JianWei Liu

Summary

Affiliation: AstraZeneca R and D

Publications

  1. ncbi request reprint A homogeneous in vitro functional assay for estrogen receptors: coactivator recruitment
    JianWei Liu
    AstraZeneca Pharmaceuticals, Wilmington, Delaware 19850, USA
    Mol Endocrinol 17:346-55. 2003
  2. ncbi request reprint Real-time monitoring in vitro transcription using molecular beacons
    JianWei Liu
    DuPont Pharmaceuticals, Wilmington, Deleware 19880, USA
    Anal Biochem 300:40-5. 2002
  3. ncbi request reprint Microplate gel-filtration method for radioligand-binding assays
    JianWei Liu
    AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, Delaware 19850, USA
    Anal Biochem 308:127-33. 2002
  4. doi request reprint De novo design of a picomolar nonbasic 5-HT(1B) receptor antagonist
    David A Nugiel
    Department of CNS Chemistry, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, Delaware 19850, USA
    J Med Chem 53:1876-80. 2010
  5. ncbi request reprint Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs
    Matthew F Peters
    AstraZeneca Pharmaceuticals LP, Wilmington, DE 19803, USA
    J Biomol Screen 12:312-9. 2007

Collaborators

Detail Information

Publications5

  1. ncbi request reprint A homogeneous in vitro functional assay for estrogen receptors: coactivator recruitment
    JianWei Liu
    AstraZeneca Pharmaceuticals, Wilmington, Delaware 19850, USA
    Mol Endocrinol 17:346-55. 2003
    ..Therefore, this simple in vitro functional assay is predictive of ligand-dependent transactivation function of the receptor and, as such, is useful in nuclear receptor applications including mechanistic studies...
  2. ncbi request reprint Real-time monitoring in vitro transcription using molecular beacons
    JianWei Liu
    DuPont Pharmaceuticals, Wilmington, Deleware 19880, USA
    Anal Biochem 300:40-5. 2002
    ..The results from the RNA MB assay were comparable to those from other methods...
  3. ncbi request reprint Microplate gel-filtration method for radioligand-binding assays
    JianWei Liu
    AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, Delaware 19850, USA
    Anal Biochem 308:127-33. 2002
    ..This microplate gel-filtration method was optimized in studies of receptor-ligand interactions using estrogen receptors as examples and can be used in other radioligand-binding assays...
  4. doi request reprint De novo design of a picomolar nonbasic 5-HT(1B) receptor antagonist
    David A Nugiel
    Department of CNS Chemistry, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, Delaware 19850, USA
    J Med Chem 53:1876-80. 2010
    ..Pyrazole-based ideas were designed and synthesized among a small library of piperazine replacements. To our knowledge, these are the first potent, nonbasic, functionally active antagonists of the 5-HT(1B) receptor...
  5. ncbi request reprint Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs
    Matthew F Peters
    AstraZeneca Pharmaceuticals LP, Wilmington, DE 19803, USA
    J Biomol Screen 12:312-9. 2007
    ....