Silvia Sookoian

Summary

Affiliation: Universidad de Buenos Aires
Country: Argentina

Publications

  1. doi request reprint The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease
    Silvia Sookoian
    Clinical and Molecular Hepatology Laboratory, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Argentina
    Pharmacogenet Genomics 20:1-8. 2010
  2. ncbi request reprint Genetic determinants of acquired cholestasis: a systems biology approach
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Front Biosci (Landmark Ed) 17:206-20. 2012
  3. ncbi request reprint Liver disease during pregnancy: acute viral hepatitis
    Silvia Sookoian
    Instituto de Investigaciones Medicas, Alfredo Lanari Facultad de Medicina, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Argentina
    Ann Hepatol 5:231-6. 2006
  4. doi request reprint Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review
    Silvia Sookoian
    Laboratory of Clinical and Molecular Hepatology, Department of Molecular Genetics and Biology of Complex Diseases, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    J Hepatol 49:600-7. 2008
  5. doi request reprint Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Hepatology 53:1883-94. 2011
  6. doi request reprint Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Cytokine 44:201-6. 2008
  7. doi request reprint Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, University of Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
    Atherosclerosis 218:378-85. 2011
  8. ncbi request reprint Effect of pregnancy on pre-existing liver disease: chronic viral hepatitis
    Silvia Sookoian
    Instituto de Investigaciones Medicas, Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Ann Hepatol 5:190-7. 2006
  9. doi request reprint Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease
    Silvia Sookoian
    Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, 1427 Ciudad Autonoma de Buenos Aires, Argentina
    J Nutr Biochem 20:765-70. 2009
  10. doi request reprint A diagnostic model to differentiate simple steatosis from nonalcoholic steatohepatitis based on the likelihood ratio form of Bayes theorem
    Silvia Sookoian
    Department of Molecular Genetics and Biology of Complex Diseases, Laboratory of Clinical and Molecular Hepatology, Institute of Medical Research, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Clin Biochem 42:624-9. 2009

Collaborators

  • Gustavo Castano
  • Victoria Alfonso
  • V A Mbayed
  • Bernardo Frider
  • Laura Quintana
  • Carlos J Pirola
  • Carolina Gemma
  • Tomas Fernandez Gianotti
  • Adriana L Burgueño
  • Tomas F Gianotti
  • Claudio D Gonzalez
  • Maria Soledad Rosselli
  • Silvia I Garcia
  • Romina Cabrerizo
  • Carlos Jose Pirola
  • Adriana Burgueno
  • Julieta Carabelli
  • Diego Flichman
  • Noelia Gonzales Mansilla
  • Adriana Laura Burgueño
  • Guillermo Dieuzeide
  • Federico Di Lello
  • Jorge Alvarinas
  • Diego Kanevsky
  • Rodolfo Campos
  • Veronica Kott
  • María Mora Gonzalez Lopez Ledesma
  • Noelia G Mansilla
  • Nestor R Lago
  • Mariano Schuman
  • Gabriel Garcia

Detail Information

Publications63

  1. doi request reprint The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease
    Silvia Sookoian
    Clinical and Molecular Hepatology Laboratory, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Argentina
    Pharmacogenet Genomics 20:1-8. 2010
    ..To explore the contribution of gene variants and derived haplotypes of the pregnane X receptor (NR1I2) to the severity of nonalcoholic fatty liver disease (NAFLD)...
  2. ncbi request reprint Genetic determinants of acquired cholestasis: a systems biology approach
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Front Biosci (Landmark Ed) 17:206-20. 2012
    ....
  3. ncbi request reprint Liver disease during pregnancy: acute viral hepatitis
    Silvia Sookoian
    Instituto de Investigaciones Medicas, Alfredo Lanari Facultad de Medicina, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Argentina
    Ann Hepatol 5:231-6. 2006
    ..Pregnant women who think they may have been exposed to hepatitis B may be given and hepatitis B immunoglobulin (ideally within 72 hours of exposure), as well as the hepatitis B vaccine...
  4. doi request reprint Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review
    Silvia Sookoian
    Laboratory of Clinical and Molecular Hepatology, Department of Molecular Genetics and Biology of Complex Diseases, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    J Hepatol 49:600-7. 2008
    ..To perform a systematic review of the studies addressing the association between non-alcoholic fatty liver disease (NAFLD) and carotid intima-media thickness (IMT)...
  5. doi request reprint Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Hepatology 53:1883-94. 2011
    ..45 ± 1.04; P < 0.02). The rs738409 GG genotype versus the CC genotype was associated with a 28% increase in serum alanine aminotransferase levels...
  6. doi request reprint Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Cytokine 44:201-6. 2008
    ..To investigate the role of gene variants and derived haplotypes of the STAT3 transcription factor in nonalcoholic fatty liver disease (NAFLD) and their relation with the clinical disease severity...
  7. doi request reprint Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, University of Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
    Atherosclerosis 218:378-85. 2011
    ....
  8. ncbi request reprint Effect of pregnancy on pre-existing liver disease: chronic viral hepatitis
    Silvia Sookoian
    Instituto de Investigaciones Medicas, Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Ann Hepatol 5:190-7. 2006
    ..Lastly, it is included a list of recommendations to decrease vertical transmission rates of chronic viral hepatitis as well as some information for the reproduction team...
  9. doi request reprint Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease
    Silvia Sookoian
    Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, 1427 Ciudad Autonoma de Buenos Aires, Argentina
    J Nutr Biochem 20:765-70. 2009
    ..We hypothesized that ABCC2 gene variants may contribute to susceptibility to nonalcoholic fatty liver disease (NAFLD). Additionally, we tested the hypothesis of a relation between gene variants and disease severity...
  10. doi request reprint A diagnostic model to differentiate simple steatosis from nonalcoholic steatohepatitis based on the likelihood ratio form of Bayes theorem
    Silvia Sookoian
    Department of Molecular Genetics and Biology of Complex Diseases, Laboratory of Clinical and Molecular Hepatology, Institute of Medical Research, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Clin Biochem 42:624-9. 2009
    ....
  11. doi request reprint Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research, Buenos Aires, Argentina
    Hepatology 52:1992-2000. 2010
    ..Decreased liver mtDNA content concomitantly contributes to peripheral IR...
  12. doi request reprint Metabolic syndrome: from the genetics to the pathophysiology
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Av Combatiente de Malvinas 3150, C1427ARO, Ciudad Autonoma de Buenos Aires, Argentina
    Curr Hypertens Rep 13:149-57. 2011
    ....
  13. doi request reprint Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease
    Silvia Sookoian
    Laboratory of Clinical and Molecular Hepatology, Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research, Ciudad Autonoma de Buenos Aires, Argentina
    Atherosclerosis 209:585-91. 2010
    ..We further explored liver protein expression of ICAM-1, CD40 and PAI-1 in patients with different histological forms of NAFLD and control liver biopsies...
  14. pmc A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
    Silvia Sookoian
    Laboratory of Clinical and Molecular Hepatology, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    J Lipid Res 50:2111-6. 2009
    ..3% (beta 0.23 +/- 0.07; P < 0.002). Our data suggest that the rs738409 G allele is associated not only with fat accumulation in the liver but also with liver injury, possibly triggered by lipotoxicity...
  15. doi request reprint Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns
    Carolina Gemma
    Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research, A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    Obesity (Silver Spring) 17:1032-9. 2009
    ..In conclusion, our findings suggest a potential role of promoter PPARGC1A methylation in metabolic programming...
  16. doi request reprint A decreased mitochondrial DNA content is related to insulin resistance in adolescents
    Tomas F Gianotti
    Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Obesity (Silver Spring) 16:1591-5. 2008
    ..This result seems not to be related with the previously mentioned variants in genes involved in the regulation of mitochondrial biogenesis...
  17. doi request reprint Study of genetic variation in the STAT3 on obesity and insulin resistance in male adults
    Tomas F Gianotti
    Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research, A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Obesity (Silver Spring) 16:1702-7. 2008
    ....
  18. ncbi request reprint Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity
    Silvia Sookoian
    Departamento de Genética y Biología Molecular de Enfermedades Complejas, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Clin Nutr 87:1606-15. 2008
    ..Altering circadian rhythmicity results in pathophysiologic changes resembling metabolic syndrome and fat accumulation...
  19. ncbi request reprint Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease
    Silvia Sookoian
    Instituto de Investigaciones Medicas, A Lanari Universidad de Buenos Aires, CONICET, Combatiente de Malvinas 3150, 1427 Ciudad Autonoma de Buenos Aires, Argentina
    World J Gastroenterol 13:4242-8. 2007
    ..To investigate the role of gene variants and derived haplotypes of the CLOCK transcription factor in nonalcoholic fatty liver disease (NAFLD) and their relation with the disease severity...
  20. doi request reprint Gene-gene interaction between serotonin transporter (SLC6A4) and CLOCK modulates the risk of metabolic syndrome in rotating shiftworkers
    Silvia Sookoian
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Chronobiol Int 27:1202-18. 2010
    ..In conclusion, these data suggest a potential interaction (epistatic effect) of serotonin transporter and CLOCK gene variation on the genetic susceptibility to develop MS by rotating shiftworkers...
  21. doi request reprint Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescents
    Carolina Gemma
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, A Lanari IDIM, University of Buenos Aires, National Council of Scientific and Technological Research CONICET, Ciudad Autónoma de Buenos Aires C1427ARO, Argentina
    Mol Genet Metab 100:83-7. 2010
    ..To explore whether DNA methylation of the mitochondrial transcription factor A (TFAM) promoter is associated with insulin resistance in a sample of adolescents with features of metabolic syndrome...
  22. ncbi request reprint Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy
    Silvia Sookoian
    Instituto de Investigaciones Medicas A Lanari, Departamento de Genética y Biología Molecular de Enfermedades Complejas, Universidad de Buenos Aires, CONICET, Combatientes de Malvinas 3150, Buenos Aires 1427, Argentina
    J Hepatol 48:125-32. 2008
    ..Hence we studied the association of single nucleotide polymorphisms (SNPs) of promoter, coding and non-coding regions of ABCC2 and intrahepatic cholestasis of pregnancy (ICP)...
  23. ncbi request reprint The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome
    Silvia Sookoian
    Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Hypertens 18:1271-5. 2005
    ..We investigated the possible contribution of the G-308A TNF-alpha mutant to explain variables of the metabolic syndrome...
  24. doi request reprint Diversity of hepatitis C virus genotype 1b in Buenos Aires, Argentina: description of a new cluster associated with response to treatment
    Federico Di Lello
    Cátedra de Virología de la Facultad de Farmacia y Bioquímica Universidad de Buenos Aires, Buenos Aires, Argentina
    J Med Virol 80:619-27. 2008
    ..This cluster, which appears to be highly susceptible to therapy, suggests that the virus itself might be more important than individual patient characteristics when responding to treatment...
  25. doi request reprint Contribution of the functional 5-HTTLPR variant of the SLC6A4 gene to obesity risk in male adults
    Silvia Sookoian
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, A Lanari, University of Buenos Aires CONICET, Buenos Aires, Argentina
    Obesity (Silver Spring) 16:488-91. 2008
    ..We have previously found that the S allele is a genetic risk factor for obesity in adolescents...
  26. doi request reprint High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia
    Julieta Carabelli
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    J Cell Mol Med 15:1329-38. 2011
    ..In conclusion, we found that HFD promotes an increase in liver mitochondrial biogenesis in response to hypoxia via HIF-1α, probably to enhance the mitochondrial function as well as to accommodate the metabolic load...
  27. doi request reprint Increased levels of resistin in rotating shift workers: a potential mediator of cardiovascular risk associated with circadian misalignment
    Adriana Burgueno
    Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Atherosclerosis 210:625-9. 2010
    ....
  28. ncbi request reprint Short allele of serotonin transporter gene promoter is a risk factor for obesity in adolescents
    Silvia Sookoian
    Molecular Cardiology, Institute of Medical Research, A Lanari, University of Buenos Aires, Buenos Aires, Argentina
    Obesity (Silver Spring) 15:271-6. 2007
    ..47 +/- 1.09 vs. 0.51 +/- 1.4; p < 0.002) and were more frequent in overweight children. In conclusion, the S allele of the SLC6A4 promoter variant is associated with overweight being an independent genetic risk factor for obesity...
  29. ncbi request reprint Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis
    Silvia Sookoian
    Cardiologia Molecular, Instituto de Investigaciones Medicas, A Lanari, Facultad de Medicina, Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
    J Hypertens 25:5-13. 2007
    ..The CYP11B2 gene (CYP11B2) encoding aldosterone synthase has been associated with essential hypertension and some, but not all, studies have reported that the C-344T variant may influence the risk of the disease...
  30. doi request reprint Mitochondrial DNA copy number is modulated by genetic variation in the signal transducer and activator of transcription 3 (STAT3)
    Tomas Fernandez Gianotti
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Metabolism 60:1142-9. 2011
    ..The proportion of the total variance of the mtDNA/nDNA ratio accounted for by the rs6503695 and rs9891119 genotypes was 4.7% and 6.53%, respectively. Common variation in the STAT3 may influence mtDNA copy number...
  31. pmc PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires, National Council of Scientific and Technological Research CONICET, Autonomous City of Buenos Aires 1427, Argentina
    World J Gastroenterol 18:6018-26. 2012
    ..Finally, an interaction between PNPLA3 and glycerol-3-phosphate acyltransferase 2 is suggested by data miming...
  32. doi request reprint Fetal metabolic programming and epigenetic modifications: a systems biology approach
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires, National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Pediatr Res 73:531-42. 2013
    ..Conversely, a maternal obesogenic environment is most probably associated with metabolic reprogramming of glucose and lipid metabolism, as well as future risk of metabolic syndrome (MS), fatty liver, and insulin (INS) resistance...
  33. doi request reprint Influence of hepatocyte nuclear factor 4alpha (HNF4alpha) gene variants on the risk of type 2 diabetes: a meta-analysis in 49,577 individuals
    Silvia Sookoian
    Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari, University of Buenos Aires National Council of Scientific and Technological Research, Combatientes de Malvinas 3150, Buenos Aires 1427, Argentina
    Mol Genet Metab 99:80-9. 2010
    ..The nuclear receptor hepatocyte nuclear factor 4alpha (HNF4alpha) contributes to the regulation of a large fraction of liver and pancreatic islet transcriptomes...
  34. doi request reprint Losartan reduces liver expression of plasminogen activator inhibitor-1 (PAI-1) in a high fat-induced rat nonalcoholic fatty liver disease model
    Maria Soledad Rosselli
    Laboratory of Clinical and Molecular Hepatology, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Atherosclerosis 206:119-26. 2009
    ....
  35. ncbi request reprint Intra-host evolutionary dynamics of hepatitis C virus E2 in treated patients
    Victoria Alfonso
    Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, 4to piso, Buenos Aires 1113, Argentina
    J Gen Virol 86:2781-6. 2005
    ..Moreover, HVR1 heterogeneity seemed to be strongly constrained. This work contributes to the knowledge of HCV intra-host evolution during chronicity...
  36. doi request reprint Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A
    Adriana Laura Burgueño
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autónoma de Buenos Aires 1427, Argentina
    J Nutr Biochem 24:6-13. 2013
    ....
  37. doi request reprint DNA methylation and hepatic insulin resistance and steatosis
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, University of Buenos Aires, Buenos Aires, Argentina
    Curr Opin Clin Nutr Metab Care 15:350-6. 2012
    ....
  38. pmc Serotonin and serotonin transporter gene variant in rotating shift workers
    Silvia Sookoian
    Cardiologia Molecular Instituto de Investigaciones Medicas, A Lanari Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    Sleep 30:1049-53. 2007
    ....
  39. ncbi request reprint Mitochondrial DNA depletion in small- and large-for-gestational-age newborns
    Carolina Gemma
    Molecular Cardiology, Institute of Medical Research A Lanari, University of Buenos Aires, Buenos Aires, Argentina
    Obesity (Silver Spring) 14:2193-9. 2006
    ..To investigate whether mitochondrial DNA (mtDNA) content may be associated with clinical features, anthropometric variables, and laboratory findings in both extremes of abnormal fetal growth: small and large size for gestational age...
  40. doi request reprint Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1α in a rat model
    Adriana L Burgueño
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research, Ciudad Autonoma de Buenos Aires, Argentina
    Clin Sci (Lond) 124:53-63. 2013
    ..Sirt1 and Hif1a mRNAs were significantly correlated (R=0.71, P<0.00002). In conclusion, CVD is associated with Hif1a-related liver damage, hepatomegaly and reprogramming of liver metabolism, probably to compensate metabolic demands...
  41. doi request reprint Role of genetic variation in insulin-like growth factor 1 receptor on insulin resistance and arterial hypertension
    Silvia Sookoian
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, A Lanari IDIM, University of Buenos Aires, National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    J Hypertens 28:1194-202. 2010
    ..To perform a two-stage study to explore the role of gene variants in the risk of insulin resistance and arterial hypertension...
  42. ncbi request reprint Evolutionary study of HVR1 of E2 in chronic hepatitis C virus infection
    Victoria Alfonso
    Junin 956, 4to piso, Buenos Aires 1113, Catedra de Virologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    J Gen Virol 85:39-46. 2004
    ..The prevalence of a quasispecies shift mechanism was revealed by the cloning analysis during the follow-up period of the evolutionary process...
  43. pmc Systems biology elucidates common pathogenic mechanisms between nonalcoholic and alcoholic-fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    PLoS ONE 8:e58895. 2013
    ..In conclusion, similar underlying disease mechanisms lead to NAFLD and AFLD, but specific ones depict a particular disease signature that has a different impact on the systemic context...
  44. doi request reprint The genetic epidemiology of nonalcoholic fatty liver disease: toward a personalized medicine
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research, Ciudad Autonoma de Buenos Aires, Argentina
    Clin Liver Dis 16:467-85. 2012
    ..This article explores new tools designed toward moving genomic data into clinical medicine, providing putative answers to more practical questions...
  45. pmc Alanine and aspartate aminotransferase and glutamine-cycling pathway: their roles in pathogenesis of metabolic syndrome
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autónoma de Buenos Aires 1427, Argentina
    World J Gastroenterol 18:3775-81. 2012
    ....
  46. ncbi request reprint A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension
    Silvia Sookoian
    Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Gastroenterol 100:636-42. 2005
    ....
  47. doi request reprint Promoter DNA methylation of farnesoid x receptor and pregnane x receptor modulates the intrahepatic cholestasis of pregnancy phenotype
    Romina Cabrerizo
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    PLoS ONE 9:e87697. 2014
    ..In conclusion, the identification of epigenetic marks in target genes provides a basis for the understanding of adverse liver-related pregnancy outcomes, including ICP. ..
  48. ncbi request reprint Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy
    Gustavo Castano
    Gastroenterology Section, Department of Internal Medicine, Hospital J M Penna, Buenos Aires, Argentina
    Clin Sci (Lond) 110:459-65. 2006
    ..In conclusion, the present study has shown a clear difference in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a characteristic hydrophobic composition in women with ICP...
  49. doi request reprint Odor perception between heterosexual partners: its association with depression, anxiety, and genetic variation in odorant receptor OR7D4
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Biol Psychol 86:153-7. 2011
    ..19 ± 0.09, p = 0.028). These findings suggest that odor perception between heterosexual partners may have an impact on the development of depression and anxiety, and that it might be influenced by genetic variation in OR7D4...
  50. ncbi request reprint Effects of six months losartan administration on liver fibrosis in chronic hepatitis C patients: a pilot study
    Silvia Sookoian
    Instituto de Investigaciones Medicas, A Lanari Cardiologia Molecular, Combatientes de Malvinas 3150, Buenos Aires 1427, Argentina
    World J Gastroenterol 11:7560-3. 2005
    ..To evaluate the safety and efficacy of chronic administration of losartan on hepatic fibrosis in chronic hepatitis C patients...
  51. pmc Fatty liver is associated with transcriptional downregulation of stearoyl-CoA desaturase and impaired protein dimerization
    Tomas Fernandez Gianotti
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    PLoS ONE 8:e76912. 2013
    ..The adult rats were given standard chow diet (CD) or HFD for 10 weeks. In all the animals, we explored the hepatic Scd1 transcriptional activity and protein levels...
  52. doi request reprint Epigenetics of insulin resistance: an emerging field in translational medicine
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Curr Diab Rep 13:229-37. 2013
    ..Finally, we highlight relevant information about epigenetic marks and IR so that clinicians practicing in the community may envision future areas of medical intervention and predict putative biomarkers for early disease detection...
  53. ncbi request reprint Hepatic focal fatty change in a chronic hepatitis C patient
    Gustavo Castano
    Internal Medicine Department, Liver Unit, Hosptial Argerich, Buenos Aires, Argentina
    Ann Hepatol 1:147. 2002
  54. ncbi request reprint Genetics of the cardiometabolic syndrome: new insights and therapeutic implications
    Silvia Sookoian
    Departamento de Sustancias Vasoactivas y Cardiología Molecular, Instituto de Investigaciones A Lanari, Universidad de Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Ther Adv Cardiovasc Dis 1:37-47. 2007
    ..Lastly, the involvement of genes whose products are already the targets for approved drugs, such as SLC6A4, PPARalpha and PPARgamma , in the development of CMS suggests new avenues for CMS pharmacological treatment...
  55. ncbi request reprint Evaluation of a third generation anti-HCV assay in predicting viremia in patients with positive HCV antibodies
    Silvia Sookoian
    Unidad de Hepatologia, Departamento de Medicina Interna, Hospital Dr Cosme Argerich, Buenos Aires, Argentina
    Ann Hepatol 1:179-82. 2002
    ..In conclusion, our data demonstrate that viremic HCV patients had higher S/CO values in the MEIA test in comparison with non viremic patients. Hence, this assay may be used to predict HCV viraemia in anti-HCV positive individuals...
  56. ncbi request reprint How to distinguish normal liver from chronic hepatitis in anti-HCV positive individuals with normal alanine aminotransferase levels
    Silvia Sookoian
    Unidad de Hepatologia, Departamento de Medicina Interna, Hospital Dr Cosme Argerich, Buenos Aires, Argentina
    Medicina (B Aires) 62:226-30. 2002
    ....
  57. ncbi request reprint Vitamin A toxicity in a physical culturist patient: a case report and review of the literature
    Gustavo Castano
    Department of Internal Medicine, Hospital J M Penna, Buenos Aires, Argentina
    Ann Hepatol 5:293-395. 2006
    ..In conclusion, chronic vitamin A toxicity may produce severe liver damage and should be recognized in the differential diagnosis of chronic liver diseases...
  58. doi request reprint Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes
    Silvia Sookoian
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Genet Med 11:338-43. 2009
    ..We present an approach to prioritize single nucleotide polymorphisms for further follow-up in genome-wide association studies of type 2 diabetes...
  59. doi request reprint Obstructive sleep apnea is associated with fatty liver and abnormal liver enzymes: a meta-analysis
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Obes Surg 23:1815-25. 2013
    ..Our secondary purpose was to investigate the potential influence of OSA on histological severity of NAFLD to explore whether chronic intermittent hypoxia is associated with inflammation and fibrosis...
  60. ncbi request reprint Genetic characterization of hepatitis A virus isolates from Buenos Aires, Argentina
    Viviana Andrea Mbayed
    Catedra de Virologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Med Virol 68:168-74. 2002
    ..Other sequences were more scattered along the phylogenetic tree. However, we demonstrated that a consistent genetic relatedness of sequences could only be inferred on the basis of a more extensive sequencing of each isolate...
  61. ncbi request reprint Acute hepatitis C in a chronically HIV-infected patient: evolution of different viral genomic regions
    Diego Flichman
    Catedra de Virologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    World J Gastroenterol 9:1496-500. 2003
    ..To analyze the molecular evolution of different viral genomic regions of HCV in an acute HCV infected patient chronically infected with HIV through a 42-month follow-up...
  62. ncbi request reprint A randomized study of losartan vs propranolol: Effects on hepatic and systemic hemodynamics in cirrhotic patients
    Gustavo Castano
    Liver Unit, Department of Internal Medicine, Hospital Argerich, Alen 963, Burzaco 1852, Buenos Aires, Argentina
    Ann Hepatol 2:36-40. 2003
    ..This randomized controlled trial compared the effects of losartan vs. propranolol on portal and systemic hemodynamics in patients with cirrhosis...
  63. ncbi request reprint Effects of ribavirin on cytokine production of recall antigens and phytohemaglutinin-stimulated peripheral blood mononuclear cells. (Inhibitory effects of ribavirin on cytokine production)
    Silvia Sookoian
    Gastroenterology Section, Internal Medicine Department, Hospital JM Penna, GCBA
    Ann Hepatol 3:104-7. 2004
    ..To evaluate the effects of ribavirin on cytokine production of recall antigen and PHA-stimulated PBMC obtained from healthy individuals...