Matthew J Winter

Summary

Affiliation: AstraZeneca R and D

Publications

  1. ncbi request reprint Comparative physiology, pharmacology and toxicology of beta-blockers: mammals versus fish
    Stewart F Owen
    Institute for the Environment, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Aquat Toxicol 82:145-62. 2007
  2. doi request reprint Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs
    Matthew J Winter
    AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, UK
    J Pharmacol Toxicol Methods 57:176-87. 2008
  3. pmc Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna
    Rhiannon M David
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Chemosphere 88:912-7. 2012
  4. doi request reprint Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas)
    Matthew J Winter
    AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom
    Aquat Toxicol 86:361-9. 2008
  5. ncbi request reprint Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide
    Matthew J Winter
    AstraZeneca Global Safety, Health and Environment, United Kingdom
    Mutat Res 629:89-99. 2007
  6. doi request reprint Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and challenges
    Matthew J Winter
    AstraZeneca, Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom
    Integr Environ Assess Manag 6:38-51. 2010
  7. doi request reprint In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol
    Abigail E Bartram
    AstraZeneca, Safety Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon, TQ5 8BA, UK
    Environ Toxicol 27:573-82. 2012
  8. ncbi request reprint DNA strand breaks and adducts determined in feral and caged chub (Leuciscus cephalus) exposed to rivers exhibiting variable water quality around Birmingham, UK
    Matthew J Winter
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutat Res 552:163-75. 2004
  9. doi request reprint Approaches to seizure risk assessment in preclinical drug discovery
    Alison Easter
    Safety Assessment US, AstraZeneca R and D Wilmington, DE 19850, USA
    Drug Discov Today 14:876-84. 2009
  10. doi request reprint Zebrafish assays as early safety pharmacology screens: paradigm shift or red herring?
    William S Redfern
    Safety Pharmacology Department, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Cheshire, UK
    J Pharmacol Toxicol Methods 58:110-7. 2008

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Comparative physiology, pharmacology and toxicology of beta-blockers: mammals versus fish
    Stewart F Owen
    Institute for the Environment, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Aquat Toxicol 82:145-62. 2007
    ..Finally, accurate citation of CAS numbers is essential for pharmaceuticals in order to compare nominal concentration data in terms of either the drug free base or the drug salt complex...
  2. doi request reprint Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs
    Matthew J Winter
    AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, UK
    J Pharmacol Toxicol Methods 57:176-87. 2008
    ..Here, we present methodology and validation data (on 25 compounds) from a larval zebrafish (Zf) convulsant assay, based on the quantification of high speed locomotion after exposure to a range of test compounds...
  3. pmc Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna
    Rhiannon M David
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Chemosphere 88:912-7. 2012
    ....
  4. doi request reprint Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas)
    Matthew J Winter
    AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom
    Aquat Toxicol 86:361-9. 2008
    ..The data produced for atenolol here fit well with both approaches, but also highlight the importance of generating 'real' experimental data with which to calibrate and validate such models...
  5. ncbi request reprint Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide
    Matthew J Winter
    AstraZeneca Global Safety, Health and Environment, United Kingdom
    Mutat Res 629:89-99. 2007
    ..Consequently, further clarifying work is required to delineate the response shown, considering the extensive use of this species in ecotoxicology research and regulatory testing...
  6. doi request reprint Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and challenges
    Matthew J Winter
    AstraZeneca, Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom
    Integr Environ Assess Manag 6:38-51. 2010
    ....
  7. doi request reprint In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol
    Abigail E Bartram
    AstraZeneca, Safety Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon, TQ5 8BA, UK
    Environ Toxicol 27:573-82. 2012
    ....
  8. ncbi request reprint DNA strand breaks and adducts determined in feral and caged chub (Leuciscus cephalus) exposed to rivers exhibiting variable water quality around Birmingham, UK
    Matthew J Winter
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutat Res 552:163-75. 2004
    ..Overall, these data are consistent with exposure of both feral and caged chub to contaminants which are able to induce specific, moderately genotoxic effects...
  9. doi request reprint Approaches to seizure risk assessment in preclinical drug discovery
    Alison Easter
    Safety Assessment US, AstraZeneca R and D Wilmington, DE 19850, USA
    Drug Discov Today 14:876-84. 2009
    ..Here we review the current techniques available to assess this issue and describe how they may be combined in a rational step-wise cascade allowing more effective assessment of seizure risk...
  10. doi request reprint Zebrafish assays as early safety pharmacology screens: paradigm shift or red herring?
    William S Redfern
    Safety Pharmacology Department, Safety Assessment UK, AstraZeneca R and D, Alderley Park, Cheshire, UK
    J Pharmacol Toxicol Methods 58:110-7. 2008
    ....
  11. doi request reprint Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish
    Lauren M J Buck
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Hear Res 284:67-81. 2012
    ..Collectively, these data provide evidence to support the use of the zebrafish as a pre-clinical indicator of drug-induced histological and functional ototoxicity...
  12. doi request reprint A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function
    Thomas Parker
    AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Freshwater Quarry, Brixham, Devon TQ5 8BA, United Kingdom
    J Pharmacol Toxicol Methods 69:30-8. 2014
    ..Consequently, we developed a novel larval Zf model capable of simultaneous quantification of chronotropic, inotropic and arrhythmic effects, alongside measures of blood flow and vessel diameter...
  13. ncbi request reprint Tissue levels and biomarkers of organic contaminants in feral and caged chub (Leuciscus cephalus) from rivers in the West Midlands, UK
    Matthew J Winter
    Brixham Environmental Laboratory, AstraZeneca UK Ltd, Brixham, Devon TQ58BA, UK
    Aquat Toxicol 73:394-405. 2005
    ....
  14. ncbi request reprint Does exhaustive exercise result in oxidative stress and associated DNA damage in the chub (Leuciscus cephalus)?
    Stanley O Aniagu
    Molecular Pathobiology Unit, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Environ Mol Mutagen 47:616-23. 2006
    ..These observations suggest that fish living in fast flowing and polluted rivers are at increased risk of DNA damage...
  15. ncbi request reprint Cloning of a chub metallothionein cDNA and development of competitive RT-PCR of chub metallothionein mRNA as a potential biomarker of heavy metal exposure
    Ruth A Hayes
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mar Environ Res 58:665-9. 2004
    ..A lack of elevation of hepatic metallothionein mRNA in chub exposed to zinc, copper and manganese for 24 h and 10 days in the laboratory also suggests a non-responsiveness of this species...
  16. ncbi request reprint High plasma concentrations of human urotensin II do not alter local or systemic hemodynamics in man
    Ian B Wilkinson
    Clinical Pharmacology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2LH, Scotland, UK
    Cardiovasc Res 53:341-7. 2002
    ..We examined, for the first time, the local and systemic hemodynamic response to hUII in man in vivo...