Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae)G A Asare
School of Allied Health Sciences, University of Ghana, Legon, Ghana
Genet Mol Res 11:100-11. 2012
..The CC(50) was 26.3 mg/mL and hepato-renal toxicity after subchronic extract administration was nil. We conclude that ethanol extract of P. niruri is not cytotoxic or genotoxic, and is generally non-toxic on subchronic administration...
- Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels
George Awuku Asare
University of Ghana School of Allied Health Sciences SAHS, Korle Bu, Ghana
J Ethnopharmacol 139:265-72. 2012
..Genotoxicity results have hitherto not been shown. Moringa oleifera is genotoxic at supra-supplementation levels of 3,000 mg/kg b.wt. However, intake is safe at levels ≤ 1,000 mg/kg b.wt...
- Acute toxicity studies of Croton membranaceus root extract
George A Asare
University of Ghana School of Allied Health Sciences SAHS, Korle Bu, Ghana
J Ethnopharmacol 134:938-43. 2011
..Despite claims of success there is paucity of information on its toxicity. The aim of this study was to determine if Croton membranaceus has acute toxicity properties...
- Possible adverse effect of high delta-alpha-tocopherol intake on hepatic iron overload: enhanced production of vitamin C and the genotoxin, 8-hydroxy-2'- deoxyguanosine
George A Asare
MRC Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
Toxicol Mech Methods 20:96-104. 2010
..05). Oxidative liver damage, as determined by serum AST and ALT levels, was not attenuated by alpha-tocopherol. A positive correlation existed between vitamin C and 8-OHdG, suggesting possible delta-alpha-tocopherol toxicity...
- Serum levels of Cu, Se, and Zn in adult rural/urban residents in Ghana: paradigm shift?
George A Asare
Chemical Pathology Unit, Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, P O Box KB143, Accra, Ghana
Biol Trace Elem Res 137:139-49. 2010
..0028). In conclusion, Cu, Se, and Zn were higher in the rural group compared to the urban group, and the generally low Zn levels were confirmed in another cohort follow-up study...
Hepatocellular carcinoma caused by iron overload: a possible mechanism of direct hepatocarcinogenicityGeorge A Asare
MRC/University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa
Toxicology 219:41-52. 2006
..CONCLUSIONS: Our findings are compatible with the hypothesis that the direct hepatocarcinogenic effect of free iron is mediated by the generation of oxygen reactive species and oxidative damage that are mutagenic and carcinogenic...
- Synergistic interaction between excess hepatic iron and alcohol ingestion in hepatic mutagenesis
George A Asare
MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
Toxicology 254:11-8. 2008
..Alcohol may be one such factor. The aim therefore was to determine the extent of synergistic interaction between free hepatic iron and alcohol, complicating dietary iron overload in HCC pathogenesis...
- Interactions between aflatoxin B1 and dietary iron overload in hepatic mutagenesis
George A Asare
MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Medical School, Parktown 2193, Johannesburg, South Africa
Toxicology 234:157-66. 2007
..Dietary aflatoxin B(1) (AFB(1)) exposure and iron overload are important causes of hepatocellular carcinoma in sub-Saharan Africa. The aim of this study was to investigate if the two risk factors have an interactive effect...
- Iron-free neoplastic nodules and hepatocellular carcinoma without cirrhosis in Wistar rats fed a diet high in iron
George A Asare
MRC/University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand and Johannesburg Academic and Baragwanath Hospitals, South Africa
J Pathol 208:82-90. 2006
....
- Dietary iron overload in the African and hepatocellular carcinoma
Michael C Kew
MRC CANSA University Molecular Hepatology Research Unit, Department of Medicine, Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
Liver Int 27:735-41. 2007
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