Ayodeji A Asuni

Summary

Publications

  1. doi request reprint Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease
    A A Asuni
    CNS Inflammation Group, University of Southampton, UK
    Neuroscience 165:662-74. 2010
  2. doi request reprint Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease
    Ayodeji A Asuni
    CNS Inflammation Group, University of Southampton, Southampton SO16 7PX, UK
    Biochem Soc Trans 38:545-51. 2010
  3. pmc Differential molecular chaperone response associated with various mouse adapted scrapie strains
    Ayodeji A Asuni
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Neurosci Lett 538:26-31. 2013
  4. doi request reprint Unaltered SNARE complex formation in an in vivo model of prion disease
    Ayodeji A Asuni
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    Brain Res 1233:1-7. 2008
  5. pmc Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration
    Magdalena A Kuszczyk
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Am J Pathol 182:1750-68. 2013
  6. ncbi request reprint Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model
    Ayodeji A Asuni
    Department of Neurology, New York University School of Medicine, New York, NY
    Ann Neurol 75:684-99. 2014
  7. doi request reprint Biochemical evidence for the differential association of metabotropic glutamate receptors within synaptic complexes
    Ayodeji A Asuni
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Neurosci Lett 444:27-30. 2008
  8. ncbi request reprint Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
    Ayodeji A Asuni
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:9115-29. 2007

Collaborators

Detail Information

Publications8

  1. doi request reprint Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease
    A A Asuni
    CNS Inflammation Group, University of Southampton, UK
    Neuroscience 165:662-74. 2010
    ..Our data suggest that alpha-synuclein deficiency does not contribute to the compartment specific processes that give rise to prion disease mediated synaptotoxicity and neurodegeneration...
  2. doi request reprint Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease
    Ayodeji A Asuni
    CNS Inflammation Group, University of Southampton, Southampton SO16 7PX, UK
    Biochem Soc Trans 38:545-51. 2010
    ..These data suggest that the changes in tau phosphorylation recorded here and observed by others relate to end-stage prion pathology when early dysfunctions have progressed to overt neuronal loss...
  3. pmc Differential molecular chaperone response associated with various mouse adapted scrapie strains
    Ayodeji A Asuni
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Neurosci Lett 538:26-31. 2013
    ..Our results highlight the probability that different mechanisms of MCs regulation exist driven by amyloidogenic and non-amyloidogenic nature of prion strains...
  4. doi request reprint Unaltered SNARE complex formation in an in vivo model of prion disease
    Ayodeji A Asuni
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    Brain Res 1233:1-7. 2008
    ..Thus the accumulation of PrP(Sc) although deleterious to synaptic function in vivo, does not exert its synaptic effects by disrupting the formation of SNARE complexes that are core to transmitter release...
  5. pmc Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration
    Magdalena A Kuszczyk
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Am J Pathol 182:1750-68. 2013
    ..Data from our co-culture and in vivo experiments indicate an essential role of ApoE in the mechanism of intraneuronal Aβ accumulation and provide evidence that ApoE/Aβ binding antagonists can effectively prevent this process...
  6. ncbi request reprint Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model
    Ayodeji A Asuni
    Department of Neurology, New York University School of Medicine, New York, NY
    Ann Neurol 75:684-99. 2014
    ..Prolonged accumulation of Aβ in the brain underlies the pathogenesis of Alzheimer disease (AD) and is regarded as a principal target for development of disease-modifying therapeutics...
  7. doi request reprint Biochemical evidence for the differential association of metabotropic glutamate receptors within synaptic complexes
    Ayodeji A Asuni
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Neurosci Lett 444:27-30. 2008
    ..We have also applied the approach to scaffolding proteins implicated in mGlu localisation to define the biochemical correlates of mGlu scaffolding...
  8. ncbi request reprint Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
    Ayodeji A Asuni
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:9115-29. 2007
    ..Currently, no treatment is available for clearing tau aggregates. Our present findings may lead to a novel therapy targeting one of the major hallmarks of Alzheimer's disease and frontotemporal dementia...