Research Topics
Genomes and Genes
| Silvia SookoianSummaryAffiliation: Universidad de Buenos Aires Country: Argentina Publications
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Detail Information
Publications
The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver diseaseSilvia Sookoian
Clinical and Molecular Hepatology Laboratory, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Argentina
Pharmacogenet Genomics 20:1-8. 2010..To explore the contribution of gene variants and derived haplotypes of the pregnane X receptor (NR1I2) to the severity of nonalcoholic fatty liver disease (NAFLD)...
Genetic determinants of acquired cholestasis: a systems biology approachSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Front Biosci 17:206-20. 2012....- Liver disease during pregnancy: acute viral hepatitisSilvia Sookoian
Instituto de Investigaciones Medicas, Alfredo Lanari Facultad de Medicina, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Argentina
Ann Hepatol 5:231-6. 2006..Pregnant women who think they may have been exposed to hepatitis B may be given and hepatitis B immunoglobulin (ideally within 72 hours of exposure), as well as the hepatitis B vaccine... - Genetic variants in STAT3 are associated with nonalcoholic fatty liver diseaseSilvia Sookoian
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Cytokine 44:201-6. 2008..To investigate the role of gene variants and derived haplotypes of the STAT3 transcription factor in nonalcoholic fatty liver disease (NAFLD) and their relation with the clinical disease severity... - Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver diseaseSilvia Sookoian
Department of Clinical and Molecular Hepatology, University of Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
Atherosclerosis 218:378-85. 2011.... - Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic reviewSilvia Sookoian
Laboratory of Clinical and Molecular Hepatology, Department of Molecular Genetics and Biology of Complex Diseases, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
J Hepatol 49:600-7. 2008..To perform a systematic review of the studies addressing the association between non-alcoholic fatty liver disease (NAFLD) and carotid intima-media thickness (IMT)... - Effect of pregnancy on pre-existing liver disease: chronic viral hepatitisSilvia Sookoian
Instituto de Investigaciones Medicas, Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina
Ann Hepatol 5:190-7. 2006..Lastly, it is included a list of recommendations to decrease vertical transmission rates of chronic viral hepatitis as well as some information for the reproduction team... - Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver diseaseSilvia Sookoian
Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, 1427 Ciudad Autonoma de Buenos Aires, Argentina
J Nutr Biochem 20:765-70. 2009..We hypothesized that ABCC2 gene variants may contribute to susceptibility to nonalcoholic fatty liver disease (NAFLD). Additionally, we tested the hypothesis of a relation between gene variants and disease severity... - Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver diseaseSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Hepatology 53:1883-94. 2011..CONCLUSION: By summarizing the amount of evidence, this study provided unequivocal evidence of rs738409 as a strong modifier of the natural history of NAFLD in different populations around the world... 
A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severitySilvia Sookoian
Laboratory of Clinical and Molecular Hepatology, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
J Lipid Res 50:2111-6. 2009..3% (beta 0.23 +/- 0.07; P < 0.002). Our data suggest that the rs738409 G allele is associated not only with fat accumulation in the liver but also with liver injury, possibly triggered by lipotoxicity...- Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoterSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research, Buenos Aires, Argentina
Hepatology 52:1992-2000. 2010..Decreased liver mtDNA content concomitantly contributes to peripheral IR... - A diagnostic model to differentiate simple steatosis from nonalcoholic steatohepatitis based on the likelihood ratio form of Bayes theoremSilvia Sookoian
Department of Molecular Genetics and Biology of Complex Diseases, Laboratory of Clinical and Molecular Hepatology, Institute of Medical Research, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Clin Biochem 42:624-9. 2009.... - Metabolic syndrome: from the genetics to the pathophysiologySilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Av Combatiente de Malvinas 3150, C1427ARO, Ciudad Autonoma de Buenos Aires, Argentina
Curr Hypertens Rep 13:149-57. 2011.... - Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver diseaseSilvia Sookoian
Laboratory of Clinical and Molecular Hepatology, Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research, Ciudad Autonoma de Buenos Aires, Argentina
Atherosclerosis 209:585-91. 2010..We further explored liver protein expression of ICAM-1, CD40 and PAI-1 in patients with different histological forms of NAFLD and control liver biopsies... - Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newbornsCarolina Gemma
Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research, A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Obesity (Silver Spring) 17:1032-9. 2009..In conclusion, our findings suggest a potential role of promoter PPARGC1A methylation in metabolic programming... - A decreased mitochondrial DNA content is related to insulin resistance in adolescentsTomas F Gianotti
Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Obesity (Silver Spring) 16:1591-5. 2008..This result seems not to be related with the previously mentioned variants in genes involved in the regulation of mitochondrial biogenesis... - Study of genetic variation in the STAT3 on obesity and insulin resistance in male adultsTomas F Gianotti
Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research, A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Obesity (Silver Spring) 16:1702-7. 2008.... - Genetic variants of Clock transcription factor are associated with individual susceptibility to obesitySilvia Sookoian
Departamento de Genética y Biología Molecular de Enfermedades Complejas, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
Am J Clin Nutr 87:1606-15. 2008..Altering circadian rhythmicity results in pathophysiologic changes resembling metabolic syndrome and fat accumulation... - Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver diseaseSilvia Sookoian
Instituto de Investigaciones Medicas, A Lanari Universidad de Buenos Aires, CONICET, Combatiente de Malvinas 3150, 1427 Ciudad Autonoma de Buenos Aires, Argentina
World J Gastroenterol 13:4242-8. 2007..To investigate the role of gene variants and derived haplotypes of the CLOCK transcription factor in nonalcoholic fatty liver disease (NAFLD) and their relation with the disease severity... - Gene-gene interaction between serotonin transporter (SLC6A4) and CLOCK modulates the risk of metabolic syndrome in rotating shiftworkersSilvia Sookoian
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Chronobiol Int 27:1202-18. 2010..In conclusion, these data suggest a potential interaction (epistatic effect) of serotonin transporter and CLOCK gene variation on the genetic susceptibility to develop MS by rotating shiftworkers... - Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancySilvia Sookoian
Instituto de Investigaciones Medicas A Lanari, Departamento de Genética y Biología Molecular de Enfermedades Complejas, Universidad de Buenos Aires, CONICET, Combatientes de Malvinas 3150, Buenos Aires 1427, Argentina
J Hepatol 48:125-32. 2008..Hence we studied the association of single nucleotide polymorphisms (SNPs) of promoter, coding and non-coding regions of ABCC2 and intrahepatic cholestasis of pregnancy (ICP)... - Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescentsCarolina Gemma
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, A Lanari IDIM, University of Buenos Aires, National Council of Scientific and Technological Research CONICET, Ciudad Autónoma de Buenos Aires C1427ARO, Argentina
Mol Genet Metab 100:83-7. 2010..To explore whether DNA methylation of the mitochondrial transcription factor A (TFAM) promoter is associated with insulin resistance in a sample of adolescents with features of metabolic syndrome... - Diversity of hepatitis C virus genotype 1b in Buenos Aires, Argentina: description of a new cluster associated with response to treatmentFederico Di Lello
Cátedra de Virología de la Facultad de Farmacia y Bioquímica Universidad de Buenos Aires, Buenos Aires, Argentina
J Med Virol 80:619-27. 2008..This cluster, which appears to be highly susceptible to therapy, suggests that the virus itself might be more important than individual patient characteristics when responding to treatment... - The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndromeSilvia Sookoian
Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
Am J Hypertens 18:1271-5. 2005..We investigated the possible contribution of the G-308A TNF-alpha mutant to explain variables of the metabolic syndrome... - Contribution of the functional 5-HTTLPR variant of the SLC6A4 gene to obesity risk in male adultsSilvia Sookoian
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, A Lanari, University of Buenos Aires CONICET, Buenos Aires, Argentina
Obesity (Silver Spring) 16:488-91. 2008..We have previously found that the S allele is a genetic risk factor for obesity in adolescents... - Increased levels of resistin in rotating shift workers: a potential mediator of cardiovascular risk associated with circadian misalignmentAdriana Burgueno
Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Atherosclerosis 210:625-9. 2010.... - High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxiaJulieta Carabelli
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
J Cell Mol Med 15:1329-38. 2011..In conclusion, we found that HFD promotes an increase in liver mitochondrial biogenesis in response to hypoxia via HIF-1α, probably to enhance the mitochondrial function as well as to accommodate the metabolic load... - Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysisSilvia Sookoian
Cardiologia Molecular, Instituto de Investigaciones Medicas, A Lanari, Facultad de Medicina, Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
J Hypertens 25:5-13. 2007..The CYP11B2 gene (CYP11B2) encoding aldosterone synthase has been associated with essential hypertension and some, but not all, studies have reported that the C-344T variant may influence the risk of the disease... - Short allele of serotonin transporter gene promoter is a risk factor for obesity in adolescentsSilvia Sookoian
Molecular Cardiology, Institute of Medical Research, A Lanari, University of Buenos Aires, Buenos Aires, Argentina
Obesity (Silver Spring) 15:271-6. 2007..47 +/- 1.09 vs. 0.51 +/- 1.4; p < 0.002) and were more frequent in overweight children. In conclusion, the S allele of the SLC6A4 promoter variant is associated with overweight being an independent genetic risk factor for obesity... - Mitochondrial DNA copy number is modulated by genetic variation in the signal transducer and activator of transcription 3 (STAT3)Tomas Fernandez Gianotti
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Metabolism 60:1142-9. 2011..The proportion of the total variance of the mtDNA/nDNA ratio accounted for by the rs6503695 and rs9891119 genotypes was 4.7% and 6.53%, respectively. Common variation in the STAT3 may influence mtDNA copy number... - Losartan reduces liver expression of plasminogen activator inhibitor-1 (PAI-1) in a high fat-induced rat nonalcoholic fatty liver disease modelMaria Soledad Rosselli
Laboratory of Clinical and Molecular Hepatology, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Atherosclerosis 206:119-26. 2009.... - Influence of hepatocyte nuclear factor 4alpha (HNF4alpha) gene variants on the risk of type 2 diabetes: a meta-analysis in 49,577 individualsSilvia Sookoian
Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research A Lanari, University of Buenos Aires National Council of Scientific and Technological Research, Combatientes de Malvinas 3150, Buenos Aires 1427, Argentina
Mol Genet Metab 99:80-9. 2010..The nuclear receptor hepatocyte nuclear factor 4alpha (HNF4alpha) contributes to the regulation of a large fraction of liver and pancreatic islet transcriptomes... - DNA methylation and hepatic insulin resistance and steatosisSilvia Sookoian
Department of Clinical and Molecular Hepatology, University of Buenos Aires, Buenos Aires, Argentina
Curr Opin Clin Nutr Metab Care 15:350-6. 2012.... - Serotonin and serotonin transporter gene variant in rotating shift workersSilvia Sookoian
Cardiologia Molecular Instituto de Investigaciones Medicas, A Lanari Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Sleep 30:1049-53. 2007.... - Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1α in a rat modelAdriana L Burgueño
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research, Ciudad Autonoma de Buenos Aires, Argentina
Clin Sci (Lond) 124:53-63. 2013..Sirt1 and Hif1a mRNAs were significantly correlated (R=0.71, P<0.00002). In conclusion, CVD is associated with Hif1a-related liver damage, hepatomegaly and reprogramming of liver metabolism, probably to compensate metabolic demands... - Role of genetic variation in insulin-like growth factor 1 receptor on insulin resistance and arterial hypertensionSilvia Sookoian
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, A Lanari IDIM, University of Buenos Aires, National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
J Hypertens 28:1194-202. 2010..To perform a two-stage study to explore the role of gene variants in the risk of insulin resistance and arterial hypertension... - Intra-host evolutionary dynamics of hepatitis C virus E2 in treated patientsVictoria Alfonso
, Universidad de Buenos Aires, , 4to piso, Buenos Aires 1113, Argentina
J Gen Virol 86:2781-6. 2005..Moreover, HVR1 heterogeneity seemed to be strongly constrained. This work contributes to the knowledge of HCV intra-host evolution during chronicity... - Alanine and aspartate aminotransferase and glutamine-cycling pathway: their roles in pathogenesis of metabolic syndromeSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autónoma de Buenos Aires 1427, Argentina
World J Gastroenterol 18:3775-81. 2012.... - The genetic epidemiology of nonalcoholic fatty liver disease: toward a personalized medicineSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research, Ciudad Autonoma de Buenos Aires, Argentina
Clin Liver Dis 16:467-85. 2012..This article explores new tools designed toward moving genomic data into clinical medicine, providing putative answers to more practical questions... - Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancyGustavo Castano
Gastroenterology Section, Department of Internal Medicine, Hospital J M Penna, Buenos Aires, Argentina
Clin Sci (Lond) 110:459-65. 2006..In conclusion, the present study has shown a clear difference in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a characteristic hydrophobic composition in women with ICP... - A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertensionSilvia Sookoian
Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
Am J Gastroenterol 100:636-42. 2005.... - Evolutionary study of HVR1 of E2 in chronic hepatitis C virus infectionVictoria Alfonso
, 4to. piso, Buenos Aires (1113, , , Universidad de Buenos Aires, Argentina
J Gen Virol 85:39-46. 2004..The prevalence of a quasispecies shift mechanism was revealed by the cloning analysis during the follow-up period of the evolutionary process... - Mitochondrial DNA depletion in small- and large-for-gestational-age newbornsCarolina Gemma
Molecular Cardiology, Institute of Medical Research A. Lanari, University of Buenos Aires, Buenos Aires, Argentina
Obesity (Silver Spring) 14:2193-9. 2006..On the basis of a cumulative body of evidence, we speculate that mtDNA depletion is one of the putative links between abnormal fetal growth and metabolic and cardiovascular complications in later life... - Effects of six months losartan administration on liver fibrosis in chronic hepatitis C patients: a pilot studySilvia Sookoian
Instituto de Investigaciones Medicas, A Lanari Cardiologia Molecular, Combatientes de Malvinas 3150, Buenos Aires 1427, Argentina
World J Gastroenterol 11:7560-3. 2005..To evaluate the safety and efficacy of chronic administration of losartan on hepatic fibrosis in chronic hepatitis C patients... - Odor perception between heterosexual partners: its association with depression, anxiety, and genetic variation in odorant receptor OR7D4Silvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Biol Psychol 86:153-7. 2011..19 ± 0.09, p = 0.028). These findings suggest that odor perception between heterosexual partners may have an impact on the development of depression and anxiety, and that it might be influenced by genetic variation in OR7D4... - Hepatic focal fatty change in a chronic hepatitis C patientGustavo Castano
Internal Medicine Department, Liver Unit, Hosptial Argerich, Buenos Aires, Argentina
Ann Hepatol 1:147. 2002 - Genetics of the cardiometabolic syndrome: new insights and therapeutic implicationsSilvia Sookoian
Departamento de Sustancias Vasoactivas y Cardiología Molecular, Instituto de Investigaciones A Lanari, Universidad de Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Ther Adv Cardiovasc Dis 1:37-47. 2007..Lastly, the involvement of genes whose products are already the targets for approved drugs, such as SLC6A4, PPARalpha and PPARgamma , in the development of CMS suggests new avenues for CMS pharmacological treatment... - How to distinguish normal liver from chronic hepatitis in anti-HCV positive individuals with normal alanine aminotransferase levelsSilvia Sookoian
Unidad de Hepatologia, Departamento de Medicina Interna, Hospital Dr Cosme Argerich, Buenos Aires, Argentina
Medicina (B Aires) 62:226-30. 2002.... - Vitamin A toxicity in a physical culturist patient: a case report and review of the literatureGustavo Castano
Department of Internal Medicine, Hospital J M Penna, Buenos Aires, Argentina
Ann Hepatol 5:293-395. 2006..In conclusion, chronic vitamin A toxicity may produce severe liver damage and should be recognized in the differential diagnosis of chronic liver diseases... - Evaluation of a third generation anti-HCV assay in predicting viremia in patients with positive HCV antibodiesSilvia Sookoian
Unidad de Hepatologia, Departamento de Medicina Interna, Hospital Dr Cosme Argerich, Buenos Aires, Argentina
Ann Hepatol 1:179-82. 2002..In conclusion, our data demonstrate that viremic HCV patients had higher S/CO values in the MEIA test in comparison with non viremic patients. Hence, this assay may be used to predict HCV viraemia in anti-HCV positive individuals... - Fetal metabolic programming and epigenetic modifications: a systems biology approachSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires, National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Pediatr Res 73:531-42. 2013..Conversely, a maternal obesogenic environment is most probably associated with metabolic reprogramming of glucose and lipid metabolism, as well as future risk of metabolic syndrome (MS), fatty liver, and insulin (INS) resistance... - Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetesSilvia Sookoian
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Genet Med 11:338-43. 2009..We present an approach to prioritize single nucleotide polymorphisms for further follow-up in genome-wide association studies of type 2 diabetes... - Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1AAdriana Laura Burgueño
Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autónoma de Buenos Aires 1427, Argentina
J Nutr Biochem 24:6-13. 2013.... - Systems biology elucidates common pathogenic mechanisms between nonalcoholic and alcoholic-fatty liver diseaseSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
PLoS ONE 8:e58895. 2013..In conclusion, similar underlying disease mechanisms lead to NAFLD and AFLD, but specific ones depict a particular disease signature that has a different impact on the systemic context... - Epigenetics of insulin resistance: an emerging field in translational medicineSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Curr Diab Rep 13:229-37. 2013..Finally, we highlight relevant information about epigenetic marks and IR so that clinicians practicing in the community may envision future areas of medical intervention and predict putative biomarkers for early disease detection... - PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver diseaseSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires, National Council of Scientific and Technological Research CONICET, Autonomous City of Buenos Aires 1427, Argentina
World J Gastroenterol 18:6018-26. 2012..Finally, an interaction between PNPLA3 and glycerol-3-phosphate acyltransferase 2 is suggested by data miming... - Acute hepatitis C in a chronically HIV-infected patient: evolution of different viral genomic regionsDiego Flichman
Catedra de Virologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
World J Gastroenterol 9:1496-500. 2003..Most of the nucleotide substitutions observed are non-synonymous and clustered in previously described epitopes, thus suggesting an immune-driven evolutionary process... - Genetic characterization of hepatitis A virus isolates from Buenos Aires, ArgentinaViviana Andrea Mbayed
Catedra de Virologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
J Med Virol 68:168-74. 2002..Other sequences were more scattered along the phylogenetic tree. However, we demonstrated that a consistent genetic relatedness of sequences could only be inferred on the basis of a more extensive sequencing of each isolate... - A randomized study of losartan vs propranolol: Effects on hepatic and systemic hemodynamics in cirrhotic patientsGustavo Castano
Liver Unit, Department of Internal Medicine, Hospital Argerich, Alen 963, Burzaco 1852, Buenos Aires, Argentina
Ann Hepatol 2:36-40. 2003..This randomized controlled trial compared the effects of losartan vs. propranolol on portal and systemic hemodynamics in patients with cirrhosis... - Effects of ribavirin on cytokine production of recall antigens and phytohemaglutinin-stimulated peripheral blood mononuclear cells. (Inhibitory effects of ribavirin on cytokine production)Silvia Sookoian
Gastroenterology Section, Internal Medicine Department, Hospital JM Penna, GCBA
Ann Hepatol 3:104-7. 2004..To evaluate the effects of ribavirin on cytokine production of recall antigen and PHA-stimulated PBMC obtained from healthy individuals...