A Dray

Summary

Affiliation: AstraZeneca R and D

Publications

  1. ncbi A pro-nociceptive role of neuromedin U in adult mice
    Chang Qing Cao
    AstraZeneca R and D Montreal, 7171 Frederick Banting, St Laurent, Montreal, Quebec, Canada H4S 1Z9
    Pain 104:609-16. 2003
  2. ncbi Neuropathic pain: emerging treatments
    A Dray
    AstraZeneca Research and Development, 7171 Frederick Banting Street, Montreal, Canada
    Br J Anaesth 101:48-58. 2008
  3. ncbi Arthritis and pain. Future targets to control osteoarthritis pain
    Andy Dray
    AstraZeneca R and D Montreal, Frederick Banting St, Montreal H4S 1Z9, Canada
    Arthritis Res Ther 9:212. 2007
  4. ncbi Future pharmacologic management of neuropathic pain
    Andy Dray
    AstraZeneca Research and Development, Montreal, Quebec, Canada
    J Orofac Pain 18:381-5. 2004
  5. ncbi Priming enhances endotoxin-induced thermal hyperalgesia and mechanical allodynia in rats
    C M Cahill
    Pain Mechanisms Laboratory, Clinical Research Institute of Montreal, 110 Pine Ave West, Montreal, Canada
    Brain Res 808:13-22. 1998
  6. ncbi Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats
    M E Fundytus
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    Br J Pharmacol 132:354-67. 2001
  7. ncbi Selective depression of nociceptive responses of dorsal horn neurones by SNC 80 in a perfused hindquarter preparation of adult mouse
    C Q Cao
    Department of Pharmacology, AstraZeneca R and D Montreal, 7171 Frederick Banting, St Laurent Montreal, QC, Canada H4S 1Z9
    Neuroscience 107:329-38. 2001
  8. ncbi Spinal delta-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat
    C Q Cao
    Department of Pharmacology, AstraZeneca R and D Montreal, 7171 Frederick-Banting, H4S 1Z9, St. Laurent, Quebec, Canada
    Eur J Pharmacol 418:79-87. 2001
  9. ncbi Pro-nociceptive effects of neuromedin U in rat
    X H Yu
    AstraZeneca Research and Development Montreal, 7171 Frederick Banting, St Laurent, Montreal, Quebec, Canada H4S 1Z9
    Neuroscience 120:467-74. 2003
  10. ncbi Osteoarthritic pain: a review of current, theoretical and emerging therapeutics
    Simon J Read
    AstraZeneca R and D, Office 12AF1A, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
    Expert Opin Investig Drugs 17:619-40. 2008

Detail Information

Publications15

  1. ncbi A pro-nociceptive role of neuromedin U in adult mice
    Chang Qing Cao
    AstraZeneca R and D Montreal, 7171 Frederick Banting, St Laurent, Montreal, Quebec, Canada H4S 1Z9
    Pain 104:609-16. 2003
    ..These electrophysiological and behavioral results suggest that NMU may be a novel physiological regulator in spinal nociceptive transmission and processing...
  2. ncbi Neuropathic pain: emerging treatments
    A Dray
    AstraZeneca Research and Development, 7171 Frederick Banting Street, Montreal, Canada
    Br J Anaesth 101:48-58. 2008
    ..Finally of note is the emergence of biological approaches, for example, antibodies, siRNA, gene therapy, offering powerful therapeutic additions with which to redress the neurological disease imbalances causing neuropathic pain...
  3. ncbi Arthritis and pain. Future targets to control osteoarthritis pain
    Andy Dray
    AstraZeneca R and D Montreal, Frederick Banting St, Montreal H4S 1Z9, Canada
    Arthritis Res Ther 9:212. 2007
    ..Future neurological treatments of pain appear optimistic but will require the systematic evaluation of emerging opportunities...
  4. ncbi Future pharmacologic management of neuropathic pain
    Andy Dray
    AstraZeneca Research and Development, Montreal, Quebec, Canada
    J Orofac Pain 18:381-5. 2004
    ..Improvement in translating these approaches into the development of drugs for use in the pain clinic remains a significant but surmountable challenge...
  5. ncbi Priming enhances endotoxin-induced thermal hyperalgesia and mechanical allodynia in rats
    C M Cahill
    Pain Mechanisms Laboratory, Clinical Research Institute of Montreal, 110 Pine Ave West, Montreal, Canada
    Brain Res 808:13-22. 1998
    ..p. injection of LPS. This study demonstrates that priming is an effective protocol for the induction of central inflammation and increases the duration of these behaviors after i.c. v. administration...
  6. ncbi Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats
    M E Fundytus
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    Br J Pharmacol 132:354-67. 2001
    ....
  7. ncbi Selective depression of nociceptive responses of dorsal horn neurones by SNC 80 in a perfused hindquarter preparation of adult mouse
    C Q Cao
    Department of Pharmacology, AstraZeneca R and D Montreal, 7171 Frederick Banting, St Laurent Montreal, QC, Canada H4S 1Z9
    Neuroscience 107:329-38. 2001
    ..The potentiation of neuronal activity by HS 378 may reflect an autoregulatory role of the endogenous delta-opioid in nociceptive transmission in mouse...
  8. ncbi Spinal delta-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat
    C Q Cao
    Department of Pharmacology, AstraZeneca R and D Montreal, 7171 Frederick-Banting, H4S 1Z9, St. Laurent, Quebec, Canada
    Eur J Pharmacol 418:79-87. 2001
    ..5 nmol). These results indicate that systemic injection of SNC80 exerted antihypersensitivity in models of both acute and tonic nociception and these effects are mediated mainly through a spinal delta-opioid mechanism...
  9. ncbi Pro-nociceptive effects of neuromedin U in rat
    X H Yu
    AstraZeneca Research and Development Montreal, 7171 Frederick Banting, St Laurent, Montreal, Quebec, Canada H4S 1Z9
    Neuroscience 120:467-74. 2003
    ..The restricted distribution of NMU receptors to a region of the spinal cord involved in nociception suggests that this peptide receptor system may play a role in nociception...
  10. ncbi Osteoarthritic pain: a review of current, theoretical and emerging therapeutics
    Simon J Read
    AstraZeneca R and D, Office 12AF1A, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
    Expert Opin Investig Drugs 17:619-40. 2008
    ..There is an emerging diversity of algogenic mechanisms suggesting heterogeneity in pain aetiology in the OA patient population...
  11. ncbi Novel G protein-coupled receptors as pain targets
    Sultan Ahmad
    AstraZeneca Research and Development Montreal, 7171 Frederick Banting St, Montreal H4S 1Z9, Canada
    Curr Opin Investig Drugs 5:67-70. 2004
    ....
  12. ncbi Enhanced thermal antinociceptive potency and anti-allodynic effects of morphine following spinal administration of endotoxin
    Catherine M Cahill
    Department of Pharmacology and Toxicology, Queen's University, Kingston, Ont, Canada
    Brain Res 960:209-18. 2003
    ..This study demonstrates the presence of both heat hyperalgesia and mechanical allodynia following central administration of LPS, and an increased antinociceptive potency of i.t. morphine in this model...
  13. ncbi Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs
    Paola M C Lembo
    AstraZeneca R and D Montreal, 7171 Frederick Banting, Ville Saint Laurent, Quebec H4S 1Z9, Canada
    Nat Neurosci 5:201-9. 2002
    ..The unique localization of SNSRs and their activation by proenkephalin A peptide fragments indicate a possible function for SNSRs in sensory neuron regulation and in the modulation of nociception...
  14. ncbi Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain
    Catherine M Cahill
    Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, Canada
    Neuropharmacology 45:543-52. 2003
    ....
  15. ncbi Antisense oligonucleotide knockdown of mGluR1 alleviates hyperalgesia and allodynia associated with chronic inflammation
    Marian E Fundytus
    Department of Physiology, McGill University, Montreal, Canada
    Pharmacol Biochem Behav 73:401-10. 2002
    ..Thus, the present data suggest a role for mGluR1 in persistent inflammatory nociception...