Michel Arthur



  1. Bhattacharjee N, Triboulet S, Dubée V, Fonvielle M, Edoo Z, Hugonnet J, et al. Negative Impact of Carbapenem Methylation on the Reactivity of β-Lactams for Cysteine Acylation as Revealed by Quantum Calculations and Kinetic Analyses. Antimicrob Agents Chemother. 2019;63: pubmed publisher
    ..We concluded that the rate of Ldtfm acylation is largely determined by the β-lactam reactivity with one exception, as the enzyme catalytic pocket fully compensated for the detrimental effect of carbapenem methylation. ..
  2. Lefebvre A, Le Moigne V, Bernut A, Veckerlé C, Compain F, Herrmann J, et al. Inhibition of the β-Lactamase BlaMab by Avibactam Improves the In Vitro and In Vivo Efficacy of Imipenem against Mycobacterium abscessus. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..The in vitro evaluation of imipenem may underestimate the impact of BlaMab, since the production of the β-lactamase is inducible in macrophages. ..
  3. Dubée V, Bernut A, Cortes M, Lesne T, Dorchene D, Lefebvre A, et al. β-Lactamase inhibition by avibactam in Mycobacterium abscessus. J Antimicrob Chemother. 2015;70:1051-8 pubmed publisher
    ..Our data identify avibactam as the first efficient inhibitor of BlaMab and strongly suggest that β-lactamase inhibition should be evaluated to provide improved therapeutic options for M. abscessus infections. ..
  4. Sacco E, Cortes M, Josseaume N, Bouchier C, Dubée V, Hugonnet J, et al. Mutation landscape of acquired cross-resistance to glycopeptide and β-lactam antibiotics in Enterococcus faecium. Antimicrob Agents Chemother. 2015;59:5306-15 pubmed publisher
    ..The high number of mutations required for activation of the l,d-transpeptidase pathway may strongly limit emergence of cross-resistance to ampicillin and glycopeptides by this mechanism. ..
  5. Compain F, Dorchene D, Arthur M. Combination of Amino Acid Substitutions Leading to CTX-M-15-Mediated Resistance to the Ceftazidime-Avibactam Combination. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Acquisition of resistance could be restricted to rare variants harboring predisposing polymorphisms such as Q at position 169 detected in a single naturally occurring CTX-M enzyme (CTX-M-93). ..
  6. Fonvielle M, Sakkas N, Iannazzo L, Le Fournis C, Patin D, Mengin Lecreulx D, et al. Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes. Angew Chem Int Ed Engl. 2016;55:13553-13557 pubmed publisher
    ..Thus, squaramate-RNAs provide specificity for cross-linking with defined groups in complex biomolecules due to its unique reactivity. ..
  7. Arthur M. Regulation of Bacterial Peptidoglycan Polymerization. Trends Microbiol. 2016;24:519-521 pubmed publisher
  8. Ourghanlian C, Soroka D, Arthur M. Inhibition by Avibactam and Clavulanate of the β-Lactamases KPC-2 and CTX-M-15 Harboring the Substitution N132G in the Conserved SDN Motif. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Fortunately, the substitution does not lead to resistance to the ceftazidime-avibactam combination. ..
  9. Compain F, Arthur M. Impaired Inhibition by Avibactam and Resistance to the Ceftazidime-Avibactam Combination Due to the D179Y Substitution in the KPC-2 β-Lactamase. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..In contrast, the D179Y substitution abolished the hydrolysis of aztreonam and imipenem, indicating that these drugs might provide therapeutic alternatives. ..

More Information


  1. Edoo Z, Arthur M, Hugonnet J. Reversible inactivation of a peptidoglycan transpeptidase by a β-lactam antibiotic mediated by β-lactam-ring recyclization in the enzyme active site. Sci Rep. 2017;7:9136 pubmed publisher
    ..Ring strain is therefore not sufficient to account for irreversible acylation of peptidoglycan transpeptidases observed for most β-lactam antibiotics. ..
  2. Sütterlin L, Edoo Z, Hugonnet J, Mainardi J, Arthur M. Peptidoglycan Cross-Linking Activity of l,d-Transpeptidases from Clostridium difficile and Inactivation of These Enzymes by β-Lactams. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..These observations indicate that LdtCd1 and LdtCd2 are inactivated only by β-lactams of the carbapenem class due to a combination of rapid acylation and the stability of the resulting covalent adducts. ..