Research Topics
| T E AdamsSummaryCountry: Australia Publications
| Collaborators
|
Detail Information
Publications
Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signalingT E Adams
Centre for Animal Biotechnology, University of Melbourne, Parkville, Victoria, Australia
J Biol Chem 273:1285-7. 1998..Co-transfection studies revealed that constitutive expression of SOCS-1 and SOCS-3, but not SOCS-2 or CIS, blocked GH-induced transactivation of the GH-responsive serine protease inhibitor 2.1 gene promoter...
Transcription from the P2 promoter of the growth hormone receptor gene involves members of the Sp transcription factor familyT E Adams
Centre for Animal Biotechnology, University of Melbourne, Parkville, Victoria 3052, Australia
Biochem J 344:867-72. 1999....
Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic miceK J Snibson
Centre for Animal Biotechnology, School of Veterinary Science, Victoria 3010, Australia
Liver 21:149-58. 2001..Growth hormone (GH), when overexpressed in male and female GH-transgenic mice, is known to induce liver tumours within 1 year. This study aimed to gain a clearer understanding of the interaction between GH and tumour cells in vivo...
The three dimensional structure of the type I insulin-like growth factor receptorC W Ward
CSIRO Health Sciences and Nutrition, Parkville Laboratory, 343 Royal Parade, Parkville, Victoria, 3052, Australia
Mol Pathol 54:125-32. 2001..The Cys rich region is composed of eight disulphide bonded modules, seven of which form a rod shaped domain with modules associated in an unusual manner...
Structure and function of the type 1 insulin-like growth factor receptorT E Adams
CSIRO Health Sciences and Nutrition, Parkville, Victoria, Australia
Cell Mol Life Sci 57:1050-93. 2000..Recent progress towards the elucidation of the three-dimensional structure of the extracellular domain of the IGF-1R represents an opportunity for the rational assembly of small molecule antagonists of receptor function for clinical use...
Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomainT C Elleman
CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
Biochemistry 40:8930-9. 2001..All three mutants bound hTGF-alpha and were recognized by Mab528. However, mutant Gly(441)Lys showed markedly reduced binding to hEGF, implicating Gly(441), in the L2 domain, as part of the binding site that recognizes Arg(45) of hEGF...
Differential expression of growth hormone receptor messenger RNA from a second promoterT E Adams
Centre for Animal Biotechnology, University of Melbourne, Parkville, Victoria, Australia
Mol Cell Endocrinol 108:23-33. 1995....
High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic miceK J Snibson
Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia
Liver 19:242-52. 1999..In order to understand more about hepatocarcinogenesis in the GH-transgenic mouse model we quantitated the rates of hepatocellular proliferation and apoptosis in these mice...
The sheep growth hormone receptor: molecular cloning and ontogeny of mRNA expression in the liverT E Adams
School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
Mol Cell Endocrinol 73:135-45. 1990..At least one transcript appears to be expressed in a liver-specific fashion, supporting a role for alternative RNA splicing in the tissue-specific regulation of sheep GH receptor expression...
