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Genomes and Genes | Paul S FosterSummaryAffiliation: Australian National University Country: Australia Publications
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Publications
Interleukin-5 and eosinophils as therapeutic targets for asthmaPaul S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
Trends Mol Med 8:162-7. 2002..The contribution of these IL-5-independent pathways should be considered when assessing the role of eosinophils in disease processes...- Elemental signals regulating eosinophil accumulation in the lungP S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Acton, Canberra ACT
Immunol Rev 179:173-81. 2001..These data highlight the importance of targeting both IL-5 and CCR3 signalling systems for the resolution of inflammation and AHR associated with asthma... - Interleukin-4 and interleukin-5 as targets for the inhibition of eosinophilic inflammation and allergic airways hyperreactivityP S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Mem Inst Oswaldo Cruz 92:55-61. 1997..The central role of IL-5 in both components of allergic disease highlights the requirements for highly specific therapeutic agents which inhibit the production or action of this cytokine... - Dissociation of inflammatory and epithelial responses in a murine model of chronic asthmaP S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra
Lab Invest 80:655-62. 2000..The dissociation between airway wall remodeling and airway hyperreactivity has important implications for therapeutic approaches to chronic asthma... - Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidaseElizabeth Forbes
Allergy and Inflammation Research Group, Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
J Immunol 172:5664-75. 2004..These findings provide direct evidence of a central role for eosinophils and EPO in GI dysfunction and potentially the immunopathogenesis of UC... - Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13-/- miceDianne C Webb
Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia 2601
J Immunol 172:1092-8. 2004..Collectively, these data show that polymorphisms in IL-4Ralpha, which have been shown to affect the interaction with IL-4, correlate with the ability of IL-4 to regulate allergic responses in IL-13(-/-) mice... - Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivityMing Yang
Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, ACT
J Allergy Clin Immunol 112:935-43. 2003..CONCLUSION: These investigations demonstrate important cooperativity between eotaxin-2, IL-5, and IL-13 signaling systems and eosinophils for the development of hallmark features of allergic disease of the lung... 
Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthmaJoerg Mattes
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Exp Med 195:1433-44. 2002....- Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell functionDianne C Webb
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
J Immunol 178:219-27. 2007..The affinity of IL-4Ralpha also appears to be a determinant in the balance between Th2 and IFN-gamma responses and thus the severity of allergic disease... 
Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammationYeping Cai
John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 182:5393-9. 2009..In summary, our results suggest that production of Ym1/2 in response to IL-13 promotes Th2 cytokine production and allergic airways inflammation by inhibiting the production of 12(S)-HETE by 12/15-LOX...- Mechanistic analysis of experimental food allergen-induced cutaneous reactionsVanessa E Prescott
Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Leukoc Biol 80:258-66. 2006..Collectively, these studies demonstrate that food allergy can predispose to cutaneous inflammatory reactions, and these processes are critically regulated by Th2 immune factors... - Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivityDianne C Webb
Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
Eur J Immunol 33:3377-85. 2003..Collectively, these results demonstrate that IL-13-dependent processes regulating the development of AHR and T helper bias persist in the in the lungs of allergic IL-4Ralpha(-/-) mice... - T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in miceElizabeth Forbes
Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Gastroenterology 127:105-18. 2004.... - Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumenKristopher Clark
Division of Molecular Biosciences, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 0200, Australia
J Leukoc Biol 75:1001-9. 2004..Understanding the mechanism of eosinophil degranulation in the airway lumen may provide important insights into how this process occurs in human respiratory diseases... - ICAM-1-dependent pathways regulate colonic eosinophilic inflammationElizabeth Forbes
Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Leukoc Biol 80:330-41. 2006..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury... - Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthmaJiansheng Zhou
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Am J Respir Crit Care Med 178:1202-10. 2008.... - Chemokines in eosinophil-associated gastrointestinal disordersSimon P Hogan
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australia 0200
Curr Allergy Asthma Rep 4:74-82. 2004..In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases... - Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillanceLjubov Simson
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Mills Road Acton, Canberra, Australian Capital Territory, Australia
J Immunol 178:4222-9. 2007..In addition, subsequent in vitro studies found that eosinophils could directly kill MCA-induced fibrosarcoma cells. Collectively, our data support a potential role for the eosinophil as an effector cell in tumor immune surveillance... - Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsivenessMing Yang
Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 177:5595-603. 2006.... - IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lungJ Mattes
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Immunol 167:1683-92. 2001..We show that this novel pathway for IL-13 signaling is dependent on T cell activation in the lung and is critically linked to downstream effector pathways regulated by eotaxin and STAT6... - A plant-based allergy vaccine suppresses experimental asthma via an IFN-gamma and CD4+CD45RBlow T cell-dependent mechanismVanessa Smart
Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
J Immunol 171:2116-26. 2003.... - Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivityT Sharkhuu
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Clin Exp Allergy 36:1575-83. 2006..Although IL-25 up-regulates IL-13 in the lung, the contribution of this and other type 2 cytokine signalling pathways to the induction and persistence of airways hyper-reactivity (AHR) and allergic inflammation are unclear... - Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthmaP S Foster
Division of Molecular Biosciences, John Curtin School of Medical Research, Australian National University, Canberra Australia
Clin Exp Allergy 33:688-95. 2003..Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the pathogenesis of asthma... - Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicityVanessa E Prescott
Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
J Agric Food Chem 53:9023-30. 2005..Thus, transgenic expression of non-native proteins in plants may lead to the synthesis of structural variants possessing altered immunogenicity... - CD4(+) T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthmaPaul S Foster
Department of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Lab Invest 82:455-62. 2002.... - Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxinM Yang
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
Am J Respir Cell Mol Biol 25:522-30. 2001..Furthermore, IL-13-induced AHR, eosinophilia, and mucus production are critically dependent on the IL-4Ralpha chain and STAT-6... - Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivityD C Webb
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra
J Immunol 165:108-13. 2000..Taken together, our data suggest both a modulatory role for IL-13 during sensitization and a proinflammatory role during aeroallergen challenge. The latter process appears redundant with respect to IL-4... - Inhibition of allergic airway inflammation in mice lacking nitric oxide synthase 2Y Xiong
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra
J Immunol 162:445-52. 1999.... - Distinct spatial requirement for eosinophil-induced airways hyperreactivityD C Webb
Leukocyte Signalling and Regulation Laboratory, Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Australia
Immunol Cell Biol 79:165-9. 2001.... - Experimental analysis of eosinophil-associated gastrointestinal diseasesSimon P Hogan
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Curr Opin Allergy Clin Immunol 2:239-48. 2002.... - A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5S P Hogan
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT
J Immunol 161:1501-9. 1998..These findings may provide an explanation for the dissociation of airways eosinophilia from the development of airways hyperreactivity observed in some cases of asthma and in animal models of this disease... - Interleukins-4, -5, and -13: emerging therapeutic targets in allergic diseasePaul S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200 Australia
Pharmacol Ther 94:253-64. 2002..While promising, newer therapies face a gauntlet of developmental challenges, but offer the hope of reducing allergic diseases once again to minor public health concerns... - Antiviral potential of chemokinesS Mahalingam
Leukocyte Signaling and Regulation Laboratory, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, The Australian National University, Canberra ACT, Australia
Bioessays 23:428-35. 2001.... - Interleukin-5 and eosinophils induce airway damage and bronchial hyperreactivity during allergic airway inflammation in BALB/c miceS P Hogan
Cellular Signal Transduction Laboratory, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Immunol Cell Biol 75:284-8. 1997..Thus, there are at least two distinct pathophysiological mechanisms for the induction of aeroallergen-induced airway occlusion... - Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated proteinD C Webb
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia
J Biol Chem 276:41969-76. 2001.... - Eosinophils promote allergic disease of the lung by regulating CD4(+) Th2 lymphocyte functionJ R MacKenzie
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 167:3146-55. 2001..This investigation highlights the potential of eosinophils to not only act as terminal effector cells but also to actively modulate allergic inflammation by amplifying Th2 cell responses... - Enhanced resistance in STAT6-deficient mice to infection with ectromelia virusS Mahalingam
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
Proc Natl Acad Sci U S A 98:6812-7. 2001..Furthermore, in the absence of this transcription factor, the immune system defaults toward a protective Th1-like response, conferring pronounced resistance to EV infection and disease progression... - Interferon-inducible chemokines and immunity to poxvirus infectionsS Mahalingam
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra ACT
Immunol Rev 177:127-33. 2000..The results of these investigations demonstrate that the mechanisms of Mig- and Crg-2-induced viral clearance involve natural killer cells and interferons... - Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma modelP S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Exp Med 183:195-201. 1996..These results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease... - The viral manipulation of the host cellular and immune environments to enhance propagation and survival: a focus on RNA virusesSurendran Mahalingam
Division of Molecular Biosciences, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
J Leukoc Biol 72:429-39. 2002..A detailed insight into interactions of viruses with the immune system may provide direction in the development of new vaccine strategies and novel antiviral compounds... - Structural model of human IL-13 defines the spatial interactions with the IL-13Ralpha/IL-4Ralpha receptorJ Zuegg
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research and Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 79:332-9. 2001..From these studies we predict that helices A and C of HuIL-13 interact with the IL-4 receptor alpha (IL-4Ralpha) region and helix D is responsible for the interaction with the IL-13 receptor alpha 1 (IL-13Ralpha1) receptor... - Transcription of the interferon gamma (IFN-gamma )-inducible chemokine Mig in IFN-gamma-deficient miceS Mahalingam
School of Human and Biomedical Sciences, Division of Science and Design, University of Canberra, Canberra, ACT 2601, Australia
J Biol Chem 276:7568-74. 2001..We have found that, in the absence of IFN-gamma, IFN-alpha/beta are able to induce Mig in response to a viral infection in vivo... - Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway diseaseMarkus Weckmann
Department of Paediatrics and Adolescent Medicine, Albert Ludwigs University Freiburg, 79106 Freiburg, Germany
Nat Med 13:1308-15. 2007..TRAIL is also increased in sputum of asthmatics. The function of TRAIL in the airway epithelium identifies this molecule as a target for the treatment of asthma... - Eosinophil trafficking in allergy and asthmaHelene F Rosenberg
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Allergy Clin Immunol 119:1303-10; quiz 1311-2. 2007.... - Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophilsDamon J Tumes
School of Molecular and Biomedical Science, University of Adelaide, North Tce, Adelaide, South Australia, Australia
J Leukoc Biol 81:1362-73. 2007..Restricting survival of a key effector cell may thus limit pathogenesis in this experimental model and in humans... - The "classical" ovalbumin challenge model of asthma in miceRakesh K Kumar
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
Curr Drug Targets 9:485-94. 2008..Nevertheless, careful use of well-defined models allows investigators to answer specific questions that are otherwise difficult to address... - Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthmaKazuhiro Ito
Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
Am J Respir Cell Mol Biol 39:543-50. 2008..We conclude that impaired nuclear recruitment of HDAC2 could be an important mechanism of steroid resistance of the neutrophilic inflammation in exacerbations of asthma. Oxidative stress may contribute to decreased HDAC2 activity... - Eosinophils: biological properties and role in health and diseaseSimon P Hogan
Clin Exp Allergy 38:709-50. 2008..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized... - Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisisMichelle L Knott
School of Molecular and Biomedical Science, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
Int J Parasitol 37:1367-78. 2007..These observations may be of particular significance for the development of successful vaccines against hookworms and other nematodes... - IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivityElizabeth E Forbes
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, USA
J Exp Med 205:897-913. 2008..These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy... - Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway diseaseJay C Horvat
Priority Research Centre for Asthma and Respiratory Disease, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, Australia
Am J Respir Crit Care Med 176:556-64. 2007..Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown... - Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivityGerard E Kaiko
School of Biomedical Sciences and The Asthma and Respiratory Diseases Priority Research Centre, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
J Immunol 180:2225-32. 2008..In the setting of allergic airways inflammation, this infection may then contribute to exacerbation of the asthmatic phenotype... - The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammationKelly L Asquith
Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Callaghan, Australia
J Immunol 180:1199-206. 2008.... - Physiological concentrations of transforming growth factor beta1 selectively inhibit human dendritic cell functionMirjana Fogel-Petrovic
Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, WA, Australia
Int Immunopharmacol 7:1924-33. 2007.... - Eosinophils from lineage-ablated Delta dblGATA bone marrow progenitors: the dblGATA enhancer in the promoter of GATA-1 is not essential for differentiation ex vivoKimberly D Dyer
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health NIAID NIH, Bethesda, MD 20892, USA
J Immunol 179:1693-9. 2007.... - Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniaeJulie A Preston
Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences, Faculty of Health, The University of Newcastle, Newcastle, Australia
Vaccine 25:8154-62. 2007..This indicates the potential of Spn as an IMT for asthma... - Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virusSimon Phipps
Centre for Asthma and Respiratory Diseases CARD, School of Biomedical Sciences, University of Newcastle, Newcastle, Australia
Blood 110:1578-86. 2007..Collectively, our results demonstrate that eosinophils can protect against RSV in vivo, as they promote virus clearance and may thus limit virus-induced lung dysfunction... - Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migrationCornelia M Bertram
Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, Australia
J Leukoc Biol 81:1445-54. 2007..BK, which increases the migration of immature hMo-DC in vitro, may play an important role in the migration of immature DC in noninflammatory conditions and may also be involved in the recruitment of immature DC to sites of inflammation... - Eotaxin expression by epithelial cells and plasma cells in chronic asthmaRakesh K Kumar
Inflammation Research Unit, Department of Pathology, University of New South Wales, Sydney, Australia
Lab Invest 82:495-504. 2002..Although high eotaxin levels alone are not sufficient to cause recruitment of eosinophils into the airways, recurrent exposure may generate or up-regulate additional signals required for eosinophil chemotaxis... - Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer Guang W Wong
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:41906-15. 2002..Based on these data, we conclude that TMT is an exocytosed MC neutral protease that induces AHR in lungs primarily by activating an IL-13/IL-4Ralpha/STAT6-dependent pathway... - Modeling allergic asthma in mice: pitfalls and opportunitiesRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Am J Respir Cell Mol Biol 27:267-72. 2002..This more realistic model of asthma offers a number of opportunities for investigation of pathogenetic mechanisms and novel therapeutic agents... - Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammationAi Q Truong-Tran
Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
Am J Respir Cell Mol Biol 27:286-96. 2002..These findings provide the first data for adverse effects of Zn deficiency on the respiratory epithelium and support a role for altered Zn homeostasis and caspase upregulation in asthma... - Chemokines in asthma: cooperative interaction between chemokines and IL-13Nives Zimmermann
Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
J Allergy Clin Immunol 111:227-42; quiz 243. 2003.... - Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesisNives Zimmermann
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Clin Invest 111:1863-74. 2003..Based on the ability of arginase to regulate generation of NO, polyamines, and collagen, these results provide a basis for pharmacologically targeting arginine metabolism in allergic disorders... - Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
J Pharmacol Exp Ther 307:349-55. 2003..Roflumilast did not diminish accumulation of transforming growth factor-beta1, suggesting that it might affect remodeling by mechanisms distinct from glucocorticoids... - Regulation of eosinophil migration and Th2 cell function by IL-5 and eotaxinJoerg Mattes
Department of Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstr 1, 79106 Freiburg, Germany
Curr Drug Targets Inflamm Allergy 2:169-74. 2003..Blocking IL-13, or pathways that may promote IL-13-associated allergic lung responses (IL-5 and eotaxin) could provide an important strategy to improve the specificity of asthma therapy... - Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in miceRichard Leigh
Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 169:860-7. 2004..Our results confirm that IL-4 and IL-13, but not IL-5, are critical for the development of sustained airway hyperreactivity and airway remodeling after allergen exposure... - Interferon-gamma as a possible target in chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Inflamm Allergy Drug Targets 5:253-6. 2006..This may be particularly relevant to acute exacerbations of asthma, in which setting there may be justification for therapeutic inhibition of IFN-gamma... - Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivoJonas Bystrom
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
Eur J Haematol 77:181-90. 2006..Two variants encoding soluble forms of the alpha subunit (sIL-5R alpha) have been described, although the signals promoting and/or limiting differential transcription remain to be clarified... - Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammationJessica S Siegle
Department of Pathology, University of New South Wales, Sydney, Australia
Am J Respir Cell Mol Biol 35:565-70. 2006..The inflammatory response involves distal airways and is associated with a distinct pattern of AHR, which develops independent of the enhanced eosinophilic inflammation... - Schistosoma mansoni infection in eosinophil lineage-ablated miceJonathan M Swartz
Laboratory of Allergic Diseases, NIAID, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1883, USA
Blood 108:2420-7. 2006..However, eosinophils may have unexplored immunomodulatory contributions to this disease process... - Effects of anticytokine therapy in a mouse model of chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
Am J Respir Crit Care Med 170:1043-8. 2004.... - Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)Patricia C Fulkerson
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
Proc Natl Acad Sci U S A 101:1987-92. 2004..The identification of a naturally occurring eosinophil inhibitory chemokine pathway in vivo provides a strategic basis for future therapeutic consideration... - Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil traffickingAnil Mishra
Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Biol Chem 277:4406-12. 2002.... - Polymorphisms in the IL 18 gene are associated with specific sensitization to common allergens and allergic rhinitisSusanne Kruse
Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
J Allergy Clin Immunol 111:117-22. 2003..quot; Thus a suspected direct role of IL18 in the pathogenesis of atopy has been strengthened by the presence of 8 common SNPs in the promoter regions of IL18... - TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophagesMichael P Gantier
Centre for Cancer Research, Monash Institute of Medical Research, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
J Immunol 180:2117-24. 2008..Our results suggest that differential sequence-specific sensing of RNA oligonucleotides between human and mouse macrophages is due to the modulation of TLR7 sensing by human TLR8... - Targeting eosinophils in asthmaPaul S Foster
Discipline of Immunology and Microbiology, Faculty of Health, University of Newcastle, Newcastle NSW, Australia
Curr Mol Med 8:585-90. 2008..This may predispose to the development of acute exacerbations of asthma, an outcome that would have significant clinical implications... - The contribution of toll-like receptors to the pathogenesis of asthmaSimon Phipps
Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences, University of Newcastle, David Maddison Clinical Sciences Building, Newcastle, New South Wales, Australia
Immunol Cell Biol 85:463-70. 2007..We review here the cellular distribution of TLR in the lung and their potential contribution to the processes that promote T helper 2 (Th2) immunity and infection-induced exacerbations of allergic lung disease...