G M Kasof

Summary

Affiliation: AstraZeneca R and D

Publications

  1. ncbi request reprint Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB
    G M Kasof
    Department of Enabling Science and Technology, AstraZeneca Pharmaceuticals, 3 Biotech Park, One Innovation Drive, Worcester, Massachusetts, MA 01605, USA
    Oncogene 20:7965-75. 2001
  2. ncbi request reprint The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria
    G M Kasof
    AstraZeneca Pharmaceuticals, Enabling Science and Technology Department, 1800 Concord Pike, Wilmington, DE 19803, USA
    FEBS Lett 473:285-91. 2000
  3. ncbi request reprint Livin, a novel inhibitor of apoptosis protein family member
    G M Kasof
    AstraZeneca Pharmaceuticals, Enabling Sciences and Technology, Wilmington, Delaware 19803, USA
    J Biol Chem 276:3238-46. 2001
  4. pmc Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins
    G M Kasof
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 19:4390-404. 1999

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB
    G M Kasof
    Department of Enabling Science and Technology, AstraZeneca Pharmaceuticals, 3 Biotech Park, One Innovation Drive, Worcester, Massachusetts, MA 01605, USA
    Oncogene 20:7965-75. 2001
    ..These results demonstrate that TNF-alpha signaling induces the expression of a member of its own receptor family through activation of NF-kappaB...
  2. ncbi request reprint The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria
    G M Kasof
    AstraZeneca Pharmaceuticals, Enabling Science and Technology Department, 1800 Concord Pike, Wilmington, DE 19803, USA
    FEBS Lett 473:285-91. 2000
    ..RIP3 was localized by immunofluorescence to the mitochondrion and may play a key role in the mitochondrial disruptions often associated with apoptosis...
  3. ncbi request reprint Livin, a novel inhibitor of apoptosis protein family member
    G M Kasof
    AstraZeneca Pharmaceuticals, Enabling Sciences and Technology, Wilmington, Delaware 19803, USA
    J Biol Chem 276:3238-46. 2001
    ..This was associated with an increase in DNA fragmentation and in DEVD-like caspase activity. Thus, disruption of Livin may provide a strategy to induce apoptosis in certain cancer cells...
  4. pmc Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins
    G M Kasof
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 19:4390-404. 1999
    ..Thus, btf may represent a novel tumor suppressor gene residing in a unique pathway by which the Bcl-2 family can regulate apoptosis...