M L Selley
Affiliation: Angiogen Pharmaceuticals Pty. Ltd
- Homocysteine increases the production of asymmetric dimethylarginine in cultured neuronsMichael L Selley
Angiogen Pharmaceuticals Pty Ltd, Sydney, New South Wales, Australia
J Neurosci Res 77:90-3. 2004..The preservation of DDAH activity and the reduction of ADMA accumulation in neurons may be a new strategy for the treatment of Alzheimer's disease and cognitive impairment in normal aging...
- Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer's diseaseM L Selley
Angiogen Pharmaceuticals Pty Ltd, P O Box 512, Turramurra, NSW 2074, Australia
Neurobiol Aging 24:903-7. 2003..The inhibition of neuronal nitric oxide synthesis by ADMA may cause cognitive dysfunction in Alzheimer's disease...
- The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's diseaseM L Selley
Angiogen Pharmaceuticals Pty Ltd, Turramurra, New South Wales 2074, Australia
Neurobiol Aging 23:383-8. 2002..850, P = 0.007) and HNE (r = 0.092, P = 0.002). These results demonstrate that there is a relationship between increased homocysteine concentrations and increased HNE concentrations in Alzheimer's disease...
- Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depressionMichael L Selley
Angiogen Pharmaceuticals Pty Ltd, P O Box 512, Turramurra, N S W 2074, Australia
J Affect Disord 80:249-56. 2004..Major depression is associated with the development of coronary heart disease (CHD) and greatly increases morbidity and mortality. There is an increase in circulating ADMA in CHD and vascular risk factors...
- Increased homocysteine and decreased adenosine formation in Alzheimer's diseaseMichael L Selley
Angiogen Pharmaceuticals Pty Ltd, Sydney, N S W, Australia
Neurol Res 26:554-7. 2004..773, p < 0.0001). The decrease in adenosine formation may play a role in the vascular pathology of homocysteine in Alzheimer's disease...
- Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in miceMichael L Selley
Angiogen Pharmaceuticals Pty Ltd, Level 31, ABN AMRO Tower, 88 Phillip Street, Sydney, N S W 2000, Australia
Brain Res 1037:1-6. 2005..Simvastatin may be a potential new treatment to slow the progression of Parkinson's disease...
- A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's diseaseMichael L Selley
Angiogen Pharmaceuticals Pty Ltd, Level 31, ABN AMRO Tower, 88 Phillip Street, Sydney, NSW 2000, Australia
Neurobiol Aging 28:1834-9. 2007..The evidence suggests that a metabolic link between the increased production of SAH and phospholipid metabolism may contribute to cerebrovascular and neurodegenerative changes in Alzheimer's disease...
- Treatment of autoimmune neuroinflammation with a synthetic tryptophan metaboliteMichael Platten
Department of Neurology and Neurological Sciences, Beckman Center for Molecular Medicine, Stanford University, Stanford, CA 94305, USA
Science 310:850-5. 2005..Trp catabolites and their derivatives offer a new strategy for treating T(H)1-mediated autoimmune diseases such as MS...