J I Kourie

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. ncbi request reprint Diversity of amyloid beta protein fragment [1-40]-formed channels
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra City, Australian Capital Territory, Australia
    Cell Mol Neurobiol 21:255-84. 2001
  2. pmc Characteristics of two types of chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle
    J I Kourie
    John Curtin School of Medical Research, Australian National University, Canberra City, Australia
    Biophys J 70:202-21. 1996
  3. ncbi request reprint Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, Canberra City, Australian Capital Territory, 0200 Australia
    J Membr Biol 193:35-45. 2003
  4. ncbi request reprint Prion channel proteins and their role in vacuolation and neurodegenerative diseases
    Joseph I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, Building 33, Science Road, The Australian National University, Canberra City, ACT 0200, Australia
    Eur Biophys J 31:409-16. 2002
  5. ncbi request reprint Heterogeneous amyloid-formed ion channels as a common cytotoxic mechanism: implications for therapeutic strategies against amyloidosis
    Joseph I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra, ACT
    Cell Biochem Biophys 36:191-207. 2002
  6. ncbi request reprint Mechanisms of prion-induced modifications in membrane transport properties: implications for signal transduction and neurotoxicity
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, ACT, 0200, Canberra, Australia
    Chem Biol Interact 138:1-26. 2001
  7. ncbi request reprint Channel activity of deamidated isoforms of prion protein fragment 106-126 in planar lipid bilayers
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Australian National University, Bldg 33, Science Road, Canberra City, ACT 0200, Australia
    J Neurosci Res 66:214-20. 2001
  8. ncbi request reprint Mechanisms of amyloid beta protein-induced modification in ion transport systems: implications for neurodegenerative diseases
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, ACT, Canberra
    Cell Mol Neurobiol 21:173-213. 2001
  9. ncbi request reprint Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra City, ACT
    Can J Physiol Pharmacol 79:654-64. 2001
  10. ncbi request reprint Protein aggregation and deposition: implications for ion channel formation and membrane damage
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, Building 33, Science Road, The Australian National University, Canberra City, ACT 0200, Australia
    Croat Med J 42:359-74. 2001

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Diversity of amyloid beta protein fragment [1-40]-formed channels
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra City, Australian Capital Territory, Australia
    Cell Mol Neurobiol 21:255-84. 2001
    ..3. Furthermore, the formation of beta-sheet based oligomers could be an important common step in the formation of cytotoxic amyloid channels...
  2. pmc Characteristics of two types of chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle
    J I Kourie
    John Curtin School of Medical Research, Australian National University, Canberra City, Australia
    Biophys J 70:202-21. 1996
    ..BCl channels had 7-13 predominant levels plus many more short-lived substates. SCl channels have not been described in previous reports of Cl- channels in skeletal muscle SR...
  3. ncbi request reprint Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, Canberra City, Australian Capital Territory, 0200 Australia
    J Membr Biol 193:35-45. 2003
    ..We further suggest that the conversions of the normal cellular isoform of prion protein (PrP(c)) to abnormal scrapie isoform (PrP(Sc)) and intermediates represent conversions to protease-resistant neurotoxic channel conformations...
  4. ncbi request reprint Prion channel proteins and their role in vacuolation and neurodegenerative diseases
    Joseph I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, Building 33, Science Road, The Australian National University, Canberra City, ACT 0200, Australia
    Eur Biophys J 31:409-16. 2002
    ....
  5. ncbi request reprint Heterogeneous amyloid-formed ion channels as a common cytotoxic mechanism: implications for therapeutic strategies against amyloidosis
    Joseph I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra, ACT
    Cell Biochem Biophys 36:191-207. 2002
    ..The pharmacological diversity of the amyloid-forming channels implies that multiple therapeutic interventions may be necessary for blocking and reversing heterogeneous channel formations and preventing their associated diseases...
  6. ncbi request reprint Mechanisms of prion-induced modifications in membrane transport properties: implications for signal transduction and neurotoxicity
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, ACT, 0200, Canberra, Australia
    Chem Biol Interact 138:1-26. 2001
    ..e. beta sheets, protein aggregation, hydrophobicity, functional significance of specific amino acids (e.g. methionine, histidine) and regulation with low pH...
  7. ncbi request reprint Channel activity of deamidated isoforms of prion protein fragment 106-126 in planar lipid bilayers
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Australian National University, Bldg 33, Science Road, Canberra City, ACT 0200, Australia
    J Neurosci Res 66:214-20. 2001
    ....
  8. ncbi request reprint Mechanisms of amyloid beta protein-induced modification in ion transport systems: implications for neurodegenerative diseases
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, ACT, Canberra
    Cell Mol Neurobiol 21:173-213. 2001
    ..This mechanism of membrane damage is not only central for AD but also may explain other malfunctioned protein-processing-related pathologies...
  9. ncbi request reprint Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra City, ACT
    Can J Physiol Pharmacol 79:654-64. 2001
    ....
  10. ncbi request reprint Protein aggregation and deposition: implications for ion channel formation and membrane damage
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, Building 33, Science Road, The Australian National University, Canberra City, ACT 0200, Australia
    Croat Med J 42:359-74. 2001
    ..This mechanism of membrane damage is a general mechanism that may explain other malfunctioning protein processing-related pathologies...
  11. ncbi request reprint Synthetic mammalian C-type natriuretic peptide forms large cation channels
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra
    FEBS Lett 445:57-62. 1999
    ....
  12. pmc Characterization of a C-type natriuretic peptide (CNP-39)-formed cation-selective channel from platypus (Ornithorhynchus anatinus) venom
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, Canberra City, ACT 0200, Australia
    J Physiol 518:359-69. 1999
    ..05). 5. It is proposed that some of the symptoms of envenomation by platypus venom may be caused partly by changes in cellular functions mediated via the OaCNP-39-formed fast cation-selective channel, which affects signal transduction...
  13. ncbi request reprint Calcium dependence of C-type natriuretic peptide-formed fast K(+) channel
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, Canberra City, Australian Capital Territory 0200, Australia
    Am J Physiol 277:C43-50. 1999
    ..g., ischemic heart and muscle fatigue. The channel could modify a cascade of physiological functions that are dependent on the Ca(2+)-activated K(+) channels, e.g., vasodilation and salt secretion...
  14. ncbi request reprint Properties of cytotoxic peptide-formed ion channels
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Australian National University, Canberra City, Australian Capital Territory, 0200 Australia
    Am J Physiol Cell Physiol 278:C1063-87. 2000
    ..These two nonexclusive mechanisms of action lead to changes in second messenger systems that further augment the abnormal electrical activity and distortion of the signal transduction causing cell death...
  15. ncbi request reprint Biophysical and molecular properties of annexin-formed channels
    J I Kourie
    Department of Chemistry, Membrane Transport Group, The Faculties, The Australian National University, ACT 0200, Canberra City, Australia
    Prog Biophys Mol Biol 73:91-134. 2000
    ....
  16. ncbi request reprint Prion peptide fragment PrP[106-126] forms distinct cation channel types
    J I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, Canberra City, Australia
    J Neurosci Res 62:120-33. 2000
    ..The biophysical properties of these channels indicate that they are capable of modifying cellular functions via modification of V(m) and electrolyte homeostasis of the cell...
  17. ncbi request reprint Role of natriuretic peptides in ion transport mechanisms
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra City, ACT
    Med Res Rev 19:75-94. 1999
    ..g., ovCNP-22 and ovCNP-39, appear to confer on them the ability to form ion channels. These CNP-formed ion channels can modify the trans-membrane signal transduction and second messenger systems underlying NP-induced pathological effects...
  18. ncbi request reprint Quinacrine blocks PrP (106-126)-formed channels
    Peter V Farrelly
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, Canberra City, Australian Capital Territory, Australia
    J Neurosci Res 74:934-41. 2003
    ..The QC-induced changes in the kinetic parameters of this channel suggest that they are pathophysiologically significant because these channels could be the mechanisms by which amyloids induce membrane damage in vivo...
  19. ncbi request reprint Channels formed with a mutant prion protein PrP(82-146) homologous to a 7-kDa fragment in diseased brain of GSS patients
    Randa Bahadi
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, Canberra, Australian Capital Territory 0200, Australia
    Am J Physiol Cell Physiol 285:C862-72. 2003
    ..We propose that Cd2+ may accentuate the neurotoxicity of this channel-forming PrP fragment by enhancing its incorporation into the membrane...
  20. ncbi request reprint Cu2+-induced modification of the kinetics of A beta(1-42) channels
    Randa Bahadi
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, Canberra, Australian Capital Territory 0200, Australia
    Am J Physiol Cell Physiol 285:C873-80. 2003
    ....
  21. ncbi request reprint Ion channel formation and membrane-linked pathologies of misfolded hydrophobic proteins: the role of dangerous unchaperoned molecules
    Joseph I Kourie
    Membrane Transport Group, Department of Chemistry, The Faculties, The Australian National University, Science Road, Canberra, ACT 0200, Australia
    Clin Exp Pharmacol Physiol 29:741-53. 2002
    ..4. It is hypothesized that the membrane damage induced by amyloids, antibacterial toxins and viral proteins represents a common mechanism for cell malfunction, which underlies the associated pathologies and cytotoxicity of such proteins...
  22. ncbi request reprint The role of bacterial and non-bacterial toxins in the induction of changes in membrane transport: implications for diarrhea
    Karina N Laohachai
    Membrane Transport Group, Department of Chemistry, Building 33, The Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia
    Toxicon 42:687-707. 2003
    ....