephalitis virus... - A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in miceWen Jun Liu
School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Australia
J Virol 80:2396-404. 2006.... - The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in miceJulian Pardo
Metschnikoff Laboratory, Max Planck Institut fur Immunbiologie, D 79108 Freiburg, Germany
J Cell Biol 174:509-19. 2006..The elucidation of the molecular basis opens new strategies for the development of therapeutic regimens to combat A. fumigatus and related fungal infections... - Cytotoxic T-cell immunity as a target for influenza vaccinesArno Mullbacher
Lancet Infect Dis 6:255-6. 2006