F L Rosenfeldt

Summary

Affiliation: Alfred Hospital
Country: Australia

Publications

  1. ncbi request reprint Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials
    F L Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital, Melbourne, Australia
    J Hum Hypertens 21:297-306. 2007
  2. ncbi request reprint Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Melbourne, Victoria, Australia
    Biofactors 18:91-100. 2003
  3. ncbi request reprint Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q10 therapy
    Franklin L Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia
    Int J STD AIDS 16:827-9. 2005
  4. ncbi request reprint The clinical application of metabolic therapy for cardiovascular disease
    Anthony Hadj
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital and Baker Heart Research Institute, Victoria, Australia
    Heart Lung Circ 16:S56-64. 2007
  5. doi request reprint Initial clinical experience with the VentrAssist left ventricular assist device: the pilot trial
    Donald S Esmore
    Department of Cardiothoracic Surgery, Alfred Hospital, Prahran, Victoria, Australia
    J Heart Lung Transplant 27:479-85. 2008
  6. doi request reprint Bacteraemia in Ventricular Assist Devices: A Common Complication that Need Not Affect Clinical Outcomes
    Franklin L Rosenfeldt
    Department of Cardiothoracic Surgery, The Alfred Hospital, Melbourne, Australia Electronic address
    Heart Lung Circ 23:234-41. 2014
  7. doi request reprint Oxidative stress in surgery in an ageing population: pathophysiology and therapy
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital, Department of Surgery, Monash University, Melbourne, Australia
    Exp Gerontol 48:45-54. 2013
  8. doi request reprint Coronary artery bypass surgery provides long-term results superior to percutaneous coronary intervention
    Franklin L Rosenfeldt
    Department of Surgery, The University of Melbourne, Australia
    Heart Lung Circ 21:1-11. 2012
  9. pmc Physical conditioning and mental stress reduction--a randomised trial in patients undergoing cardiac surgery
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital, Department of Surgery, Monash University, Baker IDI Institute Melbourne, Australia
    BMC Complement Altern Med 11:20. 2011
  10. ncbi request reprint Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute Wynn Domain, Melbourne, Prahran Victoria 3181, Australia
    Ann N Y Acad Sci 1019:78-84. 2004

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials
    F L Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital, Melbourne, Australia
    J Hum Hypertens 21:297-306. 2007
    ..3 (8.4-12.3, P<0.001) mm Hg. We conclude that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects...
  2. ncbi request reprint Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Melbourne, Victoria, Australia
    Biofactors 18:91-100. 2003
    ..Further trials of CoQ10 in physical exercise and in hypertension are recommended...
  3. ncbi request reprint Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q10 therapy
    Franklin L Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia
    Int J STD AIDS 16:827-9. 2005
    ..This suggests a novel therapy for further investigation targeted at ZDV induced myopathy, potentially allowing continuation of antiviral treatments including ZDV...
  4. ncbi request reprint The clinical application of metabolic therapy for cardiovascular disease
    Anthony Hadj
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital and Baker Heart Research Institute, Victoria, Australia
    Heart Lung Circ 16:S56-64. 2007
    ....
  5. doi request reprint Initial clinical experience with the VentrAssist left ventricular assist device: the pilot trial
    Donald S Esmore
    Department of Cardiothoracic Surgery, Alfred Hospital, Prahran, Victoria, Australia
    J Heart Lung Transplant 27:479-85. 2008
    ..The VentrAssist (VA) is a novel, continuous flow left ventricular assist device (LVAD). The purpose of this trial was to investigate the safety and efficacy of the VA in elderly patients with end-stage heart failure...
  6. doi request reprint Bacteraemia in Ventricular Assist Devices: A Common Complication that Need Not Affect Clinical Outcomes
    Franklin L Rosenfeldt
    Department of Cardiothoracic Surgery, The Alfred Hospital, Melbourne, Australia Electronic address
    Heart Lung Circ 23:234-41. 2014
    ..The aim of this study was to describe the incidence and microbiological aetiology of bacteraemia in patients with VADs, and to assess the impact of bacteraemia on clinical outcomes...
  7. doi request reprint Oxidative stress in surgery in an ageing population: pathophysiology and therapy
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital, Department of Surgery, Monash University, Melbourne, Australia
    Exp Gerontol 48:45-54. 2013
    ..We conclude that in surgical patients the assessment of oxidative stress, improvement of the understanding of its role, both positive and negative, and devising appropriate therapies represent fruitful fields for future research...
  8. doi request reprint Coronary artery bypass surgery provides long-term results superior to percutaneous coronary intervention
    Franklin L Rosenfeldt
    Department of Surgery, The University of Melbourne, Australia
    Heart Lung Circ 21:1-11. 2012
    ....
  9. pmc Physical conditioning and mental stress reduction--a randomised trial in patients undergoing cardiac surgery
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital, Department of Surgery, Monash University, Baker IDI Institute Melbourne, Australia
    BMC Complement Altern Med 11:20. 2011
    ..Secondary aims were to evaluate the effect of these programs on quality of life (QOL), rates of postoperative atrial fibrillation (AF) and length of stay (LOS) in hospital...
  10. ncbi request reprint Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute Wynn Domain, Melbourne, Prahran Victoria 3181, Australia
    Ann N Y Acad Sci 1019:78-84. 2004
    ....
  11. ncbi request reprint Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients
    Franklin L Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Prahran 3181, Australia
    Ann N Y Acad Sci 959:355-9; discussion 463-5. 2002
    ..We hypothesized that CoQ10 pretreatment prior to stress could improve the recovery of the myocardium after stress...
  12. ncbi request reprint The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium
    Franklin L Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital, Baker Institute, Melbourne, Australia
    Biogerontology 3:37-40. 2002
    ..4) Oral CoQ10 therapy before cardiac surgery improves efficiency of mitochondrial energy production, improves post-operative heart function, reduces intra-operative myocardial damage and shortens hospital stay...
  13. ncbi request reprint Occlusive wrap dressing reduces infection rate in saphenous vein harvest site
    Franklin L Rosenfeldt
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Victoria, Australia
    Ann Thorac Surg 75:101-5; discussion 105. 2003
    ..Data were collected in the hospital and then 4 to 6 weeks postoperatively. Superficial and deep wound infections were defined by the standard criteria from the Centers for Disease Control and Prevention...
  14. ncbi request reprint Weak beta-adrenoceptor-mediated relaxation in the human internal mammary artery
    G W He
    Baker Medical Research Institute, Melbourne, Australia
    J Thorac Cardiovasc Surg 97:259-66. 1989
    ..We conclude that beta-adrenoceptors would contribute little to the reactivity of the human internal mammary artery graft to sympathomimetic drugs...
  15. ncbi request reprint Pharmacological relaxation of the saphenous vein during harvesting for coronary artery bypass grafting
    G W He
    Baker Medical Research Institute, Melbourne, Australia
    Ann Thorac Surg 55:1210-7. 1993
    ..We now use a mixture of glyceryl trinitrate and verapamil (pH 7.4) topically and intraluminally during harvesting of the saphenous vein to provide a relaxed conduit for coronary artery bypass grafting...
  16. ncbi request reprint Mitral valve replacement via a right mini-thoracotomy in the dog: use of carbon dioxide to reduce intracardiac air
    W S Peters
    Cardiac Surgical Research Unit, Baker Medical Research Institute, Prahran Vic, Australia
    Eur J Cardiothorac Surg 11:1067-73. 1997
    ..To develop a clinically applicable method of minimally invasive mitral valve replacement (MVR) with cardioplegia, and examine the ability of carbon dioxide (CO2) to improve de-airing...
  17. ncbi request reprint Similar therapeutic serum levels attained with emulsified and oil-based preparations of coenzyme Q10
    W Lyon
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Melbourne, Victoria, Australia
    Asia Pac J Clin Nutr 10:212-5. 2001
    ..There was no change in any of the serum lipids following the 7 days treatment. We conclude that administration of either a soy oil suspension or a complex emulsion of CoQ10 increases serum levels to the therapeutic range within 1 week...
  18. ncbi request reprint Evaluation of techniques for lung transplantation following donation after cardiac death
    Gregory I Snell
    Lung Transplant Service, Alfred Hospital, Monash University, Melbourne, Australia
    Ann Thorac Surg 81:2014-9. 2006
    ....
  19. doi request reprint Effect of multiorgan donation after cardiac death retrieval on lung performance
    Gregory I Snell
    Lung Transplant Service, Alfred Hospital and Monash University, Melbourne, Victoria, Australia
    ANZ J Surg 78:262-5. 2008
    ..Although there are several novel individual techniques recently described for DCD lung donation, they have not been evaluated or compared in a DCD multiorgan scenario...
  20. ncbi request reprint Total leukocyte control for elective coronary bypass surgery does not improve short-term outcome
    Robert F Salamonsen
    Department of Intensive Care, Alfred Hospital, Melbourne, Australia
    Ann Thorac Surg 79:2032-8. 2005
    ..Despite early promise as a means of reducing the inflammatory response to surgery and subsequent organ damage, the evidence of the clinical value of leukocyte filtration remains equivocal...
  21. ncbi request reprint Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue
    Franklin Rosenfeldt
    The Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital, Baker Heart Research Institute, Melbourne, Australia
    J Thorac Cardiovasc Surg 129:25-32. 2005
    ....
  22. doi request reprint Veno-right ventricular cannulation reduces recirculation in extracorporeal membrane oxygenation
    S J Lindstrom
    Internal Medicine, The Alfred Hospital, Melbourne, Australia
    Perfusion 27:464-9. 2012
    ..We compared recirculation in veno-right ventricular support with that in conventional veno-venous support and its relationship with pump flow...
  23. ncbi request reprint Minimally invasive right heart operations: techniques for bicaval occlusion and cardioplegia
    W S Peters
    Department of Cardiac Surgical Research, Baker Medical Research Institute, Melbourne, Australia
    Ann Thorac Surg 64:1843-5. 1997
    ..In 4 canine studies, three variants of bicaval cannulation techniques were successfully used for atrial septal defect repair via a right minithoracotomy...
  24. ncbi request reprint Aspartate improves recovery of the recently infarcted rat heart after cardioplegic arrest
    F L Rosenfeldt
    Cardiac Surgical Research Unit, Baker Medical Research Institute and Alfred Hospital, Melbourne, Australia
    Eur J Cardiothorac Surg 14:185-90. 1998
    ..We have previously shown that aspartate improves the tolerance of normal hearts to cardioplegia. The aim of this study was to investigate whether aspartate is also beneficial in the recently infarcted heart...
  25. ncbi request reprint Pharmacology of coronary artery bypass grafts
    F L Rosenfeldt
    Cardiac Surgical Research Laboratory, Baker Medical Research Institute and Alfred Hospital, Prahran, Victoria, Australia
    Ann Thorac Surg 67:878-88. 1999
    ....
  26. ncbi request reprint Techniques of reconstruction for inadequate donor left atrial cuff in lung transplantation
    Takahiro Oto
    Department of Cardiothoracic Surgery, The Alfred Hospital, Monash University, Melbourne, Australia
    Ann Thorac Surg 81:1199-204. 2006
    ..This study aims to describe the incidence, efficacy, and various techniques of LA cuff reconstruction in lung transplantation...
  27. doi request reprint Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNA
    Francis Miller
    Cardiac Surgical Research Unit, Alfred Hospital, Dept of Surgery, Monash University, and Baker Heart Research Institute, Commercial Road Prahran, Victoria 3181, Australia
    Mech Ageing Dev 130:742-7. 2009
    ..We conclude that, although mtDNA mutations (as exemplified by mtDNA(4977)) accumulate in the ageing heart, they are unlikely to make a major contribution to loss of contractile function...
  28. ncbi request reprint Extracorporeal membrane oxygenation after lung transplantation: evolving technique improves outcomes
    Takahiho Oto
    Heart and Lung Transplant Unit, The Alfred Hospital, Monash University Medical School, Melbourne, Vic, Australia
    Ann Thorac Surg 78:1230-5. 2004
    ..Extracorporeal membrane oxygenation (ECMO) may provide lifesaving temporary support; however, its longer-term efficacy is controversial...
  29. ncbi request reprint A practical approach to clinical lung transplantation from a Maastricht Category III donor with cardiac death
    Takahiro Oto
    Lung Transplant Service, The Alfred Hospital and Monash University, Melbourne, Australia
    J Heart Lung Transplant 26:196-9. 2007
    ....
  30. doi request reprint Focal cerebral oxygenation and neurological outcome with or without brain tissue oxygen-guided therapy in patients with traumatic brain injury
    A A Adamides
    Department of Neurosurgery, Alfred Hospital, Prahran, Victoria 3181, Australia
    Acta Neurochir (Wien) 151:1399-409. 2009
    ..This study aimed to evaluate the efficacy of brain oxygen-guided therapy in improving cerebral oxygenation and neurological outcome in severe TBI patients...
  31. ncbi request reprint Early outcomes comparing Perfadex, Euro-Collins, and Papworth solutions in lung transplantation
    Takahiro Oto
    Heart and Lung Transplant Unit, The Alfred Hospital, Melbourne, Australia
    Ann Thorac Surg 82:1842-8. 2006
    ..This study aimed to investigate the effect of the three solutions most commonly used (Perfadex [Vitrolife, Göteborg, Sweden], Papworth, and Euro-Collins [Baxter Healthcare, Old Toongabbie NSW, Australia]) on posttransplant outcomes...
  32. ncbi request reprint Pre-operative preparation for cardiac surgery utilising a combination of metabolic, physical and mental therapy
    Anthony Hadj
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Monash University, Alfred Hospital, Melbourne, Vic, Australia
    Heart Lung Circ 15:172-81. 2006
    ....
  33. ncbi request reprint Antioxidant therapy for severe cardiac failure induced by iron overload secondary to dyserythropoietic anaemia
    Juliana van der Merwe
    Department of Cardiothoracic Surgery, Melbourne, Victoria, Australia
    Heart Lung Circ 16:394-7. 2007
    ..This therapy may have wider application in refractory heart failure and in the prevention of cardiomyopathy in patients receiving regular red cell transfusions who are at risk of transfusional haemosiderosis...
  34. ncbi request reprint High-flow endobronchial cooled humidified air protects non-heart-beating donor rat lungs against warm ischemia
    Takahiro Oto
    Heart and Lung Transplant Unit, The Alfred Hospital, Monash University, Melbourne, Australia
    J Thorac Cardiovasc Surg 132:413-9. 2006
    ..This study investigated the preservative effect of high-flow endobronchial cooled humidified air during warm ischemia in non-heart-beating donor rat lungs...
  35. pmc Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse
    Phyllis Chew
    Oxidative Stress Laboratory, Diabetes Division, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Diabetes 59:3198-207. 2010
    ..To investigate the effect of the GPx1-mimetic ebselen on diabetes-associated atherosclerosis and renal injury in a model of increased oxidative stress...
  36. ncbi request reprint Extended pericardiotomy avoids cardiopulmonary bypass during bilateral sequential lung transplantation
    Takahiro Oto
    Department of Cardiothoracic Surgery, The Alfred Hospital, Monash University, Melbourne, Australia
    J Thorac Cardiovasc Surg 129:466-7. 2005
  37. ncbi request reprint A reinforced sternal wiring technique for transverse thoracosternotomy closure in bilateral lung transplantation: from biomechanical test to clinical application
    Takahiro Oto
    Department of Cardiothoracic Surgery, Heart and Lung Transplant Unit, The Alfred Hospital, Monash University, Melbourne, Australia
    J Thorac Cardiovasc Surg 134:218-24. 2007
    ..The aims of this study were to investigate the biomechanical and clinical efficacy of the proposed reinforced sternal closure technique...
  38. ncbi request reprint Heterotopic heart transplantation: an expanding role in the twenty-first century?
    Andrew E Newcomb
    Heart and Lung Transplantation Service, Alfred Hospital, Melbourne, Victoria, Australia
    Ann Thorac Surg 78:1345-50; discussion 1350-1. 2004
    ..We also anticipated an increased cardiac allograft utilization, and improvement of our waiting list times...
  39. ncbi request reprint Coenzyme Q10 in cardiovascular disease
    Salvatore Pepe
    CJOB Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Australia
    Mitochondrion 7:S154-67. 2007
    ..3. Presently, due to the notable absence of clinically significant side effects and likely therapeutic benefit, CoQ(10) can be considered a safe adjunct to standard therapies in cardiovascular disease...
  40. pmc Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age
    Francis J Miller
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Institute, Commercial Road, Prahran, Victoria 3181, Australia
    Nucleic Acids Res 31:e61. 2003
    ..This PCR-based assay not only enables accurate determination of mtDNA relative to nuclear DNA but also has the potential to quantify accurately any DNA sequence in relation to any other...
  41. ncbi request reprint Early institution of mechanical support improves outcomes in primary cardiac allograft failure
    Silvana F Marasco
    CJOB Cardiothoracic Surgery Unit, The Alfred Hospital, Melbourne, Australia
    J Heart Lung Transplant 24:2037-42. 2005
    ....
  42. ncbi request reprint Initial in vivo experience of the VentrAssist implantable rotary blood pump in sheep
    Anita L van der Meer
    VentrAssist Division, Ventracor Ltd, Sydney, New South Wales, Australia
    Artif Organs 27:21-6. 2003
    ..These studies demonstrate the suitability of the animal model for evaluation of the VentrAssist rotary blood pump. Further in vivo studies prior to preclinical trials are in progress...
  43. ncbi request reprint In vitro comparison of glyceryl trinitrate-verapamil with other dilators of human saphenous vein
    L S Bruno Jesuthasan
    Cardiac Surgical Research Unit, The Alfred Hospital and Baker Institute, Department of Pharmacology, The University of Melbourne, Melbourne, Australia
    ANZ J Surg 73:313-20. 2003
    ..The present organ bath study was designed (i) to determine the best vasodilator agents for the saphenous vein during harvesting and (ii) to investigate the presence of any synergistic effect when vasodilator agents are combined...
  44. ncbi request reprint The split radial technique: an alternative to the Y-graft for total arterial myocardial revascularisation
    Donald S Esmore
    Department of Cardiothoracic Surgery, Alfred Hospital and Cardiac Surgical Research Unit Alfred Hospital and Baker Medical Research Institute, The Alfred, Commercial Road, Melbourne, VIC 3004, Australia
    Heart Lung Circ 14:32-5. 2005
    ..We describe the split radial technique of constructing two aorto-coronary graft segments from a single radial artery that can be used to avoid the use of Y-grafts...
  45. ncbi request reprint What is the role of leukocyte depletion in cardiac surgery?
    Hou Kiat Lim
    Cardiac Surgical Research Unit, Alfred Hospital, Melbourne, Australia
    Heart Lung Circ 16:243-53. 2007
    ..Future trials should be powered to detect important clinical end points and be designed to avoid premature exhaustion of the filter...
  46. ncbi request reprint First clinical implant of the VentrAssist left ventricular assist system as destination therapy for end-stage heart failure
    Donald S Esmore
    Department of Cardiothoracic Surgery, Alfred Hospital, Prahran, Victoria, Australia
    J Heart Lung Transplant 24:1150-4. 2005
    ..The implant and recovery were uneventful, and the patient survives at 17 months, is NYHA class II, and lives at home. This device shows promise in end-stage heart failure for permanent implantation and bridge to transplantation...
  47. doi request reprint Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression
    Olivier W V van den Brink
    Department of Cardiothoracic Surgery, Alfred Hospital and Department of Surgery, Monash University, Melbourne, Australia
    J Renin Angiotensin Aldosterone Syst 8:153-9. 2007
    ..The goal of this investigation was to examine how cardiac levels of enkephalin production are altered in the development of normotensive primary hypertrophy due to elevated intra-cardiac angiotensin II (Ang II) production...
  48. ncbi request reprint Mechanical circulatory support for the failing heart: past, present and future
    Donald Esmore
    Heart Lung Circ 14:163-6. 2005