Affiliation: Australian National University
Lobigs M, Diamond M. Feasibility of cross-protective vaccination against flaviviruses of the Japanese encephalitis serocomplex. Expert Rev Vaccines. 2012;11:177-87 pubmed publisher
..The review will also focus on the structural and mechanistic basis for cross-protective immunity among this group of flaviviruses, which is predominantly mediated by antibodies against a single viral surface protein. ..
Lobigs M, Pavy M, Hall R, Lobigs P, Cooper P, Komiya T, et al
. An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses. J Gen Virol. 2010;91:1407-17 pubmed publisher
..There is also an ongoing lack of human vaccines against other JEV serocomplex flaviviruses, such as MVEV, making this adjuvanted, cell culture-grown JEV vaccine a promising candidate to address both needs with one vaccine. ..
Lobigs M, Mullbacher A, Blanden R, Hammerling G, Momburg F. Antigen presentation in syrian hamster cells: substrate selectivity of TAP controlled by polymorphic residues in TAP1 and differential requirements for loading of H2 class I molecules. Immunogenetics. 1999;49:931-41 pubmed
..Thus, polymorphic residues in TAP1 can influence the substrate selectivity of the Syrian hamster peptide transporter...
Lobigs M, Mullbacher A, Wang Y, Pavy M, Lee E. Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus. J Gen Virol. 2003;84:567-72 pubmed
..In contrast, mice deficient in IFN-gamma or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus...
Lobigs M, Pavy M, Hall R. Cross-protective and infection-enhancing immunity in mice vaccinated against flaviviruses belonging to the Japanese encephalitis virus serocomplex. Vaccine. 2003;21:1572-9 pubmed
..Immunepotentiation of heterologous flavivirus disease was apparent in animals immunized with a 'killed' virus preparation when humoral antiviral immunity of low magnitude was elicited. ..
Lobigs M, Mullbacher A, Regner M. MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen. Immunol Cell Biol. 2003;81:217-23 pubmed
Lobigs M, Lee E. Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranes. J Virol. 2004;78:178-86 pubmed
..Our results support a model for flavivirus morphogenesis involving temporal and spatial coordination of NC assembly and envelopment by regulated cleavages of an ER membrane-spanning capsid-prM intermediate...
Lobigs M, Mullbacher A, Lee E. Evidence that a mechanism for efficient flavivirus budding upregulates MHC class I. Immunol Cell Biol. 2004;82:184-8 pubmed