J G Altin

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. ncbi request reprint The role of CD45 and CD45-associated molecules in T cell activation
    J G Altin
    Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, Australian National University, Canberra, Australia
    Immunol Cell Biol 75:430-45. 1997
  2. ncbi request reprint Synthesis of the chelator lipid nitrilotriacetic acid ditetradecylamine (NTA-DTDA) and its use with the IAsys biosensor to study receptor-ligand interactions on model membranes
    J G Altin
    School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia
    Biochim Biophys Acta 1513:131-48. 2001
  3. ncbi request reprint Liposomal vaccines--targeting the delivery of antigen
    Joseph G Altin
    School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia
    Methods 40:39-52. 2006
  4. ncbi request reprint Targeting dendritic cells with antigen-containing liposomes: antitumour immunity
    Joseph G Altin
    The Australian National University, School of Biochemistry and Molecular Biology, Faculty of Science, Canberra, ACT 0200, Australia
    Expert Opin Biol Ther 4:1735-47. 2004
  5. ncbi request reprint A novel system for convenient detection of low-affinity receptor-ligand interactions: chelator-lipid liposomes engrafted with recombinant CD4 bind to cells expressing MHC class II
    C L Van Broekhoven
    School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 79:274-84. 2001
  6. ncbi request reprint Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chains
    N N Gorgani
    Division of Immunology, The John Curtin School of Medical Research, Faculty of Science, Canberra, Australia
    J Biol Chem 274:29633-40. 1999
  7. doi request reprint Liposomal Ag engrafted with peptides of sequence derived from HMGB1 induce potent Ag-specific and anti-tumour immunity
    Abdus Faham
    Biochemistry and Molecular Biology, Research School of Biology, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, 0200, Australia
    Vaccine 27:5846-54. 2009
  8. ncbi request reprint The novel chelator lipid 3(nitrilotriacetic acid)-ditetradecylamine (NTA(3)-DTDA) promotes stable binding of His-tagged proteins to liposomal membranes: potent anti-tumor responses induced by simultaneously targeting antigen, cytokine and costimulatory si
    Christina L van Broekhoven
    School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia
    Biochim Biophys Acta 1716:104-16. 2005
  9. doi request reprint Antigen-containing liposomes engrafted with flagellin-related peptides are effective vaccines that can induce potent antitumor immunity and immunotherapeutic effect
    Abdus Faham
    Division of Biomedical Science and Biochemistry, Research School of Biology, College of Medicine, Biology and Environment, Australian National University, Canberra, Australia
    J Immunol 185:1744-54. 2010
  10. ncbi request reprint Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy
    Christina L van Broekhoven
    School of Biochemistry and Molecular Biology, Faculty of Science, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Cancer Res 64:4357-65. 2004

Collaborators

  • C R Parish
  • H S Warren
  • Christina L van Broekhoven
  • Abdus Faham
  • Thomas P Herringson
  • N N Gorgani
  • C L Van Broekhoven
  • Ram R Patlolla
  • David Bennett
  • Warwick J Britton
  • Caroline Demangel

Detail Information

Publications15

  1. ncbi request reprint The role of CD45 and CD45-associated molecules in T cell activation
    J G Altin
    Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, Australian National University, Canberra, Australia
    Immunol Cell Biol 75:430-45. 1997
    ..This review aims to summarize recent findings on the role of CD45 and CD45-associated molecules in T cell activation, and to highlight issues that seem relevant to ongoing research in this area...
  2. ncbi request reprint Synthesis of the chelator lipid nitrilotriacetic acid ditetradecylamine (NTA-DTDA) and its use with the IAsys biosensor to study receptor-ligand interactions on model membranes
    J G Altin
    School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia
    Biochim Biophys Acta 1513:131-48. 2001
    ..In addition to the biological applications reported recently, the results show that NTA-DTDA can be a useful reagent in the study of receptor-ligand interactions...
  3. ncbi request reprint Liposomal vaccines--targeting the delivery of antigen
    Joseph G Altin
    School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia
    Methods 40:39-52. 2006
    ....
  4. ncbi request reprint Targeting dendritic cells with antigen-containing liposomes: antitumour immunity
    Joseph G Altin
    The Australian National University, School of Biochemistry and Molecular Biology, Faculty of Science, Canberra, ACT 0200, Australia
    Expert Opin Biol Ther 4:1735-47. 2004
    ..Liposomal targeting of antigen and maturation signals directly to DCs in vivo, therefore, represents a much simpler strategy for cancer immunotherapy than antigen loading DCs ex vivo...
  5. ncbi request reprint A novel system for convenient detection of low-affinity receptor-ligand interactions: chelator-lipid liposomes engrafted with recombinant CD4 bind to cells expressing MHC class II
    C L Van Broekhoven
    School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 79:274-84. 2001
    ..1 with CD154- and CD28-expressing cells, respectively, and the interaction of CD4 with MHC Class II, which has hitherto defied direct detection except through mutational analysis and mAb blocking studies...
  6. ncbi request reprint Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chains
    N N Gorgani
    Division of Immunology, The John Curtin School of Medical Research, Faculty of Science, Canberra, Australia
    J Biol Chem 274:29633-40. 1999
    ....
  7. doi request reprint Liposomal Ag engrafted with peptides of sequence derived from HMGB1 induce potent Ag-specific and anti-tumour immunity
    Abdus Faham
    Biochemistry and Molecular Biology, Research School of Biology, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, 0200, Australia
    Vaccine 27:5846-54. 2009
    ..The results show that vaccination with Ag-containing liposomes/PMVs engrafted with HMGB1 peptides could be an effective approach for developing novel vaccines and cancer immunotherapies...
  8. ncbi request reprint The novel chelator lipid 3(nitrilotriacetic acid)-ditetradecylamine (NTA(3)-DTDA) promotes stable binding of His-tagged proteins to liposomal membranes: potent anti-tumor responses induced by simultaneously targeting antigen, cytokine and costimulatory si
    Christina L van Broekhoven
    School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia
    Biochim Biophys Acta 1716:104-16. 2005
    ....
  9. doi request reprint Antigen-containing liposomes engrafted with flagellin-related peptides are effective vaccines that can induce potent antitumor immunity and immunotherapeutic effect
    Abdus Faham
    Division of Biomedical Science and Biochemistry, Research School of Biology, College of Medicine, Biology and Environment, Australian National University, Canberra, Australia
    J Immunol 185:1744-54. 2010
    ..Therefore, vaccination with Ag-containing liposomes engrafted with 9Flg or 42Flg is a powerful strategy to exploit the innate and adaptive immune systems for the development of potent vaccines and cancer immunotherapies...
  10. ncbi request reprint Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy
    Christina L van Broekhoven
    School of Biochemistry and Molecular Biology, Faculty of Science, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Cancer Res 64:4357-65. 2004
    ..The results show that the targeting of antigen to DCs in this way is highly effective at inducing immunity and protection against the tumor, with protection being at least partially dependent on the eosinophil chemokine eotaxin...
  11. doi request reprint Targeting of plasmid DNA-lipoplexes to cells with molecules anchored via a metal chelator lipid
    Thomas P Herringson
    Research School of Biology, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, Australia
    J Gene Med 11:1048-63. 2009
    ..In the present study, we utilized liposomes containing NTA(3)-DTDA and the ionizable aminolipid 1,2-dioleoyl-3-dimethyl-ammonium-propane (DODAP) to incorporate pDNA into complexes for targeting to cells...
  12. ncbi request reprint Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes
    N N Gorgani
    Division of Immunology and Cell Biology, The John Curtin School of Medical Research, Faculty of Science, Australian National University, Canberra, ACT 0200, Australia
    Int Immunol 11:1275-82. 1999
    ..Thus HRG can interact with FcgammaRI on monocytes and block monomeric IgG binding, whereas when incorporated in IgG containing IC, HRG can enhance the uptake of IC by monocytes, probably via its heparan sulfate binding domain...
  13. ncbi request reprint Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells
    J G Altin
    Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra
    Immunol Cell Biol 72:87-96. 1994
    ....
  14. ncbi request reprint A novel approach for modifying tumor cell-derived plasma membrane vesicles to contain encapsulated IL-2 and engrafted costimulatory molecules for use in tumor immunotherapy
    Christina L van Broekhoven
    School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT, Australia
    Int J Cancer 98:63-72. 2002
    ..1 and CD40 and incorporation of IL-2 can be used to modulate immune responses, which provides a novel approach for the development of anti-tumor vaccines and cancer immunotherapies...
  15. doi request reprint Convenient targeting of stealth siRNA-lipoplexes to cells with chelator lipid-anchored molecules
    Thomas P Herringson
    Biochemistry and Molecular Biology, Research School of Biology, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, 0200, Australia
    J Control Release 139:229-38. 2009
    ..The results show that NTA(3)-DTDA can be used to target siRNA-lipoplexes to cells, and could provide a convenient approach for targeting siRNA to cells in vivo for therapeutic applications...