Trevor D Lamb
Affiliation: Australian National University
- The kinetics of regeneration of rhodopsin under enzyme-limited availability of 11-cis retinoidTrevor D Lamb
Eccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia Electronic address
Vision Res 110:23-33. 2015..Finally, we present arguments favouring the enzymatic model as the cellular basis for normal human rod and cone pigment regeneration. ..
- Evolution of phototransduction, vertebrate photoreceptors and retinaTrevor D Lamb
Department of Neuroscience, and ARC Centre of Excellence in Vision Science, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia
Prog Retin Eye Res 36:52-119. 2013..The exact timing of the emergence of 'true rods' is not yet clear, but it may not have occurred until after the divergence of jawed and jawless vertebrates. ..
- The photocurrent response of human cones is fast and monophasicJ H van Hateren
Department of Neurobiophysics, University of Groningen, Groningen, The Netherlands
BMC Neurosci 7:34. 2006..As a check, we also compare the predictions with previous single-cell measurements of ground squirrel cone responses...
- Evolution of vertebrate retinal photoreceptionTrevor D Lamb
ARC Centre of Excellence in Vision Science, The Australian National University, Canberra ACT 0200, Australia
Philos Trans R Soc Lond B Biol Sci 364:2911-24. 2009..Accordingly, it has been possible to propose a plausible scenario for the sequence of evolutionary steps that led to the emergence of vertebrate photoreceptors and retina...
- Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cupTrevor D Lamb
Australian National University, Division of Neuroscience, The John Curtin School of Medical Research, Garran Road, The Australian National University, Canberra, Australian Capital Territory 2600, Australia
Nat Rev Neurosci 8:960-76. 2007..Here, we review a wide range of findings that capture glimpses of the gradations that appear to have occurred during eye evolution, and provide a scenario for the unseen steps that have led to the emergence of the vertebrate eye...
- Phototransduction, dark adaptation, and rhodopsin regeneration the proctor lectureTrevor D Lamb
Division of Neuroscience, John Curtin School of Medical Research, and ARC Centre of Excellence in Vision Science, The Australian National University, Canberra, Australia
Invest Ophthalmol Vis Sci 47:5137-52. 2006
- Dark adaptation and the retinoid cycle of visionT D Lamb
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
Prog Retin Eye Res 23:307-80. 2004....
- Dark adaptation of human rod bipolar cells measured from the b-wave of the scotopic electroretinogramA M Cameron
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Physiol 575:507-26. 2006..We attribute the S2 component to the presence of unregenerated opsin, and we speculate that the S3 component results from ion channel closure by all-trans retinal...
- Dark adaptation recovery of human rod bipolar cell response kinetics estimated from scotopic b-wave measurementsA M Cameron
Division of Neuroscience, John Curtin School of Medical Research and ARC Centre of Excellence in Vision Science, Australian National University, Canberra, ACT 0200, Australia
J Physiol 586:5419-36. 2008..While the recovery of rod bipolar cell response kinetics can be described accurately by a declining level of opsin in the rods, the sensitivity of these cells is reduced further than expected by this mechanism alone...
- Inverted photocurrent responses from amphibian rod photoreceptors: role of membrane voltage in response recoveryJaakko L P Jarvinen
Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 566:455-66. 2005..Our work suggests a novel role for membrane voltage in accelerating the inactivation phase of the response to light...
- Extremely rapid recovery of human cone circulating current at the extinction of bleaching exposuresJ S Kenkre
Division of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia
J Physiol 567:95-112. 2005....
- Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responsesF Vogalis
Department of Neuroscience, Australian National University, Canberra, ACT 0200, Australia
J Physiol 589:2321-48. 2011..These results help provide an understanding for the molecular basis of the electrophysiological differences between cones and rods...
- The retinal G protein-coupled receptor (RGR) enhances isomerohydrolase activity independent of lightAndreas Wenzel
Laboratory for Retinal Cell Biology, University Hospital Zurich, Eye Clinic, Switzerland
J Biol Chem 280:29874-84. 2005..Furthermore, we find that light accelerates rhodopsin regeneration, independent of RGR...
- G proteins and phototransductionVadim Y Arshavsky
Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
Annu Rev Physiol 64:153-87. 2002..We examine how the interplay between the mechanisms that contribute to amplification and those that govern termination of G protein activity determine the speed and the sensitivity of the cellular response to light...