I K Wiklund

Summary

Affiliation: AstraZeneca R and D

Publications

  1. pmc An instrument for measuring health-related quality of life in patients with Deep Venous Thrombosis (DVT): development and validation of Deep Venous Thrombosis Quality of Life (DVTQOL) questionnaire
    Ewa Hedner
    Experimental Medicine, AstraZeneca, R and D, SE 431 83 Molndal, Sweden
    Health Qual Life Outcomes 2:30. 2004
  2. pmc A new instrument for measuring anticoagulation-related quality of life: development and preliminary validation
    Greg Samsa
    Department of Biometry and Bioinformatics, Duke University Medical Center, Wachovia Plaza, Suite 220, 2200 West Main Street, Durham, NC 27705, USA
    Health Qual Life Outcomes 2:22. 2004
  3. pmc The influence of demographic factors and health-related quality of life on treatment satisfaction in patients with gastroesophageal reflux disease treated with esomeprazole
    Alessio Degl' Innocenti
    AstraZeneca R and D, 431 83 Mölndal, Sweden
    Health Qual Life Outcomes 3:4. 2005
  4. pmc Psychometric validation of the German translation of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in patients with reflux disease
    Károly R Kulich
    Clinical Science, AstraZeneca R and D Molndal, Sweden
    Health Qual Life Outcomes 1:62. 2003
  5. pmc The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
    Samer El-Dika
    Division of Gastroenterology, Veterans Affairs Medical Center, Salem, Virginia, USA
    BMC Gastroenterol 5:23. 2005
  6. ncbi request reprint Psychological factors as a predictor of treatment response in patients with heartburn: a pooled analysis of clinical trials
    Ingela Wiklund
    AstraZeneca R and D Molndal, Molndal, Sweden
    Scand J Gastroenterol 41:288-93. 2006
  7. ncbi request reprint Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Swedish Alternative Medicine Group
    I K Wiklund
    Department of Health and Primary Health Care, University of Bergen, Norway
    Int J Clin Pharmacol Res 19:89-99. 1999
  8. ncbi request reprint Review of the quality of life and burden of illness in gastroesophageal reflux disease
    Ingela Wiklund
    AstraZeneca R and D, Molndal, Sweden
    Dig Dis 22:108-14. 2004
  9. ncbi request reprint Assessment of patient-reported outcomes in clinical trials: the example of health-related quality of life
    Ingela Wiklund
    Outcomes Research, AstraZeneca, S 431 83 Molndal, Sweden
    Fundam Clin Pharmacol 18:351-63. 2004
  10. ncbi request reprint An irritable bowel syndrome-specific symptom questionnaire: development and validation
    I K Wiklund
    AstraZeneca R and D Molndal, Sweden
    Scand J Gastroenterol 38:947-54. 2003

Detail Information

Publications35

  1. pmc An instrument for measuring health-related quality of life in patients with Deep Venous Thrombosis (DVT): development and validation of Deep Venous Thrombosis Quality of Life (DVTQOL) questionnaire
    Ewa Hedner
    Experimental Medicine, AstraZeneca, R and D, SE 431 83 Molndal, Sweden
    Health Qual Life Outcomes 2:30. 2004
    ....
  2. pmc A new instrument for measuring anticoagulation-related quality of life: development and preliminary validation
    Greg Samsa
    Department of Biometry and Bioinformatics, Duke University Medical Center, Wachovia Plaza, Suite 220, 2200 West Main Street, Durham, NC 27705, USA
    Health Qual Life Outcomes 2:22. 2004
    ..We describe the development and preliminary validation of such an instrument - the Duke Anticoagulation Satisfaction Scale (DASS)...
  3. pmc The influence of demographic factors and health-related quality of life on treatment satisfaction in patients with gastroesophageal reflux disease treated with esomeprazole
    Alessio Degl' Innocenti
    AstraZeneca R and D, 431 83 Mölndal, Sweden
    Health Qual Life Outcomes 3:4. 2005
    ..The objective of this study was to assess correlates of treatment satisfaction in patients with GERD receiving a proton pump inhibitor, esomeprazole...
  4. pmc Psychometric validation of the German translation of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in patients with reflux disease
    Károly R Kulich
    Clinical Science, AstraZeneca R and D Molndal, Sweden
    Health Qual Life Outcomes 1:62. 2003
    ..The aim is to document the psychometric characteristics of the German translation of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire...
  5. pmc The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
    Samer El-Dika
    Division of Gastroenterology, Veterans Affairs Medical Center, Salem, Virginia, USA
    BMC Gastroenterol 5:23. 2005
    ..Gastro-esophageal reflux disease (GERD) is a common disease. It impairs health related quality of life (HRQL). However, the impact on utility scores and work productivity in patients with moderate to severe GERD is not well known...
  6. ncbi request reprint Psychological factors as a predictor of treatment response in patients with heartburn: a pooled analysis of clinical trials
    Ingela Wiklund
    AstraZeneca R and D Molndal, Molndal, Sweden
    Scand J Gastroenterol 41:288-93. 2006
    ....
  7. ncbi request reprint Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Swedish Alternative Medicine Group
    I K Wiklund
    Department of Health and Primary Health Care, University of Bergen, Norway
    Int J Clin Pharmacol Res 19:89-99. 1999
    ....
  8. ncbi request reprint Review of the quality of life and burden of illness in gastroesophageal reflux disease
    Ingela Wiklund
    AstraZeneca R and D, Molndal, Sweden
    Dig Dis 22:108-14. 2004
    ..Understanding patients' experience of GERD and its treatment through the study of HRQoL is one way to address this problem...
  9. ncbi request reprint Assessment of patient-reported outcomes in clinical trials: the example of health-related quality of life
    Ingela Wiklund
    Outcomes Research, AstraZeneca, S 431 83 Molndal, Sweden
    Fundam Clin Pharmacol 18:351-63. 2004
    ..Successful evaluation of PROs in clinical trials relies on careful planning provided the treatment shows sufficient effectiveness...
  10. ncbi request reprint An irritable bowel syndrome-specific symptom questionnaire: development and validation
    I K Wiklund
    AstraZeneca R and D Molndal, Sweden
    Scand J Gastroenterol 38:947-54. 2003
    ..No self-assessment instruments are available to assess symptoms of irritable bowel syndrome (IBS). Our aim was to develop a disease-specific symptom questionnaire for use in patients with IBS...
  11. ncbi request reprint Burden of illness in patients with reflux disease--evidence from a recent comparative methodological study in Hungary
    Laszlo Ujszaszy
    Semmelweis Hospital, Internal Medicine, Miskolc, Hungary
    Orv Hetil 145:717-22, 733-8. 2004
    ..The primary symptom of GERD is heartburn, but it may also be associated with extraesophageal manifestations, such as asthma, chest pain and otolaryngologic disorders...
  12. ncbi request reprint [Psychometric validation of the Polish translation of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) Questionnaire in patients with reflux disease]
    Károly R Kulich
    Clinical Science, AstraZeneca R and D Molndal, Sweden
    Pol Arch Med Wewn 113:241-9. 2005
    ..GSRS domains "abdominal pain" and "indigestion" were related to all SF-36 domains. All QOLRAD domains significantly correlated with all SF-36 domains...
  13. ncbi request reprint Managing gastroesophageal reflux disease in primary care: the patient perspective
    Harley Liker
    David Geffen School of Medicine at UCLA, Beverly Hills, California 90210, USA
    J Am Board Fam Pract 18:393-400. 2005
    ..In conclusion, many aspects of HRQL are impaired in GERD patients. The primary-care physician is uniquely placed to assess and address the impact of GERD on patients' lives...
  14. ncbi request reprint Felodipine-metoprolol combination tablet: maintained health-related quality of life in the presence of substantial blood pressure reduction
    Bjorn Dahlof
    Clinical Experimental Research Laboratory, Department of Medicine, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Am J Hypertens 18:1313-9. 2005
    ..The primary objective of this study was to compare the effects on HRQL of initiating treatment with felodipine + metoprolol (F+M) fixed combination tablets, or enalapril (E), or placebo (P)...
  15. ncbi request reprint Gastroesophageal reflux symptoms and well-being in a random sample of the general population of a Swedish community
    Ingela Wiklund
    Outcomes Research, AstraZeneca R and D, Molndal, Sweden
    Am J Gastroenterol 101:18-28. 2006
    ..This study aimed to investigate this relationship and determine the severity threshold at which reflux symptoms meaningfully affect patients' well-being...
  16. ncbi request reprint Validity of a Work Productivity and Activity Impairment questionnaire for patients with symptoms of gastro-esophageal reflux disease (WPAI-GERD)--results from a cross-sectional study
    Peter Wahlqvist
    Health Economics AstraZeneca R and D, Molndal, Sweden
    Value Health 5:106-13. 2002
    ..To validate a Work Productivity and Activity Impairment questionnaire (WPAI-GERD) developed to measure lost productivity due to symptoms of gastro-esophageal reflux disease (GERD)...
  17. ncbi request reprint Personality and mode of delivery
    Ingela Wiklund
    Division of Obstetrics and Gynaecology, R and D Section, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Acta Obstet Gynecol Scand 85:1225-30. 2006
    ..The aim was also to study differences between the groups in age, perceived health, and place of birth, IVF treatment, and family size planning...
  18. ncbi request reprint Cesarean section on maternal request: reasons for the request, self-estimated health, expectations, experience of birth and signs of depression among first-time mothers
    Ingela Wiklund
    Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden
    Acta Obstet Gynecol Scand 86:451-6. 2007
    ..We also aimed to study if signs of depression postpartum are more common in this group...
  19. ncbi request reprint The Work Productivity and Activity Impairment Questionnaire for Patients with Gastroesophageal Reflux Disease (WPAI-GERD): responsiveness to change and English language validation
    Peter Wahlqvist
    AstraZeneca R and D, Molndal, Sweden
    Pharmacoeconomics 25:385-96. 2007
    ..A validated productivity questionnaire, the Work Productivity and Activity Impairment questionnaire for Gastroesophageal Reflux Disease (WPAI-GERD), exists for Swedish patients with GERD...
  20. ncbi request reprint Application of generalizability theory confirmed lower reliability of the standard gamble than the feeling thermometer
    Holger J Schunemann
    Department of Epidemiology, INFORMA Unit CLARITY Research Group, Italian National Cancer Institute Regina Elena, Via Elio Chianesi 53, 00144 Rome, Italy
    J Clin Epidemiol 60:1256-62. 2007
    ..Further, lack of interrater reliability may compromise the use of CMS in interpreting health state ratings. The aim of this study was to assess the reliability of CMS ratings for the SG and the FT...
  21. pmc The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials
    Michael Shaw
    Park Nicollet Clinic and University of Minnesota Medical School, Minneapolis, MN 55416 2699, USA
    Health Qual Life Outcomes 6:31. 2008
    ....
  22. ncbi request reprint Beyond heartburn: a systematic review of the extra-oesophageal spectrum of reflux-induced disease
    A Pali S Hungin
    Cetre for Integrated Health Care Research, University of Durham Stockton Campus, Wolfson Research Institute, Stockton on Tees TS176BH, UK
    Fam Pract 22:591-603. 2005
    ..GORD is characterized by heartburn and acid regurgitation, but is reported to be associated with a spectrum of extra-oesophageal symptoms...
  23. ncbi request reprint [Burden of illness in Polish patients with reflux disease]
    Jarosław Reguła
    Klinika Gastroenterologii CMKP, Centrum Onkologii Instytut im Marii Skłodowskiej Curie, Warszawa
    Przegl Epidemiol 59:75-85. 2005
    ..7). Using HAD, 32% of heartburn patients were anxious and 10% were depressed. In conclusion it should be stated that there is consistent evidence that GERD substantially impairs all aspects of health-related quality of life...
  24. ncbi request reprint Psychometric validation of the Hungarian translation of the gastrointestinal symptom rating scale (GSRS) and quality of life in reflux and dyspepsia (QOLRAD) questionnaire in patients with reflux disease
    R Károly Kulich
    AstraZeneca R and D Molndal, Sweden
    Orv Hetil 145:723-9, 739-44. 2004
    ..The aim of the paper is to document the psychometric characteristics of the Hungarian translation of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire...
  25. ncbi request reprint Factor structure of the Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire evaluated in patients with heartburn predominant reflux disease
    Károly R Kulich
    AstraZeneca R and D Molndal, Molndal, Sweden
    Qual Life Res 12:699-708. 2003
    ..To test whether the original factor structure of the Quality of Life in Reflux and Dyspepsia (QOLRAD) can be replicated in Nordic patients and English speaking patients...
  26. ncbi request reprint A randomized multicenter trial to evaluate simple utility elicitation techniques in patients with gastroesophageal reflux disease
    Holger J Schunemann
    Department of Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA
    Med Care 42:1132-42. 2004
    ..We evaluated whether the administration of marker states improves measurement properties of the FT and SG...
  27. ncbi request reprint Cognitive function and health-related quality of life in elderly patients with hypertension--baseline data from the study on cognition and prognosis in the elderly (SCOPE)
    Alessio degl'Innocenti
    AstroZeneca R and D, Molndal, Sweden
    Blood Press 11:157-65. 2002
    ..Age and the use of psychotropic drugs, but not gender and education level, influenced this relationship significantly...
  28. ncbi request reprint Assessing symptoms in gastroesophageal reflux disease: how well do clinicians' assessments agree with those of their patients?
    Elaine McColl
    Centre for Health Services Research, School of Population and Health Sciences, University of Newcastle upon Tyne, 21 Claremont Place, Newcastle upon Tyne NE2 4AA, United Kingdom
    Am J Gastroenterol 100:11-8. 2005
    ..This study aimed to determine the extent of agreement between clinicians and patients regarding assessments of reflux symptom severity in patients with gastroesophageal reflux disease...
  29. ncbi request reprint Patient reported outcomes in gastroesophageal reflux disease: an overview of available measures
    Nicholas J Talley
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
    Qual Life Res 14:21-33. 2005
    ..The most frequently used instruments in GERD are reviewed here, in terms of their psychometric properties...
  30. ncbi request reprint Health-related quality of life and gastrointestinal disease
    Hans Glise
    GI Therapy Area, AstraZeneca, Molndal, Sweden
    J Gastroenterol Hepatol 17:S72-84. 2002
    ..Health-related quality of life evaluations, as an additional tool in the management of patients, are here to stay...
  31. doi request reprint An international comparison of the burden of illness in patients with dyspepsia
    Katarina Halling
    AstraZeneca R and D Molndal, Molndal, Sweden
    Dig Dis 26:264-73. 2008
    ..This study investigates the symptoms and the impact of symptoms on health-related quality of life (HRQL) in patients consulting with dyspepsia...
  32. ncbi request reprint Symptom recording in a randomised clinical trial: paper diaries vs. electronic or telephone data capture
    Karsten Lauritsen
    Department of Gastroenterology, Odense University Hospital, Odense, Denmark
    Control Clin Trials 25:585-97. 2004
    ..We aimed to compare accuracy, autocorrelations of consecutive entries, and responsiveness in paper diaries (P-Diaries) with electronic diaries (E-Diaries) and telephone diaries (T-Diaries)...
  33. ncbi request reprint A comparative study in Stockholm, Sweden of labour outcome and women's perceptions of being referred in labour
    Ingela Wiklund
    Department of Obstetrics and Gynaecology, Danderyd Hospital S 182 88, Stockholm, Sweden
    Midwifery 18:193-9. 2002
    ..to study the outcome of labour and women's perceptions of being referred after onset of labour...
  34. ncbi request reprint [The county of Stockholm pays for home childbirth in certain cases. Strict medical criteria and requirements when it comes to midwives must be fulfilled]
    Ingela Wiklund
    Karolinska institutet Danderyds Sjukhus, Stockholm
    Lakartidningen 100:4272-7. 2003
  35. ncbi request reprint [Swedish obstetrical care must be made safer]
    Charlotta Grunewald
    Svensk förening för obstetrik och gynekologi
    Lakartidningen 105:196. 2008