Fraser Murray

Summary

Affiliation: AstraZeneca R and D

Publications

  1. ncbi Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists
    Fraser Murray
    Merck Sharp and Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    Eur J Pharmacol 569:41-7. 2007
  2. doi Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice
    Fraser Murray
    Merck Sharp and Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR United Kingdom
    Eur J Pharmacol 583:115-27. 2008
  3. ncbi N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists
    Jason M Elliott
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 16:5748-51. 2006
  4. ncbi Proteomic analysis identifies alterations in cellular morphology and cell death pathways in mouse brain after chronic corticosterone treatment
    Heather A Skynner
    Department of Molecular and Cellular Neuroscience, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK
    Brain Res 1102:12-26. 2006
  5. ncbi The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze
    Martin R Guscott
    Merck, Sharp and Dohme, The Neuroscience Research Centre, Behavioural Neuroscience, Terlings Park, Harlow CM20 2QR, UK
    Eur J Pharmacol 476:193-9. 2003
  6. ncbi A rapid method for the quantification of mouse hippocampal neurogenesis in vivo by flow cytometry. Validation with conventional and enhanced immunohistochemical methods
    James George Bilsland
    Department of Molecular and Cellular Neuroscience, Merck, Sharp and Dohme Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    J Neurosci Methods 157:54-63. 2006
  7. ncbi Mechanisms of action of the antidepressants fluoxetine and the substance P antagonist L-000760735 are associated with altered neurofilaments and synaptic remodeling
    Paul C Guest
    Neuroscience Research Centre, Merck, Sharp and Dohme, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Brain Res 1002:1-10. 2004
  8. ncbi N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II
    Jason M Elliott
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 16:5752-6. 2006
  9. ncbi Nucleus accumbens NMDA receptor subunit expression and function is enhanced in morphine-dependent rats
    Fraser Murray
    AstraZeneca, Alderley Park, Macclesfiled, Cheshire, SK10 4TG, UK
    Eur J Pharmacol 562:191-7. 2007

Detail Information

Publications9

  1. ncbi Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists
    Fraser Murray
    Merck Sharp and Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    Eur J Pharmacol 569:41-7. 2007
    ..The induction of hippocampal Bcl-2 expression by long-term antidepressant treatment may contribute to the clinical efficacy of such compounds via its well described neurotrophic and/or anti-apoptotic effects on neuronal function...
  2. doi Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice
    Fraser Murray
    Merck Sharp and Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR United Kingdom
    Eur J Pharmacol 583:115-27. 2008
    ..The results presented here demonstrate that moderately elevated corticosterone for a prolonged period is sufficient to induce cellular changes in the hippocampus that are prevented by chronic administration of antidepressants...
  3. ncbi N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists
    Jason M Elliott
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 16:5748-51. 2006
    ..In an ex vivo assay in gerbil, the lead compound 2g occupies receptors within the CNS following oral dosing (Occ(90) 30 mg/kg po; plasma Occ(90) 0.95 microM) and has good selectivity and promising PK properties...
  4. ncbi Proteomic analysis identifies alterations in cellular morphology and cell death pathways in mouse brain after chronic corticosterone treatment
    Heather A Skynner
    Department of Molecular and Cellular Neuroscience, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK
    Brain Res 1102:12-26. 2006
    ..Further elucidation of these pathways could lead to identification of biomarkers for the development of pharmacological therapies targeted at neuropsychiatric disorders...
  5. ncbi The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze
    Martin R Guscott
    Merck, Sharp and Dohme, The Neuroscience Research Centre, Behavioural Neuroscience, Terlings Park, Harlow CM20 2QR, UK
    Eur J Pharmacol 476:193-9. 2003
    ..These results suggest that antagonists selective for NR1/NR2B subunit-containing receptors may not impair spatial memory in rats in the Morris watermaze...
  6. ncbi A rapid method for the quantification of mouse hippocampal neurogenesis in vivo by flow cytometry. Validation with conventional and enhanced immunohistochemical methods
    James George Bilsland
    Department of Molecular and Cellular Neuroscience, Merck, Sharp and Dohme Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    J Neurosci Methods 157:54-63. 2006
    ..The robust changes compared to control groups observed in these models were similar to previously reported studies, thus offering a more rapid and streamlined means to quantify effects of compounds on hippocampal proliferation...
  7. ncbi Mechanisms of action of the antidepressants fluoxetine and the substance P antagonist L-000760735 are associated with altered neurofilaments and synaptic remodeling
    Paul C Guest
    Neuroscience Research Centre, Merck, Sharp and Dohme, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Brain Res 1002:1-10. 2004
    ....
  8. ncbi N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II
    Jason M Elliott
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 16:5752-6. 2006
    ..The lead compound (8m) occupies receptors within the CNS following oral dosing (Occ(90) 7 mg/kg po; plasma Occ(90) 0.4 microM) and has good selectivity and excellent PK properties...
  9. ncbi Nucleus accumbens NMDA receptor subunit expression and function is enhanced in morphine-dependent rats
    Fraser Murray
    AstraZeneca, Alderley Park, Macclesfiled, Cheshire, SK10 4TG, UK
    Eur J Pharmacol 562:191-7. 2007
    ..Taken together, these data support several studies in the literature indicating that NMDA receptors in the nucleus accumbens are involved in the process of opiate dependence...