Rinaldo Bellomo

Summary

Affiliation: Austin Health
Country: Australia

Publications

  1. ncbi request reprint The pathophysiology of cardiac surgery-associated acute kidney injury (CSA-AKI)
    R Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Int J Artif Organs 31:166-78. 2008
  2. ncbi request reprint Why is there such a difference in outcome between Australian intensive care units and others?
    Rinaldo Bellomo
    Intensive Care Research, Austin Hospital, Australia
    Curr Opin Anaesthesiol 20:100-5. 2007
  3. doi request reprint A controlled trial of electronic automated advisory vital signs monitoring in general hospital wards
    Rinaldo Bellomo
    Department of Intensive Care, Austin Health, Melbourne, Australia
    Crit Care Med 40:2349-61. 2012
  4. pmc Long term effect of a medical emergency team on cardiac arrests in a teaching hospital
    Daryl Jones
    Department of Intensive Care, Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
    Crit Care 9:R808-15. 2005
  5. pmc The effects of terlipressin on regional hemodynamics and kidney function in experimental hyperdynamic sepsis
    Ken Ishikawa
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 7:e29693. 2012
  6. ncbi request reprint Invasive blood pressure recording comparing nursing charts with an electronic monitor: a technical report
    Benjamin T Wong
    Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
    Crit Care Resusc 16:73-5. 2014
  7. ncbi request reprint Systemic and renal haemodynamic effects of fluid bolus therapy: sodium chloride versus sodium octanoate-balanced solution
    Lu Ke
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Vic, Australia
    Crit Care Resusc 16:29-33. 2014
  8. ncbi request reprint Near-infrared spectroscopy of the thenar eminence to estimate forearm blood flow
    Nicholas C Z Woinarski
    Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Vic, Australia
    Crit Care Resusc 15:323-6. 2013
  9. ncbi request reprint Infusion of hydroxyethyl starch-containing fluids
    C Aubron
    Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Minerva Anestesiol 79:1088-92. 2013
  10. pmc Hepatorenal syndrome: the 8th International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Mitra K Nadim
    Department of Medicine, University of Southern California, 1520 San Pablo Street, Suite 4300, Los Angeles, CA 90033, USA
    Crit Care 16:R23. 2012

Collaborators

Detail Information

Publications216 found, 100 shown here

  1. ncbi request reprint The pathophysiology of cardiac surgery-associated acute kidney injury (CSA-AKI)
    R Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Int J Artif Organs 31:166-78. 2008
    ..The administration of N-acetylcysteine to protect the kidney from oxidative stress is not recommended. There is marked lack of randomised controlled trials in this field...
  2. ncbi request reprint Why is there such a difference in outcome between Australian intensive care units and others?
    Rinaldo Bellomo
    Intensive Care Research, Austin Hospital, Australia
    Curr Opin Anaesthesiol 20:100-5. 2007
    ..The aim of this article is to assess the data on clinical outcomes for critically ill patients admitted to Australian and New Zealand intensive care units in comparison to information available for similar patients in other counties..
  3. doi request reprint A controlled trial of electronic automated advisory vital signs monitoring in general hospital wards
    Rinaldo Bellomo
    Department of Intensive Care, Austin Health, Melbourne, Australia
    Crit Care Med 40:2349-61. 2012
    ..Deteriorating ward patients are at increased risk. Electronic automated advisory vital signs monitors may help identify such patients and improve their outcomes...
  4. pmc Long term effect of a medical emergency team on cardiac arrests in a teaching hospital
    Daryl Jones
    Department of Intensive Care, Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
    Crit Care 9:R808-15. 2005
    ..It is unknown whether the reported short-term reduction in cardiac arrests associated with the introduction of the medical emergency team (MET) system can be sustained...
  5. pmc The effects of terlipressin on regional hemodynamics and kidney function in experimental hyperdynamic sepsis
    Ken Ishikawa
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 7:e29693. 2012
    ..We investigated the effects of TP on regional hemodynamics and kidney function in experimental hyperdynamic sepsis...
  6. ncbi request reprint Invasive blood pressure recording comparing nursing charts with an electronic monitor: a technical report
    Benjamin T Wong
    Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
    Crit Care Resusc 16:73-5. 2014
    ..Blood pressure management (assessed using nursing charts) in the early phase of septic shock may have an effect on renal outcomes. Assessment of mean arterial pressure (MAP) values as recorded on nursing charts may be inaccurate...
  7. ncbi request reprint Systemic and renal haemodynamic effects of fluid bolus therapy: sodium chloride versus sodium octanoate-balanced solution
    Lu Ke
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Vic, Australia
    Crit Care Resusc 16:29-33. 2014
    ..We compared the systemic and renal haemodynamic effects of a bolus of NS with those of a novel isotonic solution containing a physiological concentration of chloride and sodium octanoate (SOct) in healthy conscious sheep...
  8. ncbi request reprint Near-infrared spectroscopy of the thenar eminence to estimate forearm blood flow
    Nicholas C Z Woinarski
    Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Vic, Australia
    Crit Care Resusc 15:323-6. 2013
    ..Its ability to estimate forearm blood flow (FBF) has not previously been assessed...
  9. ncbi request reprint Infusion of hydroxyethyl starch-containing fluids
    C Aubron
    Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Minerva Anestesiol 79:1088-92. 2013
    ..At least in Europe, the clinical story of HES seems to have come to an end. ..
  10. pmc Hepatorenal syndrome: the 8th International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Mitra K Nadim
    Department of Medicine, University of Southern California, 1520 San Pablo Street, Suite 4300, Los Angeles, CA 90033, USA
    Crit Care 16:R23. 2012
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  11. pmc Age of red blood cells and transfusion in critically ill patients
    Cecile Aubron
    ANZIC Research Center, School of Public Health and Preventive Medicine, Monash University, The Alfred Center, 99 Commercial Road, Melbourne, Vic, 3004, Australia
    Ann Intensive Care 3:2. 2013
    ....
  12. pmc Continuous beta-lactam infusion in critically ill patients: the clinical evidence
    Mohd H Abdul-Aziz
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia
    Ann Intensive Care 2:37. 2012
    ..To further ascertain whether benefits of continuous infusion in critically ill patients do exist, a large-scale, prospective, multinational trial with a robust design is required...
  13. ncbi request reprint Normothermic extracorporeal human liver perfusion following donation after cardiac death
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
    Crit Care Resusc 15:78-82. 2013
    ..There was essentially normal liver and biliary tract histology after 8 hours of perfusion. Our experiment justifies further investigation of the feasibility and efficacy of human DCD liver preservation by NELP. ..
  14. ncbi request reprint Safety evaluation of a trial of lipocalin-directed sodium bicarbonate infusion for renal protection in at-risk critically ill patients
    Antoine G Schneider
    Department of Intensive Care, Austin Health, Melbourne, Vic, Australia
    Crit Care Resusc 15:126-33. 2013
    ..The safety and feasibility of urine alkalinisation in patients at risk of s-AKI has never been tested...
  15. ncbi request reprint Early acid-base and blood pressure effects of continuous renal replacement therapy intensity in patients with metabolic acidosis
    Rinaldo Bellomo
    ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
    Intensive Care Med 39:429-36. 2013
    ..We aimed to compare key aspects of acidosis and MAP and vasopressor therapy in patients treated with two different CRRT intensities...
  16. pmc Near infrared spectroscopy (NIRS) of the thenar eminence in anesthesia and intensive care
    Miklos Lipcsey
    Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
    Ann Intensive Care 2:11. 2012
    ..Minimal data are available on static or dynamic StO2 used to guide therapy.Although the available data are promising, further studies are necessary before NIRSth can become part of routine clinical practice...
  17. doi request reprint Acute kidney injury
    Rinaldo Bellomo
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
    Lancet 380:756-66. 2012
    ..However, evidence suggests that patients who have had acute kidney injury are at increased risk of subsequent chronic kidney disease...
  18. pmc Urine hepcidin has additive value in ruling out cardiopulmonary bypass-associated acute kidney injury: an observational cohort study
    Anja Haase-Fielitz
    Department of Nephrology and Hypertension and Endocrinology and Metabolic Diseases, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Crit Care 15:R186. 2011
    ..Recently, interest has focused on hepcidin, a regulator of iron homeostasis, as a unique renal biomarker...
  19. pmc Totem and taboo: fluids in sepsis
    Andrew K Hilton
    Department of Intensive Care, Alfred Hospital, Commercial Road, Melbourne, Australia, Victoria 3181, Australia
    Crit Care 15:164. 2011
    ....
  20. pmc Bench-to-bedside review: contrast enhanced ultrasonography--a promising technique to assess renal perfusion in the ICU
    Antoine Schneider
    Intensive Care Unit, Austin Hospital, 145 Studley Road, 3084 Heidelberg, Victoria, Australia
    Crit Care 15:157. 2011
    ....
  21. pmc Clinical review: Optimal dose of continuous renal replacement therapy in acute kidney injury
    John R Prowle
    Department of Intensive Care, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia
    Crit Care 15:207. 2011
    ..In this review, we discuss the concept of dose of CRRT, its relationship with clinical outcomes, and what target optimal dose of CRRT should be pursued in light of the high-quality evidence now available...
  22. pmc A critique of fluid bolus resuscitation in severe sepsis
    Andrew K Hilton
    Department of Intensive Care, Alfred Hospital, and Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Centre, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
    Crit Care 16:302. 2012
    ..In the present article, we contend that the concept of large fluid bolus resuscitation in sepsis needs to be investigated further...
  23. ncbi request reprint Near-infrared spectroscopy of the thenar eminence: comparison of dynamic testing protocols
    Miklos Lipcsey
    Department of Surgery, Section of Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden
    Crit Care Resusc 14:142-7. 2012
    ..VOT has been applied to assess the microcirculation by NIRSth in critically ill patients. The optimal mode of performing such VOT, however, remains controversial...
  24. pmc Septic acute kidney injury: hemodynamic syndrome, inflammatory disorder, or both?
    Miklos Lipcsey
    Crit Care 15:1008. 2011
    ....
  25. doi request reprint Severe acute kidney injury not treated with renal replacement therapy: characteristics and outcome
    Antoine G Schneider
    Department of Intensive Care, Austin Health, Heidelberg, Australia
    Nephrol Dial Transplant 27:947-52. 2012
    ..The aim of this study was to study the characteristics and outcome of patients with severe (RIFLE-F) AKI who did not receive RRT...
  26. doi request reprint Effect of mean arterial pressure, haemoglobin and blood transfusion during cardiopulmonary bypass on post-operative acute kidney injury
    Michael Haase
    Department of Nephrology and Intensive Care, Charite University Medicine Berlin, Berlin, Germany
    Nephrol Dial Transplant 27:153-60. 2012
    ..During cardiopulmonary bypass (CPB) surgery, modifiable factors may contribute to post-operative AKI. Their avoidance might be a potential target for nephroprotection...
  27. pmc Baseline hospital performance and the impact of medical emergency teams: modelling vs. conventional subgroup analysis
    Jack Chen
    The Simpson Centre for Health Services Research, University of New South Wales, Sydney, New South Wales, Australia
    Trials 10:117. 2009
    ..To compare two approaches to the statistical analysis of the relationship between the baseline incidence of adverse events and the effect of medical emergency teams (METs)...
  28. pmc The SPARK Study: a phase II randomized blinded controlled trial of the effect of furosemide in critically ill patients with early acute kidney injury
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 12 Walter C, Mackenzie Centre, 8440 112 Street, Edmonton, Alberta, Canada
    Trials 11:50. 2010
    ..There remains controversy on whether furosemide can impact clinical outcomes in critically ill patients with AKI; however, a survey of intensivists and nephrologists showed equipoise for high-quality evidence on this important issue...
  29. pmc Clinical review: anticoagulation for continuous renal replacement therapy--heparin or citrate?
    Heleen M Oudemans-van Straaten
    Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091 AC Amsterdam, The Netherlands
    Crit Care 15:202. 2011
    ..Citrate can, however, with inadequate use cause metabolic derangements. Full advantages of citrate can only be realized if its risks are well controlled. These observations suggest a greater role for citrate...
  30. pmc Acquired bloodstream infection in the intensive care unit: incidence and attributable mortality
    John R Prowle
    Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidelberg, Victoria 3084, Australia
    Crit Care 15:R100. 2011
    ..To estimate the incidence of intensive care unit (ICU)-acquired bloodstream infection (BSI) and its independent effect on hospital mortality...
  31. pmc Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
    ..Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients...
  32. pmc Bench-to-bedside review: Chloride in critical illness
    Nor azim Mohd Yunos
    Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, VIC 33084, Australia
    Crit Care 14:226. 2010
    ..Finally, the review examines the potential intensive care unit practice implications of a better understanding of chloride...
  33. pmc Circadian pattern of activation of the medical emergency team in a teaching hospital
    Daryl Jones
    Department of Intensive Care, Melbourne University, Austin Hospital, Melbourne, Australia
    Crit Care 9:R303-6. 2005
    ..The timing and system factors associated with their activation are poorly understood. We sought to determine the circadian pattern of MET activation and to relate it to nursing and medical activities...
  34. pmc Medical emergency team syndromes and an approach to their management
    Daryl Jones
    Intensive Care Unit, The Alfred Hospital, Commercial Road Melbourne, Victoria, Australia, 3004
    Crit Care 10:R30. 2006
    ..Most literature on the medical emergency team (MET) relates to its effects on patient outcome. Less information exists on the most common causes of MET calls or on possible approaches to their management...
  35. pmc Effect of the medical emergency team on long-term mortality following major surgery
    Daryl Jones
    Australian and New Zealand Intensive Care Research Centre ANZIC RC, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, 3004, Australia
    Crit Care 11:R12. 2007
    ..The purpose of the present study was to assess the effect of the MET and other variables on long-term mortality in this patient population...
  36. pmc Angiotensin II in experimental hyperdynamic sepsis
    Li Wan
    Howard Florey Institute, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia
    Crit Care 13:R190. 2009
    ..However, unlike other vasopressors, its systemic, regional blood flow and renal functional effects in hypotensive hyperdynamic sepsis have not been investigated...
  37. pmc Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery -- a systematic literature review
    Michael Gillies
    Department of Intensive Care and Medicine, University of Melbourne, Austin Hospital, Melbourne, Australia
    Crit Care 9:266-79. 2005
    ..Multicentre randomized controlled trials focusing on clinical rather than physiological outcomes are needed...
  38. pmc Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Canada
    Crit Care 11:R68. 2007
    ..There is limited information on whether the incidence of acute kidney injury (AKI) in critically ill patients has changed over time and there is controversy on whether its outcome has improved...
  39. pmc Renal blood flow in sepsis
    Christoph Langenberg
    Department of Intensive Care, Austin Hospital, and University of Melbourne, Heidelberg, Melbourne, Australia
    Crit Care 9:R363-74. 2005
    ..To assess changes in renal blood flow (RBF) in human and experimental sepsis, and to identify determinants of RBF...
  40. pmc Introduction of a rapid response system: why we are glad we MET
    Daryl Jones
    Department of Intensive Care Monash University, Alfred Hospital, Commercial Road, Melbourne, Australia
    Crit Care 10:121. 2006
    ..Furthermore, they have allowed improved analysis and characterization of 'at-risk' patients and their needs. Four years later, we remain glad we MET...
  41. pmc Cost of acute renal replacement therapy in the intensive care unit: results from The Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) study
    Nattachai Srisawat
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Crit Care 14:R46. 2010
    ..The aim of this study was to estimate the cost difference between CRRT and IRRT in the intensive care unit (ICU)...
  42. pmc Bench-to-bedside review: The MET syndrome--the challenges of researching and adopting medical emergency teams
    Augustine Tee
    Department of Intensive Care, Austin Hospital, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia
    Crit Care 12:205. 2008
    ..It appears likely that the accumulation of evidence from different settings and situations, though methodologically imperfect, will increase the rationale and logic of RRS. A conclusive randomised controlled trial is unlikely to occur...
  43. pmc Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study
    Alistair D Nichol
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital Campus, 75 Commercial Road, Prahran, VIC 31821, Australia
    Crit Care 14:R25. 2010
    ..We tested the hypothesis that relative hyperlactatemia is independently associated with an increased risk of hospital death...
  44. pmc Bench-to-bedside review: the evaluation of complex interventions in critical care
    Anthony Delaney
    Northern Clinical School, Faculty of Medicine, University of Sydney, Intensive Care Unit, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW, 2065, Australia
    Crit Care 12:210. 2008
    ..These aspects of study design impact upon the evaluation of complex interventions in critical care. Clinicians should also consider these specific issues when implementing new complex interventions into their practice...
  45. pmc Is reducing variability of blood glucose the real but hidden target of intensive insulin therapy?
    Moritoki Egi
    Department of Anesthesiology and Resuscitology, Okayama University Hospital, Shikata City, Japan 700 8558
    Crit Care 13:302. 2009
    ..Clinicians need to be aware of this controversy when considering the application of intensive insulin therapy and interpreting future trials...
  46. pmc Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review
    Dinna N Cruz
    Department of Nephrology, Ospedale San Bortolo, Viale Rodolfi 37, 36100 Vicenza, Italy
    Crit Care 11:R47. 2007
    ..We performed a systematic review to describe the effect in septic patients of direct hemoperfusion with PMX-F on outcomes of blood pressure, use of vasoactive drugs, oxygenation, and mortality reported in published studies...
  47. pmc A quantitative analysis of the acidosis of cardiac arrest: a prospective observational study
    Jun Makino
    Tertiary Emergency Medical Center, Tokyo Metropolitan Bokuto Hospital, Tokyo, Japan
    Crit Care 9:R357-62. 2005
    ..We proposed that hyperlactatemia is not the sole cause of cardiac arrest acidosis and that other factors participate significantly in its development...
  48. pmc Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report
    Toshio Naka
    Department of Intensive Care, Melbourne University, Austin Hospital, Melbourne, Australia
    Crit Care 9:R90-5. 2005
    ..To test the ability of a novel super high-flux (SHF) membrane with a larger pore size to clear myoglobin from serum...
  49. pmc Pulmonary artery catheter versus pulse contour analysis: a prospective epidemiological study
    Shigehiko Uchino
    Department of Emergency and Critical Care Medicine, Saitama Medical Center, 1981 Tsujido machi, Kamoda, Kawagoe shi, Saitama, 350 8550, Japan
    Crit Care 10:R174. 2006
    ..Accordingly, we sought to study and compare the features and outcomes of patients who receive haemodynamic monitoring with either the pulmonary artery catheter (PAC) or pulse contour cardiac output (PiCCO) technology...
  50. pmc Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial
    Michael C Reade
    Department of Intensive Care Medicine, Austin Hospital and the University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia
    Crit Care 13:R75. 2009
    ..Dexmedetomidine, a novel sedative and anxiolytic agent, may have particular utility in these patients. We sought to compare the efficacy of haloperidol and dexmedetomidine in facilitating extubation...
  51. ncbi request reprint The epidemiology of acute renal failure: 1975 versus 2005
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital and University of Melbourne, Heidelberg, Melbourne, Australia
    Curr Opin Crit Care 12:557-60. 2006
    ..Data from the mid 1970s relating to the clinical features, pathogenesis, treatment and outcome of patients affected by acute renal failure were compared with data reported in the literature in 2005...
  52. pmc Evidence-based medicine: classifying the evidence from clinical trials--the need to consider other dimensions
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Studley Rd, Heidelberg, Victoria 3084, Australia
    Crit Care 10:232. 2006
    ..Accordingly, we argue for more reflection, definition and consensus on these aspects of the evaluation of evidence...
  53. doi request reprint Diuretic therapy in fluid-overloaded and heart failure patients
    Rinaldo Bellomo
    Department of Intensive Care, Austin Health, Melbourne, Vic, Australia
    Contrib Nephrol 164:153-63. 2010
    ..The combination of diuretic therapy and/or ultrafiltration can achieve volume control in essentially all patients with heart failure...
  54. pmc Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest
    Rinaldo Bellomo
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 5 Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
    Crit Care 15:R90. 2011
    ..Hyperoxia has recently been reported as an independent risk factor for mortality in patients resuscitated from cardiac arrest. We examined the independent relationship between hyperoxia and outcomes in such patients...
  55. pmc Oliguria as predictive biomarker of acute kidney injury in critically ill patients
    John R Prowle
    Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidleberg, Victoria 3084, Australia
    Crit Care 15:R172. 2011
    ..During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development of AKI has not been prospectively evaluated...
  56. pmc Bicarbonate in diabetic ketoacidosis - a systematic review
    Horng Ruey Chua
    Department of Intensive Care, Austin Health, Melbourne, Victoria, Australia
    Ann Intensive Care 1:23. 2011
    ..abstract:..
  57. doi request reprint Septic acute kidney injury: the glomerular arterioles
    Rinaldo Bellomo
    Department of Intensive Care, Austin Health, University of Melbourne, Melbourne, Australia
    Contrib Nephrol 174:98-107. 2011
    ..These observations imply that changes in the vasoconstrictor tone of both the afferent and efferent arterioles are an important component of the pathogenesis of septic AKI...
  58. ncbi request reprint The dangers of dogma in medicine
    Rinaldo Bellomo
    Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia
    Med J Aust 195:372-3. 2011
    ..As yet in Australia, there is no systematic provision of reliable guidance for practitioners...
  59. doi request reprint Acute renal failure
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Semin Respir Crit Care Med 32:639-50. 2011
    ..Finally, there is a growing appreciation that acute renal failure may identify patients who are at increased risk of subsequent chronic renal dysfunction and mortality, opening the way to post-ICU interventional trials...
  60. ncbi request reprint Defining and classifying acute renal failure: from advocacy to consensus and validation of the RIFLE criteria
    Rinaldo Bellomo
    Department of Intensive Care and Department of Medicine, Austin Hospital and University of Melbourne, Heidelberg, Melbourne, Australia
    Intensive Care Med 33:409-13. 2007
    ..This editorial aims to summarize and interpret recent findings concerning the application of the RIFLE criteria to the assessment of the epidemiology and the prediction of the outcome of ARF...
  61. doi request reprint Why we should be wary of single-center trials
    Rinaldo Bellomo
    Department of Intensive Care Medicine, Austin Hospital and University of Melbourne, Australia
    Crit Care Med 37:3114-9. 2009
    ....
  62. ncbi request reprint Effects of saline or albumin resuscitation on standard coagulation tests
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Vic
    Crit Care Resusc 11:250-6. 2009
    ..To explore whether fluid resuscitation with normal saline or 4% albumin is associated with differential changes in routine clinical coagulation tests...
  63. doi request reprint Fluid management in septic acute kidney injury and cardiorenal syndromes
    Rinaldo Bellomo
    Department of Intensive Care, Austin Health, Heidelberg, Melbourne, Vic, Australia
    Contrib Nephrol 165:206-18. 2010
    ..Thus, accurate assessment of fluid status and careful definition of targets are needed to improve clinical outcomes. Controlled studies of conservative versus liberal fluid management in patients with AKI or CRS seem justified...
  64. pmc The pursuit of a high central venous oxygen saturation in sepsis: growing concerns
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Studley Rd, Heidelberg, Victoria 3084, Australia
    Crit Care 12:130. 2008
    ..Until such studies are completed, basing international treatment guidelines on a single centre study performed in what may turn out to be a highly atypical environment would seem premature...
  65. doi request reprint Vasoactive drugs and acute kidney injury
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Hospital, Melbourne, Australia
    Crit Care Med 36:S179-86. 2008
    ..Whether it is superior to noradrenaline in this setting remains uncertain, and more studies are needed before recommendations can be made...
  66. doi request reprint Septic acute kidney injury: new concepts
    Rinaldo Bellomo
    Department of Intensive Care and Department of Medicine, Austin Health, and Howard Florey Institute, University of Melbourne, Melbourne, Vic, Australia
    Nephron Exp Nephrol 109:e95-100. 2008
    ..While these findings need to be confirmed, they challenge established paradigms and offer a new conceptual framework of reference for further investigation and intervention in man...
  67. ncbi request reprint Pre-renal azotemia: a flawed paradigm in critically ill septic patients?
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
    Contrib Nephrol 156:1-9. 2007
    ....
  68. doi request reprint Recent advances in critical care medicine relevant to cardiac surgery
    Rinaldo Bellomo
    Department of Intensive Care and Department of Medicine, Austin Hospital, Studley Rd, Heidelberg, Victoria 3084, Australia
    Heart Lung Circ 20:170-2. 2011
    ..Such findings suggest caution with excessive transfusion after cardiac surgery and the need for a large randomised controlled trial...
  69. ncbi request reprint Bowel motions in critically ill patients: a pilot observational study
    Stephanie Bishop
    Department of Intensive Care, Austin Hospital, Melbourne, Vic
    Crit Care Resusc 12:182-5. 2010
    ..We hypothesised that most stools in critically ill patients are not formed and that both diarrhoea and non-defecation are common...
  70. ncbi request reprint Do we know the optimal dose for renal replacement therapy in the intensive care unit?
    R Bellomo
    Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Kidney Int 70:1202-4. 2006
    ..The results of these two studies should be available in 2008. Before making any major changes to practice, it seems prudent to wait for the publication of the findings of these two pivotal trials...
  71. ncbi request reprint Extracorporeal blood treatment (EBT) methods in SIRS/Sepsis
    R Bellomo
    Department of Intensive Care and Department of Medicine, Austin Hospital and Melbourne University, Melbourne Australia
    Int J Artif Organs 28:450-8. 2005
    ..Their role in the management of SIRS/Sepsis remains controversial...
  72. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  73. ncbi request reprint A prospective before-and-after trial of a medical emergency team
    Rinaldo Bellomo
    Austin and Repatriation Medical Centre, Melbourne, Vic
    Med J Aust 179:283-7. 2003
    ..To determine the effect on cardiac arrests and overall hospital mortality of an intensive care-based medical emergency team...
  74. ncbi request reprint Intravenous fluids and acid-base balance
    Rinaldo Bellomo
    Department of Intensive Care, University of Melbourne, Melbourne, Australia
    Contrib Nephrol 144:105-18. 2004
  75. ncbi request reprint Defining, quantifying, and classifying acute renal failure
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Heidelberg 3084, Melbourne, Victoria, Australia
    Crit Care Clin 21:223-37. 2005
    ..Important steps are being taken toward improving the outcome of these patients. Critical care physicians need to understand and participate in this process...
  76. ncbi request reprint Defining acute renal failure: physiological principles
    Rinaldo Bellomo
    Department of Intensive Care and Division of Surgery, Austin and Repatriation Medical Centre, 3084 Heidelberg, Melbourne, Victoria, Australia
    Intensive Care Med 30:33-7. 2004
  77. ncbi request reprint Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals
    Rinaldo Bellomo
    Department of Intensive Care and Department of Surgery, Austin and Repatriation Medical Centre, 3084 Heidelberg, Melbourne, Victoria, Australia
    Intensive Care Med 30:911-7. 2004
    ..To assess multicentre, randomised, controlled trials (MC-RCTs) of systemic inflammatory response syndrome (SIRS) and sepsis conducted in Japan, published in Japanese and not available to English-language medical databases...
  78. ncbi request reprint Bolus hypertonic or normal saline resuscitation in gram-negative sepsis: systemic and regional haemodynamic effects in sheep
    Li Wan
    Department of Intensive Care, Austin Health, Melbourne, Vic, Australia
    Crit Care Resusc 13:262-70. 2011
    ..Fluid resuscitation with saline in severe sepsis is controversial. Hypertonic (3%) saline (HTS) may be superior to normal (0.9%) saline (NS)...
  79. ncbi request reprint A pilot study of the epidemiology and associations of pulse pressure variation in cardiac surgery patients
    In Byung Kim
    Department of Emergency Medicine, Kwan Dong University, Seoul, Korea
    Crit Care Resusc 13:17-23. 2011
    ..Pulse pressure variation (PPV) is an accepted measure of intravascular filling. It can now be estimated automatically. However, there is limited knowledge of the epidemiology and associations of such estimates in cardiac surgery patients...
  80. doi request reprint Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    J Crit Care 24:129-40. 2009
    ..The aim of this study is to evaluate the relationship between timing of renal replacement therapy (RRT) in severe acute kidney injury and clinical outcomes...
  81. ncbi request reprint Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    Clin J Am Soc Nephrol 2:431-9. 2007
    ..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT...
  82. doi request reprint The interaction of chronic and acute glycemia with mortality in critically ill patients with diabetes
    Moritoki Egi
    Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan
    Crit Care Med 39:105-11. 2011
    ..We tested whether the degree of preexisting hyperglycemia would modulate the association between glycemia and outcome during critical illness in patients with diabetes mellitus...
  83. doi request reprint Greater increase in urinary hepcidin predicts protection from acute kidney injury after cardiopulmonary bypass
    John R Prowle
    Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Nephrol Dial Transplant 27:595-602. 2012
    ..Acute kidney injury (AKI) is a common and serious complication of cardiopulmonary bypass (CPB) surgery. Hepcidin, a peptide hormone that regulates iron homeostasis, is a potential biomarker of AKI following CPB...
  84. doi request reprint Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study
    Anja Haase-Fielitz
    Department of Intensive Care, Austin Health, Melbourne, Australia
    Crit Care Med 37:553-60. 2009
    ..To compare the value of novel with conventional serum biomarkers in the prediction of acute kidney injury (AKI) in adult cardiac surgical patients according to preoperative renal function...
  85. ncbi request reprint Prospective controlled trial of effect of medical emergency team on postoperative morbidity and mortality rates
    Rinaldo Bellomo
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    Crit Care Med 32:916-21. 2004
    ....
  86. doi request reprint Ionized calcium concentration and outcome in critical illness
    Moritoki Egi
    Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan
    Crit Care Med 39:314-21. 2011
    ..To assess the association of abnormalities of ionized calcium levels with mortality in a heterogeneous cohort of critically ill patients...
  87. ncbi request reprint Long-term effect of a Medical Emergency Team on mortality in a teaching hospital
    Daryl Jones
    Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Resuscitation 74:235-41. 2007
    ..To assess the effect of a Medical Emergency Team (MET) service on patient mortality in the 4 years since its introduction into a teaching hospital...
  88. ncbi request reprint Renal blood flow and function during recovery from experimental septic acute kidney injury
    Christoph Langenberg
    Austin and Repatriation Medical Centre, Department of Intensive Care, 3084, Heidelberg, Victoria, Australia
    Intensive Care Med 33:1614-8. 2007
    ..To measure renal blood flow (RBF) and renal function during recovery from experimental septic acute kidney injury (AKI)...
  89. ncbi request reprint Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators
    Shigehiko Uchino
    Jikei University School of Medicine, Intensive Care Unit, Department of Anesthesiology, Tokyo, Japan
    Intensive Care Med 33:1563-70. 2007
    ..Little information is available regarding current practice in continuous renal replacement therapy (CRRT) for the treatment of acute renal failure (ARF) and the possible clinical effect of practice variation...
  90. pmc Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Studley Road, Heidelberg, VIC 3084, Australia
    Crit Care 13:R45. 2009
    ..The primary objective was to evaluate the rate, characteristics and outcomes of very old (age >or= 80 years) patients admitted to intensive care units (ICUs)...
  91. ncbi request reprint Unmeasured anions in critically ill patients: can they predict mortality?
    Jens Rocktaeschel
    Department of Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Australia
    Crit Care Med 31:2131-6. 2003
    ..To determine whether base excess, base excess caused by unmeasured anions, and anion gap can predict lactate in adult critically ill patients, and also to determine whether acid-base variables can predict mortality in these patients...
  92. doi request reprint Blood glucose concentration and outcome of critical illness: the impact of diabetes
    Moritoki Egi
    Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan
    Crit Care Med 36:2249-55. 2008
    ..To study the impact of diabetes mellitus on the relationship between glycemia and mortality in critically ill patients...
  93. doi request reprint Recent trials in critical care nephrology
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia, USA
    Contrib Nephrol 165:299-309. 2010
    ....
  94. doi request reprint The systemic and regional hemodynamic effects of phenylephrine in sheep under normal conditions and during early hyperdynamic sepsis
    Hiroshi Morimatsu
    Department of Intensive Care, Austin Health, Melbourne, Victoria, Heidelberg, Victoria 3084, Australia
    Anesth Analg 115:330-42. 2012
    ..Phenylephrine treatment of hypotension in sepsis raises concern because it may decrease vital organ bloodflow. Accordingly, we investigated the effects of phenylephrine on systemic and regional bloodflow in normal and septic sheep...
  95. ncbi request reprint Documentation of clinical review and vital signs after major surgery
    Forbes McGain
    Western Hospital, Melbourne, Vic
    Med J Aust 189:380-3. 2008
    ..To describe the quality of postoperative documentation of vital signs and of medical and nursing review and to identify the patient and hospital factors associated with incomplete documentation...
  96. ncbi request reprint External validation of severity scoring systems for acute renal failure using a multinational database
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Crit Care Med 33:1961-7. 2005
    ..Therefore, it is not known whether such severity scoring systems may be widely applied...
  97. ncbi request reprint Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients
    Michael Haase
    Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
    Crit Care Med 35:1324-31. 2007
    ..To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure...
  98. ncbi request reprint Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study
    Joel M Dulhunty
    Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, and Burns, Trauma and Critical Care Research Centre, University of Queensland, Herston, QLD, 4029, Australia
    Intensive Care Med 34:1654-61. 2008
    ..To compare the time course of organ dysfunction/failure, mortality and cause of death in patients with severe sepsis (SS) and patients with severe non-infectious systemic inflammatory response syndrome (SNISIRS)...
  99. doi request reprint Pilot double-blind, randomized controlled trial of short-term atorvastatin for prevention of acute kidney injury after cardiac surgery
    John R Prowle
    Department of Intensive Care, Austin Health, Melbourne, Victoria, Australia
    Nephrology (Carlton) 17:215-24. 2012
    ..To test whether short-term perioperative administration of oral atorvastatin could reduce incidence of postoperative acute kidney injury (AKI) in cardiac surgical patients...
  100. ncbi request reprint Solute mass balance during isovolaemic high volume haemofiltration
    Shigehiko Uchino
    Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia
    Intensive Care Med 29:1541-6. 2003
    ..To evaluate the effect of changing the amount of pre-dilution replacement fluid on the sieving coefficient (SC) and mass transfer of small solutes during isovolaemic high-volume haemofiltration (HVHF)...