George A Asare

Summary

Publications

  1. pmc Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies
    Dan K Afriyie
    Department of Pharmacology, University of Ghana Medical School, Ghana
    Pharmacognosy Res 5:10-6. 2013
  2. pmc Acute toxicity studies of aqueous leaf extract of Phyllanthus niruri
    George Awuku Asare
    University of Ghana School of Allied Health Sciences SAHS, Korle Bu, Ghana
    Interdiscip Toxicol 4:206-10. 2011
  3. doi Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthus niruri
    George Awuku Asare
    Chemical Pathology Unit, Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, Korle Bu, Accra, Ghana
    Pharm Biol 51:691-9. 2013
  4. doi Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae)
    G A Asare
    School of Allied Health Sciences, University of Ghana, Legon, Ghana
    Genet Mol Res 11:100-11. 2012
  5. doi Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels
    George Awuku Asare
    University of Ghana School of Allied Health Sciences SAHS, Korle Bu, Ghana
    J Ethnopharmacol 139:265-72. 2012
  6. doi Acute toxicity studies of Croton membranaceus root extract
    George A Asare
    University of Ghana School of Allied Health Sciences SAHS, Korle Bu, Ghana
    J Ethnopharmacol 134:938-43. 2011
  7. doi Possible adverse effect of high delta-alpha-tocopherol intake on hepatic iron overload: enhanced production of vitamin C and the genotoxin, 8-hydroxy-2'- deoxyguanosine
    George A Asare
    MRC Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Toxicol Mech Methods 20:96-104. 2010
  8. doi Serum levels of Cu, Se, and Zn in adult rural/urban residents in Ghana: paradigm shift?
    George A Asare
    Chemical Pathology Unit, Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, P O Box KB143, Accra, Ghana
    Biol Trace Elem Res 137:139-49. 2010
  9. ncbi Hepatocellular carcinoma caused by iron overload: a possible mechanism of direct hepatocarcinogenicity
    George A Asare
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa
    Toxicology 219:41-52. 2006
  10. doi Synergistic interaction between excess hepatic iron and alcohol ingestion in hepatic mutagenesis
    George A Asare
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Toxicology 254:11-8. 2008

Collaborators

Detail Information

Publications14

  1. pmc Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies
    Dan K Afriyie
    Department of Pharmacology, University of Ghana Medical School, Ghana
    Pharmacognosy Res 5:10-6. 2013
    ..Croton membranaceus (CM) is used for benign prostate hyperplasia treatment...
  2. pmc Acute toxicity studies of aqueous leaf extract of Phyllanthus niruri
    George Awuku Asare
    University of Ghana School of Allied Health Sciences SAHS, Korle Bu, Ghana
    Interdiscip Toxicol 4:206-10. 2011
    ..Examination of the various body organs did not show any abnormality. Thus no toxicity was observed at the levels administered. The LD(50) of the aqueous extract is>5000 mg/kg. b.w...
  3. doi Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthus niruri
    George Awuku Asare
    Chemical Pathology Unit, Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, Korle Bu, Accra, Ghana
    Pharm Biol 51:691-9. 2013
    ..Phyllanthus niruri L. (Euphorbiaceae), a medicinal plant traditionally known for dissolving kidney stones, is used prophylactically as an antimalarial agent...
  4. doi Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae)
    G A Asare
    School of Allied Health Sciences, University of Ghana, Legon, Ghana
    Genet Mol Res 11:100-11. 2012
    ..The CC(50) was 26.3 mg/mL and hepato-renal toxicity after subchronic extract administration was nil. We conclude that ethanol extract of P. niruri is not cytotoxic or genotoxic, and is generally non-toxic on subchronic administration...
  5. doi Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels
    George Awuku Asare
    University of Ghana School of Allied Health Sciences SAHS, Korle Bu, Ghana
    J Ethnopharmacol 139:265-72. 2012
    ..Genotoxicity results have hitherto not been shown. Moringa oleifera is genotoxic at supra-supplementation levels of 3,000 mg/kg b.wt. However, intake is safe at levels ≤ 1,000 mg/kg b.wt...
  6. doi Acute toxicity studies of Croton membranaceus root extract
    George A Asare
    University of Ghana School of Allied Health Sciences SAHS, Korle Bu, Ghana
    J Ethnopharmacol 134:938-43. 2011
    ..Despite claims of success there is paucity of information on its toxicity. The aim of this study was to determine if Croton membranaceus has acute toxicity properties...
  7. doi Possible adverse effect of high delta-alpha-tocopherol intake on hepatic iron overload: enhanced production of vitamin C and the genotoxin, 8-hydroxy-2'- deoxyguanosine
    George A Asare
    MRC Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Toxicol Mech Methods 20:96-104. 2010
    ..05). Oxidative liver damage, as determined by serum AST and ALT levels, was not attenuated by alpha-tocopherol. A positive correlation existed between vitamin C and 8-OHdG, suggesting possible delta-alpha-tocopherol toxicity...
  8. doi Serum levels of Cu, Se, and Zn in adult rural/urban residents in Ghana: paradigm shift?
    George A Asare
    Chemical Pathology Unit, Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, P O Box KB143, Accra, Ghana
    Biol Trace Elem Res 137:139-49. 2010
    ..0028). In conclusion, Cu, Se, and Zn were higher in the rural group compared to the urban group, and the generally low Zn levels were confirmed in another cohort follow-up study...
  9. ncbi Hepatocellular carcinoma caused by iron overload: a possible mechanism of direct hepatocarcinogenicity
    George A Asare
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa
    Toxicology 219:41-52. 2006
    ..The aim of this study was to determine if generation of reactive oxygen species and the resulting oxidative damage induced by free hepatic iron is directly hepatocarcinogenic...
  10. doi Synergistic interaction between excess hepatic iron and alcohol ingestion in hepatic mutagenesis
    George A Asare
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Toxicology 254:11-8. 2008
    ..Alcohol may be one such factor. The aim therefore was to determine the extent of synergistic interaction between free hepatic iron and alcohol, complicating dietary iron overload in HCC pathogenesis...
  11. ncbi Interactions between aflatoxin B1 and dietary iron overload in hepatic mutagenesis
    George A Asare
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Medical School, Parktown 2193, Johannesburg, South Africa
    Toxicology 234:157-66. 2007
    ..Dietary aflatoxin B(1) (AFB(1)) exposure and iron overload are important causes of hepatocellular carcinoma in sub-Saharan Africa. The aim of this study was to investigate if the two risk factors have an interactive effect...
  12. ncbi Iron-free neoplastic nodules and hepatocellular carcinoma without cirrhosis in Wistar rats fed a diet high in iron
    George A Asare
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand and Johannesburg Academic and Baragwanath Hospitals, South Africa
    J Pathol 208:82-90. 2006
    ....
  13. ncbi Dietary iron overload in the African and hepatocellular carcinoma
    Michael C Kew
    MRC CANSA University Molecular Hepatology Research Unit, Department of Medicine, Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Liver Int 27:735-41. 2007
    ....