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Genomes and Genes | Sharon R LewinSummaryAffiliation: Alfred Hospital Country: Australia Publications
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Finding a cure for HIV: will it ever be achievable?Sharon R Lewin
Department of Medicine, Monash University, Melbourne, Australia
J Int AIDS Soc 14:4. 2011....
Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patientTheo Gouskos
Department of Medicine (RMH, University of Melbourne, Melbourne, Australia
AIDS 18:1734-7. 2004..However, a strong HBV-specific CD8 T-cell response was identified and may have resulted in the severe hepatitis...- Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapySonia Fernandez
School of Surgery and Pathology, University of Western Australia, Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, The University of Melbourne, Melbourne, Australia
AIDS Res Hum Retroviruses 22:163-70. 2006..However, the data are consistent with extrathymic T cell production contributing to the naive T cell pool in some patients... - The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infectionMiranda Shehu-Xhilaga
Infectious Diseases Unit, Alfred Hospital, Prahran, Australia
Retrovirology 4:7. 2007..Little is known about the progression and pathogenesis of HIV-1 infection within the male genital tract (MGT), particularly during the early stages of infection... - Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individualsPeter A Revill
Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, Victoria 3051, Australia
AIDS 21:1701-10. 2007..To test this hypothesis, we have analysed genome-length sequences of HBV DNA from patients both prior to and during antiviral therapy... - Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infectionSharon R Lewin
Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
J Acquir Immune Defic Syndr 47:140-47. 2008..Commencing ARVs during primary HIV-1 infection (PHI) may limit the size of the latent pool and lead to improved control of viral replication during structured treatment interruption (STI)... - HIV research in Australia: linking basic research findings with clinical and public health outcomesSharon R Lewin
Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
Retrovirology 3:86. 2006..The meeting is expected to attract over 5000 participants and will have a dynamic and innovative programme within the three major themes of HIV basic science, clinical research and biomedical prevention... - Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: similar effectiveness of lamivudine, tenofovir, or combination therapySharon R Lewin
Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
Hepatology 49:1113-21. 2009..HIV-1 coinfection has minimal effect on HBV viral dynamics, even in the setting of advanced HIV-1-related immunosuppression... - No increase in hepatitis B virus (HBV)-specific CD8+ T cells in patients with HIV-1-HBV coinfections following HBV-active highly active antiretroviral therapyMegan Crane
Department of Medicine, Monash University, Melbourne, Australia
J Virol 84:2657-65. 2010..These findings may have implications for the duration of treatment of HBV in HIV-HBV coinfected patients, particularly in HBeAg-positive disease... 
Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated agingEdwin Leeansyah
Department of Medicine, Monash University, Melbourne, Australia
J Infect Dis 207:1157-65. 2013..We hypothesized that nucleos(t)ide reverse transcriptase inhibitors (NRTI) may contribute to accelerated aging in HIV-infected individuals on cART via inhibition of telomerase activity...- Factors associated with elevated ALT in an international HIV/HBV co-infected cohort on long-term HAARTJennifer Audsley
Department of Medicine, Monash University, Melbourne, Australia
PLoS ONE 6:e26482. 2011.... - Both CD31(+) and CD31⁻ naive CD4(+) T cells are persistent HIV type 1-infected reservoirs in individuals receiving antiretroviral therapyFiona Wightman
Department of Medicine, Monash University, Melbourne, Australia
J Infect Dis 202:1738-48. 2010..Naive T cell recovery is critical for successful immune reconstitution after antiretroviral therapy (ART), but the relative contribution of CD31(+) and CD31⁻ naive T cells to immune reconstitution and viral persistence is unknown... - HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entryMichael Roche
Center for Virology, Burnet Institute, Melbourne, Victoria, Australia
Retrovirology 8:89. 2011..However, the CCR5-using CC1/85 strain appears to be uniquely predisposed to acquiring resistance to several CCR5 antagonists in vitro including MVC, vicriviroc and AD101... - Coinfection of hepatic cell lines with human immunodeficiency virus and hepatitis B virus leads to an increase in intracellular hepatitis B surface antigenDavid M Iser
Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
J Virol 84:5860-7. 2010.... - HBV mutations in untreated HIV-HBV co-infection using genomic length sequencingJennifer Audsley
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Virology 405:539-47. 2010..Further work is needed to determine if these mutational patterns influence the differences in liver disease progression in HIV-HBV co-infected and HBV mono-infected patients... - The anti-HIV activity of entecavir: a multicentre evaluation of lamivudine-experienced and lamivudine-naive patientsJoe Sasadeusz
The Alfred Hospital, Melbourne, Victoria, Australia
AIDS 22:947-55. 2008.... - Increased intrahepatic apoptosis but reduced immune activation in HIV-HBV co-infected patients with advanced immunosuppressionDavid M Iser
Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Australia
AIDS 25:197-205. 2011.... - Human thymic dendritic cells: regulators of T cell development in health and HIV-1 infectionVanessa A Evans
Monash University, Department of Medicine, Central and Eastern Clinical School, Alfred Campus, Melbourne, Victoria, Australia
Clin Immunol 126:1-12. 2008..Here we review the phenotype and function of different DC subsets found within the human thymus and discuss potential mechanisms of how DCs may be important in CD4(+) T cell dysfunction in HIV-1 infection... - Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeletonPaul U Cameron
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria 3004, Australia
Proc Natl Acad Sci U S A 107:16934-9. 2010..We propose a unique pathway for establishment of latency by direct HIV-1 infection of resting CD4(+) T cells during normal chemokine-directed recirculation of CD4(+) T cells between blood and tissue... - Reduced hepatitis B virus (HBV)-specific CD4+ T-cell responses in human immunodeficiency virus type 1-HBV-coinfected individuals receiving HBV-active antiretroviral therapyJ Judy Chang
Infectious Diseases Unit, Alfred Hospital, Commercial Rd, Melbourne, Victoria 3004, Australia
J Virol 79:3038-51. 2005..Therefore, HIV-1 infection has a significant and specific effect on HBV-specific T-cell immunity... - Highly reproducible transient transfections for the study of hepatitis B virus replication based on an internal GFP reporter systemTheo Gouskos
Department of Medicine (RMH, University of Melbourne, Vic, Australia
J Virol Methods 121:65-72. 2004..The presence of an internal GFP reporter increased the efficiency of generating highly reproducible results and facilitated multiple forms of analysis from a single transfection accurately... - The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivoPhilip J Ellery
AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
J Immunol 178:6581-9. 2007..Collectively, these data show that CD16+ monocytes are preferentially susceptible to HIV-1 entry, more permissive for replication, and constitute a continuing source of viral persistence during HAART... - Immunopathogenesis of hepatic flare in HIV/hepatitis B virus (HBV)-coinfected individuals after the initiation of HBV-active antiretroviral therapyMegan Crane
Department of Medicine, Monash University, and Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
J Infect Dis 199:974-81. 2009..The pathogenesis of and risk factors for hepatic flare (HF) after the initiation of hepatitis B virus (HBV)-active antiretroviral therapy (ART) in HIV/HBV-coinfected individuals is not well understood... - Differential expression of CD163 on monocyte subsets in healthy and HIV-1 infected individualsEmma Tippett
Centre for Virology, The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
PLoS ONE 6:e19968. 2011..Levels of CD163 expression on monocytes may be a potential biomarker reflecting efforts by the immune system to resolve immune activation and inflammation in HIV-infected individuals... - Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cellsSuha Saleh
Department of Medicine, Monash University, Melbourne, Vic, Australia
Retrovirology 8:80. 2011..The main aim of this study was to fully define the post-integration blocks to virus replication in this model of CCL19-induced HIV latency... - Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activationGregor F Lichtfuss
Centre for Virology, Burnet Institute, Melbourne, Victoria 3004, Australia
J Immunol 189:1491-9. 2012..This suggests that NK cells respond to factors different from those driving T cell activation, but which are associated with inflammation in HIV patients... - HIV replication is associated with increased severity of liver biopsy changes in HIV-HBV and HIV-HCV co-infectionJennifer Audsley
The Alfred Hospital, Melbourne, Victoria, Australia
J Med Virol 84:993-1001. 2012..The association between HIV RNA and necroinflammation supports current recommendations for earlier initiation of HAART in patients with HIV-hepatitis co-infection... - Impaired quality of the hepatitis B virus (HBV)-specific T-cell response in human immunodeficiency virus type 1-HBV coinfectionJ Judy Chang
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia
J Virol 83:7649-58. 2009..The quality of the HBV-specific T-cell response is impaired in the setting of HIV-1-HBV coinfection and is related to the CD4+ T-cell count... - The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cellsMiranda Shehu-Xhilaga
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
AIDS 23:2047-50. 2009..Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients... - Decreased NK Cell FcRgamma in HIV-1 infected individuals receiving combination antiretroviral therapy: a cross sectional studyEdwin Leeansyah
Centre for Virology, The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
PLoS ONE 5:e9643. 2010..Previous study from our laboratory showed that FcRgamma is down-regulated in HIV-infected macrophages in vitro. FcRgamma expression in immune cells present in HIV-infected individuals is unknown... - Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavirJennifer F Hoy
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
J Infect Dis 190:688-92. 2004..During the 24-week study, there was no significant change in mtDNA copy numbers in PBMCs in either treatment group, despite improvement in peripheral lipoatrophy among patients whose treatment was switched to abacavir... - HIV persistence: chemokines and their signalling pathwaysVanessa A Evans
Department of Medicine, Monash University, Melbourne, 3004, Australia
Cytokine Growth Factor Rev 23:151-7. 2012..Here we review the role of chemokines in HIV persistence; the main signalling pathways that are involved; and how these pathways may be exploited to develop novel strategies to reduce or eliminate latently infected cells... - CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latencySuha Saleh
Departments of Medicine, Alfred Hospital, Melbourne, Australia
Blood 110:4161-4. 2007..CCR7 ligands facilitate efficient entry of HIV-1 into resting CD4(+) T cells. These studies demonstrate a unique action of the chemokines CCL19 and CCL21 and provide a novel model with which to study HIV-1 latency in vitro... - The role of naïve T-cells in HIV-1 pathogenesis: an emerging key playerGabriela Khoury
Department of Medicine, Monash University, Melbourne Victoria, 3004, Australia
Clin Immunol 141:253-67. 2011..Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naïve CD4+ T-cells... - Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophagesClare L V Westhorpe
Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
J Leukoc Biol 85:1027-35. 2009.... - Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytesPaul U Cameron
Department of Immunology, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia
J Virol 81:2297-306. 2007..Early selective infection of immature blood DCs by R5 virus and upregulation of viral expression during DC-T-cell interaction and transmission provide a potential pathway for R5 selection following parenteral transmission... - Enhanced replicative capacity and pathogenicity of HIV-1 isolated from individuals infected with drug-resistant virus and declining CD4+ T-cell countsAjantha Solomon
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
J Acquir Immune Defic Syndr 40:140-8. 2005..In summary, although drug resistance may lead to impaired viral fitness, the capacity of virus quasispecies from PBMCs to use CXCR4 may have significant consequences on viral replicative capacity and potentially on clinical outcome... - Variable uptake of recommended interventions to reduce mother-to-child transmission of HIV in Australia, 1982-2005Michelle L Giles
Department of Medicine, Monash University, Melbourne, Vic, Australia
Med J Aust 189:151-4. 2008..To analyse the uptake of interventions known to reduce the risk of perinatal HIV transmission among Australian women with HIV infection (who knew their HIV status before delivery), and identify predictors of uptake... - Clinical predictors of immune reconstitution following combination antiretroviral therapy in patients from the Australian HIV Observational DatabaseReena Rajasuriar
Department of Medicine, Monash University, Melbourne, Victoria, Australia
PLoS ONE 6:e20713. 2011..These patients remain at risk of AIDS and non-AIDS defining illnesses. The aim of this study was to identify clinical factors associated with CD4 T-cell recovery following long-term cART... - Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocationReena Rajasuriar
Department of Medicine, Monash University, Burnet Institute, University of Melbourne, Melbourne, Australia
J Infect Dis 202:1254-64. 2010..We hypothesized that residual immune activation and polymorphisms in the interleukin 7 (IL-7) receptor α (IL-7Rα) gene were important for immune recovery... - Chronic hepatitis B infection and pregnancyMichelle L Giles
Department of Infectious Diseases, Monash Medical Centre, and Infectious Disease Unit, The Alfred Hospital, Melbourne, Australia
Obstet Gynecol Surv 67:37-44. 2012.... - Extremely prolonged HIV seroconversion associated with an MHC haplotype carrying disease susceptibility genes for antibody deficiency disordersAlex Padiglione
Infectious Diseases Unit, Monash Medical Centre, Clayton, Victoria, Australia
Clin Immunol 137:199-208. 2010..This highlights the need for multiparameter testing, in particular use of a fourth generation HIV test, for confirming HIV infection and underscores the importance of host factors in HIV pathogenesis... - A novel, rapid method to detect infectious HIV-1 from plasma of persons infected with HIV-1Alyssa Cornall
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
J Virol Methods 165:90-6. 2010..This technique could be used for rapid evaluation of viral fitness, co-receptor usage or drug resistance without the need for viral amplification... - The pathogenesis of liver disease in the setting of HIV-hepatitis B virus coinfectionDavid M Iser
Department of Medicine, The University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
Antivir Ther 14:155-64. 2009..In addition, an impaired HBV-specific T-cell immune response is likely to be important. The roles of microbial translocation, immune activation and increased hepatic stellate cell activation will be important areas for future study... - HIV inhibits early signal transduction events triggered by CD16 cross-linking on NK cells, which are important for antibody-dependent cellular cytotoxicityGregor F Lichtfuss
Centre for Virology, Burnet Institute, Melbourne, Victoria 3004, Australia
J Leukoc Biol 89:149-58. 2011.... - Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitroVanessa A Evans
Monash University, Department of Medicine, Central and Eastern Clinical School, Alfred Campus, Commercial Rd, Melbourne, Victoria 3004, Australia
Retrovirology 8:43. 2011..Transfer of productive HIV-1 infection from thymic mDC and pDC was determined by culturing these DC subsets either alone or with sorted thymocytes... - Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infectionGregor F Lichtfuss
Centre for Virology, Burnet Institute, Melbourne, Australia
Biomark Med 5:171-86. 2011.... - HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropismMichael Roche
Centers for Virology, Monash University, Australia
J Virol 85:4330-42. 2011.... - A new way of measuring apoptosis by absolute quantitation of inter-nucleosomally fragmented genomic DNADavid J Hooker
Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia
Nucleic Acids Res 40:e113. 2012.... - HDAC inhibitors in HIVFiona Wightman
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Immunol Cell Biol 90:47-54. 2012..In this review, we will review the rationale as well as in vitro and clinical trial data that support the role of histone deacetylase inhibitors as one approach to cure HIV... - Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative diseaseChristopher P Desmond
Department of Gastroenterology, The Alfred, Melbourne, Australia
J Virol 86:1181-92. 2012..003). Thus, HBV appears to be under immune pressure in chronic HBV infection, particularly in HBeAg-negative disease... - Phase 1 single dose studies to optimize the pharmacokinetics of DG17, a novel HIV-protease inhibitor pro-drug, using sodium bicarbonate and ritonavirCatherine L Cherry
Burnet Institute, Melbourne, Australia
Curr HIV Res 6:272-5. 2008..No significant adverse events occurred. Single dose DG17 is safe and best administered in a manner preventing gastric acid degradation and with low-dose ritonavir... - What are the barriers to offering HIV testing in an antenatal setting? A national study of obstetriciansMichelle L Giles
Department of Medicine Monash University, and Centre for Epidemiology and Population Health Research, Macfarlane Burnet Institute, Melbourne, Victoria 3004, Australia
AIDS 21:1601-6. 2007..To investigate factors that influence the antenatal screening practice of obstetricians and identify barriers to the implementation of universal antenatal HIV screening... - Antenatal screening practice for infectious diseases by general practitioners in AustraliaMichelle L Giles
Centre for Population Health Research, Burnet Institute, Melbourne, Victoria, Australia
Aust N Z J Obstet Gynaecol 49:39-44. 2009..This study aimed to assess self-reported screening practice in the antenatal setting, factors associated with screening, barriers to universal testing for HIV and follow-up for infants born to hepatitis C virus (HCV)-infected women... - Differential dynamics of donor DC and non-DC peripheral blood mononuclear cell microchimerism in lung transplantationJoel Van der Meulen
Department of Medicine, Monash University, Melbourne, Australia
Clin Immunol 133:179-83. 2009..49, p=0.001). Preferential DC persistence compared to non-DC may indicate tolerance induction but future studies are required to determine if DC microchimerism after transplantation affects clinical outcomes... - Early events of HIV-1 infection: can signaling be the next therapeutic target?Kate L Jones
Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia
J Neuroimmune Pharmacol 6:269-83. 2011..We argue that these pathways may represent novel targets for antiviral therapy... - Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivoPaul R Gorry
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Retrovirology 4:66. 2007.... - Immunopathogenesis of hepatitis B virus infectionJ Judy Chang
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
Immunol Cell Biol 85:16-23. 2007..In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease... - Ten years of highly active antiretroviral therapy for HIV infectionLuke F Chen
Infectious Diseases Unit, The Alfred Hospital, Melbourne, Vic
Med J Aust 186:146-51. 2007..Drug-drug interactions are common and caution is required when prescribing ARVs that inhibit or induce the cytochrome P450 pathway... - Comparison of sequence analysis and a novel discriminatory real-time PCR assay for detection and quantification of Lamivudine-resistant hepatitis B virus strainsFiona Wightman
Department of Medicine, Monash University, Melbourne, Australia
J Clin Microbiol 42:3809-12. 2004..Excellent concordance was demonstrated between sequencing and the discriminatory real-time assay; however, a mixture of quasispecies was more frequently detected by discriminatory real-time PCR... - A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeuticsChristopher P Desmond
Department of Gastroenterology, Alfred Hospital, Melbourne, Australia
Antivir Ther 13:161-75. 2008..The immune response to hepatitis B virus (HBV) is important for both viral control and disease pathogenesis. A detailed understanding of the HBV-specific T-cell responses may potentially lead to novel therapeutic strategies for HBV... - The "work" of women when considering and using interventions to reduce mother-to-child transmission (MTCT) of HIVMichelle L Giles
The Alfred Hospital, Infectious Diseases Unit, Melbourne, Australia
AIDS Care 21:1230-7. 2009..Even in circumstances where access to and acceptance of interventions are high, women continue to engage in this work even after they have a made a decision about a particular intervention... - HIV reservoirs and strategies for eradicationMiranda Z Smith
Department of Medicine, Central Clinical School, Monash University, Melbourne, Australia
Curr HIV/AIDS Rep 9:5-15. 2012..Finally, we review the scientific rationale of and clinical experience with pharmacotherapeutic strategies aimed at eliminating latently infected cells... - HIV-1 cell entry and advances in viral entry inhibitor therapyLouise A Cooley
Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Parkville, Vic, Australia
J Clin Virol 26:121-32. 2003..A greater number of HIV-1 entry inhibitors are in preclinical development. This review outlines the mechanisms involved in HIV-1 entry and the sites of action of specific HIV-1 inhibitors... - Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndromeLachlan Gray
Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, 3001 Victoria, Australia Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
Virology 337:384-98. 2005..Thus, reduced CD4/CCR5 dependence is a phenotype of R5 HIV-1 associated with M-tropism and late stage infection, which may affect the efficacy of HIV-1 entry inhibitors... - Human immunodeficiency virus infection and the liverMegan Crane
Megan Crane, Sharon R Lewin, Department of Medicine, Monash University, Melbourne 3004, Australia
World J Hepatol 4:91-8. 2012.... - Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S geneJoseph Torresi
Department of Medicine RMH WH, University of Melbourne, Melbourne, Victoria 3050, Australia
Virology 299:88-99. 2002..Since these viruses carry mutations in the a determinant of HBsAg that may potentially decrease the ability of anti-HBs antibody to neutralize these viruses, these HBV mutants also have the potential to behave as vaccine escape mutants... - The evidence for a change in antenatal HIV screening policy in AustraliaMichelle L Giles
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Med J Aust 185:217-20. 2006..A universal antenatal HIV screening program meets many of the Wilson and Jungner criteria for population-based screening programs. This should be considered in the current review of Australia's HIV testing policy... - Hepatitis virus immune restoration disease of the liverMegan Crane
aDepartment of Medicine, Monash University, Melbourne, Sydney bNational Centre for HIV Epidemiology and Clinical Research and St Vincent s Hospital, Sydney cInfectious Diseases Unit, Alfred Hospital, Melbourne, Australia
Curr Opin HIV AIDS 3:446-52. 2008..SUMMARY: Further randomized clinical trials are needed to develop improved management strategies for hepatitis immune restoration disease... - HIV cure and eradication: how will we get from the laboratory to effective clinical trials?Sharon R Lewin
Infectious Diseases Unit, Alfred Hospital, 85 Commercial Road, Melbourne, VIC 3004, Australia
AIDS 25:885-97. 2011..In addition, we discuss key issues that need to be addressed to successfully move laboratory research to clinical trials aimed at curing HIV... - Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fatCatherine L Cherry
Department of Infectious Diseases and Microbiology, The Alfred Hospital, Melbourne, Australia
J Acquir Immune Defic Syndr 30:271-7. 2002..A reliable and valid laboratory test to detect this is not yet available. The objective of this study was to correlate tissue mtDNA quantification in HIV-infected patients with exposure to nucleoside analogs... - A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naïve individuals in ThailandGail V Matthews
Viral Hepatitis Program, National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Darlinghurst, Sydney, NSW, Australia
Hepatology 48:1062-9. 2008..This study confirms current treatment guidelines that recommend a TDF-based regimen as the treatment of choice for HIV/HBV coinfection, but does not demonstrate any advantage of HBV combination therapy in this short-term setting... - Immunological and virological failure after antiretroviral therapy is associated with enhanced peripheral and thymic pathogenicityAjantha Solomon
Department of Microbiology and Immunology, University of Melbourne, and Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia
J Infect Dis 187:1915-23. 2003..Although there was a high prevalence of mutations in the protease and reverse transcriptase genes in discordant immunological responders, these changes were also observed in nonresponders... - Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infectionSharon R Lewin
Department of Microbiology and Immunology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
J Immunol 169:4657-66. 2002.... - A phase I study of the pharmacokinetics and safety of passive immunotherapy with caprine anti-HIV antibodies, (PE)HRG214, in HIV-1-infected individualsSarah L Pett
HIV, Immunology and Infectious Diseases Clinical Services, St Vincent s Hospital, Sydney, and National Centre in HIV Epidemiology and Clinical Research, University of NSW, Darlinghurst, Sydney, Australia
HIV Clin Trials 5:91-8. 2004..To establish the pharmacokinetics and safety of single-dose polyclonal caprine anti-HIV antibodies ((PE)HRG214)in HIV-1-infected individuals... - Incidence of putative HIV superinfection and sexual practices among HIV-infected men who have sex with menMohsin M Sidat
School of Population Health, The University of Melbourne, VIC 3010, Australia
Sex Health 5:61-7. 2008..To determine the upper limit for the incidence of clinically important HIV superinfection among HIV-infected men who have sex with men (MSM) and its relationship with engagement in unsafe sexual practices... - HIV-1 down-modulates gamma signaling chain of Fc gamma R in human macrophages: a possible mechanism for inhibition of phagocytosisKatherine Kedzierska
AIDS Pathogenesis Research Unit, Macfarlane Burnet Center, Victoria, Australia
J Immunol 168:2895-903. 2002.... - Sexually transmissible infection and HIV management among men who have sex with men with and without HIV: survey of medical practitioners who are members of the Australasian Society for HIV MedicineChristopher K Fairley
Melbourne Sexual Health Centre, 580 Swanston Street, Carlton, VIC 3053, Australia
Sex Health 5:155-9. 2008..Our aim was to determine if the use of suppressive treatment for genital herpes, the treatment of HIV or STI screening practices were different between states in Australia... - Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistanceScott Preiss
Victorian Infectious Diseases Reference Laboratories, Research and Molecular Development, North Melbourne, Victoria, Australia
Hepatology 48:741-9. 2008....
Research Grants
- Interaction in vivo between HIV and Hepatitis B VirusSharon Lewin; Fiscal Year: 2005..abstract_text> ..