R T Baker

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. ncbi Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases
    R T Baker
    Division of Molecular Medicine, Australian National University, Canberra, ACT, 2601, Australia
    Genomics 59:264-74. 1999
  2. pmc Deubiquitylating enzymes and disease
    Shweta Singhal
    Ubiquitin Laboratory, Division of Molecular Bioscience, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia
    BMC Biochem 9:S3. 2008
  3. ncbi Protein expression using ubiquitin fusion and cleavage
    R T Baker
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Curr Opin Biotechnol 7:541-6. 1996
  4. ncbi Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12
    G C Webb
    Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra
    Genomics 19:567-9. 1994
  5. ncbi Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1
    A T Whittington
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, 2601, Australia
    Genomics 33:105-11. 1996
  6. pmc Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12
    G C Webb
    Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra
    Am J Hum Genet 46:308-15. 1990
  7. pmc The Ubp6 family of deubiquitinating enzymes contains a ubiquitin-like domain: SUb
    A M Wyndham
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra ACT
    Protein Sci 8:1268-75. 1999
  8. ncbi The yeast homolog of mammalian ribosomal protein S30 is expressed from a duplicated gene without a ubiquitin-like protein fusion sequence. Evolutionary implications
    R T Baker
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, P O Box 334, Canberra, Australian Capital Territory 2601, Australia
    J Biol Chem 271:13549-55. 1996
  9. ncbi Characterization of the ubiquitin-specific protease activity of the mouse/human Unp/Unph oncoprotein
    C A Gilchrist
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, GPO Box 334, ACT 2601, Canberra, Australia
    Biochim Biophys Acta 1481:297-309. 2000
  10. ncbi Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22
    K L Tan
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra
    Genomics 25:381-7. 1995

Collaborators

  • G Chelvanayagam
  • C R Parish
  • C Freeman
  • Yu Min Huang
  • Katsunori Tanaka
  • M D Hulett
  • Shweta Singhal
  • P G Board
  • C A Gilchrist
  • S H Baek
  • A M Wyndham
  • G C Webb
  • C H Chung
  • L M DeSalle
  • Y J Yoo
  • K C Park
  • P Blanchette
  • K E Sloper-Mould
  • Matthew C Taylor
  • A T Whittington
  • D Lin
  • M Loda
  • M Pagano
  • D A Gray
  • E Graner
  • A Montagnoli
  • E Latres
  • K L Tan
  • G R Sutherland
  • X W Wang
  • H J Eyre
  • K I Kim
  • J I Lee
  • K S Choi
  • S K Woo
  • L S Jermiin
  • J M Cho
  • M Coggan
  • J Vuust
  • K Fagan

Detail Information

Publications26

  1. ncbi Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases
    R T Baker
    Division of Molecular Medicine, Australian National University, Canberra, ACT, 2601, Australia
    Genomics 59:264-74. 1999
    ..A systematic nomenclature for the human USPs is proposed...
  2. pmc Deubiquitylating enzymes and disease
    Shweta Singhal
    Ubiquitin Laboratory, Division of Molecular Bioscience, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia
    BMC Biochem 9:S3. 2008
    ..PUBLICATION HISTORY : Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com)...
  3. ncbi Protein expression using ubiquitin fusion and cleavage
    R T Baker
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Curr Opin Biotechnol 7:541-6. 1996
    ..The recent availability of cloned ubiquitin-cleaving enzymes has enhanced this technique for both bacterial and eukaryotic host systems...
  4. ncbi Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12
    G C Webb
    Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra
    Genomics 19:567-9. 1994
    ..1-p12 was consistently the strongest in five individuals, it is likely that this is the location of the UBA52 gene. Thus far, three of the four transcriptionally active ubiquitin genes have been assigned to separate chromosomes...
  5. ncbi Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1
    A T Whittington
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, 2601, Australia
    Genomics 33:105-11. 1996
    ..The encoded protein shares amino acid sequence identities of 92, 77, 51, and 55% with rat subunit Yrs, human subunit GSTT2, rat subunit 5, and human subunit GSTT1, respectively...
  6. pmc Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12
    G C Webb
    Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra
    Am J Hum Genet 46:308-15. 1990
    ..1-17p12. This region showed the strongest hybridization with the coding-region probe and is presumably also the location of the duplicated UbB pseudogene...
  7. pmc The Ubp6 family of deubiquitinating enzymes contains a ubiquitin-like domain: SUb
    A M Wyndham
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra ACT
    Protein Sci 8:1268-75. 1999
    ..cerevisiae SUb and ubiquitin. The homology model supports a ubiquitin-like fold for SUb and suggests that two conserved Lys residues, corresponding to Lys48 and Lys63 of ubiquitin, are functionally important...
  8. ncbi The yeast homolog of mammalian ribosomal protein S30 is expressed from a duplicated gene without a ubiquitin-like protein fusion sequence. Evolutionary implications
    R T Baker
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, P O Box 334, Canberra, Australian Capital Territory 2601, Australia
    J Biol Chem 271:13549-55. 1996
    ..Analysis of available DNA sequence data bases reveals that rpS30 is synthesized as a fusion to a ubiquitin-like protein in nematodes and mammals but unfused in yeast, plants, and protazoa...
  9. ncbi Characterization of the ubiquitin-specific protease activity of the mouse/human Unp/Unph oncoprotein
    C A Gilchrist
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, GPO Box 334, ACT 2601, Canberra, Australia
    Biochim Biophys Acta 1481:297-309. 2000
    ..These data suggest that Unp is not a general modulator of ubiquitin-dependent proteolysis. However, Unp may have a role in the regulation of the degradation of a specific, as yet undescribed, substrate(s)...
  10. ncbi Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22
    K L Tan
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra
    Genomics 25:381-7. 1995
    ..Southern blot analysis of human DNA digested with BamHI shows that the size of the GSTT2 gene is relatively small, as the coding sequence falls within a 3.6-kb BamHI fragment...
  11. pmc Zeta, a novel class of glutathione transferases in a range of species from plants to humans
    P G Board
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, GPO Box 34, Canberra, ACT 2601, Australia
    Biochem J 328:929-35. 1997
    ..The members of the Zeta class have been conserved over a long evolutionary period, suggesting that they might have a role in the metabolism of a compound that is common in many living cells...
  12. ncbi Characterization and chromosomal localization of USP3, a novel human ubiquitin-specific protease
    K E Sloper-Mould
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, G P O Box 334, Canberra, Australian Capital Territory 2601, Australia
    J Biol Chem 274:26878-84. 1999
    ..USP3 is also only the second known ubiquitin-specific protease capable of efficiently cleaving a ubiquitin-proline bond...
  13. ncbi Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
    M D Hulett
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, ANU, Canberra, ACT, Australia
    Nat Med 5:803-9. 1999
    ..Exhaustive studies have shown only one heparanase sequence, consistent with the idea that this enzyme is the dominant endoglucuronidase in mammalian tissues...
  14. ncbi The human ubiquitin/52-residue ribosomal protein fusion gene subfamily (UbA52) is composed primarily of processed pseudogenes
    R T Baker
    Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Genomics 14:520-2. 1992
    ....
  15. pmc Unequal crossover generates variation in ubiquitin coding unit number at the human UbC polyubiquitin locus
    R T Baker
    Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra
    Am J Hum Genet 44:534-42. 1989
    ....
  16. pmc The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes
    R T Baker
    Human Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra
    Nucleic Acids Res 19:1035-40. 1991
    ..Thus, in spite of its unusual feature of being translationally fused to ubiquitin, the 52 amino acid tail ribosomal protein is expressed from a structurally typical ribosomal protein gene...
  17. ncbi Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3
    P G Board
    Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra
    Genomics 12:639-42. 1992
    ..In addition, these studies demonstrate the utility of intron or flanking sequence probes in the specific chromosomal assignment of members of highly conserved gene families...
  18. pmc A novel family of ubiquitin-specific proteases in chick skeletal muscle with distinct N- and C-terminal extensions
    S H Baek
    Department of Molecular Biology and Research Center for Cell Differentiation, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    Biochem J 334:677-84. 1998
    ..These results suggest that the chick UBPs may play an important role in production of free ubiquitin from linear polyubiquitin chains and of certain ribosomal proteins from ubiquitin fusion proteins...
  19. ncbi Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family
    R T Baker
    Division of Biology, California Institute of Technology, Pasadena 91125
    J Biol Chem 267:23364-75. 1992
    ..coli. Null yuh1 ubp1 ubp2 ubp3 quadruple mutants are viable and retain the ability to deubiquitinate ubiquitin fusions, indicating the presence of at least one more ubiquitin-specific processing protease in S. cerevisiae...
  20. ncbi The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein
    L M DeSalle
    Department of Pathology and Kaplan Comprehensive Cancer Center, MSB 548, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
    Oncogene 20:5538-42. 2001
    ..Unp is a human isopeptidase with still poorly understood biological functions. Here, we show that cellular Unp specifically interacts with the retinoblastoma gene product (pRb)...
  21. ncbi Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130
    P Blanchette
    Centre for Cancer Therapeutics, Ottawa Regional Cancer Centre, 503 Smyth Road, Ottawa, Canada K1H 1C4
    Oncogene 20:5533-7. 2001
    ..We conclude that within cells UNP does physically associate with pRb, and can also associate with p107 and p130...
  22. ncbi Purification and characterization of UBP6, a new ubiquitin-specific protease in Saccharomyces cerevisiae
    K C Park
    College of Natural Sciences, Seoul National University, Seoul, 151 742, Korea
    Arch Biochem Biophys 347:78-84. 1997
    ....
  23. pmc The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily
    R T Baker
    Nucleic Acids Res 15:443-63. 1987
    ..Hybridisation analysis of restricted human genomic DNA suggests the presence of one other closely related gene within the genome...
  24. ncbi Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway
    R T Baker
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    J Biol Chem 270:12065-74. 1995
    ..The effects of overexpressing Nt-amidase and other components of the N-end rule pathway suggest interactions between these components and the existence of a multienzyme targeting complex...
  25. ncbi Control of cell fate by a deubiquitinating enzyme encoded by the fat facets gene
    Y Huang
    Department of Zoology, University of Texas, Austin 78712, USA
    Science 270:1828-31. 1995
    ..Flies bearing fat facets gene mutations were used to show that a Ubp is cell type--and substrate-specific and a regulator of cell fate decisions in a multicellular organism...
  26. ncbi Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle
    S H Baek
    Department of Molecular Biology and Research Center for Cell Differentiation, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 272:25560-5. 1997
    ....