Ian A Clark

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. ncbi request reprint The advent of the cytokine storm
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Immunol Cell Biol 85:271-3. 2007
  2. pmc Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?
    Ian A Clark
    Research School of Biology, Australian National University, Canberra, ACT, Australia
    J Alzheimers Dis 27:691-9. 2011
  3. doi request reprint Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales
    Ian Clark
    Division of Medical Science and Biochemistry, Research School of Biology, Australian National University, Canberra ACT, Australia
    Pharmacol Rev 64:1004-26. 2012
  4. pmc Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient
    Ian A Clark
    School of Biochemistry and Molecular Biology Australian National University, Canberra, ACT 0200, Australia
    Malar J 5:69. 2006
  5. pmc Human malarial disease: a consequence of inflammatory cytokine release
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Malar J 5:85. 2006
  6. ncbi request reprint How TNF was recognized as a key mechanism of disease
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT, Australia
    Cytokine Growth Factor Rev 18:335-43. 2007
  7. doi request reprint Understanding the role of inflammatory cytokines in malaria and related diseases
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Travel Med Infect Dis 6:67-81. 2008
  8. pmc Sickness behaviour pushed too far--the basis of the syndrome seen in severe protozoal, bacterial and viral diseases and post-trauma
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australia
    Malar J 7:208. 2008
  9. doi request reprint Along a TNF-paved road from dead parasites in red cells to cerebral malaria, and beyond
    I A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Parasitology 136:1457-68. 2009
  10. doi request reprint Is human malarial coma caused, or merely deepened, by sequestration?
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Trends Parasitol 25:314-8. 2009

Detail Information

Publications33

  1. ncbi request reprint The advent of the cytokine storm
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Immunol Cell Biol 85:271-3. 2007
  2. pmc Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?
    Ian A Clark
    Research School of Biology, Australian National University, Canberra, ACT, Australia
    J Alzheimers Dis 27:691-9. 2011
    ..This convergence of dyotic signaling on TNF-mediated degeneration and dysfunction has important implications for understanding the pathophysiology of AD, stroke, and traumatic brain disease, and also for the treatment of these diseases...
  3. doi request reprint Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales
    Ian Clark
    Division of Medical Science and Biochemistry, Research School of Biology, Australian National University, Canberra ACT, Australia
    Pharmacol Rev 64:1004-26. 2012
    ..This pathway also has therapeutic implications for other circumstances in which brain TNF is pathologically increased, such as stroke, traumatic brain injury, and the infectious disease encephalopathies...
  4. pmc Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient
    Ian A Clark
    School of Biochemistry and Molecular Biology Australian National University, Canberra, ACT 0200, Australia
    Malar J 5:69. 2006
    ..The importance of vascular occlusion in the pathogenesis of human haemoprotozoal disease is unresolved...
  5. pmc Human malarial disease: a consequence of inflammatory cytokine release
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Malar J 5:85. 2006
    ....
  6. ncbi request reprint How TNF was recognized as a key mechanism of disease
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT, Australia
    Cytokine Growth Factor Rev 18:335-43. 2007
    ..Its neutralization has proven to be a potent treatment for rheumatoid arthritis and Crohn's disease...
  7. doi request reprint Understanding the role of inflammatory cytokines in malaria and related diseases
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Travel Med Infect Dis 6:67-81. 2008
    ..We approach these issues by examining aspects of malaria, sepsis and influenza in parallel, and discuss the insights that comparisons of the literature can provide on the validity of possible anti-disease therapies...
  8. pmc Sickness behaviour pushed too far--the basis of the syndrome seen in severe protozoal, bacterial and viral diseases and post-trauma
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australia
    Malar J 7:208. 2008
    ....
  9. doi request reprint Along a TNF-paved road from dead parasites in red cells to cerebral malaria, and beyond
    I A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Parasitology 136:1457-68. 2009
    ..It also gives the author's views on aspects of how the field of malaria disease pathogenesis seems to be developing. The hope is to inspire another generation to follow a similarly original course...
  10. doi request reprint Is human malarial coma caused, or merely deepened, by sequestration?
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Trends Parasitol 25:314-8. 2009
    ....
  11. doi request reprint The roles of TNF in brain dysfunction and disease
    Ian A Clark
    Research School of Biology, Australian National University, Canberra, Australia
    Pharmacol Ther 128:519-48. 2010
    ..Clearly, the most relevant research is focussed on Alzheimer's disease, but the principles may also apply to other encephalopathies...
  12. doi request reprint TNF and leptin tell essentially the same story in Alzheimer's disease
    Ian A Clark
    Research School of Biology, Australian National University, Canberra, Australia
    J Alzheimers Dis 26:201-5. 2011
    ..This association, which has not been specifically addressed in the Alzheimer's disease literature, may be a useful link to expedite future study into the pathogenesis of this condition...
  13. pmc Pathogenesis of malaria and clinically similar conditions
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Clin Microbiol Rev 17:509-39, table of contents. 2004
    ..The pathogenesis of the disease caused by falciparum malaria is then considered in the light of what has been learned about the roles of these mediators in these other diseases, as well as in malaria itself...
  14. ncbi request reprint Genes, nitric oxide and malaria in African children
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Trends Parasitol 19:335-7. 2003
    ..Only when genetic comparisons from across tropical Africa are examined, in conjunction with the newly recognized complexities in the events of systemic inflammation, will this relationship be understood...
  15. ncbi request reprint Pathogenesis of malaria
    I A Clark
    Australian National University, ACT 0200, Canberra, Australia
    Parasitol Today 16:451-4. 2000
    ..Here, Ian Clark and Louis Schofield discuss recent work presented at the Molecular Approaches to Malaria conference, Lorne, Australia, 2-5 February 2000, that updates the cytokine-based concept of malarial disease...
  16. ncbi request reprint Heterologous immunity revisited
    I A Clark
    Division of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, Canberra, ACT
    Parasitology 122:S51-9. 2001
    ..This has led to a discernable pattern across heterologous immunity as a whole, and its lessons influence a range of areas, including vaccine development...
  17. ncbi request reprint Salicylates, nitric oxide, malaria, and Reye's syndrome
    I Clark
    Division of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, Canberra, Australian Capital Territory
    Lancet 357:625-7. 2001
    ..This finding suggests that Reye's syndrome can be mediated through salicylate enhancement of iNOS expression, the initial trigger in this instance usually being a viral infection...
  18. pmc Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African children
    Ian A Clark
    Dept of Biochemistry, Australian National University, Canberra, Australia
    Malar J 2:6. 2003
    ..Here we report on the cellular distribution, by immunohistochemistry, of migration inhibitory factor (MIF) and inducible nitric oxide synthase (iNOS) in this disease, and in sepsis...
  19. ncbi request reprint The pathophysiology of falciparum malaria
    Ian A Clark
    School of Biochemistry and Molecular Biology, Australian National University, ACT 0200, Canberra, Australia
    Pharmacol Ther 99:221-60. 2003
    ....
  20. ncbi request reprint The biological basis of malarial disease
    I A Clark
    School of Life Sciences, Australian National University, Canberra, Australia
    Int J Parasitol 27:1237-49. 1997
    ..In addition, new evidence incriminating nitric oxide in the mechanism of tolerance to endotoxin rationalises the raised nitric oxide generation seen in malarial tolerance...
  21. ncbi request reprint Why is the pathology of falciparum worse than that of vivax malaria?
    I A Clark
    Division of Biochemistry and Molecular Biology, School of Life Sciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Parasitol Today 15:458-61. 1999
    ..Thus sequestration, through localized hypoxia, might contribute to pathology by enhancing cytokine-induced iNOS. Generalized hypoxia might have the same effect...
  22. ncbi request reprint Do babesiosis and malaria share a common disease process?
    I A Clark
    Division of Molecular Biology and Biochemistry, School of Biological Sciences, Australian National University, Canberra, Australia ian
    Ann Trop Med Parasitol 92:483-8. 1998
    ..For these reasons, as discussed in this review, the diseases caused by these two genera of intra-erythrocytic protozoan parasites will probably prove to be conceptually identical...
  23. ncbi request reprint The ratio of reactive nitrogen intermediates to tumour necrosis factor and clinical outcome of falciparum malaria disease
    F M al-Yaman
    Division of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, Canberra, ACT, Australia
    Trans R Soc Trop Med Hyg 92:417-20. 1998
    ..118 vs. -0.789; P < 0.001). We concluded that the ratio of serum RNI to serum TNF is a more useful indicator of outcome of falciparum malaria in this population than the absolute levels of either alone...
  24. ncbi request reprint Serum creatinine levels and reactive nitrogen intermediates in children with cerebral malaria in Papua New Guinea
    F Al-Yaman
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, Australia
    Trans R Soc Trop Med Hyg 91:303-5. 1997
    ..None of these 9 children had elevated creatinine levels. Elevated RNI levels in severe cases were thus not associated with renal function in these children in Papua New Guinea...
  25. ncbi request reprint The war on malaria and Nora Heysen's documentation of Australian medical research through art between 1943 and 1945
    Cherie L Prosser
    ART Section, Australian War Memorial, Canberra, ACT
    Med J Aust 194:418-9. 2011
    ..The documentation of this research became a significant subject for leading Australian artist Nora Heysen, when she was commissioned as the first female war artist by the Australian War Memorial in 1943...
  26. pmc Using Complementary and Alternative Medicines to Target the Host Response during Severe Influenza
    Lisa M Alleva
    Research School of Biology, The Australian National University, Canberra and Chinese Treatment Centre, Suite 4 Professional Centre, Turner, Australia
    Evid Based Complement Alternat Med 7:501-10. 2010
    ....
  27. ncbi request reprint Systemic release of high mobility group box 1 protein during severe murine influenza
    Lisa M Alleva
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 181:1454-9. 2008
    ..Further work is required to determine whether influenza virus infection induces passive release of HMGB1, and whether HMGB1 neutralization with a specific Ab would improve survival...
  28. ncbi request reprint High mobility group box 1 (HMGB1) protein: possible amplification signal in the pathogenesis of falciparum malaria
    L M Alleva
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
    Trans R Soc Trop Med Hyg 99:171-4. 2005
    ..These data provide an additional argument that malaria is fundamentally a systemic inflammatory state. In keeping with its developing role in sepsis, HMGB1 may enhance and prolong the inflammatory processes, and thus illness, in malaria...
  29. ncbi request reprint Tumor necrosis factor in malaria-induced abortion
    I A Clark
    Zoology Department, Australian National University, Canberra, ACT
    Am J Trop Med Hyg 39:246-9. 1988
    ..Thus, TNF-induced abortion may occur in a range of infections in which systemic macrophage activation occurs and a trigger for TNF release is present...
  30. ncbi request reprint Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malaria
    Gordon A Awandare
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Trop Med Hyg 76:1033-6. 2007
    ..These results suggest that increased basal MIF production may be important in generating immune responses that protect against the development of severe malaria...
  31. ncbi request reprint Successful model vaccine against malaria
    Ian A Clark
    Trends Parasitol 18:481. 2002
  32. ncbi request reprint Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria
    Gordon A Awandare
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 603 Parran Hall, Pittsburgh, PA 15261, USA
    Clin Immunol 119:219-25. 2006
    ..These findings suggest that reduced MIF production may promote enhanced disease severity in children with falciparum malaria...
  33. ncbi request reprint Severe malaria increases the list of heme oxygenase-1-protected diseases
    Ana Pamplona
    Future Microbiol 2:361-3. 2007