Bhattacharjee N, Triboulet S, Dubée V, Fonvielle M, Edoo Z, Hugonnet J, et al
. Negative Impact of Carbapenem Methylation on the Reactivity of β-Lactams for Cysteine Acylation as Revealed by Quantum Calculations and Kinetic Analyses. Antimicrob Agents Chemother. 2019;63: pubmed publisher
..We concluded that the rate of Ldtfm acylation is largely determined by the β-lactam reactivity with one exception, as the enzyme catalytic pocket fully compensated for the detrimental effect of carbapenem methylation. ..
Lefebvre A, Le Moigne V, Bernut A, VeckerlÃ© C, Compain F, Herrmann J, et al
. Inhibition of the Î²-Lactamase BlaMab by Avibactam Improves the In Vitro and In Vivo Efficacy of Imipenem against Mycobacterium abscessus. Antimicrob Agents Chemother. 2017;61: pubmed publisher
..The in vitro evaluation of imipenem may underestimate the impact of BlaMab, since the production of the Î²-lactamase is inducible in macrophages. ..
DubÃ©e V, Bernut A, Cortes M, Lesne T, Dorchene D, Lefebvre A, et al
. Î²-Lactamase inhibition by avibactam in Mycobacterium abscessus. J Antimicrob Chemother. 2015;70:1051-8 pubmed publisher
..Our data identify avibactam as the first efficient inhibitor of BlaMab and strongly suggest that Î²-lactamase inhibition should be evaluated to provide improved therapeutic options for M. abscessus infections. ..
Sacco E, Cortes M, Josseaume N, Bouchier C, DubÃ©e V, Hugonnet J, et al
. Mutation landscape of acquired cross-resistance to glycopeptide and Î²-lactam antibiotics in Enterococcus faecium. Antimicrob Agents Chemother. 2015;59:5306-15 pubmed publisher
..The high number of mutations required for activation of the l,d-transpeptidase pathway may strongly limit emergence of cross-resistance to ampicillin and glycopeptides by this mechanism. ..
Compain F, Dorchene D, Arthur M. Combination of Amino Acid Substitutions Leading to CTX-M-15-Mediated Resistance to the Ceftazidime-Avibactam Combination. Antimicrob Agents Chemother. 2018;62: pubmed publisher
..Acquisition of resistance could be restricted to rare variants harboring predisposing polymorphisms such as Q at position 169 detected in a single naturally occurring CTX-M enzyme (CTX-M-93). ..
Fonvielle M, Sakkas N, Iannazzo L, Le Fournis C, Patin D, Mengin Lecreulx D, et al
. Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes. Angew Chem Int Ed Engl. 2016;55:13553-13557 pubmed publisher
..Thus, squaramate-RNAs provide specificity for cross-linking with defined groups in complex biomolecules due to its unique reactivity. ..
Arthur M. Regulation of Bacterial Peptidoglycan Polymerization. Trends Microbiol. 2016;24:519-521 pubmed publisher
Ourghanlian C, Soroka D, Arthur M. Inhibition by Avibactam and Clavulanate of the β-Lactamases KPC-2 and CTX-M-15 Harboring the Substitution N132G in the Conserved SDN Motif. Antimicrob Agents Chemother. 2017;61: pubmed publisher
..Fortunately, the substitution does not lead to resistance to the ceftazidime-avibactam combination. ..
Compain F, Arthur M. Impaired Inhibition by Avibactam and Resistance to the Ceftazidime-Avibactam Combination Due to the D179Y Substitution in the KPC-2 Î²-Lactamase. Antimicrob Agents Chemother. 2017;61: pubmed publisher
..In contrast, the D179Y substitution abolished the hydrolysis of aztreonam and imipenem, indicating that these drugs might provide therapeutic alternatives. ..