Folkert W Asselbergs

Summary

Publications

  1. ncbi request reprint Cost-effectiveness of screening for albuminuria with subsequent fosinopril treatment to prevent cardiovascular events: A pharmacoeconomic analysis linked to the prevention of renal and vascular endstage disease (PREVEND) study and the prevention of renal
    Jarir Atthobari
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen UniversityInstitute for Drug Exploration, Groningen, The Netherlands
    Clin Ther 28:432-44. 2006
  2. pmc Gene ontology analysis of pairwise genetic associations in two genome-wide studies of sporadic ALS
    Nora Chung Kim
    Institute for Quantitative Biomedical Sciences, Department of Genetics, Dartmouth Medical School, One Medical Center Dr, Lebanon, NH 03756, USA
    BioData Min 5:9. 2012
  3. ncbi request reprint Long-term effects of pravastatin and fosinopril on peripheral endothelial function in albuminuric subjects
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Atherosclerosis 196:349-55. 2008
  4. ncbi request reprint Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease
    Folkert W Asselbergs
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, U S A
    Clin Sci (Lond) 112:291-8. 2007
  5. ncbi request reprint Acute intermittent porphyria as a cause of respiratory failure: case report
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, and Department of Internal Medicine, Martini Hospital, Groningen, The Netherlands
    Am J Crit Care 18:180, 178-9. 2009
  6. ncbi request reprint Genetic architecture of tissue-type plasminogen activator and plasminogen activator inhibitor-1
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Semin Thromb Hemost 34:562-8. 2008
  7. pmc Association of renal function with cardiac calcifications in older adults: the cardiovascular health study
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 24:834-40. 2009
  8. pmc A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Med Genet 7:39. 2006
  9. pmc Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
  10. ncbi request reprint The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental context
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Hum Genet 122:275-81. 2007

Detail Information

Publications50

  1. ncbi request reprint Cost-effectiveness of screening for albuminuria with subsequent fosinopril treatment to prevent cardiovascular events: A pharmacoeconomic analysis linked to the prevention of renal and vascular endstage disease (PREVEND) study and the prevention of renal
    Jarir Atthobari
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen UniversityInstitute for Drug Exploration, Groningen, The Netherlands
    Clin Ther 28:432-44. 2006
    ....
  2. pmc Gene ontology analysis of pairwise genetic associations in two genome-wide studies of sporadic ALS
    Nora Chung Kim
    Institute for Quantitative Biomedical Sciences, Department of Genetics, Dartmouth Medical School, One Medical Center Dr, Lebanon, NH 03756, USA
    BioData Min 5:9. 2012
    ..abstract:..
  3. ncbi request reprint Long-term effects of pravastatin and fosinopril on peripheral endothelial function in albuminuric subjects
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Atherosclerosis 196:349-55. 2008
    ..01). In conclusion, after 4 years of follow-up, pravastatin treatment tended to increase FMD and this effect was predominantly present in men. Fosinopril treatment did not modify FMD during long-term follow-up...
  4. ncbi request reprint Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease
    Folkert W Asselbergs
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, U S A
    Clin Sci (Lond) 112:291-8. 2007
    ..05). However, no overall effect was demonstrated between LTA gene polymorphisms and risk of CHD...
  5. ncbi request reprint Acute intermittent porphyria as a cause of respiratory failure: case report
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, and Department of Internal Medicine, Martini Hospital, Groningen, The Netherlands
    Am J Crit Care 18:180, 178-9. 2009
    ..The patient died 10 months after the first manifestation of acute intermittent porphyria...
  6. ncbi request reprint Genetic architecture of tissue-type plasminogen activator and plasminogen activator inhibitor-1
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Semin Thromb Hemost 34:562-8. 2008
    ....
  7. pmc Association of renal function with cardiac calcifications in older adults: the cardiovascular health study
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 24:834-40. 2009
    ..It is less well established whether milder kidney disease is associated with cardiac calcifications. We evaluated the relationships between renal function and MAC, aortic annular calcification (AAC) and AVS in the elderly...
  8. pmc A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Med Genet 7:39. 2006
    ..We aimed to investigate the association between several environmental factors and loci of candidate genes, which might be related to the presence of AF...
  9. pmc Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
    ..These results support the idea that the interplay between the renin-angiotensin, bradykinin, and fibrinolytic systems might play an important role in t-PA and PAI-1 biology...
  10. ncbi request reprint The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental context
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Hum Genet 122:275-81. 2007
    ..The present study emphasizes the importance of including environmental factors in genetic analyses to fully comprehend the genetic architecture of a specific trait...
  11. ncbi request reprint Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Circulation 110:2809-16. 2004
    ..We assessed whether therapeutic intervention aimed at lowering urinary albumin excretion would reduce cardiovascular events in microalbuminuric subjects (15 to 300 mg/24 hours)...
  12. doi request reprint Effect of fosinopril treatment on serum C-reactive protein levels in patients with microalbuminuria
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 102:223-5. 2008
    ..Male gender was associated with a significantly larger reduction in CRP compared to female gender. In conclusion, contrary to previous observational studies, no effect of angiotensin-converting enzyme inhibition on CRP levels was found...
  13. ncbi request reprint High prevalence of microalbuminuria in chronic heart failure patients
    Ruud M A van de Wal
    Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands
    J Card Fail 11:602-6. 2005
    ..In this cross-sectional study, we aim to evaluate the prevalence of microalbuminuria and the association with neurohormonal parameters in severe chronic heart failure patients...
  14. ncbi request reprint Determination of vessel size: a putative framework to assess clinical outcome
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Int J Cardiol 103:135-9. 2005
    ..The present study investigated the prognostic value of the proximal non-stenotic left anterior descending coronary artery (LAD) diameter in patients referred for a first diagnostic angiogram without a previous revascularisation...
  15. ncbi request reprint Impact of statins in microalbuminuric subjects with the metabolic syndrome: a substudy of the PREVEND Intervention Trial
    Christiane A Geluk
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Postbus 30001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Eur Heart J 26:1314-20. 2005
    ..We evaluated the impact of pravastatin treatment on the incidence of major adverse cardiac events in microalbuminuric subjects with the metabolic syndrome...
  16. ncbi request reprint Effect of withdrawal of pravastatin therapy on C-reactive protein and low-density lipoprotein cholesterol
    Pim van der Harst
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 100:1548-51. 2007
    ..In conclusion, withdrawal from pravastatin treatment resulted in an increase in CRP to approximately baseline levels, which is not related to the increase in LDL cholesterol...
  17. ncbi request reprint Mild renal dysfunction is associated with electrocardiographic left ventricular hypertrophy
    Tom D J Smilde
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Gronigen, The Netherlands
    Am J Hypertens 18:342-7. 2005
    ..We studied the relation between renal dysfunction and LVH in a cross-sectional study in 8592 inhabitants from Groningen, The Netherlands...
  18. ncbi request reprint The effect of statins on urinary albumin excretion and glomerular filtration rate: results from both a randomized clinical trial and an observational cohort study
    Jarir Atthobari
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University for Drug Exploration GUIDE, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Nephrol Dial Transplant 21:3106-14. 2006
    ....
  19. doi request reprint Long-term effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria:Ten years of follow-up of Prevention of Renal and Vascular End-stage Disease Intervention Trial (PREVEND IT)
    Frank P Brouwers
    Department of Cardiology, Thoraxcenter, Universitair Medical Center Groningen, University of Groningen, The Netherlands
    Am Heart J 161:1171-8. 2011
    ..We obtained extended follow-up data to approximately 10 years to investigate the long-term effects of fosinopril 20 mg and pravastatin 40 mg on cardiovascular outcomes in subjects with UAE >15 mg per 24 hours...
  20. ncbi request reprint C-reactive protein and microalbuminuria differ in their associations with various domains of vascular disease
    Erik M Stuveling
    Department of Internal Medicine, University Medical Centre Groningen, Groningen, The Netherlands
    Atherosclerosis 172:107-14. 2004
    ..Thus, CRP and MA are risk markers for vascular disease, each showing a different risk profiling for different vascular beds...
  21. ncbi request reprint C-reactive protein and microalbuminuria are associated with atrial fibrillation
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Int J Cardiol 98:73-7. 2005
    ..We hypothesized that microalbuminuria and C-reactive protein (CRP), a marker of generalized vascular damage and inflammation, respectively, are associated with AF...
  22. ncbi request reprint Effects of fosinopril and pravastatin on carotid intima-media thickness in subjects with increased albuminuria
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Stroke 36:649-53. 2005
    ....
  23. ncbi request reprint The gender-specific role of polymorphisms from the fibrinolytic, renin-angiotensin, and bradykinin systems in determining plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Thromb Haemost 96:471-7. 2006
    ..In addition, the results support the idea that the biology of t-PA and PAI-1 is different between females and males...
  24. ncbi request reprint Assessing the prognostic value of coronary endothelial function in patients referred for a first coronary angiogram
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 94:1063-7. 2004
    ..The data suggest that endothelial function assessment does not contribute to the prediction of outcomes in patients referred for a first coronary angiogram...
  25. doi request reprint Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1
    Niek Verweij
    Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Hypertension 61:602-8. 2013
    ..The discovery of genetic variants in the kallikrein-kinin system and in the genes encoding pre-pro-ET-1 and pre-pro-ADM provides novel insights into the (co-)regulation of these vasoactive peptides in the vascular system...
  26. ncbi request reprint Effects of C-reactive protein and cholesterol on responsiveness in vitro of the internal thoracic artery to angiotensin II in patients having coronary artery bypass grafting
    Pim van der Harst
    Department of Cardiology, Thoraxcenter, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 98:751-3. 2006
    ..In conclusion, our results suggest that CRP and cholesterol act synergistically on vascular responsiveness to angiotensin II...
  27. ncbi request reprint Worsening renal function and prognosis in heart failure: systematic review and meta-analysis
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Card Fail 13:599-608. 2007
    ..The present study was designed to establish the proportion of patients with HF that exhibits (WRF) and the associated risk for mortality and hospitalization by conducting a systematic review and meta-analysis...
  28. ncbi request reprint Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Vascul Pharmacol 42:125-40. 2005
    ..Overall, at this moment, there is no place in clinical practice for the use of endothelial function as a method for risk assessment or target of pharmacological interventions...
  29. ncbi request reprint Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci
    Vinicius Tragante
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Am J Hum Genet 94:349-60. 2014
    ..In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification...
  30. ncbi request reprint Coronary vasomotor response is related to the angiographic extent of coronary sclerosis in patients with stable angina pectoris
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands
    Clin Sci (Lond) 106:115-20. 2004
    ..These data suggest that, in patients with advanced atherosclerosis or multiple risk factors, the vasomotor dysfunction is not solely restricted to the endothelium...
  31. ncbi request reprint Relation of electrocardiographic abnormalities to levels of serum C-reactive protein
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Am J Cardiol 91:1358-60. 2003
  32. ncbi request reprint Angiotensin converting enzyme inhibition in cardiovascular risk populations: a practical approach to identify the patient who will benefit most
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Cardiol 22:267-72. 2007
    ..This review will summarize the current literature about the therapeutic potential of ACE inhibition and provide a practical approach for clinicians to identify patients who benefit most from ACE inhibition...
  33. ncbi request reprint Functional characteristics of coronary vasomotor function following intramyocardial gene therapy with naked DNA encoding for vascular endothelial growth factor165
    Ren A Tio
    Department of Cardiology, Thoraxcentre, University Hospital Groningen, The Netherlands
    Endothelium 12:103-6. 2005
    ..Therefore, this therapy can potentially play an important role in all stages of the atherosclerotic process...
  34. doi request reprint The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk
    Vinicius Tragante
    Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Heart J 34:2896-904. 2013
    ..The aim of this study is to investigate the cumulative effects of risk alleles associated with CAD/MI on ischaemic stroke (IS), abdominal aortic aneurysm (AAA), and peripheral artery disease (PAD)...
  35. pmc Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
    Folkert W Asselbergs
    Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hum Genet 91:823-38. 2012
    ..The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids...
  36. ncbi request reprint Correlates of endothelial function and their relationship with inflammation in patients with familial hypercholesterolaemia
    Paul L van Haelst
    Department of Cardiology, University Hospital Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Clin Sci (Lond) 104:627-32. 2003
    ..Moreover, aggressive lipid-lowering therapy with simvastatin does not result in improved endothelial function or in a reduction of markers of inflammation in these patients...
  37. ncbi request reprint Interaction between dietary fat intake and the cholesterol ester transfer protein TaqIB polymorphism in relation to HDL-cholesterol concentrations among US diabetic men
    Tricia Y Li
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:1524-9. 2007
    ..Cholesterol ester transfer protein (CETP) plays an important role in the regulation of HDL metabolism, and the TaqIB polymorphism of the CETP gene has been associated with elevated HDL concentrations...
  38. doi request reprint Progress in genetic association studies of plasma lipids
    Folkert W Asselbergs
    Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Lipidol 24:123-8. 2013
    ..A supplemental file with all genetic loci is provided for research purposes and we performed bioinformatic analyses of the genetic variants to give an oversight of involved pathways...
  39. doi request reprint Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy: overview of 10 years' experience
    Karin Y van Spaendonck-Zwarts
    Department of Genetics, University of Groningen, University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 15:628-36. 2013
    ..With more than 40 dilated cardiomyopathy (DCM)-related genes known, genetic analysis of patients with idiopathic DCM is costly and time-consuming. We describe the yield from genetic analysis in DCM patients in a large Dutch cohort...
  40. doi request reprint Genetics of coronary artery disease: genome-wide association studies and beyond
    Bram P Prins
    Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Atherosclerosis 225:1-10. 2012
    ..This approach that integrates genetic, epigenetic, transcriptomic, proteomic, metabolic and intermediate outcome variables has potential to significantly aid the understanding of CAD etiology...
  41. doi request reprint Measuring and targeting aldosterone and renin in atherosclerosis-a review of clinical data
    Marieke A Hillaert
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Am Heart J 162:585-96. 2011
    ..For this purpose, a literature search was performed, focusing on available clinical data regarding renin or aldosterone and cardiovascular outcome...
  42. ncbi request reprint The ENCODE project and perspectives on pathways
    Vinicius Tragante
    Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, GA Utrecht, The Netherlands Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, CX Utrecht, The Netherlands
    Genet Epidemiol 38:275-80. 2014
    ..Further, we must determine which computational methods will be most useful in this pursuit. In this paper, we speculate over the possible methods that will emerge in this new, challenging field. ..
  43. pmc Seventy-five genetic loci influencing the human red blood cell
    Pim van der Harst
    Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Nature 492:369-75. 2012
    ..Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function...
  44. pmc Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies
    Ilja M Nolte
    Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 4:e6138. 2009
    ..These data offer further mechanistic insights into genetic influence on the QT interval which may predispose to life threatening arrhythmias and sudden cardiac death...
  45. ncbi request reprint Thrombospondin-4 Ala387Pro polymorphism is not associated with vascular function and risk of coronary heart disease in US men and women
    Folkert W Asselbergs
    Thromb Haemost 95:589-90. 2006
  46. ncbi request reprint Prognostic value of myeloperoxidase in patients with chest pain
    Folkert W Asselbergs
    N Engl J Med 350:516-8; author reply 516-8. 2004
  47. ncbi request reprint Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease
    Folkert W Asselbergs
    Am J Med 116:429-30. 2004
  48. pmc Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition
    Eric Arehart
    Department of Pharmacology and Toxicology, Dartmouth Hitchcock Medical Center, Hanover, NH 03755, USA
    Circ Res 102:986-93. 2008
    ..Combining both biochemical and clinical approaches, we conclude that diminished prostacyclin receptor signaling may contribute, in part, to the underlying adverse cardiovascular outcomes observed with cyclooxygenase-2 inhibition...
  49. ncbi request reprint Urinary albumin excretion and carotid intima-media thickness
    Folkert W Asselbergs
    Hypertension 46:e20. 2005
  50. ncbi request reprint Letter regarding article by Arnlov et al, "low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals"
    Folkert W Asselbergs
    Circulation 113:e406; author reply e406-7. 2006