Anders Lehmann

Summary

Affiliation: AstraZeneca R and D

Publications

  1. ncbi request reprint Activation of the GABA(B) receptor inhibits transient lower esophageal sphincter relaxations in dogs
    A Lehmann
    Gastrointestinal Pharmacology, Astra Zeneca R and D Mölndal, Molndal, Sweden
    Gastroenterology 117:1147-54. 1999
  2. pmc Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs: comparison to baclofen and other GABAB receptor-selective agonists
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland, 21224, USA
    Cough 8:7. 2012
  3. pmc Different in vitro and in vivo profiles of substituted 3-aminopropylphosphinate and 3-aminopropyl(methyl)phosphinate GABA(B) receptor agonists as inhibitors of transient lower oesophageal sphincter relaxation
    A Lehmann
    AstraZeneca R and D, Molndal, Sweden
    Br J Pharmacol 165:1757-72. 2012
  4. pmc Effects of (2R)-(3-amino-2-fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxation in dogs and mechanism of hypothermic effects in mice
    Anders Lehmann
    Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca R and D Molndal, Molndal, Sweden
    Br J Pharmacol 146:89-97. 2005
  5. doi request reprint GABAB receptors as drug targets to treat gastroesophageal reflux disease
    Anders Lehmann
    AstraZeneca R and D, Molndal, Sweden
    Pharmacol Ther 122:239-45. 2009
  6. ncbi request reprint Z-338. Zeria/Yamanouchi
    Anders Lehmann
    Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca R and D Molndal, Sweden
    Curr Opin Investig Drugs 5:760-5. 2004
  7. doi request reprint (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action
    Anders Lehmann
    AstraZeneca R and D, Molndal, Sweden
    J Pharmacol Exp Ther 331:504-12. 2009
  8. ncbi request reprint Effects of repeated administration of baclofen to rats on GABAB receptor binding sites and subunit expression in the brain
    Anders Lehmann
    Integrative Pharmacology, Gastrointestinal Biology, AstraZenea R and D Mölndal, Sweden
    Neurochem Res 28:387-93. 2003
  9. ncbi request reprint Cannabinoid receptor agonism inhibits transient lower esophageal sphincter relaxations and reflux in dogs
    Anders Lehmann
    Gastrointestinal Biology, Integrative Pharmacology, AstraZeneca R and D Molndal, Molndal, Sweden
    Gastroenterology 123:1129-34. 2002
  10. ncbi request reprint Inhibitory effects of GABA(B) receptor agonists on swallowing in the dog
    Anders Lehmann
    Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca R and D Molndal, Molndal, Sweden
    Eur J Pharmacol 448:67-70. 2002

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Activation of the GABA(B) receptor inhibits transient lower esophageal sphincter relaxations in dogs
    A Lehmann
    Gastrointestinal Pharmacology, Astra Zeneca R and D Mölndal, Molndal, Sweden
    Gastroenterology 117:1147-54. 1999
    ....
  2. pmc Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs: comparison to baclofen and other GABAB receptor-selective agonists
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland, 21224, USA
    Cough 8:7. 2012
    ..abstract:..
  3. pmc Different in vitro and in vivo profiles of substituted 3-aminopropylphosphinate and 3-aminopropyl(methyl)phosphinate GABA(B) receptor agonists as inhibitors of transient lower oesophageal sphincter relaxation
    A Lehmann
    AstraZeneca R and D, Molndal, Sweden
    Br J Pharmacol 165:1757-72. 2012
    ....
  4. pmc Effects of (2R)-(3-amino-2-fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxation in dogs and mechanism of hypothermic effects in mice
    Anders Lehmann
    Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca R and D Molndal, Molndal, Sweden
    Br J Pharmacol 146:89-97. 2005
    ..High doses of the compound induce hypothermia in the mouse, which probably is attributable to activation of the GABA(A) receptor. The latter effect may be caused both by AFPSiA and its oxidised sulphonic acid metabolite AFPSoA...
  5. doi request reprint GABAB receptors as drug targets to treat gastroesophageal reflux disease
    Anders Lehmann
    AstraZeneca R and D, Molndal, Sweden
    Pharmacol Ther 122:239-45. 2009
    ..Compounds that target TLESRs may therefore present a new add-on treatment for patients with persistent GERD symptoms despite PPI therapy...
  6. ncbi request reprint Z-338. Zeria/Yamanouchi
    Anders Lehmann
    Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca R and D Molndal, Sweden
    Curr Opin Investig Drugs 5:760-5. 2004
    ..Zeria and Yamanouchi are co-developing Z-338, a thiazole-4-carboxamide derivative with prokinetic activities, as a potential treatment for dyspepsia and gastric motility disorders. This compound is currently in phase II clinical trials...
  7. doi request reprint (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action
    Anders Lehmann
    AstraZeneca R and D, Molndal, Sweden
    J Pharmacol Exp Ther 331:504-12. 2009
    ..In summary, AZD3355 probably inhibits TLESR through stimulation of peripheral GABA(B) receptors and may offer a potential new approach to treatment of GERD...
  8. ncbi request reprint Effects of repeated administration of baclofen to rats on GABAB receptor binding sites and subunit expression in the brain
    Anders Lehmann
    Integrative Pharmacology, Gastrointestinal Biology, AstraZenea R and D Mölndal, Sweden
    Neurochem Res 28:387-93. 2003
    ..Receptor protein levels were also unchanged. It is concluded that baclofen induces tolerance through mechanisms other than down-regulation of GABAB receptor transcription or translation...
  9. ncbi request reprint Cannabinoid receptor agonism inhibits transient lower esophageal sphincter relaxations and reflux in dogs
    Anders Lehmann
    Gastrointestinal Biology, Integrative Pharmacology, AstraZeneca R and D Molndal, Molndal, Sweden
    Gastroenterology 123:1129-34. 2002
    ..The functional similarity between GABA(B) and cannabinoid receptors (CBRs) prompted us to study the role of CBRs on mechanisms of gastric distention-induced TLESRs...
  10. ncbi request reprint Inhibitory effects of GABA(B) receptor agonists on swallowing in the dog
    Anders Lehmann
    Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca R and D Molndal, Molndal, Sweden
    Eur J Pharmacol 448:67-70. 2002
    ..It is concluded that centrally acting GABA(B) receptor agonists inhibit spontaneous and stimulated swallowing probably through an action in the central pattern generator for swallowing...
  11. ncbi request reprint Effects of antagonism of NMDA receptors on transient lower esophageal sphincter relaxations in the dog
    A Lehmann
    Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Eur J Pharmacol 431:253-8. 2001
    ....
  12. ncbi request reprint Effects of repeated administration of baclofen on transient lower esophageal sphincter relaxation in the dog
    A Lehmann
    Gastrointestinal Pharmacology, AstraZeneca R and D Molndal, S 431 83, Molndal, Sweden
    Eur J Pharmacol 403:163-7. 2000
    ....
  13. ncbi request reprint Novel treatments of GERD: focus on the lower esophageal sphincter
    A Lehmann
    Bioscience, AstraZeneca R and D, Molndal, Sweden
    Eur Rev Med Pharmacol Sci 12:103-10. 2008
    ..Agents that target TLESR activity may therefore offer a promising new add-on treatment for patients who suffer from GERD symptoms despite PPI therapy...
  14. ncbi request reprint Transient lower esophageal sphincter relaxations in dogs are inhibited by a metabotropic glutamate receptor 5 antagonist
    Jorgen Jensen
    AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Eur J Pharmacol 519:154-7. 2005
    ..It is concluded that the mGlu5 receptor antagonist MPEP potently inhibits transient lower esophageal sphincter relaxations and that the mGlu5 receptor is a potential target for treatment of gastroesophageal reflux disease...
  15. pmc Effects of GABA agonists on body temperature regulation in GABA(B(1))-/- mice
    Christophe Queva
    Transgenic Research Laboratory, AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Br J Pharmacol 140:315-22. 2003
    ..Using this model, GHB was shown to be a selective GABAB receptor agonist. In addition, GABAB(1)-/- mice are hypersensitive to GABAA receptor stimulation, indicating that GABAB tone normally balances GABAA-mediated effects...
  16. doi request reprint The novel, peripherally restricted GABAB receptor agonist lesogaberan (AZD3355) inhibits acid reflux and reduces esophageal acid exposure as measured with 24-h pHmetry in dogs
    Lena Brändén
    AstraZeneca R and D, SE 431 83 Molndal, Sweden
    Eur J Pharmacol 634:138-41. 2010
    ..2 (4.5) min for control versus 23.6 (3.8) min for lesogaberan (P<0.0001) and 35.4 (6.5) min with baclofen (P=0.05). It is concluded that lesogaberan significantly reduces acid reflux in dogs, with comparable efficacy to baclofen...
  17. doi request reprint Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors
    Christer Alstermark
    AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    J Med Chem 51:4315-20. 2008
    ....
  18. doi request reprint Discovery of agonists of cannabinoid receptor 1 with restricted central nervous system penetration aimed for treatment of gastroesophageal reflux disease
    Alleyn T Plowright
    AstraZeneca Research and Development, Pepparedsleden 1, Mölndal 43183, Sweden
    J Med Chem 56:220-40. 2013
    ..A range of compounds demonstrated a dose-dependent inhibition of transient lower esophageal sphincter relaxations in a dog model...
  19. doi request reprint GABAB receptor agonism as a novel therapeutic modality in the treatment of gastroesophageal reflux disease
    Anders Lehmann
    AstraZeneca R and D, Molndal, Sweden
    Adv Pharmacol 58:287-313. 2010
    ....
  20. pmc 4-aminobutyrate aminotransferase (ABAT): genetic and pharmacological evidence for an involvement in gastro esophageal reflux disease
    Johan Jirholt
    AstraZeneca R and D, Molndal, Sweden
    PLoS ONE 6:e19095. 2011
    ..1 ± 0.4 to 0.8 ± 0.4 (p = 0.007). Our results demonstrate the direct involvement of ABAT in pathways affecting lower esophageal sphincter (LES) control and identifies ABAT as a genetic risk factor for GERD...
  21. ncbi request reprint Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons
    Amanda J Page
    Nerve Gut Research Laboratory, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Gastroenterology 128:402-10. 2005
    ..Metabotropic glutamate receptors (mGluR) belong to this receptor family and have great pharmacologic and molecular diversity, with 8 subtypes. We investigated mGluR in the vagal system of humans and other species...
  22. ncbi request reprint Effects of gamma-aminobutyrate B receptor modulation on normal micturition and oxyhemoglobin induced detrusor overactivity in female rats
    Rikard Pehrson
    Department of Clinical Pharmaology, Lund University Hospital, Sweden
    J Urol 168:2700-5. 2002
    ....
  23. ncbi request reprint The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors
    Anders A Jensen
    NeuroScience PharmaBiotec Research Centre, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Copenhagen, Denmark
    Mol Pharmacol 61:1377-84. 2002
    ..Hence, the anticonvulsive effects of the compound have to arise from GABA(B) receptor-independent mechanisms. This also implies that the first GABA(B) receptor splice variant-selective ligand remains to be discovered...
  24. ncbi request reprint Inhibition of transient lower esophageal sphincter relaxation and gastroesophageal reflux by metabotropic glutamate receptor ligands
    Claudine L Frisby
    Nerve Gut Research Laboratory, Royal Adelaide Hospital, Adelaide, SA, Australia
    Gastroenterology 129:995-1004. 2005
    ..This study determined the effect of mGluRs on triggering of TLESR and reflux in an established conscious ferret model...