Liver gene expression signature of mild fibrosis in patients with chronic hepatitis CTarik Asselah
Service d hépatologie and INSERM CRB3, AP HP Hôpital Beaujon, University of Paris VII, Paris, France
Gastroenterology 129:2064-75. 2005
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Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis CT Asselah
Centre de Recherche Claude Bernard sur les Hépatites Virales, AP HP Hôpital Beaujon, Clichy, France Service de Biochimie, AP HP Hôpital Beaujon, Clichy, France
Gut 52:1638-43. 2003
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Second infection with a different hepatitis C virus genotype in a intravenous drug user during interferon therapyT Asselah
Service d Hepatologie, INSERM U 481 and Centre de Recherche Claude Bernard sur les Hépatites Virales, Clichy, France
Gut 52:900-2. 2003
..An alternative explanation is that IFN, while not preventing acute hepatitis C, may prevent chronicity. The risk of multiple infection in IVDU underlines the need for preventive strategies...
Gene expression and hepatitis C virus infectionT Asselah
INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, Paris, France
Gut 58:846-58. 2009
..This paper reviews the published literature on gene expression associated with HCV infection (HCV infection, fibrosis progression), and also according to response to treatment...
Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis CT Asselah
Service d Hepatologie, Pôle des Maladies de l Appareil Digestif and INSERM U773, CRB3, University of Paris VII, AP HP Beaujon Hospital, Clichy, France
Gut 57:516-24. 2008
..Considering side effects and treatment cost, prediction of treatment response before therapy is important. The aim of this study was to identify a liver gene signature to predict sustained virological response in patients with CHC...
Management of chronic hepatitis CT Asselah
Service d Hépathologie and INSERM U 773, University of Paris VII, Beaujon Hospital, Clichy, France
Minerva Gastroenterol Dietol 53:9-23. 2007
..This paper will discuss the natural history, the factors associated with the progression of fibrosis, the predictive factors of response to treatment, and existing and future treatments for hepatitis C...
Hypervariable region 1 quasispecies in hepatitis C virus genotypes 1b and 3 infected patients with normal and abnormal alanine aminotransferase levelsT Asselah
Service d Hepatologie, INSERM U 481 and Centre de Recherche Claude Bernard sur les Hépatites Virales, Clichy, France
J Viral Hepat 9:29-35. 2002
..These results are consistent with the view that patients with normal ALT have a different immune response against HCV resulting in a low HCV heterogeneity...
Haemobilia causing acute pancreatitis after percutaneous liver biopsy: diagnosis by magnetic resonance cholangiopancreatographyT Asselah
Service d Hepatologie, INSERM U 481 and Centre de Recherche Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
Eur J Gastroenterol Hepatol 13:877-9. 2001
..We present a case of haemobilia causing acute pancreatitis after percutaneous liver biopsy in which the diagnosis could be made clearly by MRCP, thus avoiding endoscopic retrograde cholangiopancreatography and sphincterotomy...
[Treatment of chronic hepatitis B]T Asselah
Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, INSERM U773 CRB3, Université Denis Diderot Paris VII, Hopital Beaujon, Clichy, France
Gastroenterol Clin Biol 32:749-68. 2008
..More potent drugs and new combinations as well as understanding the mechanisms of viral resistance should be evaluated to improve the efficacy of treatment...
Ectopic hepatocellular carcinoma arising in the left chest wall: a long-term follow-upT Asselah
Service d Hepatologie, Hopital Beaujon, 100 Bd du Gal Leclerc, 92118 Clichy, France
Eur J Gastroenterol Hepatol 13:873-5. 2001
..We conclude that solitary extrahepatic HCC (i) may arise in ectopic liver tissue; (ii) should not be considered as a metastasis of an occult HCC; and (iii) can be amenable to cure through resection...
Steatosis in chronic hepatitis C: why does it really matter?T Asselah
Service d hépatologie and INSERM CRB3, Hopital Beaujon, Clichy 92110, France
Gut 55:123-30. 2006
..This review describes and discusses the basic and clinical aspects of the relationship between steatosis and progression of fibrosis, and response to treatment in patients with chronic hepatitis C...
Treatment of chronic hepatitis cP Marcellin
Unit of Hepatology, Claude Bernard Research Center on Viral Hepatitis, INSERM U 481, Hospital Beaujon, Clichy, France
Minerva Gastroenterol Dietol 50:29-36. 2004
..In addition, intensive research is currently done for the development of inhibitors of viral enzymes (helicase, protease or polymerase) and anti-sense oligonucleotides, ribozymes and therapeutic vaccine...
Medical therapy of patients affected by HBeAg-negative chronic hepatitis BP Marcellin
Division of Hepatology and INSERM CRB3, University of Paris VII, Beaujon Hospital, Clichy, France
Minerva Gastroenterol Dietol 52:23-38. 2006
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Treatment of chronic hepatitis BP Marcellin
Service d Hepatologie, INSERM U 481 and Centre de Recherche Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
J Viral Hepat 12:333-45. 2005
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Automation of the Hepascore and validation as a biochemical index of liver fibrosis in patients with chronic hepatitis C from the ANRS HC EP 23 Fibrostar cohortJérôme Guéchot
Laboratoire de Biochimie A, Hopital Saint Antoine, AP HP, Paris, France
Clin Chim Acta 411:86-91. 2010
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Comparison of the effect of terlipressin and albumin on arterial blood volume in patients with cirrhosis and tense ascites treated by paracentesis: a randomised pilot studyR Moreau
Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Clichy, France
Gut 50:90-4. 2002
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Kinetics of serum cytokines reflect changes in the severity of chronic hepatitis C presenting minimal fibrosisManuela G Neuman
Division of Clinical Pharmacology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
J Viral Hepat 9:134-40. 2002
..In conclusion, serum TNF-alpha reflects the progression of inflammation as seen in liver biopsies and TGF-beta reflects the degree of fibrosis in HCV patients...
Chronic hepatitis C: viral clearance several months after discontinuation of therapy in two non-respondersJ Denis
Service d Hepato Gastroenterologie, Centre Hospitalier Sud Francilien, quartier du Canal Courcouronnes, 91014 Evry Cedex, France
Infection 35:197-200. 2007
..During long-term follow-up of non-responders, when a persistent normalization of aminotransferase level is observed after stopping treatment, viral clearance could be suspected...
[Treatment "Ã la carte" of chronic hepatitis B]P Marcellin
Gastroenterol Clin Biol 32:S1-5. 2008
Treatment of chronic hepatitis C virus in allogeneic bone marrow transplant recipientsR Peffault de Latour
, , , Paris Cedex, France
Bone Marrow Transplant 36:709-13. 2005
..This study thus highlights the efficacy of combined therapy and emphasizes the fact that the undue safety concerns are not a problem when treating this particular population...