Alicia Belgorosky

Summary

Affiliation: University of Buenos Aires
Country: Argentina

Publications

  1. ncbi Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatase-deficient girl who is a compound heterocygote for two new point mutations of the CYP19 gene
    Alicia Belgorosky
    Laboratorio de Investigacion, Hospital de Pediatria Garrahan, Buenos Aires, Argentina 1245
    J Clin Endocrinol Metab 88:5127-31. 2003
  2. pmc Latin American consensus: children born small for gestational age
    Margaret C S Boguszewski
    Department of Pediatrics, Hospital de Clinicas, Federal University of Parana, Curitiba, Brazil
    BMC Pediatr 11:66. 2011
  3. doi Adrenarche: postnatal adrenal zonation and hormonal and metabolic regulation
    Alicia Belgorosky
    Servicio de Endocrinologia, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Horm Res 70:257-67. 2008
  4. doi Expression of the IGF and the aromatase/estrogen receptor systems in human adrenal tissues from early infancy to late puberty: implications for the development of adrenarche
    Alicia Belgorosky
    Endocrinology Department, Garrahan Pediatric Hospital, Buenos Aires, Argentina
    Rev Endocr Metab Disord 10:51-61. 2009
  5. ncbi [Novel heterozygous mutation in the steroidogenic acute regulatory protein gene in a 46,XY patient with congenital lipoid adrenal hyperplasia]
    Maria Sonia Baquedano
    Servicio de Endocrinologia, Hospital Nacional de Pediatria Juan P Garrahan, Buenos Aires, Argentina
    Medicina (B Aires) 73:297-302. 2013
  6. ncbi Identification and developmental changes of aromatase and estrogen receptor expression in prepubertal and pubertal human adrenal tissues
    Maria Sonia Baquedano
    Endocrinology Service, Hospital de Pediatria Garrahan, C de los Pozos 1881, Buenos Aires, Argentina
    J Clin Endocrinol Metab 92:2215-22. 2007
  7. doi Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells
    Esperanza B Berensztein
    Endocrine Service, Hospital de Pediatria Garrahan, Buenos Aires C1245 AAM, Argentina
    Pediatr Res 63:662-6. 2008
  8. ncbi [Exon 5 alternative splicing of the cytochrome P450 aromatase could be a regulatory mechanism for estrogen production in humans]
    Carolina M Pepe
    Laboratorio de Investigacion, Hospital Garrahan, Buenos Aires, Argentina
    Medicina (B Aires) 67:369-73. 2007
  9. ncbi Hydrocortisone treatment in girls with congenital adrenal hyperplasia inhibits serum dehydroepiandrosterone sulfate and affects the GH-IGF-I system
    Gabriela Guercio
    Hospital de Pediatria Garrahan, Endocrinology Service, Buenos Aires, Argentina
    J Pediatr Endocrinol Metab 22:255-61. 2009
  10. ncbi Relationship between the growth hormone/insulin-like growth factor-I axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal girls
    Gabriela Guercio
    Endocrinology Service, Garrahan Pediatric Hospital, Buenos Aires, C1245AAM, Argentina
    J Clin Endocrinol Metab 88:1389-93. 2003

Collaborators

  • Candela R Gonzalez
  • Ignacio Bergada
  • Marco A Rivarola
  • Gabriela Guercio
  • Maria Sonia Baquedano
  • Marta Ciaccio
  • Roxana Marino
  • Mercedes Maceiras
  • Esperanza Berensztein
  • Elisa Vaiani
  • Eduardo Chaler
  • Mariana Costanzo
  • Nora Saraco
  • Esperanza B Berensztein
  • Nora I Saraco
  • Carolina M Pepe
  • Diana Monica Warman
  • Pablo Ramirez
  • Marcela Bailez
  • Viviana Herzovich
  • Silvia Gil
  • Eduardo A Chaler
  • Juan Manuel Lazzatti
  • Pablo C Ramirez
  • Jesica Galeano
  • Margaret C S Boguszewski
  • Carolina Pepe
  • Roberto Ponzio
  • Andrea Bernasconi
  • Mariano Mendioroz
  • Giselle Areny
  • Amalia Turconi
  • Jessica Galeano
  • Carla Chilelli
  • Valeria De Dona
  • Vanessa Llinares
  • Juan M Lazzati
  • Norma Delgado
  • Romina Fiorenzano
  • Raúl Calzada-León
  • Peter Gunczler
  • Margarita Barrientos
  • Roberto Lanes
  • Patricio Procel
  • Natalia Perez Garrido
  • Horacio M Domene
  • Veronica Mericq
  • Mirta Gryngarten
  • Mauricio Llano
  • Orlando Jaramillo
  • Durval Damiani
  • Armando Blanco
  • Esther Pardes
  • Viviana Balbi
  • Teresa Ortiz
  • Diana M Warman
  • Carlos Rocco
  • Noelia Dujovne
  • Yesica Longueira
  • Lilien Chertkoff
  • Maria Torrado
  • Carola Saure
  • Maria Isabel Di Palma
  • Carmen Mazza
  • Mariana Prieto
  • María S Baquedano
  • Michele Bianchini
  • Christa E Flück
  • Javier Goñi
  • Amit V Pandey
  • Estrella Levy
  • Alicia Ornani
  • Matias Oleastro
  • Alejandra Ribas
  • Mariela Sciara
  • Patricia Ferrari
  • Jorge Rossi
  • Marta Zelazko
  • Rubén Paz
  • Jorge Rodriguez
  • Maria T G de Davila
  • Gabriela Vanesa Dorn
  • Maria T de Davila
  • Monica Warman
  • Mariela I Sciara
  • Carolina Montiveros
  • Mirta Ciocca
  • Oscar Imventarza
  • Miriam Cuarterolo

Detail Information

Publications29

  1. ncbi Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatase-deficient girl who is a compound heterocygote for two new point mutations of the CYP19 gene
    Alicia Belgorosky
    Laboratorio de Investigacion, Hospital de Pediatria Garrahan, Buenos Aires, Argentina 1245
    J Clin Endocrinol Metab 88:5127-31. 2003
    ....
  2. pmc Latin American consensus: children born small for gestational age
    Margaret C S Boguszewski
    Department of Pediatrics, Hospital de Clinicas, Federal University of Parana, Curitiba, Brazil
    BMC Pediatr 11:66. 2011
    ..Leading experts in pediatric endocrinology throughout Latin America established working groups in order to discuss key challenges regarding the evaluation and management of children born SGA and ultimately develop a consensus statement...
  3. doi Adrenarche: postnatal adrenal zonation and hormonal and metabolic regulation
    Alicia Belgorosky
    Servicio de Endocrinologia, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Horm Res 70:257-67. 2008
    ..However, many questions remain, transforming adrenal androgens into markers of diseases important for human health...
  4. doi Expression of the IGF and the aromatase/estrogen receptor systems in human adrenal tissues from early infancy to late puberty: implications for the development of adrenarche
    Alicia Belgorosky
    Endocrinology Department, Garrahan Pediatric Hospital, Buenos Aires, Argentina
    Rev Endocr Metab Disord 10:51-61. 2009
    ..In summary, several lines of evidence point to the action of multiple factors, such as local adrenal maturational changes and peripheral metabolic signals, on postnatal human adrenal gland ZR formation...
  5. ncbi [Novel heterozygous mutation in the steroidogenic acute regulatory protein gene in a 46,XY patient with congenital lipoid adrenal hyperplasia]
    Maria Sonia Baquedano
    Servicio de Endocrinologia, Hospital Nacional de Pediatria Juan P Garrahan, Buenos Aires, Argentina
    Medicina (B Aires) 73:297-302. 2013
    ..A misfolded p.G22_L59delStAR might interfere with WT StAR activity by blocking the transduceosome complex, causing an autosomal dominant form of StAR deficiency, explaining the clinical phenotype. ..
  6. ncbi Identification and developmental changes of aromatase and estrogen receptor expression in prepubertal and pubertal human adrenal tissues
    Maria Sonia Baquedano
    Endocrinology Service, Hospital de Pediatria Garrahan, C de los Pozos 1881, Buenos Aires, Argentina
    J Clin Endocrinol Metab 92:2215-22. 2007
    ..The mechanisms of postnatal adrenal zonation remain unclear...
  7. doi Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells
    Esperanza B Berensztein
    Endocrine Service, Hospital de Pediatria Garrahan, Buenos Aires C1245 AAM, Argentina
    Pediatr Res 63:662-6. 2008
    ..In some interstitial cells, probably in LC precursors, IGF-II/IR could be involved, among other factors, in the stimulation of PI and/or inhibition of AI, and in LC differentiation...
  8. ncbi [Exon 5 alternative splicing of the cytochrome P450 aromatase could be a regulatory mechanism for estrogen production in humans]
    Carolina M Pepe
    Laboratorio de Investigacion, Hospital Garrahan, Buenos Aires, Argentina
    Medicina (B Aires) 67:369-73. 2007
    ..Furthermore, tissue specific regulation of AS might suggest low expression of +E5mRNA from the c655G>A allele explaining residual AA evidenced in the affected girl...
  9. ncbi Hydrocortisone treatment in girls with congenital adrenal hyperplasia inhibits serum dehydroepiandrosterone sulfate and affects the GH-IGF-I system
    Gabriela Guercio
    Hospital de Pediatria Garrahan, Endocrinology Service, Buenos Aires, Argentina
    J Pediatr Endocrinol Metab 22:255-61. 2009
    ..Low levels of serum DHEAS could be involved in the regulation of IGF-I biological response in target tissues. Additional studies are necessary to confirm these findings...
  10. ncbi Relationship between the growth hormone/insulin-like growth factor-I axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal girls
    Gabriela Guercio
    Endocrinology Service, Garrahan Pediatric Hospital, Buenos Aires, C1245AAM, Argentina
    J Clin Endocrinol Metab 88:1389-93. 2003
    ..The relationship between insulin resistance and adrenal androgens persists during the transition from prepuberty to puberty, as well as during puberty...
  11. ncbi The cytochrome P450 aromatase lacking exon 5 is associated with a phenotype of nonclassic aromatase deficiency and is also present in normal human steroidogenic tissues
    Carolina M Pepe
    Molecular Biology Laboratory, Endocrinology Department, J P Garrahan Paediatric Hospital, Buenos Aires, Argentina
    Clin Endocrinol (Oxf) 67:698-705. 2007
    ..To explain the phenotype of partial aromatase deficiency observed in a female patient described with this mutation, molecular consequences of the c655G>A mutation were investigated...
  12. ncbi Expression of aromatase, estrogen receptor alpha and beta, androgen receptor, and cytochrome P-450scc in the human early prepubertal testis
    Esperanza B Berensztein
    Research Laboratory, Hospital de Pediatria Garrahan, Buenos Aires C124 5AAM, Argentina
    Pediatr Res 60:740-4. 2006
    ..The role of estrogen is less clear, but it could modulate the preservation of an adequate pool of precursor LCs and GCs...
  13. doi Effectiveness of rhGH treatment on final height of renal-transplant recipients in childhood
    Silvia Gil
    Department of Endocrinology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Pediatr Nephrol 27:1005-9. 2012
    ..Recombinant human growth hormone (rhGH) treatment has been used to improve height. Several studies in the literature have shown increased growth velocity, although data on the final height (FH) reached are scarce...
  14. ncbi Preserved fertility in a patient with a 46,XY disorder of sex development due to a new heterozygous mutation in the NR5A1/SF-1 gene: evidence of 46,XY and 46,XX gonadal dysgenesis phenotype variability in multiple members of an affected kindred
    Marta Ciaccio
    Endocrinology Service, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Horm Res Paediatr 78:119-26. 2012
    ..We confirm that preserved fertility can be observed in patients with a 46,XY disorder of sex development due to heterozygous mutations in the NR5A1 gene...
  15. doi Unique dominant negative mutation in the N-terminal mitochondrial targeting sequence of StAR, causing a variant form of congenital lipoid adrenal hyperplasia
    Maria Sonia Baquedano
    Endocrine Service, Hospital de Pediatria Garrahan, Buenos Aires C1245AAM, Argentina
    J Clin Endocrinol Metab 98:E153-61. 2013
    ..Recessive mutations cause classic and nonclassic congenital lipoid adrenal hyperplasia...
  16. doi Three new SF-1 (NR5A1) gene mutations in two unrelated families with multiple affected members: within-family variability in 46,XY subjects and low ovarian reserve in fertile 46,XX subjects
    Diana Monica Warman
    Endocrinology Service, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Horm Res Paediatr 75:70-7. 2011
    ..Three novel heterozygous SF-1 gene mutations affecting multiple members of two unrelated families with a history of 46,XY disorders of sex development (DSD) and 46,XX ovarian insufficiency are described...
  17. ncbi Expression of the IGF system in human adrenal tissues from early infancy to late puberty: implications for the development of adrenarche
    Maria Sonia Baquedano
    Laboratorio de Investigacion, Hospital de Pediatria Garrahan, Buenos Aires Argentina
    Pediatr Res 58:451-8. 2005
    ..Our data also suggest that IGF-1 is not a direct regulatory factor of adrenal androgen production by zona reticularis cells...
  18. doi Metformin, estrogen replacement therapy and gonadotropin inhibition fail to improve insulin sensitivity in a girl with aromatase deficiency
    Gabriela Guercio
    Endocrine Service, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Horm Res 72:370-6. 2009
    ..Insulin resistance (IR), abnormal lipid profile, and other features of the metabolic syndrome have been described in CYP19 gene knockout mice and in aromatase-deficient adult men but not in prepubertal affected girls...
  19. ncbi Relationship between the GH/IGF-I axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal boys
    Gabriela Guercio
    Endocrinology Service, Garrahan Pediatric Hospital, Buenos Aires C1245AAM, Argentina
    J Clin Endocrinol Metab 87:1162-9. 2002
    ....
  20. ncbi The serum growth hormone (GH) response to provocative tests is dependent on type of assay in autosomal dominant isolated GH deficiency because of an ARG(183)HIS (R183H) GH-I gene mutation
    Roxana Marino
    Research Laboratory and Endocrinology Service, Garrahan Pediatric Hospital, Buenos Aires, Argentina 1245
    Clin Chem 49:1002-5. 2003
  21. doi Steroid 21-hydroxylase gene mutational spectrum in 454 Argentinean patients: genotype-phenotype correlation in a large cohort of patients with congenital adrenal hyperplasia
    Roxana Marino
    Endocrinology Service, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Clin Endocrinol (Oxf) 75:427-35. 2011
    ..To report genotype-phenotype correlation in a large cohort of patients...
  22. doi Age-specific thyroid hormone and thyrotropin reference intervals for a pediatric and adolescent population
    Eduardo A Chaler
    Department of Endocrinology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Clin Chem Lab Med 50:885-90. 2012
    ..Moreover, knowledge of the measurement uncertainty (U) and of the reference change value (RCV) has important applications in clinical chemistry...
  23. ncbi High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis
    Nora Saraco
    Laboratorio de Investigacion, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Pediatr Dev Pathol 9:181-9. 2006
    ..In this environment, TGFbeta1 might switch from tumor suppressor to oncogenic factor and, along with estrogen-ER complexes, might favor tumor progression by inhibiting apoptosis...
  24. ncbi Hypothalamic-pituitary-testicular function in prepubertal children with chronic liver disease
    Elisa Vaiani
    Investigación Hospital de Pediatría Garrahan, Buenos Aires, Argentina
    J Pediatr Endocrinol Metab 15:289-95. 2002
    ..Furthermore, the lack of SHBG decrease and bioavailable testosterone increase with age, probably modulated by GH, suggests some degree of hepatic GH resistance in prepubertal patients with CLD...
  25. doi Thyroid axis dysfunction in patients with Prader-Willi syndrome during the first 2 years of life
    Elisa Vaiani
    Endocrine Service Genetics Service, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Clin Endocrinol (Oxf) 73:546-50. 2010
    ..Even though central hypothyroidism has been documented in 20-30% of patients with PWS, thyroid function during the first 2 years of life has not been clearly defined...
  26. doi Two novel mutations of the TSH-beta subunit gene underlying congenital central hypothyroidism undetectable in neonatal TSH screening
    Maria Sonia Baquedano
    Servicio de Endocrinologia, Hospital de Pediatria Garrahan, Buenos Aires C1245AAM, Argentina
    J Clin Endocrinol Metab 95:E98-103. 2010
    ..Patients with TSH-beta subunit defects and congenital hypothyroidism are missed by TSH-based neonatal screening...
  27. ncbi Apoptosis and proliferation of human testicular somatic and germ cells during prepuberty: high rate of testicular growth in newborns mediated by decreased apoptosis
    Esperanza B Berensztein
    Research Laboratory, Garrahan Pediatric Hospital, C de los Pozos 1881, Buenos Aires 1245, Argentina
    J Clin Endocrinol Metab 87:5113-8. 2002
    ..These changes taking place during the newborn period might be important to define testicular function in adults...
  28. ncbi Characterization of immunodeficiency in a patient with growth hormone insensitivity secondary to a novel STAT5b gene mutation
    Andrea Bernasconi
    Hospital de Pediatria Garrahan, Immunology Service, Combate de los Pozos 1881, C1245AAM Buenos Aires, Argentina
    Pediatrics 118:e1584-92. 2006
    ..Furthermore, the main immunologic findings bring about an explanation for the clinical immunodeficiency features and reveal for the first time the relevant role of STAT5b as a key protein for T-cell functions in humans...
  29. ncbi Effect of the dose of oral hydrocortisone on growth rate during long-term treatment of children with salt losing congenital adrenal hyperplasia
    Marta Ciaccio
    Servicio de Endocrinologia, Hospital de Pediatria Garrahan, Combate de los Pozos 1881, 1245 Buenos Aires, Argentina
    Medicina (B Aires) 62:551-4. 2002
    ....