Christopher Goodnow

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. doi request reprint Control systems and decision making for antibody production
    Christopher C Goodnow
    John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Nat Immunol 11:681-8. 2010
  2. pmc Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling
    Adrian Liston
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Genome Biol 8:R12. 2007
  3. ncbi request reprint Multistep pathogenesis of autoimmune disease
    Christopher C Goodnow
    John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Canberra ACT 2601, Australia
    Cell 130:25-35. 2007
  4. ncbi request reprint Immunology. Discriminating microbe from self suffers a double toll
    Christopher C Goodnow
    John Curtin School of Medical Research and Australian Phenomics Facility, Australian National University, Post Office Box 334, Canberra, ACT 0200, Australia
    Science 312:1606-8. 2006
  5. ncbi request reprint Nossal and Pike 1975: a turning point in the effort to define self-tolerance mechanisms
    Christopher C Goodnow
    Australian National University, Immunology and Genetics Division, Australian Phenomics Facility, John Curtin School of Medical Research, Canberra, Australian Capital Territory, Australia
    J Immunol 179:5617-8. 2007
  6. doi request reprint Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    Nicholas Simpson
    Australian National University, Canberra, ACT, Australia
    Arthritis Rheum 62:234-44. 2010
  7. ncbi request reprint Lyn/CD22/SHP-1 and their importance in autoimmunity
    Julie Blasioli
    Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Curr Dir Autoimmun 5:151-60. 2002
  8. ncbi request reprint Axon growth and guidance genes identify T-dependent germinal centre B cells
    Di Yu
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    Immunol Cell Biol 86:3-14. 2008
  9. pmc A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development
    Katharine M Gosling
    School of Biochemistry and Molecular Biology, John Curtin School of Medical Research, and Australian Phenomics Facility, Australian National University, Canberra ACT 0200, Australia
    Proc Natl Acad Sci U S A 104:12445-50. 2007
  10. ncbi request reprint Cellular and genetic mechanisms of self tolerance and autoimmunity
    Christopher C Goodnow
    John Curtin School of Medical Research, Canberra ACT 2601
    Nature 435:590-7. 2005

Research Grants

  1. Genes for Tolerance and Immunity Consortium
    Christopher Goodnow; Fiscal Year: 2006

Collaborators

Detail Information

Publications56

  1. doi request reprint Control systems and decision making for antibody production
    Christopher C Goodnow
    John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Nat Immunol 11:681-8. 2010
    ..Understanding the engineering of these control systems represents a challenging future step for treating disorders of antibody production in autoimmunity, allergy and immunodeficiency...
  2. pmc Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling
    Adrian Liston
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Genome Biol 8:R12. 2007
    ..negative from positive selection is poorly understood, despite the fact that inherited defects in negative selection underlie organ-specific autoimmune disease in AIRE-deficient people and the non-obese diabetic (NOD) mouse strain..
  3. ncbi request reprint Multistep pathogenesis of autoimmune disease
    Christopher C Goodnow
    John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Canberra ACT 2601, Australia
    Cell 130:25-35. 2007
    ..Multiple mutations, inherited and somatic, may be needed before a self-reactive clone bypasses sequential tolerance checkpoints resulting in the emergence of autoimmune disease...
  4. ncbi request reprint Immunology. Discriminating microbe from self suffers a double toll
    Christopher C Goodnow
    John Curtin School of Medical Research and Australian Phenomics Facility, Australian National University, Post Office Box 334, Canberra, ACT 0200, Australia
    Science 312:1606-8. 2006
  5. ncbi request reprint Nossal and Pike 1975: a turning point in the effort to define self-tolerance mechanisms
    Christopher C Goodnow
    Australian National University, Immunology and Genetics Division, Australian Phenomics Facility, John Curtin School of Medical Research, Canberra, Australian Capital Territory, Australia
    J Immunol 179:5617-8. 2007
  6. doi request reprint Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    Nicholas Simpson
    Australian National University, Canberra, ACT, Australia
    Arthritis Rheum 62:234-44. 2010
    ..The purpose of this study was to examine the hypothesis that this pathway could account for a subset of patients with systemic lupus erythematosus (SLE)...
  7. ncbi request reprint Lyn/CD22/SHP-1 and their importance in autoimmunity
    Julie Blasioli
    Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Curr Dir Autoimmun 5:151-60. 2002
  8. ncbi request reprint Axon growth and guidance genes identify T-dependent germinal centre B cells
    Di Yu
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    Immunol Cell Biol 86:3-14. 2008
    ..Finally we show some of the axon growth genes upregulated in TD-GC B cells including Basp1, Shh, Sult4alpha, Sc4mol are also preferentially expressed in post-GC B cell neoplasms...
  9. pmc A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development
    Katharine M Gosling
    School of Biochemistry and Molecular Biology, John Curtin School of Medical Research, and Australian Phenomics Facility, Australian National University, Canberra ACT 0200, Australia
    Proc Natl Acad Sci U S A 104:12445-50. 2007
    ..These data define a unique lineage-specific requirement for kleisin beta in mammalian T cell differentiation...
  10. ncbi request reprint Cellular and genetic mechanisms of self tolerance and autoimmunity
    Christopher C Goodnow
    John Curtin School of Medical Research, Canberra ACT 2601
    Nature 435:590-7. 2005
    ..This provides the bridge between clinical studies and mechanisms defined in experimental animals to understand how sets of gene products coordinate self-tolerance mechanisms and how defects in these controls lead to autoimmune disease...
  11. ncbi request reprint A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    Carola G Vinuesa
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Nature 435:452-8. 2005
    ..The Roquin protein is distinguished by the presence of a CCCH zinc-finger found in RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating messenger RNA translation and stability...
  12. ncbi request reprint Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis
    Todor Arsov
    John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia
    Mol Endocrinol 20:1610-22. 2006
    ....
  13. ncbi request reprint The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity
    Gerard F Hoyne
    Australian Cancer Research Foundation Genetics Laboratory and Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Immunol Rev 210:27-39. 2006
    ..The successful propagation and identification of the new gene variants will shed light on the various developmental checkpoints in lymphocyte development that are crucial for establishing tolerance to self-antigens...
  14. pmc Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse
    Katharine M Gosling
    School of Biochemistry and Molecular Biology, The Australian National University, Canberra, Australia
    Immunology 125:208-17. 2008
    ..These data indicate that kleisin-beta is required for a normal immune response, and represent the first demonstration of a role for kleisin-beta in T-cell function...
  15. ncbi request reprint Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor
    Peter Papathanasiou
    Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, ACT 2601, Canberra, Australia
    Immunity 19:131-44. 2003
    ....
  16. pmc Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors
    Keisuke Horikawa
    Immunogenomics Laboratory, The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra 0200, Australia
    J Exp Med 204:759-69. 2007
    ....
  17. ncbi request reprint Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
    Lixin Rui
    ACRF Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Nat Immunol 4:594-600. 2003
    ....
  18. ncbi request reprint Analysis of B cell memory formation using DNA microarrays
    Carola G Vinuesa
    Medical Genome Centre, John Curtin School of Medical Research, Australian National University, ACT, Australia
    Ann N Y Acad Sci 975:33-45. 2002
    ..This model demonstrates how genome-scale technology can be adapted to investigate specific aspects of B cell biology...
  19. ncbi request reprint Novel approaches for identifying genes regulating lymphocyte development and function
    Adèle L Loy
    Australian Cancer Research Foundation ACRF Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Curr Opin Immunol 14:260-5. 2002
    ..Alternatively, mutant phenotypes (derived using the mutagen ethylnitrosourea) can be traced back to gene sequences...
  20. ncbi request reprint Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory
    Stephen W Martin
    ACRF Genetics Laboratory, Medical Genome Centre, John Curtin School of Medical Research, Australian National University, PO Box 334, Mills Road, Canberra 2601, Australia
    Nat Immunol 3:182-8. 2002
    ..These results establish a key molecular determinant of immunological memory and define an unexpected cellular basis by which it enhances the magnitude of secondary antibody responses...
  21. ncbi request reprint Tracing the action of IL-2 in tolerance to islet-specific antigen
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
    Immunol Cell Biol 85:338-42. 2007
    ....
  22. ncbi request reprint ENU-mutagenesis: insight into immune function and pathology
    Matthew C Cook
    Frank Fenner Building, Australian National University, Canberra ACT 0200, Australia
    Curr Opin Immunol 18:627-33. 2006
    ..More than 20 of the phenotypes that exhibit a simple (Mendelian) pattern of inheritance have been mapped. Novel alleles have revealed new pathways of host defense, allergy and autoimmunity...
  23. ncbi request reprint Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system
    Peter Papathanasiou
    Australian Cancer Research Foundation Genetics Laboratory and Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601 Australia
    Annu Rev Genet 39:241-62. 2005
    ..Second, ENU alleles match those arising by natural variation. By changing individual protein domains or splice products, these alleles reveal separate gene functions specified through protein combinations...
  24. ncbi request reprint Genetic lesions in T-cell tolerance and thresholds for autoimmunity
    Adrian Liston
    John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, ACT 2601, Australia
    Immunol Rev 204:87-101. 2005
    ..These data allow us to propose a model relating efficiency of thymic deletion to T-cell tolerance and susceptibility to autoimmunity...
  25. ncbi request reprint ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-driven plasma cell differentiation
    Lixin Rui
    Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian Phenomics Facility, Australian National University, Canberra, Australia
    J Immunol 177:5337-46. 2006
    ..The architecture of this molecular switch provides a framework for understanding the specificity of antibacterial Ab responses and resistance to bacterially induced autoimmune diseases such as Guillain-Barré syndrome...
  26. pmc Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity
    Adrian Liston
    John Curtin School of Medical Research, The Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
    J Exp Med 200:1015-26. 2004
    ....
  27. doi request reprint Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
    Di Yu
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
    Nature 450:299-303. 2007
    ..These findings illuminate a critical post-transcriptional pathway within T cells that regulates lymphocyte accumulation and autoimmunity, and highlights the therapeutic potential of partially antagonising the ICOS pathway...
  28. ncbi request reprint Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis
    Jesse E Jun
    Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, ACT 2601, Canberra, Australia
    Immunity 18:751-62. 2003
    ..These results define Carma-1 as a key regulator of the plasticity in antigen receptor signaling that underpins opposing mechanisms of immunity and tolerance...
  29. ncbi request reprint Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genes
    Simon J Prasad
    Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 80:198-206. 2002
    ..Conceivably, the dysregulation of the dendritic cell system described here may contribute to the generalized defects in self-tolerance in the NOD strain...
  30. pmc Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
    Katrina L Randall
    John Curtin School of Medical Research and Australian Phenomics Facility, Australian National University, Australia
    Nat Immunol 10:1283-91. 2009
    ..Humoral immunodeficiency due to Dock8 mutation provides evidence that organization of the immunological synapse is critical for signaling the survival of B cell subsets required for long-lasting immunity...
  31. ncbi request reprint Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo
    Simon J Prasad
    Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Int Immunol 14:677-84. 2002
    ..H-2(k) donor in mixed chimeras. These results identify a striking effect of non-MHC NOD genes upon the balance of dendritic cell subsets that may contribute to the generalized defects in self-tolerance in the NOD strain...
  32. pmc Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL
    Zuopeng Wu
    John Curtin School of Medical Research, Australian Phenomics Facility, Australian National University, Canberra ACT 0200, Australia
    Immunity 29:863-75. 2008
    ..A remarkable overlap with alternative splicing in neural tissues may reflect a co-opted strategy for diversifying memory T cells...
  33. pmc Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions
    Owen M Siggs
    John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
    Immunity 27:912-26. 2007
    ..The pleiotropic functions of ZAP-70 and their differential response to graded variation provide a paradigm for understanding the complex outcomes of human genetic variation...
  34. ncbi request reprint Illuminating autoimmune regulators through controlled variation of the mouse genome sequence
    Carola G Vinuesa
    John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Mills Road, Canberra, ACT 2601, Australia
    Immunity 20:669-79. 2004
    ....
  35. ncbi request reprint Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling
    Jesse E Jun
    Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Nat Immunol 4:1057-64. 2003
    ....
  36. ncbi request reprint Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity
    Adrian Liston
    John Curtin School of Medical Research, The Australian Phenomics Facility, The Australian National University, Canberra, ACT 2601, Australia
    Novartis Found Symp 267:180-92; discussion 192-9. 2005
    ....
  37. ncbi request reprint Tolerance mechanisms in the late phase of the antibody response
    Christopher C Goodnow
    John Curtin School of Medical Research, The Australian National University, Mills Rd, Canberra, ACT, Australia 0200
    Adv Exp Med Biol 596:163-8. 2007
  38. pmc Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy
    Mathieu Blery
    John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia
    J Exp Med 203:1773-83. 2006
    ....
  39. pmc Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes
    Sylvie Lesage
    Australian Cancer Research Foundation Genetics Lab, Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    J Exp Med 196:1175-88. 2002
    ....
  40. ncbi request reprint Lymphoma and the control of B cell growth and differentiation
    Lixin Rui
    Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Curr Mol Med 6:291-308. 2006
    ..Modulation of B cell antigen receptor signaling therefore emerges as a potentially powerful strategy for controlling the growth of certain B cell lymphomas...
  41. pmc Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kappaB2 in regulating circulating B cell numbers
    Lisa A Miosge
    Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    J Exp Med 196:1113-9. 2002
    ..These findings establish the feasibility of analyzing immune regulation by genome wide mutant screens and demonstrates an intrinsic requirement for NF-kappaB2 in regulating circulating follicular B cell numbers...
  42. ncbi request reprint Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
    Immunity 21:817-30. 2004
    ..These findings establish defects in thymic deletion and Bim induction as a key mechanism in the pathogenesis of autoimmunity...
  43. doi request reprint Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation
    Zuopeng Wu
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 185:231-8. 2010
    ..In T cells with no CD45 protein, hnRNPLL mutation still diminished peripheral T cell accumulation, demonstrating that hnRNPLL regulates T cell longevity independently from its effects on CD45 splicing...
  44. ncbi request reprint Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice
    Todor Arsov
    John Curtin School of Medical Research, The Australian National University ANU, Canberra, ACT, Australia
    Biochem Biophys Res Commun 342:1152-9. 2006
    ..In this model of metabolic syndrome, transition of steatosis to steatohepatitis was associated with hypoadiponectinemia, a mediator of hepatic fatty acid disposal pathways...
  45. doi request reprint Mouse strains with point mutations in TAP1 and TAP2
    Angelo Theodoratos
    Biochemistry and Molecular Biology, Research School of Biology, The Australian National University, Canberra, Australia
    Immunol Cell Biol 88:72-8. 2010
    ..Jasmine is the first strain available with defective TAP2. The two mouse strains provide additional animal models for the human condition Bare Lymphocyte syndrome type 1, and identify new residues important for TAP function...
  46. ncbi request reprint Aire regulates negative selection of organ-specific T cells
    Adrian Liston
    ACRF Genetics Lab, Medical Genome Centre, John Curtin School of Medical Research, The Australian National University, ACT 2601 Australia
    Nat Immunol 4:350-4. 2003
    ..These results indicate that autoimmune polyendocrinopathy syndrome 1 is caused by failure of a specialized mechanism for deleting forbidden T cell clones, establishing a central role for this tolerance mechanism...
  47. doi request reprint The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs
    Vicki Athanasopoulos
    The Australian National University, Canberra, Australia
    FEBS J 277:2109-27. 2010
    ....
  48. ncbi request reprint Genes, pathways and checkpoints in lymphocyte development and homeostasis
    Lisa A Miosge
    Immunogenomics Laboratory, Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Immunol Cell Biol 83:318-35. 2005
    ....
  49. ncbi request reprint Immunology: DNA drives autoimmunity
    Carola G Vinuesa
    Nature 416:595-8. 2002
  50. doi request reprint A mechanism for Ikaros regulation of human globin gene switching
    Janelle R Keys
    Institute for Molecular Bioscience, Queensland Bioscience Precinct, University of Queensland, Queensland, Australia
    Br J Haematol 141:398-406. 2008
    ..This study provides new insights into the mechanism of stage-specific assembly of the beta-globin ACH, and HPFH...
  51. doi request reprint Two levels of protection for the B cell genome during somatic hypermutation
    Man Liu
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 451:841-5. 2008
    ..Our results demonstrate that AID acts broadly on the genome, with the ultimate distribution of mutations determined by a balance between high-fidelity and error-prone DNA repair...
  52. ncbi request reprint Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    Daniel H D Gray
    Monash Immunology and Stem Cell Laboratories MISCL, Level 3, STRIP, Building 75, Monash University, Wellington Road, Clayton, Victoria, 3800, Australia
    Blood 108:3777-85. 2006
    ..Overall, these studies show that the thymic stroma is a surprisingly dynamic population and may have a more direct role in negative selection than previously thought...
  53. ncbi request reprint Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival
    Helen Ferry
    Henry Wellcome Building of Molecular Physiology, Oxford, UK
    Eur J Immunol 35:3655-63. 2005
    ..These findings emphasize the subtle nature of regulation at the BCR and the usefulness of genetic complementation to dissect common and parallel pathways...
  54. ncbi request reprint Spontaneous B cell hyperactivity in autoimmune-prone MRL mice
    Anastasia Nijnik
    Henry Wellcome Building of Molecular Physiology, Oxford University, Roosevelt Drive, Oxford, OX3 7BN, UK
    Int Immunol 18:1127-37. 2006
    ....
  55. ncbi request reprint DNA repair is limiting for haematopoietic stem cells during ageing
    Anastasia Nijnik
    Henry Wellcome Building for Molecular Physiology, Oxford University, Oxford OX3 9DU, UK
    Nature 447:686-90. 2007
    ....
  56. pmc The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency
    Lawrence R Shiow
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143, USA
    Nat Immunol 9:1307-15. 2008
    ....

Research Grants5

  1. Genes for Tolerance and Immunity Consortium
    Christopher Goodnow; Fiscal Year: 2006
    ..abstract_text> ..