G Karupiah

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. pmc Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection
    G Karupiah
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 70:8301-9. 1996
  2. ncbi request reprint Type 1 and type 2 cytokines in antiviral defense
    G Karupiah
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT, Australia
    Vet Immunol Immunopathol 63:105-9. 1998
  3. pmc Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection
    G Karupiah
    Host Defense Laboratory, Viral Engineering and Cytokines Group, Division of Immunology and Cell Biology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    J Virol 72:7703-6. 1998
  4. pmc Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice
    G Karupiah
    Host Defense Laboratory, Viral Engineering and Cytokines Group, Division of Immunology and Cell Biology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    J Exp Med 188:1541-6. 1998
  5. pmc Poxvirus-encoded gamma interferon binding protein dampens the host immune response to infection
    Isaac G Sakala
    The John Curtin School of Medical Research, Australian National University, Acton, ACT 0200, Australia
    J Virol 81:3346-53. 2007
  6. pmc Importance of interferons in recovery from mousepox
    G Karupiah
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:4214-26. 1993
  7. ncbi request reprint Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase
    G Karupiah
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Science 261:1445-8. 1993
  8. pmc Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus
    S Mahalingam
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Proc Natl Acad Sci U S A 98:6812-7. 2001
  9. ncbi request reprint Transcription of the interferon gamma (IFN-gamma )-inducible chemokine Mig in IFN-gamma-deficient mice
    S Mahalingam
    School of Human and Biomedical Sciences, Division of Science and Design, University of Canberra, Canberra, ACT 2601, Australia
    J Biol Chem 276:7568-74. 2001
  10. ncbi request reprint Modulation of chemokines by poxvirus infections
    S Mahalingam
    Cellular Signal Transduction Laboratory, Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Curr Opin Immunol 12:409-12. 2000

Collaborators

Detail Information

Publications26

  1. pmc Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection
    G Karupiah
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 70:8301-9. 1996
    ....
  2. ncbi request reprint Type 1 and type 2 cytokines in antiviral defense
    G Karupiah
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT, Australia
    Vet Immunol Immunopathol 63:105-9. 1998
    ..IFN-gamma gene knock out mice on a B6 background were as susceptible to EV as the BALB/c and A strain mice...
  3. pmc Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection
    G Karupiah
    Host Defense Laboratory, Viral Engineering and Cytokines Group, Division of Immunology and Cell Biology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    J Virol 72:7703-6. 1998
    ..e. , gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival...
  4. pmc Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice
    G Karupiah
    Host Defense Laboratory, Viral Engineering and Cytokines Group, Division of Immunology and Cell Biology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    J Exp Med 188:1541-6. 1998
    ..This mechanism was observed only in the complete absence of NOS2 activity and appeared sufficient to control influenza A virus growth in the absence of changes in cytotoxic T lymphocyte activity...
  5. pmc Poxvirus-encoded gamma interferon binding protein dampens the host immune response to infection
    Isaac G Sakala
    The John Curtin School of Medical Research, Australian National University, Acton, ACT 0200, Australia
    J Virol 81:3346-53. 2007
    ....
  6. pmc Importance of interferons in recovery from mousepox
    G Karupiah
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:4214-26. 1993
    ....
  7. ncbi request reprint Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase
    G Karupiah
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Science 261:1445-8. 1993
    ..In mice, an inhibitor of NO synthase converted resolving ectromelia virus infection into fulminant mousepox. Thus, induction of NO synthase can be necessary and sufficient for a substantial antiviral effect of IFN-gamma...
  8. pmc Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus
    S Mahalingam
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Proc Natl Acad Sci U S A 98:6812-7. 2001
    ..Furthermore, in the absence of this transcription factor, the immune system defaults toward a protective Th1-like response, conferring pronounced resistance to EV infection and disease progression...
  9. ncbi request reprint Transcription of the interferon gamma (IFN-gamma )-inducible chemokine Mig in IFN-gamma-deficient mice
    S Mahalingam
    School of Human and Biomedical Sciences, Division of Science and Design, University of Canberra, Canberra, ACT 2601, Australia
    J Biol Chem 276:7568-74. 2001
    ..We have found that, in the absence of IFN-gamma, IFN-alpha/beta are able to induce Mig in response to a viral infection in vivo...
  10. ncbi request reprint Modulation of chemokines by poxvirus infections
    S Mahalingam
    Cellular Signal Transduction Laboratory, Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Curr Opin Immunol 12:409-12. 2000
    ..In recent years, much attention has been focused on the role of chemokines in antiviral defense...
  11. ncbi request reprint Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response
    C J Simeonovic
    Division of Molecular Medicine, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT
    Cell Transplant 8:365-73. 1999
    ..Significantly, the Th1-to-Th2-like switch resulted in the novel conversion of an allograft rejection reaction into a xenograft-like rejection process...
  12. ncbi request reprint Inhibition of allergic airway inflammation in mice lacking nitric oxide synthase 2
    Y Xiong
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra
    J Immunol 162:445-52. 1999
    ....
  13. pmc Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function
    Vijay Panchanathan
    Infection and Immunology Group, Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Mills Road, Acton, ACT 0200, Australia
    J Virol 80:6333-8. 2006
    ..Thus, antibody is essential, but CD4 or CD8 T cells are not required for recovery from secondary poxvirus infection...
  14. pmc Obligatory requirement for antibody in recovery from a primary poxvirus infection
    Geeta Chaudhri
    Infection and Immunology Group, Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Mills Road, Acton, ACT 0200, Australia
    J Virol 80:6339-44. 2006
    ..Strikingly, our results show that antibody prevents virus from seeding the skin and forming pock lesions, which are important for virus transmission between hosts...
  15. ncbi request reprint Interferon-inducible chemokines and immunity to poxvirus infections
    S Mahalingam
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra ACT
    Immunol Rev 177:127-33. 2000
    ..The results of these investigations demonstrate that the mechanisms of Mig- and Crg-2-induced viral clearance involve natural killer cells and interferons...
  16. pmc Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox
    Geeta Chaudhri
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Proc Natl Acad Sci U S A 101:9057-62. 2004
    ..This finding in the mousepox model raises the possibility that inappropriate cytokine responses may result in increased susceptibility to smallpox in humans...
  17. ncbi request reprint Correlates of protective immunity in poxvirus infection: where does antibody stand?
    Vijay Panchanathan
    Division of Biochemistry and Moelcular Biology, Australian National University, Canberra, Australia
    Immunol Cell Biol 86:80-6. 2008
    ..These findings have important clinical implications and would greatly assist the design of therapeutic interventions and new vaccines for smallpox...
  18. pmc Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice
    David C Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 80:6318-23. 2006
    ..We then use these determinants to test if predicted conservation across orthopoxvirus species matches experimental observation and find an unexpectedly cross-reactive variant peptide encoded by ectromelia (mousepox) virus...
  19. pmc Interferon function is not required for recovery from a secondary poxvirus infection
    Vijay Panchanathan
    Infection and Immunity Group, Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Proc Natl Acad Sci U S A 102:12921-6. 2005
    ..Importantly, the depletion of CD8+ T lymphocytes during a secondary challenge in IFN-deficient mice does not affect their capacity to clear ECTV, indicating that Ab is critical for the control of a secondary infection...
  20. pmc Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
    David C Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:95-104. 2005
    ..These findings have important implications for understanding poxvirus immunity in animal models and bench-marking immune responses to poxvirus vaccines in humans...
  21. doi request reprint IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection
    Yang Wang
    John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    J Immunol 183:3324-31. 2009
    ..Taken together, our data indicate that IL-12p40 and IL-18 act in concert and play an important antiviral role through the up-regulation of IFN-gamma production and cell-mediated immune responses...
  22. ncbi request reprint Genetic resistance to smallpox: lessons from mousepox
    Gunasegaran Karupiah
    Infection and Immunity Group, Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Novartis Found Symp 281:129-36; discussion 136-40, 208-9. 2007
    ..Here we present data on one virus-encoded immune modifier and its effect on the functions of two host genetic loci associ ated with resistance...
  23. pmc T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control
    Geeta Chaudhri
    Infection and Immunity Group, Immunology Program, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Proc Natl Acad Sci U S A 106:14984-9. 2009
    ..Such receptor sharing allows rapid, proliferation-independent expansion of virus-specific T cell clones of low frequency and plays a highly significant antiviral role that can protect the host from an otherwise lethal infection...
  24. doi request reprint Antiviral protection following immunization correlates with humoral but not cell-mediated immunity
    Vijay Panchanathan
    Infection and Immunity Group, Program in Immunology, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Australia
    Immunol Cell Biol 88:461-7. 2010
    ..This information could potentially prove useful in the design of safer and more efficacious vaccines against poxviruses or other diseases using poxvirus vectors...
  25. ncbi request reprint Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice
    Jerome P Jayasekera
    Department of Pathology, Bosch Institute, School of Biomedical Sciences, Blackburn Building D06, University of Sydney, NSW 2006, Australia
    J Gen Virol 87:3361-71. 2006
    ..The relationship between viral load and the development of immunopathology is discussed...
  26. ncbi request reprint Immunopathogenesis of poxvirus infections: forecasting the impending storm
    Marianne M Stanford
    BioTherapeutics Research Group, Robarts Research Institute, Ontario, Canada
    Immunol Cell Biol 85:93-102. 2007
    ..There is growing evidence that many of the symptoms associated with serious poxvirus infections are a result of a 'cytokine storm' or sepsis and that this may be the underlying cause of pathology...