Kari Auranen

Summary

Publications

  1. ncbi request reprint Design questions for Streptococcus pneumoniae vaccine trials with a colonisation endpoint
    Kari Auranen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, P O Box 30, FI 00271 Helsinki, Finland Electronic address
    Vaccine 32:159-64. 2013
  2. pmc Estimating strain-specific and overall efficacy of polyvalent vaccines against recurrent pathogens from a cross-sectional study
    Kari Auranen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Finland
    Biometrics 69:235-44. 2013
  3. ncbi request reprint Colonisation endpoints in Streptococcus pneumoniae vaccine trials
    Kari Auranen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, P O Box 30, FI 00271, Helsinki, Finland Electronic address
    Vaccine 32:153-8. 2013
  4. pmc Between-strain competition in acquisition and clearance of pneumococcal carriage--epidemiologic evidence from a longitudinal study of day-care children
    Kari Auranen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Mannerheimintie 166, Helsinki, Finland
    Am J Epidemiol 171:169-76. 2010
  5. pmc Impact of vaccination on 14 high-risk HPV type infections: a mathematical modelling approach
    Simopekka Vänskä
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, Helsinki, Finland
    PLoS ONE 8:e72088. 2013
  6. pmc Clustering of serotypes in a longitudinal study of Streptococcus pneumoniae carriage in three day care centres
    Tuija Leino
    National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    BMC Infect Dis 8:173. 2008
  7. doi request reprint Serotype-specific hyporesponsiveness to pneumococcal conjugate vaccine in infants carrying pneumococcus at the time of vaccination
    Merja Vakevainen
    National Institute for Health and Welfare, Helsinki and Oulu, Finland
    J Pediatr 157:778-83.e1. 2010
  8. ncbi request reprint The fundamental link between pneumococcal carriage and disease
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Expert Rev Vaccines 11:841-55. 2012
  9. ncbi request reprint Divergent coverage, frequency and costs of organised and opportunistic Pap testing in Finland
    Heini Salo
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, Helsinki, Finland
    Int J Cancer 135:204-13. 2014
  10. pmc Outbreaks of Streptococcus pneumoniae carriage in day care cohorts in Finland - implications for elimination of transmission
    Fabian Hoti
    Department of Vaccination and Immune Protection, Division of Health Protection, National Institute for Health and Welfare THL, Helsinki, Finland
    BMC Infect Dis 9:102. 2009

Detail Information

Publications22

  1. ncbi request reprint Design questions for Streptococcus pneumoniae vaccine trials with a colonisation endpoint
    Kari Auranen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, P O Box 30, FI 00271 Helsinki, Finland Electronic address
    Vaccine 32:159-64. 2013
    ..In addition, the statistical design with the specific aim to include information about VEcol in the licensure process of new pneumococcal vaccine products is discussed. ..
  2. pmc Estimating strain-specific and overall efficacy of polyvalent vaccines against recurrent pathogens from a cross-sectional study
    Kari Auranen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Finland
    Biometrics 69:235-44. 2013
    ..Methodologically, the proposed estimators are closely related to case-control studies with prevalent cases, with appropriate consideration of the at-risk time in choosing the controls...
  3. ncbi request reprint Colonisation endpoints in Streptococcus pneumoniae vaccine trials
    Kari Auranen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, P O Box 30, FI 00271, Helsinki, Finland Electronic address
    Vaccine 32:153-8. 2013
    ..We concentrate on methods that are based on a cross-sectional study design, in which only one nasopharyngeal sample is obtained per study subject. ..
  4. pmc Between-strain competition in acquisition and clearance of pneumococcal carriage--epidemiologic evidence from a longitudinal study of day-care children
    Kari Auranen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Mannerheimintie 166, Helsinki, Finland
    Am J Epidemiol 171:169-76. 2010
    ..In contrast, acquisition of other serotypes in already-colonized hosts was weak (relative rate of acquisition = 0.09, 95% credible interval: 0.05, 0.15)...
  5. pmc Impact of vaccination on 14 high-risk HPV type infections: a mathematical modelling approach
    Simopekka Vänskä
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, Helsinki, Finland
    PLoS ONE 8:e72088. 2013
    ..Limiting the epidemiological model to infection yielded improved understanding of the hrHPV epidemiology and of mechanisms with which vaccination impacts on hrHPV infections. ..
  6. pmc Clustering of serotypes in a longitudinal study of Streptococcus pneumoniae carriage in three day care centres
    Tuija Leino
    National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    BMC Infect Dis 8:173. 2008
    ..Here we report the first longitudinal study of pneumococcal carriage that records serotype specific exposure to pneumococci simultaneously within the two most important mixing groups, families and day care facilities...
  7. doi request reprint Serotype-specific hyporesponsiveness to pneumococcal conjugate vaccine in infants carrying pneumococcus at the time of vaccination
    Merja Vakevainen
    National Institute for Health and Welfare, Helsinki and Oulu, Finland
    J Pediatr 157:778-83.e1. 2010
    ..To determine whether pneumococcal carriage at the time of 11-valent pneumococcal conjugate vaccine (PCV-11) administration interferes with immune response in infants...
  8. ncbi request reprint The fundamental link between pneumococcal carriage and disease
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Expert Rev Vaccines 11:841-55. 2012
    ..Based on such a causal link between carriage and disease, the authors emphasize the role of information on pneumococcal carriage in vaccine trials and in public health decision-making...
  9. ncbi request reprint Divergent coverage, frequency and costs of organised and opportunistic Pap testing in Finland
    Heini Salo
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, Helsinki, Finland
    Int J Cancer 135:204-13. 2014
    ..4 million, of which 71% incurred in opportunistic screening. Of the 84,000 annual follow-up Pap tests and their €8.3 million total costs, ∼60% incurred in organised screening or in secondary health care. ..
  10. pmc Outbreaks of Streptococcus pneumoniae carriage in day care cohorts in Finland - implications for elimination of transmission
    Fabian Hoti
    Department of Vaccination and Immune Protection, Division of Health Protection, National Institute for Health and Welfare THL, Helsinki, Finland
    BMC Infect Dis 9:102. 2009
    ..Exposure within families and within DCCs are the main risk factors for colonisation with pneumococcal serotypes in DCC attendees...
  11. doi request reprint Epidemiological evidence for serotype-independent acquired immunity to pneumococcal carriage
    Simo M Granat
    National Public Health Institute, Department of Vaccines, Helsinki, Finland
    J Infect Dis 200:99-106. 2009
    ..The rate of both carriage and pneumococcal disease decreases with age. To what extent these changes are the result of developing natural immunity is currently a subject of debate...
  12. ncbi request reprint Longitudinal study on pneumococcal carriage during the first year of life in Bangladesh
    Simo M Granat
    Department of Vaccines, National Public Health Institute KTL, Helsinki, Finland
    Pediatr Infect Dis J 26:319-24. 2007
    ..To describe the development of pneumoccoccal carriage in a developing country setting we carried out a longitudinal pneumococcal carriage study in Bangladesh...
  13. ncbi request reprint Nasopharyngeal colonization: a target for pneumococcal vaccination
    Helena Kayhty
    National Public Health Institute, Department of Vaccines, Helsinki, Finland
    Expert Rev Vaccines 5:651-67. 2006
    ..Owing to the general reduced virulence of the latter, this has only had a modest effect on disease, but the possibility of more virulent nonvaccine serotypes arising cannot be ignored and should be the focus of continued surveillance...
  14. pmc Pneumococcal transmission and disease in silico: a microsimulation model of the indirect effects of vaccination
    Markku Nurhonen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 8:e56079. 2013
    ..Using modelling, we aimed to quantify these effects and their dependence on coverage of vaccination and the vaccine's efficacy against susceptibility to pneumococcal carriage...
  15. doi request reprint Estimation of vaccine efficacy against acquisition of pneumococcal carriage
    Hanna Rinta-Kokko
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, Finland
    Vaccine 27:3831-7. 2009
    ..We demonstrate the use of the method by application to a data set where it is also possible to estimate efficacy against acquisition from longitudinal measurements...
  16. doi request reprint Competition between Streptococcus pneumoniae strains: implications for vaccine-induced replacement in colonization and disease
    Juha Mehtälä
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Epidemiology 24:522-9. 2013
    ..One of the main drivers for serotype replacement is likely to be the competitive interactions between pneumococcal serotypes...
  17. ncbi request reprint Modeling transmission of multitype infectious agents: application to carriage of Streptococcus pneumoniae
    Panu Erästö
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Stat Med 31:1450-63. 2012
    ..The computationally intensive Bayesian approach is a valid method to account for incomplete observations, and we found that it performs generally better than the simple crude method, in particular with large amount of missing data...
  18. ncbi request reprint Long-term persistence of immunity after immunisation with Haemophilus influenzae type b conjugate vaccine
    P Helena Makela
    National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Vaccine 22:287-92. 2003
    ..A mathematical model, including memory, predicted accurately the Hib-ab concentrations, which are maintained through anamnestic responses to intervening stimuli (Hib or cross-reacting bacteria)...
  19. ncbi request reprint Antibody response to an eleven valent diphtheria- and tetanus-conjugated pneumococcal conjugate vaccine in Filipino infants
    Taneli Puumalainen
    National Public Health Institute, Department of Vaccines, Helsinki, Finland
    Pediatr Infect Dis J 21:309-14. 2002
    ..Pneumococcal conjugate vaccines are intended to provide effective protection against pneumococcal infections, but very little information on antibody responses in infants living in countries with high pneumococcal disease burden exists...
  20. ncbi request reprint Evolution of the capsular regulatory genes in Streptococcus pneumoniae
    Sirkka Liisa Varvio
    Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland
    J Infect Dis 200:1144-51. 2009
    ..The regulatory gene region shows mosaic structures that have signatures of recent recombination events, reminiscent of structures known from antibiotic resistance genes...
  21. pmc Optimal serotype compositions for Pneumococcal conjugate vaccination under serotype replacement
    Markku Nurhonen
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    PLoS Comput Biol 10:e1003477. 2014
    ..The serotype compositions of currently available pneumococcal vaccines are not optimal and the effectiveness of vaccination in the population at large could be improved by including new serotypes in the vaccine (e.g. 22 and 9N). ..
  22. ncbi request reprint The burden and costs of prevention and management of genital disease caused by HPV in women: a population-based registry study in Finland
    Heini Salo
    Department of Vaccination and Immune Protection Vaccination Programme Unit, National Institute for Health and Welfare THL, FI 00271, Helsinki, Finland
    Int J Cancer 133:1459-69. 2013
    ..In addition opportunistic screening among this and younger age group detects a significant number of cytological abnormalities, most of which are probably treated unnecessarily...