Silvia Melgar

Summary

Affiliation: AstraZeneca R and D

Publications

  1. ncbi request reprint Predicting and monitoring colitis development in mice by micro-computed tomography
    Maria Fritsch Fredin
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Molndal, Sweden
    Inflamm Bowel Dis 14:491-9. 2008
  2. ncbi request reprint Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis
    Silvia Melgar
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, GI Biology, SE 431 83, Sweden
    Cytokine 35:275-83. 2006
  3. ncbi request reprint Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation
    Silvia Melgar
    AstraZeneca R and D Molndal, Dept of Integrative Pharmacology, GI Biology, SE 431 83 Molndal, Sweden
    Am J Physiol Gastrointest Liver Physiol 288:G1328-38. 2005
  4. ncbi request reprint Mice with experimental colitis show an altered metabolism with decreased metabolic rate
    Silvia Melgar
    Department of Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca Research and Development, Molndal, Sweden
    Am J Physiol Gastrointest Liver Physiol 292:G165-72. 2007
  5. ncbi request reprint High-throughput magnetic resonance imaging in murine colonic inflammation
    Silvia Melgar
    Department of Integrative Pharmacology, AstraZeneca, Molndal, Sweden
    Biochem Biophys Res Commun 355:1102-7. 2007
  6. doi request reprint Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease
    Silvia Melgar
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Int Immunopharmacol 8:836-44. 2008
  7. ncbi request reprint Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice
    Agneta Karlsson
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Biochem Biophys Res Commun 367:242-8. 2008
  8. ncbi request reprint Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters
    Agneta Karlsson
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Int Immunopharmacol 8:20-7. 2008
  9. ncbi request reprint Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity
    Anna E Larsson
    DECS Imaging, AstraZeneca R and D Möldnal, Molndal, Sweden
    Inflamm Bowel Dis 12:478-85. 2006
  10. doi request reprint The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis
    Maria Fritsch Fredin
    Department of Bioscience at AstraZeneca R and D Mölndal, Sweden
    Pharmacol Res 58:222-31. 2008

Collaborators

  • Paul D Hockings
  • Lars E Olsson
  • Mikael Bjursell
  • Maria Fritsch Fredin
  • Maria Fritsch Fredin
  • Agneta Karlsson
  • Erika Rehnström
  • Liselotte Jansson
  • Per Göran Gillberg
  • Erik Michaëlsson
  • Anna E Larsson
  • Göte Forsberg
  • Helena Utkovic
  • Ake Jägervall
  • Elisabeth Hultgren Hörnquist
  • Madeleine Pettersson
  • Ann Katrin Andersson
  • Ke Jägervall
  • Leif Hultin
  • Lisa Karlsson
  • Gina Hyberg
  • Lennart Svensson
  • Anders Peterson
  • Erik Ulfhammer
  • Bjorn Mellgard
  • Magdalena Rhedin
  • Anne Israelsson
  • Marie Louise Hammarström
  • Sten Hammarström
  • Olle Hernell

Detail Information

Publications13

  1. ncbi request reprint Predicting and monitoring colitis development in mice by micro-computed tomography
    Maria Fritsch Fredin
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Molndal, Sweden
    Inflamm Bowel Dis 14:491-9. 2008
    ..The aim of this study was to evaluate colon wall thickness as a noninvasive marker in the dextran sodium sulfate (DSS) mouse model of colitis using micro-CT...
  2. ncbi request reprint Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis
    Silvia Melgar
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, GI Biology, SE 431 83, Sweden
    Cytokine 35:275-83. 2006
    ..Thus, our results show that chemokines are produced in a dynamic manner during colitis progression...
  3. ncbi request reprint Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation
    Silvia Melgar
    AstraZeneca R and D Molndal, Dept of Integrative Pharmacology, GI Biology, SE 431 83 Molndal, Sweden
    Am J Physiol Gastrointest Liver Physiol 288:G1328-38. 2005
    ..We believe that the present protocol to induce chronic colitis in C57BL/6 mice offers a robust model for validating future therapies for treatment of inflammatory bowel disease...
  4. ncbi request reprint Mice with experimental colitis show an altered metabolism with decreased metabolic rate
    Silvia Melgar
    Department of Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca Research and Development, Molndal, Sweden
    Am J Physiol Gastrointest Liver Physiol 292:G165-72. 2007
    ..These observations suggest compensatory metabolic alterations in chronic colitis resulting in a healthy appearance despite gross colon pathology...
  5. ncbi request reprint High-throughput magnetic resonance imaging in murine colonic inflammation
    Silvia Melgar
    Department of Integrative Pharmacology, AstraZeneca, Molndal, Sweden
    Biochem Biophys Res Commun 355:1102-7. 2007
    ....
  6. doi request reprint Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease
    Silvia Melgar
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Int Immunopharmacol 8:836-44. 2008
    ..Thus, three of the current tested agents showed efficacy in the disease model, arguing that DSS-induced colitis can be used as a relevant model for the translation of mice data to human disease...
  7. ncbi request reprint Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice
    Agneta Karlsson
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Biochem Biophys Res Commun 367:242-8. 2008
    ..We suggest that the R-848 inflammatory model can be useful in future validation of new drugs for gastrointestinal inflammatory conditions...
  8. ncbi request reprint Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters
    Agneta Karlsson
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Int Immunopharmacol 8:20-7. 2008
    ..In addition, DSS-exposed hamster showed alterations in hepatic fatty acids metabolism resembling human IBD, suggesting that the model can potentially be used for target discovery and validation of hepatic-related metabolic alterations...
  9. ncbi request reprint Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity
    Anna E Larsson
    DECS Imaging, AstraZeneca R and D Möldnal, Molndal, Sweden
    Inflamm Bowel Dis 12:478-85. 2006
    ..The aim of the present study was to investigate the role of MRI in quantitatively reflecting inflammation in an experimental mouse colitis model...
  10. doi request reprint The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis
    Maria Fritsch Fredin
    Department of Bioscience at AstraZeneca R and D Mölndal, Sweden
    Pharmacol Res 58:222-31. 2008
    ....
  11. ncbi request reprint Anti-inflammatory effects of budesonide in intestinal epithelial cells
    Maria Fritsch Fredin
    Department of Integrative Pharmacology, AstraZeneca AB, R and D Mölndal, Molndal, Sweden
    Pharmacol Res 52:422-8. 2005
    ..We conclude that budesonide exert an anti-inflammatory effect directly on intestinal epithelial cells, which may contribute to the overall action of budesonide in the treatment of inflammatory bowel diseases...
  12. ncbi request reprint Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease
    Göte Forsberg
    Departments of Clinical Microbiology, Immunology, and Clinical Sciences, Pediatrics, Umea University, Umea, Sweden
    Gastroenterology 123:667-78. 2002
    ..e., untreated and gluten-challenged celiac patients, was determined and compared with that of treated, symptom-free celiac patients and controls...
  13. pmc Human small intestinal mucosa harbours a small population of cytolytically active CD8+ alphabeta T lymphocytes
    Silvia Melgar
    Department of Immunology, Umea University, Umea, Sweden
    Immunology 106:476-85. 2002
    ..The observed Fas/FasL-mediated cytotoxicity may be a reflection of ongoing down-regulation of local immune responses by 'activation-induced cell death'...