Research Topics
| Trevor D LambSummaryAffiliation: Australian National University Country: Australia Publications
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Detail Information
Publications
The photocurrent response of human cones is fast and monophasicJ H van Hateren
Department of Neurobiophysics, University of Groningen, Groningen, The Netherlands
BMC Neurosci 7:34. 2006..As a check, we also compare the predictions with previous single-cell measurements of ground squirrel cone responses...
Dark adaptation and the retinoid cycle of visionT D Lamb
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
Prog Retin Eye Res 23:307-80. 2004....
Evolution of vertebrate retinal photoreceptionTrevor D Lamb
ARC Centre of Excellence in Vision Science, The Australian National University, Canberra ACT 0200, Australia
Philos Trans R Soc Lond B Biol Sci 364:2911-24. 2009..Accordingly, it has been possible to propose a plausible scenario for the sequence of evolutionary steps that led to the emergence of vertebrate photoreceptors and retina...
Phototransduction, dark adaptation, and rhodopsin regeneration the proctor lectureTrevor D Lamb
Division of Neuroscience, John Curtin School of Medical Research, and ARC Centre of Excellence in Vision Science, The Australian National University, Canberra, Australia
Invest Ophthalmol Vis Sci 47:5137-52. 2006
Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cupTrevor D Lamb
Australian National University, Division of Neuroscience, The John Curtin School of Medical Research, Garran Road, The Australian National University, Canberra, Australian Capital Territory 2600, Australia
Nat Rev Neurosci 8:960-76. 2007..Here, we review a wide range of findings that capture glimpses of the gradations that appear to have occurred during eye evolution, and provide a scenario for the unseen steps that have led to the emergence of the vertebrate eye...
Dark adaptation of human rod bipolar cells measured from the b-wave of the scotopic electroretinogramA M Cameron
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Physiol 575:507-26. 2006..We attribute the S2 component to the presence of unregenerated opsin, and we speculate that the S3 component results from ion channel closure by all-trans retinal...
Inverted photocurrent responses from amphibian rod photoreceptors: role of membrane voltage in response recoveryJaakko L P Jarvinen
Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 566:455-66. 2005..Our work suggests a novel role for membrane voltage in accelerating the inactivation phase of the response to light...
Dark adaptation recovery of human rod bipolar cell response kinetics estimated from scotopic b-wave measurementsA M Cameron
Division of Neuroscience, John Curtin School of Medical Research and ARC Centre of Excellence in Vision Science, Australian National University, Canberra, ACT 0200, Australia
J Physiol 586:5419-36. 2008..While the recovery of rod bipolar cell response kinetics can be described accurately by a declining level of opsin in the rods, the sensitivity of these cells is reduced further than expected by this mechanism alone...
Extremely rapid recovery of human cone circulating current at the extinction of bleaching exposuresJ S Kenkre
Division of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia
J Physiol 567:95-112. 2005....
Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responsesF Vogalis
Department of Neuroscience, Australian National University, Canberra, ACT 0200, Australia
J Physiol 589:2321-48. 2011..These results help provide an understanding for the molecular basis of the electrophysiological differences between cones and rods...
The retinal G protein-coupled receptor (RGR) enhances isomerohydrolase activity independent of lightAndreas Wenzel
Laboratory for Retinal Cell Biology, University Hospital Zurich, Eye Clinic, Switzerland
J Biol Chem 280:29874-84. 2005..Furthermore, we find that light accelerates rhodopsin regeneration, independent of RGR...
G proteins and phototransductionVadim Y Arshavsky
Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
Annu Rev Physiol 64:153-87. 2002..We examine how the interplay between the mechanisms that contribute to amplification and those that govern termination of G protein activity determine the speed and the sensitivity of the cellular response to light...
