Sharon R Lewin

Summary

Affiliation: Alfred Hospital
Country: Australia

Publications

  1. pmc Finding a cure for HIV: will it ever be achievable?
    Sharon R Lewin
    Department of Medicine, Monash University, Melbourne, Australia
    J Int AIDS Soc 14:4. 2011
  2. ncbi request reprint Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient
    Theo Gouskos
    Department of Medicine RMH, University of Melbourne, Melbourne, Australia
    AIDS 18:1734-7. 2004
  3. ncbi request reprint Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapy
    Sonia Fernandez
    School of Surgery and Pathology, University of Western Australia, Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, The University of Melbourne, Melbourne, Australia
    AIDS Res Hum Retroviruses 22:163-70. 2006
  4. pmc The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection
    Miranda Shehu-Xhilaga
    Infectious Diseases Unit, Alfred Hospital, Prahran, Australia
    Retrovirology 4:7. 2007
  5. ncbi request reprint Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individuals
    Peter A Revill
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, Victoria 3051, Australia
    AIDS 21:1701-10. 2007
  6. pmc HIV research in Australia: linking basic research findings with clinical and public health outcomes
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    Retrovirology 3:86. 2006
  7. ncbi request reprint Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infection
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    J Acquir Immune Defic Syndr 47:140-47. 2008
  8. pmc Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: similar effectiveness of lamivudine, tenofovir, or combination therapy
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    Hepatology 49:1113-21. 2009
  9. pmc No increase in hepatitis B virus (HBV)-specific CD8+ T cells in patients with HIV-1-HBV coinfections following HBV-active highly active antiretroviral therapy
    Megan Crane
    Department of Medicine, Monash University, Melbourne, Australia
    J Virol 84:2657-65. 2010
  10. doi request reprint The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets
    Jacqueline K Flynn
    Center for Virology, Burnet Institute, Melbourne, Vic, Australia
    Virology 442:51-8. 2013

Research Grants

Detail Information

Publications84

  1. pmc Finding a cure for HIV: will it ever be achievable?
    Sharon R Lewin
    Department of Medicine, Monash University, Melbourne, Australia
    J Int AIDS Soc 14:4. 2011
    ....
  2. ncbi request reprint Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient
    Theo Gouskos
    Department of Medicine RMH, University of Melbourne, Melbourne, Australia
    AIDS 18:1734-7. 2004
    ..However, a strong HBV-specific CD8 T-cell response was identified and may have resulted in the severe hepatitis...
  3. ncbi request reprint Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapy
    Sonia Fernandez
    School of Surgery and Pathology, University of Western Australia, Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, The University of Melbourne, Melbourne, Australia
    AIDS Res Hum Retroviruses 22:163-70. 2006
    ..However, the data are consistent with extrathymic T cell production contributing to the naive T cell pool in some patients...
  4. pmc The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection
    Miranda Shehu-Xhilaga
    Infectious Diseases Unit, Alfred Hospital, Prahran, Australia
    Retrovirology 4:7. 2007
    ..Little is known about the progression and pathogenesis of HIV-1 infection within the male genital tract (MGT), particularly during the early stages of infection...
  5. ncbi request reprint Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individuals
    Peter A Revill
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, Victoria 3051, Australia
    AIDS 21:1701-10. 2007
    ..To test this hypothesis, we have analysed genome-length sequences of HBV DNA from patients both prior to and during antiviral therapy...
  6. pmc HIV research in Australia: linking basic research findings with clinical and public health outcomes
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    Retrovirology 3:86. 2006
    ..The meeting is expected to attract over 5000 participants and will have a dynamic and innovative programme within the three major themes of HIV basic science, clinical research and biomedical prevention...
  7. ncbi request reprint Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infection
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    J Acquir Immune Defic Syndr 47:140-47. 2008
    ..Commencing ARVs during primary HIV-1 infection (PHI) may limit the size of the latent pool and lead to improved control of viral replication during structured treatment interruption (STI)...
  8. pmc Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: similar effectiveness of lamivudine, tenofovir, or combination therapy
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    Hepatology 49:1113-21. 2009
    ..9 days (6.3-11.0 days). When we compared hepatitis B e antigen (HBeAg)-positive and HBeAg-negative individuals, we found a significantly longer infected cell half-life in HBeAg-positive individuals (6.2 versus 9.0 days, P = 0.02)...
  9. pmc No increase in hepatitis B virus (HBV)-specific CD8+ T cells in patients with HIV-1-HBV coinfections following HBV-active highly active antiretroviral therapy
    Megan Crane
    Department of Medicine, Monash University, Melbourne, Australia
    J Virol 84:2657-65. 2010
    ..These findings may have implications for the duration of treatment of HBV in HIV-HBV coinfected patients, particularly in HBeAg-positive disease...
  10. doi request reprint The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets
    Jacqueline K Flynn
    Center for Virology, Burnet Institute, Melbourne, Vic, Australia
    Virology 442:51-8. 2013
    ..The pattern of HIV-1 tropism alterations for susceptible cells may therefore be variable in subjects with MVC resistance...
  11. doi request reprint Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging
    Edwin Leeansyah
    Department of Medicine, Monash University, Melbourne, Australia
    J Infect Dis 207:1157-65. 2013
    ..We hypothesized that nucleos(t)ide reverse transcriptase inhibitors (NRTI) may contribute to accelerated aging in HIV-infected individuals on cART via inhibition of telomerase activity...
  12. pmc Factors associated with elevated ALT in an international HIV/HBV co-infected cohort on long-term HAART
    Jennifer Audsley
    Department of Medicine, Monash University, Melbourne, Australia
    PLoS ONE 6:e26482. 2011
    ....
  13. doi request reprint Both CD31(+) and CD31⁻ naive CD4(+) T cells are persistent HIV type 1-infected reservoirs in individuals receiving antiretroviral therapy
    Fiona Wightman
    Department of Medicine, Monash University, Melbourne, Australia
    J Infect Dis 202:1738-48. 2010
    ..Naive T cell recovery is critical for successful immune reconstitution after antiretroviral therapy (ART), but the relative contribution of CD31(+) and CD31⁻ naive T cells to immune reconstitution and viral persistence is unknown...
  14. pmc HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry
    Michael Roche
    Center for Virology, Burnet Institute, Melbourne, Victoria, Australia
    Retrovirology 8:89. 2011
    ..However, the CCR5-using CC1/85 strain appears to be uniquely predisposed to acquiring resistance to several CCR5 antagonists in vitro including MVC, vicriviroc and AD101...
  15. pmc Coinfection of hepatic cell lines with human immunodeficiency virus and hepatitis B virus leads to an increase in intracellular hepatitis B surface antigen
    David M Iser
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
    J Virol 84:5860-7. 2010
    ....
  16. pmc HBV mutations in untreated HIV-HBV co-infection using genomic length sequencing
    Jennifer Audsley
    Department of Medicine, Monash University, Melbourne, Victoria, Australia
    Virology 405:539-47. 2010
    ..Further work is needed to determine if these mutational patterns influence the differences in liver disease progression in HIV-HBV co-infected and HBV mono-infected patients...
  17. pmc The anti-HIV activity of entecavir: a multicentre evaluation of lamivudine-experienced and lamivudine-naive patients
    Joe Sasadeusz
    The Alfred Hospital, Melbourne, Victoria, Australia
    AIDS 22:947-55. 2008
    ....
  18. pmc Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton
    Paul U Cameron
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria 3004, Australia
    Proc Natl Acad Sci U S A 107:16934-9. 2010
    ..We propose a unique pathway for establishment of latency by direct HIV-1 infection of resting CD4(+) T cells during normal chemokine-directed recirculation of CD4(+) T cells between blood and tissue...
  19. ncbi request reprint Human thymic dendritic cells: regulators of T cell development in health and HIV-1 infection
    Vanessa A Evans
    Monash University, Department of Medicine, Central and Eastern Clinical School, Alfred Campus, Melbourne, Victoria, Australia
    Clin Immunol 126:1-12. 2008
    ..Here we review the phenotype and function of different DC subsets found within the human thymus and discuss potential mechanisms of how DCs may be important in CD4(+) T cell dysfunction in HIV-1 infection...
  20. ncbi request reprint Highly reproducible transient transfections for the study of hepatitis B virus replication based on an internal GFP reporter system
    Theo Gouskos
    Department of Medicine RMH, University of Melbourne, Vic, Australia
    J Virol Methods 121:65-72. 2004
    ..The presence of an internal GFP reporter increased the efficiency of generating highly reproducible results and facilitated multiple forms of analysis from a single transfection accurately...
  21. pmc Reduced hepatitis B virus (HBV)-specific CD4+ T-cell responses in human immunodeficiency virus type 1-HBV-coinfected individuals receiving HBV-active antiretroviral therapy
    J Judy Chang
    Infectious Diseases Unit, Alfred Hospital, Commercial Rd, Melbourne, Victoria 3004, Australia
    J Virol 79:3038-51. 2005
    ..Therefore, HIV-1 infection has a significant and specific effect on HBV-specific T-cell immunity...
  22. doi request reprint Increased intrahepatic apoptosis but reduced immune activation in HIV-HBV co-infected patients with advanced immunosuppression
    David M Iser
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Melbourne, Australia
    AIDS 25:197-205. 2011
    ....
  23. pmc Differential expression of CD163 on monocyte subsets in healthy and HIV-1 infected individuals
    Emma Tippett
    Centre for Virology, The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    PLoS ONE 6:e19968. 2011
    ..Levels of CD163 expression on monocytes may be a potential biomarker reflecting efforts by the immune system to resolve immune activation and inflammation in HIV-infected individuals...
  24. doi request reprint Immunopathogenesis of hepatic flare in HIV/hepatitis B virus (HBV)-coinfected individuals after the initiation of HBV-active antiretroviral therapy
    Megan Crane
    Department of Medicine, Monash University, and Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    J Infect Dis 199:974-81. 2009
    ..The pathogenesis of and risk factors for hepatic flare (HF) after the initiation of hepatitis B virus (HBV)-active antiretroviral therapy (ART) in HIV/HBV-coinfected individuals is not well understood...
  25. ncbi request reprint The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo
    Philip J Ellery
    AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Immunol 178:6581-9. 2007
    ..Collectively, these data show that CD16+ monocytes are preferentially susceptible to HIV-1 entry, more permissive for replication, and constitute a continuing source of viral persistence during HAART...
  26. pmc Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells
    Suha Saleh
    Department of Medicine, Monash University, Melbourne, Vic, Australia
    Retrovirology 8:80. 2011
    ..The main aim of this study was to fully define the post-integration blocks to virus replication in this model of CCL19-induced HIV latency...
  27. doi request reprint HIV replication is associated with increased severity of liver biopsy changes in HIV-HBV and HIV-HCV co-infection
    Jennifer Audsley
    The Alfred Hospital, Melbourne, Victoria, Australia
    J Med Virol 84:993-1001. 2012
    ..The association between HIV RNA and necroinflammation supports current recommendations for earlier initiation of HAART in patients with HIV-hepatitis co-infection...
  28. doi request reprint Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activation
    Gregor F Lichtfuss
    Centre for Virology, Burnet Institute, Melbourne, Victoria 3004, Australia
    J Immunol 189:1491-9. 2012
    ..This suggests that NK cells respond to factors different from those driving T cell activation, but which are associated with inflammation in HIV patients...
  29. pmc Impaired quality of the hepatitis B virus (HBV)-specific T-cell response in human immunodeficiency virus type 1-HBV coinfection
    J Judy Chang
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia
    J Virol 83:7649-58. 2009
    ..The quality of the HBV-specific T-cell response is impaired in the setting of HIV-1-HBV coinfection and is related to the CD4+ T-cell count...
  30. pmc Decreased NK Cell FcRgamma in HIV-1 infected individuals receiving combination antiretroviral therapy: a cross sectional study
    Edwin Leeansyah
    Centre for Virology, The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    PLoS ONE 5:e9643. 2010
    ..Previous study from our laboratory showed that FcRgamma is down-regulated in HIV-infected macrophages in vitro. FcRgamma expression in immune cells present in HIV-infected individuals is unknown...
  31. doi request reprint The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells
    Miranda Shehu-Xhilaga
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    AIDS 23:2047-50. 2009
    ..Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients...
  32. ncbi request reprint Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir
    Jennifer F Hoy
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    J Infect Dis 190:688-92. 2004
    ..During the 24-week study, there was no significant change in mtDNA copy numbers in PBMCs in either treatment group, despite improvement in peripheral lipoatrophy among patients whose treatment was switched to abacavir...
  33. ncbi request reprint CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency
    Suha Saleh
    Departments of Medicine, Alfred Hospital, Melbourne, Australia
    Blood 110:4161-4. 2007
    ..CCR7 ligands facilitate efficient entry of HIV-1 into resting CD4(+) T cells. These studies demonstrate a unique action of the chemokines CCL19 and CCL21 and provide a novel model with which to study HIV-1 latency in vitro...
  34. doi request reprint HIV persistence: chemokines and their signalling pathways
    Vanessa A Evans
    Department of Medicine, Monash University, Melbourne, 3004, Australia
    Cytokine Growth Factor Rev 23:151-7. 2012
    ..Here we review the role of chemokines in HIV persistence; the main signalling pathways that are involved; and how these pathways may be exploited to develop novel strategies to reduce or eliminate latently infected cells...
  35. doi request reprint The role of naïve T-cells in HIV-1 pathogenesis: an emerging key player
    Gabriela Khoury
    Department of Medicine, Monash University, Melbourne Victoria, 3004, Australia
    Clin Immunol 141:253-67. 2011
    ..Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naïve CD4+ T-cells...
  36. pmc Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages
    Clare L V Westhorpe
    Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    J Leukoc Biol 85:1027-35. 2009
    ....
  37. ncbi request reprint Variable uptake of recommended interventions to reduce mother-to-child transmission of HIV in Australia, 1982-2005
    Michelle L Giles
    Department of Medicine, Monash University, Melbourne, Vic, Australia
    Med J Aust 189:151-4. 2008
    ..To analyse the uptake of interventions known to reduce the risk of perinatal HIV transmission among Australian women with HIV infection (who knew their HIV status before delivery), and identify predictors of uptake...
  38. pmc Clinical predictors of immune reconstitution following combination antiretroviral therapy in patients from the Australian HIV Observational Database
    Reena Rajasuriar
    Department of Medicine, Monash University, Melbourne, Victoria, Australia
    PLoS ONE 6:e20713. 2011
    ..These patients remain at risk of AIDS and non-AIDS defining illnesses. The aim of this study was to identify clinical factors associated with CD4 T-cell recovery following long-term cART...
  39. ncbi request reprint Enhanced replicative capacity and pathogenicity of HIV-1 isolated from individuals infected with drug-resistant virus and declining CD4+ T-cell counts
    Ajantha Solomon
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    J Acquir Immune Defic Syndr 40:140-8. 2005
    ..In summary, although drug resistance may lead to impaired viral fitness, the capacity of virus quasispecies from PBMCs to use CXCR4 may have significant consequences on viral replicative capacity and potentially on clinical outcome...
  40. doi request reprint Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocation
    Reena Rajasuriar
    Department of Medicine, Monash University, Burnet Institute, University of Melbourne, Melbourne, Australia
    J Infect Dis 202:1254-64. 2010
    ..We hypothesized that residual immune activation and polymorphisms in the interleukin 7 (IL-7) receptor α (IL-7Rα) gene were important for immune recovery...
  41. pmc Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytes
    Paul U Cameron
    Department of Immunology, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia
    J Virol 81:2297-306. 2007
    ..Early selective infection of immature blood DCs by R5 virus and upregulation of viral expression during DC-T-cell interaction and transmission provide a potential pathway for R5 selection following parenteral transmission...
  42. doi request reprint Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome
    Christina C Chang
    aDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia bDepartment of Infectious Diseases, King Edward VIII Hospital cHIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa dCentre for Virology, Burnet Institute, Melbourne, Australia eDepartment of Medical Microbiology, National Health Laboratory Services, Inkosi Albert Luthuli Central Hospital Academic Complex fDepartment of Microbiology and Infection Control, School of Laboratory Medicine and Medical Sciences, University of KwaZulu Natal, Durban, South Africa gCentre for Population Health, Burnet Institute, Melbourne, Australia hCentre for the AIDS Programme of Research in South Africa, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa iSchool of Pathology and Laboratory Medicine, University of Western Australia jDepartment of Clinical Immunology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    AIDS 27:2089-99. 2013
    ..Identifying predictors of C-IRIS could enable risk stratification...
  43. doi request reprint Chronic hepatitis B infection and pregnancy
    Michelle L Giles
    Department of Infectious Diseases, Monash Medical Centre, and Infectious Disease Unit, The Alfred Hospital, Melbourne, Australia
    Obstet Gynecol Surv 67:37-44. 2012
    ....
  44. doi request reprint A novel, rapid method to detect infectious HIV-1 from plasma of persons infected with HIV-1
    Alyssa Cornall
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    J Virol Methods 165:90-6. 2010
    ..This technique could be used for rapid evaluation of viral fitness, co-receptor usage or drug resistance without the need for viral amplification...
  45. doi request reprint HIV inhibits early signal transduction events triggered by CD16 cross-linking on NK cells, which are important for antibody-dependent cellular cytotoxicity
    Gregor F Lichtfuss
    Centre for Virology, Burnet Institute, Melbourne, Victoria 3004, Australia
    J Leukoc Biol 89:149-58. 2011
    ....
  46. doi request reprint Extremely prolonged HIV seroconversion associated with an MHC haplotype carrying disease susceptibility genes for antibody deficiency disorders
    Alex Padiglione
    Infectious Diseases Unit, Monash Medical Centre, Clayton, Victoria, Australia
    Clin Immunol 137:199-208. 2010
    ..This highlights the need for multiparameter testing, in particular use of a fourth generation HIV test, for confirming HIV infection and underscores the importance of host factors in HIV pathogenesis...
  47. doi request reprint Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection
    Gregor F Lichtfuss
    Centre for Virology, Burnet Institute, Melbourne, Australia
    Biomark Med 5:171-86. 2011
    ....
  48. ncbi request reprint The pathogenesis of liver disease in the setting of HIV-hepatitis B virus coinfection
    David M Iser
    Department of Medicine, The University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
    Antivir Ther 14:155-64. 2009
    ..In addition, an impaired HBV-specific T-cell immune response is likely to be important. The roles of microbial translocation, immune activation and increased hepatic stellate cell activation will be important areas for future study...
  49. pmc Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro
    Vanessa A Evans
    Monash University, Department of Medicine, Central and Eastern Clinical School, Alfred Campus, Commercial Rd, Melbourne, Victoria 3004, Australia
    Retrovirology 8:43. 2011
    ..Transfer of productive HIV-1 infection from thymic mDC and pDC was determined by culturing these DC subsets either alone or with sorted thymocytes...
  50. pmc A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
    Michael Roche
    Center for Virology, Monash University, Melbourne, Victoria, Australia
    Retrovirology 10:43. 2013
    ..To more precisely understand mechanisms of resistance to MVC in vivo, we characterized Envs isolated from 2 subjects who experienced virologic failure on MVC...
  51. pmc HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism
    Michael Roche
    Centers for Virology, Monash University, Australia
    J Virol 85:4330-42. 2011
    ....
  52. pmc A new way of measuring apoptosis by absolute quantitation of inter-nucleosomally fragmented genomic DNA
    David J Hooker
    Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia
    Nucleic Acids Res 40:e113. 2012
    ....
  53. doi request reprint HDAC inhibitors in HIV
    Fiona Wightman
    Department of Medicine, Monash University, Melbourne, Victoria, Australia
    Immunol Cell Biol 90:47-54. 2012
    ..In this review, we will review the rationale as well as in vitro and clinical trial data that support the role of histone deacetylase inhibitors as one approach to cure HIV...
  54. pmc Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease
    Christopher P Desmond
    Department of Gastroenterology, The Alfred, Melbourne, Australia
    J Virol 86:1181-92. 2012
    ..003). Thus, HBV appears to be under immune pressure in chronic HBV infection, particularly in HBeAg-negative disease...
  55. ncbi request reprint What are the barriers to offering HIV testing in an antenatal setting? A national study of obstetricians
    Michelle L Giles
    Department of Medicine Monash University, and Centre for Epidemiology and Population Health Research, Macfarlane Burnet Institute, Melbourne, Victoria 3004, Australia
    AIDS 21:1601-6. 2007
    ..To investigate factors that influence the antenatal screening practice of obstetricians and identify barriers to the implementation of universal antenatal HIV screening...
  56. doi request reprint Antenatal screening practice for infectious diseases by general practitioners in Australia
    Michelle L Giles
    Centre for Population Health Research, Burnet Institute, Melbourne, Victoria, Australia
    Aust N Z J Obstet Gynaecol 49:39-44. 2009
    ..This study aimed to assess self-reported screening practice in the antenatal setting, factors associated with screening, barriers to universal testing for HIV and follow-up for infants born to hepatitis C virus (HCV)-infected women...
  57. ncbi request reprint Phase 1 single dose studies to optimize the pharmacokinetics of DG17, a novel HIV-protease inhibitor pro-drug, using sodium bicarbonate and ritonavir
    Catherine L Cherry
    Burnet Institute, Melbourne, Australia
    Curr HIV Res 6:272-5. 2008
    ..No significant adverse events occurred. Single dose DG17 is safe and best administered in a manner preventing gastric acid degradation and with low-dose ritonavir...
  58. doi request reprint Differential dynamics of donor DC and non-DC peripheral blood mononuclear cell microchimerism in lung transplantation
    Joel Van der Meulen
    Department of Medicine, Monash University, Melbourne, Australia
    Clin Immunol 133:179-83. 2009
    ..49, p=0.001). Preferential DC persistence compared to non-DC may indicate tolerance induction but future studies are required to determine if DC microchimerism after transplantation affects clinical outcomes...
  59. pmc Pharmacy and self-report adherence measures to predict virological outcomes for patients on free antiretroviral therapy in Tamil Nadu, India
    James H McMahon
    Infectious Diseases Unit, Alfred Hospital, Level 2 Burnet Tower, 85 Commercial Road, Melbourne 3004, Australia
    AIDS Behav 17:2253-9. 2013
    ..Predictive adherence measures identified in this study warrant further investigation in populations receiving free ART in India to allow for identification of individuals at risk of virological failure and in need of adherence support...
  60. pmc HIV and co-infections
    Christina C Chang
    Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia
    Immunol Rev 254:114-42. 2013
    ..Finally, we discuss the opportunities and gaps in knowledge for future research...
  61. doi request reprint Early events of HIV-1 infection: can signaling be the next therapeutic target?
    Kate L Jones
    Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia
    J Neuroimmune Pharmacol 6:269-83. 2011
    ..We argue that these pathways may represent novel targets for antiviral therapy...
  62. pmc Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:66. 2007
    ....
  63. doi request reprint The "work" of women when considering and using interventions to reduce mother-to-child transmission (MTCT) of HIV
    Michelle L Giles
    The Alfred Hospital, Infectious Diseases Unit, Melbourne, Australia
    AIDS Care 21:1230-7. 2009
    ..Even in circumstances where access to and acceptance of interventions are high, women continue to engage in this work even after they have a made a decision about a particular intervention...
  64. pmc Comparison of sequence analysis and a novel discriminatory real-time PCR assay for detection and quantification of Lamivudine-resistant hepatitis B virus strains
    Fiona Wightman
    Department of Medicine, Monash University, Melbourne, Australia
    J Clin Microbiol 42:3809-12. 2004
    ..Excellent concordance was demonstrated between sequencing and the discriminatory real-time assay; however, a mixture of quasispecies was more frequently detected by discriminatory real-time PCR...
  65. ncbi request reprint Immunopathogenesis of hepatitis B virus infection
    J Judy Chang
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    Immunol Cell Biol 85:16-23. 2007
    ..In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease...
  66. ncbi request reprint Ten years of highly active antiretroviral therapy for HIV infection
    Luke F Chen
    Infectious Diseases Unit, The Alfred Hospital, Melbourne, Vic
    Med J Aust 186:146-51. 2007
    ..Drug-drug interactions are common and caution is required when prescribing ARVs that inhibit or induce the cytochrome P450 pathway...
  67. ncbi request reprint A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics
    Christopher P Desmond
    Department of Gastroenterology, Alfred Hospital, Melbourne, Australia
    Antivir Ther 13:161-75. 2008
    ..The immune response to hepatitis B virus (HBV) is important for both viral control and disease pathogenesis. A detailed understanding of the HBV-specific T-cell responses may potentially lead to novel therapeutic strategies for HBV...
  68. doi request reprint HIV reservoirs and strategies for eradication
    Miranda Z Smith
    Department of Medicine, Central Clinical School, Monash University, Melbourne, Australia
    Curr HIV/AIDS Rep 9:5-15. 2012
    ..Finally, we review the scientific rationale of and clinical experience with pharmacotherapeutic strategies aimed at eliminating latently infected cells...
  69. ncbi request reprint Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, 3001 Victoria, Australia Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    Virology 337:384-98. 2005
    ..Thus, reduced CD4/CCR5 dependence is a phenotype of R5 HIV-1 associated with M-tropism and late stage infection, which may affect the efficacy of HIV-1 entry inhibitors...
  70. ncbi request reprint HIV-1 cell entry and advances in viral entry inhibitor therapy
    Louise A Cooley
    Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Parkville, Vic, Australia
    J Clin Virol 26:121-32. 2003
    ..A greater number of HIV-1 entry inhibitors are in preclinical development. This review outlines the mechanisms involved in HIV-1 entry and the sites of action of specific HIV-1 inhibitors...
  71. pmc Human immunodeficiency virus infection and the liver
    Megan Crane
    Megan Crane, Sharon R Lewin, Department of Medicine, Monash University, Melbourne 3004, Australia
    World J Hepatol 4:91-8. 2012
    ....
  72. ncbi request reprint Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene
    Joseph Torresi
    Department of Medicine RMH WH, University of Melbourne, Melbourne, Victoria 3050, Australia
    Virology 299:88-99. 2002
    ..Since these viruses carry mutations in the a determinant of HBsAg that may potentially decrease the ability of anti-HBs antibody to neutralize these viruses, these HBV mutants also have the potential to behave as vaccine escape mutants...
  73. ncbi request reprint The evidence for a change in antenatal HIV screening policy in Australia
    Michelle L Giles
    Department of Medicine, Monash University, Melbourne, Victoria, Australia
    Med J Aust 185:217-20. 2006
    ..A universal antenatal HIV screening program meets many of the Wilson and Jungner criteria for population-based screening programs. This should be considered in the current review of Australia's HIV testing policy...
  74. ncbi request reprint Hepatitis virus immune restoration disease of the liver
    Megan Crane
    aDepartment of Medicine, Monash University, Melbourne, Sydney bNational Centre for HIV Epidemiology and Clinical Research and St Vincent s Hospital, Sydney cInfectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    Curr Opin HIV AIDS 3:446-52. 2008
    ..SUMMARY: Further randomized clinical trials are needed to develop improved management strategies for hepatitis immune restoration disease...
  75. ncbi request reprint Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat
    Catherine L Cherry
    Department of Infectious Diseases and Microbiology, The Alfred Hospital, Melbourne, Australia
    J Acquir Immune Defic Syndr 30:271-7. 2002
    ..A reliable and valid laboratory test to detect this is not yet available. The objective of this study was to correlate tissue mtDNA quantification in HIV-infected patients with exposure to nucleoside analogs...
  76. doi request reprint HIV cure and eradication: how will we get from the laboratory to effective clinical trials?
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, 85 Commercial Road, Melbourne, VIC 3004, Australia
    AIDS 25:885-97. 2011
    ..In addition, we discuss key issues that need to be addressed to successfully move laboratory research to clinical trials aimed at curing HIV...
  77. doi request reprint A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naïve individuals in Thailand
    Gail V Matthews
    Viral Hepatitis Program, National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Darlinghurst, Sydney, NSW, Australia
    Hepatology 48:1062-9. 2008
    ..Hepatitis B e antigen (HBeAg) loss was observed in 33% of HBeAg-positive subjects, and 8% experienced hepatitis B surface antigen loss. Hepatic flare was observed in 25% of subjects...
  78. ncbi request reprint Immunological and virological failure after antiretroviral therapy is associated with enhanced peripheral and thymic pathogenicity
    Ajantha Solomon
    Department of Microbiology and Immunology, University of Melbourne, and Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia
    J Infect Dis 187:1915-23. 2003
    ..Although there was a high prevalence of mutations in the protease and reverse transcriptase genes in discordant immunological responders, these changes were also observed in nonresponders...
  79. ncbi request reprint HIV-1 down-modulates gamma signaling chain of Fc gamma R in human macrophages: a possible mechanism for inhibition of phagocytosis
    Katherine Kedzierska
    AIDS Pathogenesis Research Unit, Macfarlane Burnet Center, Victoria, Australia
    J Immunol 168:2895-903. 2002
    ....
  80. ncbi request reprint Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infection
    Sharon R Lewin
    Department of Microbiology and Immunology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
    J Immunol 169:4657-66. 2002
    ....
  81. ncbi request reprint A phase I study of the pharmacokinetics and safety of passive immunotherapy with caprine anti-HIV antibodies, (PE)HRG214, in HIV-1-infected individuals
    Sarah L Pett
    HIV, Immunology and Infectious Diseases Clinical Services, St Vincent s Hospital, Sydney, and National Centre in HIV Epidemiology and Clinical Research, University of NSW, Darlinghurst, Sydney, Australia
    HIV Clin Trials 5:91-8. 2004
    ..To establish the pharmacokinetics and safety of single-dose polyclonal caprine anti-HIV antibodies ((PE)HRG214)in HIV-1-infected individuals...
  82. ncbi request reprint Sexually transmissible infection and HIV management among men who have sex with men with and without HIV: survey of medical practitioners who are members of the Australasian Society for HIV Medicine
    Christopher K Fairley
    Melbourne Sexual Health Centre, 580 Swanston Street, Carlton, VIC 3053, Australia
    Sex Health 5:155-9. 2008
    ..Our aim was to determine if the use of suppressive treatment for genital herpes, the treatment of HIV or STI screening practices were different between states in Australia...
  83. ncbi request reprint Incidence of putative HIV superinfection and sexual practices among HIV-infected men who have sex with men
    Mohsin M Sidat
    School of Population Health, The University of Melbourne, VIC 3010, Australia
    Sex Health 5:61-7. 2008
    ..To determine the upper limit for the incidence of clinically important HIV superinfection among HIV-infected men who have sex with men (MSM) and its relationship with engagement in unsafe sexual practices...
  84. pmc Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance
    Scott Preiss
    Victorian Infectious Diseases Reference Laboratories, Research and Molecular Development, North Melbourne, Victoria, Australia
    Hepatology 48:741-9. 2008
    ..0001), indicating that antiviral drug resistance alters the balance between defective and genomic length DNA in circulation. Experiments in vitro using HBV encoding LMV-R mutations confirmed these results...

Research Grants1

  1. Interaction in vivo between HIV and Hepatitis B Virus
    Sharon Lewin; Fiscal Year: 2005
    ..abstract_text> ..