Elena N Atochina

Summary

Publications

  1. ncbi request reprint SP-D-dependent regulation of NO metabolism in lipopolysaccharide-stimulated peritoneal macrophages
    E N Atochina-Vasserman
    Russian Academy of Medical Sciences, Moscow, Russia
    Bull Exp Biol Med 147:415-20. 2009
  2. ncbi request reprint Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice
    Elena N Atochina-Vasserman
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 179:8090-7. 2007
  3. pmc Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species
    Elena N Atochina
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 72:6002-11. 2004
  4. ncbi request reprint Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice
    Elena N Atochina
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6061, USA
    J Infect Dis 189:1528-39. 2004
  5. pmc Surfactant protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses
    Seth Thomas Scanlon
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Respir Res 6:97. 2005
  6. ncbi request reprint Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism
    Elena N Atochina
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Respir Cell Mol Biol 30:271-9. 2004
  7. pmc Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization
    Elena N Atochina
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Respir Res 4:15. 2003
  8. ncbi request reprint IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:3557-65. 2006
  9. pmc Surfactant protein D protects against acute hyperoxic lung injury
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4539, USA
    Am J Respir Crit Care Med 178:805-13. 2008
  10. pmc Alveolar surfactant protein D content modulates bleomycin-induced lung injury
    John Casey
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, and Division of Neonatology, Children s Hospital of Philadelphia 19104, USA
    Am J Respir Crit Care Med 172:869-77. 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint SP-D-dependent regulation of NO metabolism in lipopolysaccharide-stimulated peritoneal macrophages
    E N Atochina-Vasserman
    Russian Academy of Medical Sciences, Moscow, Russia
    Bull Exp Biol Med 147:415-20. 2009
    ..Our results suggest that surfactant protein D is involved in the immune response in the whole organism, but not only in the lungs. The effect of surfactant protein D depends on the phenotype of macrophages...
  2. ncbi request reprint Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice
    Elena N Atochina-Vasserman
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 179:8090-7. 2007
    ..Our results represent the first report linking defects in the innate immune system in the lung with alterations in NO homeostasis...
  3. pmc Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species
    Elena N Atochina
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 72:6002-11. 2004
    ..These data support the concept that SP-A is a local effector molecule in the lung host defense against P. carinii in vivo...
  4. ncbi request reprint Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice
    Elena N Atochina
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6061, USA
    J Infect Dis 189:1528-39. 2004
    ..These results indicate that SP-D plays a role in host defense against P. carinii in vivo by modulating clearance of organisms, lung inflammation, and metabolism of NO...
  5. pmc Surfactant protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses
    Seth Thomas Scanlon
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Respir Res 6:97. 2005
    ..The pulmonary surfactant protein (SP)-A has potent immunomodulatory activities but its role and regulation during allergic airway inflammation is unknown...
  6. ncbi request reprint Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism
    Elena N Atochina
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Respir Cell Mol Biol 30:271-9. 2004
    ..We speculate that the proinflammatory response due to SP-D deficiency results, in part, from a disruption of NO-mediated signaling within the innate immune system...
  7. pmc Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization
    Elena N Atochina
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Respir Res 4:15. 2003
    ..We hypothesized that an elevated SP-D production is associated with the impaired ability of C57BL/6 mice to develop allergic AHR...
  8. ncbi request reprint IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:3557-65. 2006
    ..This negative feedback regulatory circuit could be essential in protecting the airways from inflammatory damage after allergen inhalation...
  9. pmc Surfactant protein D protects against acute hyperoxic lung injury
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4539, USA
    Am J Respir Crit Care Med 178:805-13. 2008
    ..Constitutive absence of SP-D in mice is associated with lung inflammation, alteration in surfactant lipid homeostasis, and increased oxidative-nitrative stress...
  10. pmc Alveolar surfactant protein D content modulates bleomycin-induced lung injury
    John Casey
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, and Division of Neonatology, Children s Hospital of Philadelphia 19104, USA
    Am J Respir Crit Care Med 172:869-77. 2005
    ..Surfactant protein D (SP-D) is a collectin family member with demonstrated immunomodulatory properties in vitro. We hypothesized that SP-D modulates inflammation during noninfectious lung injury in vivo...