Research Topics
| Ian A ClarkSummaryAffiliation: Australian National University Country: Australia Publications
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Detail Information
Publications
The advent of the cytokine stormIan A Clark
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
Immunol Cell Biol 85:271-3. 2007
Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?Ian A Clark
Research School of Biology, Australian National University, Canberra, ACT, Australia
J Alzheimers Dis 27:691-9. 2011..This convergence of dyotic signaling on TNF-mediated degeneration and dysfunction has important implications for understanding the pathophysiology of AD, stroke, and traumatic brain disease, and also for the treatment of these diseases...- Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationalesIan Clark
Division of Medical Science and Biochemistry, Research School of Biology, Australian National University, Canberra ACT, Australia
Pharmacol Rev 64:1004-26. 2012..This pathway also has therapeutic implications for other circumstances in which brain TNF is pathologically increased, such as stroke, traumatic brain injury, and the infectious disease encephalopathies... 
Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patientIan A Clark
School of Biochemistry and Molecular Biology Australian National University, Canberra, ACT 0200, Australia
Malar J 5:69. 2006..The importance of vascular occlusion in the pathogenesis of human haemoprotozoal disease is unresolved...- Human malarial disease: a consequence of inflammatory cytokine releaseIan A Clark
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
Malar J 5:85. 2006.... - How TNF was recognized as a key mechanism of diseaseIan A Clark
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT, Australia
Cytokine Growth Factor Rev 18:335-43. 2007..Its neutralization has proven to be a potent treatment for rheumatoid arthritis and Crohn's disease... - Understanding the role of inflammatory cytokines in malaria and related diseasesIan A Clark
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
Travel Med Infect Dis 6:67-81. 2008..We approach these issues by examining aspects of malaria, sepsis and influenza in parallel, and discuss the insights that comparisons of the literature can provide on the validity of possible anti-disease therapies... 
Sickness behaviour pushed too far--the basis of the syndrome seen in severe protozoal, bacterial and viral diseases and post-traumaIan A Clark
School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australia
Malar J 7:208. 2008....- Along a TNF-paved road from dead parasites in red cells to cerebral malaria, and beyondI A Clark
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
Parasitology 136:1457-68. 2009..It also gives the author's views on aspects of how the field of malaria disease pathogenesis seems to be developing. The hope is to inspire another generation to follow a similarly original course... - Is human malarial coma caused, or merely deepened, by sequestration?Ian A Clark
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
Trends Parasitol 25:314-8. 2009.... - The roles of TNF in brain dysfunction and diseaseIan A Clark
Research School of Biology, Australian National University, Canberra, Australia
Pharmacol Ther 128:519-48. 2010..Clearly, the most relevant research is focussed on Alzheimer's disease, but the principles may also apply to other encephalopathies... - TNF and leptin tell essentially the same story in Alzheimer's diseaseIan A Clark
Research School of Biology, Australian National University, Canberra, Australia
J Alzheimers Dis 26:201-5. 2011..This association, which has not been specifically addressed in the Alzheimer's disease literature, may be a useful link to expedite future study into the pathogenesis of this condition... - Pathogenesis of malaria and clinically similar conditionsIan A Clark
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
Clin Microbiol Rev 17:509-39, table of contents. 2004..The pathogenesis of the disease caused by falciparum malaria is then considered in the light of what has been learned about the roles of these mediators in these other diseases, as well as in malaria itself... - Genes, nitric oxide and malaria in African childrenIan A Clark
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
Trends Parasitol 19:335-7. 2003..Only when genetic comparisons from across tropical Africa are examined, in conjunction with the newly recognized complexities in the events of systemic inflammation, will this relationship be understood... - Pathogenesis of malariaI A Clark
Australian National University, ACT 0200, Canberra, Australia
Parasitol Today 16:451-4. 2000..Here, Ian Clark and Louis Schofield discuss recent work presented at the Molecular Approaches to Malaria conference, Lorne, Australia, 2-5 February 2000, that updates the cytokine-based concept of malarial disease... - Heterologous immunity revisitedI A Clark
Division of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, Canberra, ACT
Parasitology 122:S51-9. 2001..This has led to a discernable pattern across heterologous immunity as a whole, and its lessons influence a range of areas, including vaccine development... - Salicylates, nitric oxide, malaria, and Reye's syndromeI Clark
Division of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, Canberra, Australian Capital Territory
Lancet 357:625-7. 2001..This finding suggests that Reye's syndrome can be mediated through salicylate enhancement of iNOS expression, the initial trigger in this instance usually being a viral infection... - Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African childrenIan A Clark
Dept of Biochemistry, Australian National University, Canberra, Australia
Malar J 2:6. 2003..Here we report on the cellular distribution, by immunohistochemistry, of migration inhibitory factor (MIF) and inducible nitric oxide synthase (iNOS) in this disease, and in sepsis... - The pathophysiology of falciparum malariaIan A Clark
School of Biochemistry and Molecular Biology, Australian National University, ACT 0200, Canberra, Australia
Pharmacol Ther 99:221-60. 2003.... - The biological basis of malarial diseaseI A Clark
School of Life Sciences, Australian National University, Canberra, Australia
Int J Parasitol 27:1237-49. 1997..In addition, new evidence incriminating nitric oxide in the mechanism of tolerance to endotoxin rationalises the raised nitric oxide generation seen in malarial tolerance... - Why is the pathology of falciparum worse than that of vivax malaria?I A Clark
Division of Biochemistry and Molecular Biology, School of Life Sciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
Parasitol Today 15:458-61. 1999..Thus sequestration, through localized hypoxia, might contribute to pathology by enhancing cytokine-induced iNOS. Generalized hypoxia might have the same effect... - Do babesiosis and malaria share a common disease process?I A Clark
Division of Molecular Biology and Biochemistry, School of Biological Sciences, Australian National University, Canberra, Australia ian
Ann Trop Med Parasitol 92:483-8. 1998..For these reasons, as discussed in this review, the diseases caused by these two genera of intra-erythrocytic protozoan parasites will probably prove to be conceptually identical... - The ratio of reactive nitrogen intermediates to tumour necrosis factor and clinical outcome of falciparum malaria diseaseF M al-Yaman
Division of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, Canberra, ACT, Australia
Trans R Soc Trop Med Hyg 92:417-20. 1998..118 vs. -0.789; P < 0.001). We concluded that the ratio of serum RNI to serum TNF is a more useful indicator of outcome of falciparum malaria in this population than the absolute levels of either alone... - Serum creatinine levels and reactive nitrogen intermediates in children with cerebral malaria in Papua New GuineaF Al-Yaman
Department of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, Australia
Trans R Soc Trop Med Hyg 91:303-5. 1997..None of these 9 children had elevated creatinine levels. Elevated RNI levels in severe cases were thus not associated with renal function in these children in Papua New Guinea... - The war on malaria and Nora Heysen's documentation of Australian medical research through art between 1943 and 1945Cherie L Prosser
ART Section, Australian War Memorial, Canberra, ACT
Med J Aust 194:418-9. 2011..The documentation of this research became a significant subject for leading Australian artist Nora Heysen, when she was commissioned as the first female war artist by the Australian War Memorial in 1943... - Using Complementary and Alternative Medicines to Target the Host Response during Severe InfluenzaLisa M Alleva
Research School of Biology, The Australian National University, Canberra and Chinese Treatment Centre, Suite 4 Professional Centre, Turner, Australia
Evid Based Complement Alternat Med 7:501-10. 2010.... - Systemic release of high mobility group box 1 protein during severe murine influenzaLisa M Alleva
School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australian Capital Territory, Australia
J Immunol 181:1454-9. 2008..Further work is required to determine whether influenza virus infection induces passive release of HMGB1, and whether HMGB1 neutralization with a specific Ab would improve survival... - High mobility group box 1 (HMGB1) protein: possible amplification signal in the pathogenesis of falciparum malariaL M Alleva
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
Trans R Soc Trop Med Hyg 99:171-4. 2005..These data provide an additional argument that malaria is fundamentally a systemic inflammatory state. In keeping with its developing role in sepsis, HMGB1 may enhance and prolong the inflammatory processes, and thus illness, in malaria... - Tumor necrosis factor in malaria-induced abortionI A Clark
Zoology Department, Australian National University, Canberra, ACT
Am J Trop Med Hyg 39:246-9. 1988..Thus, TNF-induced abortion may occur in a range of infections in which systemic macrophage activation occurs and a trigger for TNF release is present... - Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malariaGordon A Awandare
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Trop Med Hyg 76:1033-6. 2007..These results suggest that increased basal MIF production may be important in generating immune responses that protect against the development of severe malaria... - Successful model vaccine against malariaIan A Clark
Trends Parasitol 18:481. 2002 - Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malariaGordon A Awandare
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 603 Parran Hall, Pittsburgh, PA 15261, USA
Clin Immunol 119:219-25. 2006..These findings suggest that reduced MIF production may promote enhanced disease severity in children with falciparum malaria... - Severe malaria increases the list of heme oxygenase-1-protected diseasesAna Pamplona
Future Microbiol 2:361-3. 2007