Splice variants of the gamma subunit (FXYD2) and their significance in regulation of the Na, K-ATPase in kidneyElena Arystarkhova
Laboratory of Membrane Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Bioenerg Biomembr 37:381-6. 2005
..The focus is on splice variants of gamma, their structural similarity and yet distinct effects conferred to Na, K-ATPase...
- Multiplicity of expression of FXYD proteins in mammalian cells: dynamic exchange of phospholemman and gamma-subunit in response to stress
Elena Arystarkhova
Laboratory of Membrane Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Physiol Cell Physiol 292:C1179-91. 2007
..The data imply that FXYDs are obligatory rather than auxiliary components of Na-K-ATPase, and their interchangeability underlies responses of Na-K-ATPase to cellular stress...
- Distribution and oligomeric association of splice forms of Na(+)-K(+)-ATPase regulatory gamma-subunit in rat kidney
Elena Arystarkhova
Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Am J Physiol Renal Physiol 282:F393-407. 2002
..Because different mechanisms maintain and regulate Na(+) homeostasis in different nephron segments, the splice forms of the gamma-subunit may have evolved to control the renal Na(+) pump through pump properties, gene expression, or both...
- FXYD proteins as regulators of the Na,K-ATPase in the kidney
Kathleen J Sweadner
Neuroscience Center, Massachusetts General Hospital, Charlestown 02129, USA
Ann N Y Acad Sci 986:382-7. 2003
..In contrast, alpha1, beta1, and gamma were found in adjacent macula densa. Phospholemman, alpha2, and beta2 are proposed to have distinct roles in regulating the sodium pump in structures involved in tubuloglomerular feedback...
- Gamma structural variants differentially regulate Na,K-ATPase properties
Elena Arystarkhova
Neuroscience Center, Massachusetts General Hospital, Charlestown 02129, USA
Ann N Y Acad Sci 986:416-9. 2003
..The data imply an adaptive physiological mechanism of regulation of renal Na,K-ATPase through modulation of pump properties, gene expression, or both...
- Stress-induced expression of the gamma subunit (FXYD2) modulates Na,K-ATPase activity and cell growth
Randall K Wetzel
Laboratory of Membrane Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 279:41750-7. 2004
..Taken together, the data imply that induction of gammaa may have adaptive value by being a part of a general cellular response to genotoxic stress...
Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNAKathleen J Sweadner
Laboratory of Membrane Biology, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 286:18290-300. 2011
..The data confirm truncation of FXYD2b as a potential mechanism to regulate the amount of FXYD2 at the cell surface to control activity of Na,K-ATPase and cell growth...
- Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit
Elena Arystarkhova
Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Biol Chem 277:10162-72. 2002
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