Hani Atamna

Summary

Publications

  1. ncbi Human and rodent amyloid-beta peptides differentially bind heme: relevance to the human susceptibility to Alzheimer's disease
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Arch Biochem Biophys 487:59-65. 2009
  2. doi Amino acids variations in amyloid-beta peptides, mitochondrial dysfunction, and new therapies for Alzheimer's disease
    Hani Atamna
    Department of Basic Sciences, Neuroscience, The Commonwealth Medical College, 501 Madison Avenue, Scranton, PA 18510, USA
    J Bioenerg Biomembr 41:457-64. 2009
  3. doi Mitochondrial pharmacology: electron transport chain bypass as strategies to treat mitochondrial dysfunction
    Hani Atamna
    Department of Basic Sciences, Neuroscience, The Commonwealth Medical College, Scranton, PA 18509, USA
    Biofactors 38:158-66. 2012
  4. pmc Therapeutic approaches to delay the onset of Alzheimer's disease
    Raj Kumar
    Department of Basic Sciences, Neuroscience, The Commonwealth Medical College, Tobin Hall, 501 Madison Avenue, Scranton, PA 18510, USA
    J Aging Res 2011:820903. 2011
  5. pmc 5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction
    Joseph M Dhahbi
    Department of Biochemistry, University of California at Riverside, Riverside, CA 92521, USA
    BMC Genomics 14:298. 2013
  6. ncbi Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase
    Hani Atamna
    Department of Basic Sciences, Neuroscience, The Commonwealth Medical College, Scranton, PA, USA
    J Alzheimers Dis 20:S439-52. 2010
  7. ncbi Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    FASEB J 22:703-12. 2008
  8. ncbi Iron accumulation during cellular senescence
    David W Killilea
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Ann N Y Acad Sci 1019:365-7. 2004
  9. ncbi Heme, iron, and the mitochondrial decay of ageing
    Hani Atamna
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    Ageing Res Rev 3:303-18. 2004
  10. ncbi Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging
    Bruce N Ames
    Nutrition, Metabolisms and Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, U States
    Mol Aspects Med 26:363-78. 2005

Detail Information

Publications20

  1. ncbi Human and rodent amyloid-beta peptides differentially bind heme: relevance to the human susceptibility to Alzheimer's disease
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Arch Biochem Biophys 487:59-65. 2009
    ..Phylogenic variations in the amino acid sequence of Abeta explain tight heme-binding to huAbeta and likely contribute to the increased human susceptibility to AD...
  2. doi Amino acids variations in amyloid-beta peptides, mitochondrial dysfunction, and new therapies for Alzheimer's disease
    Hani Atamna
    Department of Basic Sciences, Neuroscience, The Commonwealth Medical College, 501 Madison Avenue, Scranton, PA 18510, USA
    J Bioenerg Biomembr 41:457-64. 2009
    ..Thus, MB may delay the onset and progression of AD and serve as a lead to develop novel drugs to treat AD...
  3. doi Mitochondrial pharmacology: electron transport chain bypass as strategies to treat mitochondrial dysfunction
    Hani Atamna
    Department of Basic Sciences, Neuroscience, The Commonwealth Medical College, Scranton, PA 18509, USA
    Biofactors 38:158-66. 2012
    ..Thus, mild-redox agents may prevent/delay mitochondria-driven disorders...
  4. pmc Therapeutic approaches to delay the onset of Alzheimer's disease
    Raj Kumar
    Department of Basic Sciences, Neuroscience, The Commonwealth Medical College, Tobin Hall, 501 Madison Avenue, Scranton, PA 18510, USA
    J Aging Res 2011:820903. 2011
    ..Osmolytes may inhibit the formation of Aβ oligomers in vivo, thus preventing the formation of soluble oligomers. The potential significance of combining diaminophenothiazins and osmolytes to treat AD is discussed...
  5. pmc 5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction
    Joseph M Dhahbi
    Department of Biochemistry, University of California at Riverside, Riverside, CA 92521, USA
    BMC Genomics 14:298. 2013
    ....
  6. ncbi Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase
    Hani Atamna
    Department of Basic Sciences, Neuroscience, The Commonwealth Medical College, Scranton, PA, USA
    J Alzheimers Dis 20:S439-52. 2010
    ..Osmolytes are efficient antioxidants that may also increase neural resistance to Abeta. The potential significance of combining MB and osmolytes to treat AD are discussed...
  7. ncbi Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    FASEB J 22:703-12. 2008
    ..MB may be useful to delay mitochondrial dysfunction with aging and the decrease in complex IV in Alzheimer disease...
  8. ncbi Iron accumulation during cellular senescence
    David W Killilea
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Ann N Y Acad Sci 1019:365-7. 2004
    ..Thus, iron accumulation is not a cause, but a consequence of normal cellular senescence in vitro. Senescence-associated iron accumulation may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells...
  9. ncbi Heme, iron, and the mitochondrial decay of ageing
    Hani Atamna
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    Ageing Res Rev 3:303-18. 2004
    ..This review discusses heme metabolism as related to metabolic changes seen in ageing and age-related disorders and highlights the possible role in iron deficiency...
  10. ncbi Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging
    Bruce N Ames
    Nutrition, Metabolisms and Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, U States
    Mol Aspects Med 26:363-78. 2005
    ..An optimum intake of micronutrients could tune up metabolism and give a marked increase in health, particularly for the poor, elderly, and obese, at little cost...
  11. ncbi Heme binding to Amyloid-beta peptide: mechanistic role in Alzheimer's disease
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute CHORI, Oakland, CA 94609, USA
    J Alzheimers Dis 10:255-66. 2006
    ..Genetic, nutritional, and toxicological factors that influence heme metabolism will be discussed in relevance to AD...
  12. pmc N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration
    Ludmila A Voloboueva
    Children s Hospital Oakland Research Institute, Nutrition and Metabolism Center, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    FASEB J 21:4077-86. 2007
    ..NtBHA might be useful in AMD due to its potential to reduce oxidative stress, mitochondrial damage, and age-related iron accumulation, which may damage normal RPE function and lead to loss of vision...
  13. ncbi Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    Mitochondrion 7:297-310. 2007
    ..We further discuss how protecting mitochondria could confer resistance to oxidative and environmental insults. Therapies targeted at protecting mitochondria may improve the clinical outcome of AD patients...
  14. ncbi Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Nutr 137:25-30. 2007
    ..The findings are discussed in relation to aging and birth defects in humans...
  15. pmc Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, CA 94609, USA
    Proc Natl Acad Sci U S A 103:3381-6. 2006
    ..The relevance of the binding of regulatory heme with excessive Abeta for mitochondrial dysfunction and neurotoxicity and other cytopathologies of AD is discussed...
  16. pmc A role for heme in Alzheimer's disease: heme binds amyloid beta and has altered metabolism
    Hani Atamna
    Nutritional Genomics Center, Children s Hospital Oakland Research Institute, CA 94609, USA
    Proc Natl Acad Sci U S A 101:11153-8. 2004
    ..g., heme-a) and resulting in functional heme deficiency. The model integrates disparate observations, including A beta, mitochondrial dysfunction, cholesterol, and the proposed efficacy of clioquinol...
  17. pmc Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence
    Joseph M Dhahbi
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS ONE 6:e20509. 2011
    ..This result greatly extends existing information on the role of miRNAs in cell senescence and is consistent with miRNAs having a causal role in the process...
  18. ncbi Iron accumulation during cellular senescence in human fibroblasts in vitro
    David W Killilea
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Antioxid Redox Signal 5:507-16. 2003
    ..These data indicate that iron accumulation occurs during normal cellular senescence in vitro. This accumulation of iron may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells...
  19. pmc Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging
    Hani Atamna
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 99:14807-12. 2002
    ..Thus, heme deficiency or dysregulation may be an important and preventable component of the neurodegenerative process...
  20. ncbi The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age
    Hani Atamna
    Department of Molecular and Cell Biology, University of California, Berkeley CHORI, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA
    Arch Biochem Biophys 397:345-53. 2002
    ..We review the physiological role of iron-sulfur clusters and heme in the integrity of the mitochondria and the generation of oxidants...