Ruth A Roberts

Summary

Affiliation: AstraZeneca R and D

Publications

  1. doi Reducing attrition in drug development: smart loading preclinical safety assessment
    Ruth A Roberts
    Drug Safety and Metabolism, AstraZeneca, Alderley Park, Macclesfield, SK10 4TG, UK Electronic address
    Drug Discov Today 19:341-7. 2014
  2. doi Toxicological and pathophysiological roles of reactive oxygen and nitrogen species
    Ruth A Roberts
    AstraZeneca, Alderley Park, Cheshire SK9 IDG, corrected UK
    Toxicology 276:85-94. 2010
  3. pmc Nitrative and oxidative stress in toxicology and disease
    Ruth A Roberts
    AstraZeneca R and D Safety Assessment, Alderley Park, UK SK9 1DG
    Toxicol Sci 112:4-16. 2009
  4. ncbi Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis
    Ruth A Roberts
    AstraZeneca, Safety Assessment Alderley Park, Macclesfield, Cheshire, SK10 4TG United Kingdom
    Toxicol Sci 96:2-15. 2007
  5. ncbi Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis
    Jason D Oliver
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Pharmacol Toxicol 91:1-7. 2002
  6. ncbi Evidence for cross talk between PPARalpha and p38 MAP kinase
    Ruth A Roberts
    Syngenta CTL, Alderley Park, Macclesfield, SK10 4TJ, United Kingdom
    Toxicol Sci 68:270-4. 2002
  7. doi Target organ toxicities in studies conducted to support first time in man dosing: an analysis across species and therapy areas
    Steve Horner
    Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, UK
    Regul Toxicol Pharmacol 65:334-43. 2013
  8. ncbi Species differences in response to the phthalate plasticizer monoisononylphthalate (MINP) in vitro: a comparison of rat and human hepatocytes
    David Shaw
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Arch Toxicol 76:344-50. 2002
  9. doi Species-specific kinetics and zonation of hepatic DNA synthesis induced by ligands of PPARalpha
    Abdullah Al Kholaifi
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Toxicol Sci 104:74-85. 2008
  10. pmc PPARalpha and effects of TCE
    James E Klaunig
    Environ Health Perspect 115:A14-5; authohr reply A15-6. 2007

Collaborators

Detail Information

Publications16

  1. doi Reducing attrition in drug development: smart loading preclinical safety assessment
    Ruth A Roberts
    Drug Safety and Metabolism, AstraZeneca, Alderley Park, Macclesfield, SK10 4TG, UK Electronic address
    Drug Discov Today 19:341-7. 2014
    ..This will reduce animal use overall, save significant R&D costs and improve drug pipeline quality. ..
  2. doi Toxicological and pathophysiological roles of reactive oxygen and nitrogen species
    Ruth A Roberts
    AstraZeneca, Alderley Park, Cheshire SK9 IDG, corrected UK
    Toxicology 276:85-94. 2010
    ..Examples are presented from five different perspectives ranging from in vitro model systems through to in vivo animal model systems and clinical outcomes...
  3. pmc Nitrative and oxidative stress in toxicology and disease
    Ruth A Roberts
    AstraZeneca R and D Safety Assessment, Alderley Park, UK SK9 1DG
    Toxicol Sci 112:4-16. 2009
    ..An understanding of fundamental concepts of oxidative and nitrative stress can underpin a rational plan of treatment for diseases and toxicities associated with excessive production of reactive oxygen and nitrogen species...
  4. ncbi Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis
    Ruth A Roberts
    AstraZeneca, Safety Assessment Alderley Park, Macclesfield, Cheshire, SK10 4TG United Kingdom
    Toxicol Sci 96:2-15. 2007
    ..Taken together, the data presented in this symposium illustrate to the toxicologist the central role played by Kupffer cells in mediating hepatotoxicity...
  5. ncbi Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis
    Jason D Oliver
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Pharmacol Toxicol 91:1-7. 2002
    ..This implies that changes in the expression of key target genes control proliferation and apoptosis in the xenobiotic-induced hepatocyte phenotype...
  6. ncbi Evidence for cross talk between PPARalpha and p38 MAP kinase
    Ruth A Roberts
    Syngenta CTL, Alderley Park, Macclesfield, SK10 4TJ, United Kingdom
    Toxicol Sci 68:270-4. 2002
  7. doi Target organ toxicities in studies conducted to support first time in man dosing: an analysis across species and therapy areas
    Steve Horner
    Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, UK
    Regul Toxicol Pharmacol 65:334-43. 2013
    ..Overall, our data provide new insights into drug toxicity profiles in pre-clinical species and additionally confirm the value of using non-rodents as a second species in toxicity testing to support human safety...
  8. ncbi Species differences in response to the phthalate plasticizer monoisononylphthalate (MINP) in vitro: a comparison of rat and human hepatocytes
    David Shaw
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Arch Toxicol 76:344-50. 2002
    ..These data provide evidence for species differences in the hepatic response to the phthalate ester DINP, confirming that human hepatocytes are refractory to the adverse effects noted in rodents...
  9. doi Species-specific kinetics and zonation of hepatic DNA synthesis induced by ligands of PPARalpha
    Abdullah Al Kholaifi
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Toxicol Sci 104:74-85. 2008
    ..These results characterize a markedly later hepatic induction of panlobular DNA synthesis by PPARalpha ligands in mouse, compared to rapid induction of periportal DNA synthesis in rat...
  10. pmc PPARalpha and effects of TCE
    James E Klaunig
    Environ Health Perspect 115:A14-5; authohr reply A15-6. 2007
  11. ncbi PPARalpha agonist-induced rodent tumors: modes of action and human relevance
    James E Klaunig
    Indiana University School of Medicine, Indianapolis, IN, USA
    Crit Rev Toxicol 33:655-780. 2003
    ....
  12. ncbi Regulation of apoptosis by peroxisome proliferators
    Ruth A Roberts
    Aventis Pharma, Drug Safety Evaluation, Centre de Recherche de Paris, 13 quai Jules Guesde, 94403 Paris, France
    Toxicol Lett 149:37-41. 2004
    ..These data will allow the identification of specific genes that are regulated by PPs leading to changes in apoptosis and ultimately to tumours...
  13. ncbi Characterization of the transforming growth factor-beta 1-induced apoptotic transcriptome in FaO hepatoma cells
    Beth Coyle
    Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 278:5920-8. 2003
    ....
  14. ncbi Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver
    Brett Jeffery
    School of Biology, University Park, University of Nottingham, Nottingham NG7 2RD, UK
    Arch Biochem Biophys 429:231-6. 2004
    ..Thus, PPARalpha has a specific effect on constitutive expression of Cyp4a12...
  15. ncbi Molecular analysis of peroxisome proliferation in the hamster
    Agharul I Choudhury
    School of Biology, University of Nottingham, Nottingham NG7 2RD, UK
    Toxicol Appl Pharmacol 197:9-18. 2004
    ..These results fail to support the hypothesis that the level of PPARalpha in liver is directly responsible for species differences in peroxisome proliferation...