S G Simonson
Affiliation: AstraZeneca R and D
- Comparative effects of rosuvastatin and atorvastatin across their dose ranges in patients with hypercholesterolemia and without active arterial diseaseDennis W Schneck
AstraZeneca LP, Wilmington, Delaware 19850 5437, USA
Am J Cardiol 91:33-41. 2003..Significantly greater triglyceride decreases were seen at 80 mg with atorvastatin over rosuvastatin. Both rosuvastatin and atorvastatin were well tolerated over 6 weeks...
- Pharmacokinetics and pharmacodynamics of rosuvastatin in subjects with hepatic impairmentS G Simonson
AstraZeneca, R and D Lund, Experimental Medicine, SE 221 87 Lund, Sweden
Eur J Clin Pharmacol 58:669-75. 2003..To assess the effect of chronic hepatic impairment on rosuvastatin disposition, pharmacodynamic activity and tolerability...
- The effect of rosuvastatin on oestrogen & progestin pharmacokinetics in healthy women taking an oral contraceptiveSteven G Simonson
AstraZeneca, Lund, Sweden
Br J Clin Pharmacol 57:279-86. 2004..To assess the effect of rosuvastatin on oestrogen and progestin pharmacokinetics in women taking a commonly prescribed combination oral contraceptive steroid (OCS); the effect on endogenous hormones and the lipid profile was also assessed...
- Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporineSteven G Simonson
AstraZeneca, Wilmington, Del, USA
Clin Pharmacol Ther 76:167-77. 2004..Inhibition of this transporter could increase plasma concentrations of rosuvastatin. Therefore the effect of cyclosporine on rosuvastatin uptake by cells expressing OATP-C was also examined...
- Rosuvastatin improves the atherogenic and atheroprotective lipid profiles in patients with hypertriglyceridemiaDonald B Hunninghake
Heart Disease Prevention Clinic, University of Minnesota, Minneapolis, Minnesota 55455, USA
Coron Artery Dis 15:115-23. 2004..We examined the effects of rosuvastatin treatment on triglyceride levels and lipid measures in a parallel-group multicenter trial (4522IL/0035) in patients with hypertriglyceridemia (Fredrickson Type IIb or IV)...
- Effect of rosuvastatin on warfarin pharmacodynamics and pharmacokineticsSteven G Simonson
AstraZeneca, 1800 Concord Pike, PO Box 15437, Wilmington, DE 19850 5437, USA
J Clin Pharmacol 45:927-34. 2005..Appropriate monitoring of the international normalized ratio is indicated when this drug combination is coadministered...
- Evaluation of efficacy and safety of budesonide delivered via two dry powder inhalersEdward M Kerwin
Clinical Research Institute of Southern Oregon, Medford, OR 97504, USA
Curr Med Res Opin 24:1497-510. 2008..The dry powder inhaler (DPI) device for budesonide inhalation powder 200 microg (DPI-A) was redesigned to improve dosing consistency and provide new features (budesonide inhalation powder 90 microg and 180 microg; DPI-B)...
- Zafirlukast treatment for acute asthma: evaluation in a randomized, double-blind, multicenter trialRobert A Silverman
Long Island Jewish Medical Center, 270 05 76th Ave, New Hyde Park, NY 11042, USA
Chest 126:1480-9. 2004..Acute asthma causes nearly 2 million hospital emergency department (ED) visits in the United States annually, and hospitalization after an ED visit and relapse after ED discharge are common...