Diego A Golombek

Summary

Affiliation: Universidad Nacional de Quilmes
Country: Argentina

Publications

  1. pmc cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents
    Santiago A Plano
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
    PLoS ONE 7:e37121. 2012
  2. pmc Timing of locomotor activity circadian rhythms in Caenorhabditis elegans
    Sergio H Simonetta
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes and National Research Council CONICET, Buenos Aires, Argentina
    PLoS ONE 4:e7571. 2009
  3. pmc Disruption of Transitional Stages in 24-h Blood Pressure Recording in Renal Transplant Recipients
    Marcelo E Katz
    Department of Science and Technology, University of Quilmes Buenos Aires, Argentina
    Front Neurol 3:35. 2012
  4. doi request reprint The times they're a-changing: effects of circadian desynchronization on physiology and disease
    Diego A Golombek
    Laboratory of Chronobiology, National University of Quilmes CONICET, Buenos Aires, Argentina
    J Physiol Paris 107:310-22. 2013
  5. pmc Characterization of locomotor activity circadian rhythms in athymic nude mice
    Natalia Paladino
    Laboratorio de Cronobiologia, Universidad Nacional de Quilmes, Nacional de Quilmes, R, S, Peña 180, Bernal, Buenos Aires, 1876, Argentina
    J Circadian Rhythms 11:2. 2013
  6. ncbi request reprint Signaling in the mammalian circadian clock: the NO/cGMP pathway
    Diego A Golombek
    Laboratory of Chronobiology, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal 1876, Buenos Aires, Argentina
    Neurochem Int 45:929-36. 2004
  7. pmc "Time sweet time": circadian characterization of galectin-1 null mice
    Leandro P Casiraghi
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Argentina
    J Circadian Rhythms 8:4. 2010
  8. ncbi request reprint From light to genes: moving the hands of the circadian clock
    Diego A Golombek
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
    Front Biosci 8:s285-93. 2003
  9. doi request reprint Physiology of circadian entrainment
    Diego A Golombek
    Laboratory of Chronobiology, Department of Science and Technology, University of Quilmes Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Quilmes, Argentina
    Physiol Rev 90:1063-102. 2010
  10. ncbi request reprint [Sleep is rhythm (and the rhythm, rhythm is)]
    Diego A Golombek
    Universidad Nacional de Quilmes CONICET, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
    Vertex 18:283-7. 2007

Collaborators

Detail Information

Publications44

  1. pmc cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents
    Santiago A Plano
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
    PLoS ONE 7:e37121. 2012
    ....
  2. pmc Timing of locomotor activity circadian rhythms in Caenorhabditis elegans
    Sergio H Simonetta
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes and National Research Council CONICET, Buenos Aires, Argentina
    PLoS ONE 4:e7571. 2009
    ..Our analysis of circadian rhythmicity in C. elegans opens the possibility for further screening for circadian mutations in this species...
  3. pmc Disruption of Transitional Stages in 24-h Blood Pressure Recording in Renal Transplant Recipients
    Marcelo E Katz
    Department of Science and Technology, University of Quilmes Buenos Aires, Argentina
    Front Neurol 3:35. 2012
    ....
  4. doi request reprint The times they're a-changing: effects of circadian desynchronization on physiology and disease
    Diego A Golombek
    Laboratory of Chronobiology, National University of Quilmes CONICET, Buenos Aires, Argentina
    J Physiol Paris 107:310-22. 2013
    ..Moreover, such situations might lead to an enhanced susceptibility to diverse cancer types. Possible interventions (including light exposure, scheduled timing for meals and use of chronobiotics) are also discussed. ..
  5. pmc Characterization of locomotor activity circadian rhythms in athymic nude mice
    Natalia Paladino
    Laboratorio de Cronobiologia, Universidad Nacional de Quilmes, Nacional de Quilmes, R, S, Peña 180, Bernal, Buenos Aires, 1876, Argentina
    J Circadian Rhythms 11:2. 2013
    ..abstract:..
  6. ncbi request reprint Signaling in the mammalian circadian clock: the NO/cGMP pathway
    Diego A Golombek
    Laboratory of Chronobiology, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal 1876, Buenos Aires, Argentina
    Neurochem Int 45:929-36. 2004
    ..This pathway offers a signaling window that allows peering into the circadian clock machinery in order to decipher its temporal cogs and wheels...
  7. pmc "Time sweet time": circadian characterization of galectin-1 null mice
    Leandro P Casiraghi
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Argentina
    J Circadian Rhythms 8:4. 2010
    ..To further analyze the role of endogenous galectin-1 in vivo, we aimed to characterize the circadian behavior of galectin-1 null (Lgals1-/-) mice...
  8. ncbi request reprint From light to genes: moving the hands of the circadian clock
    Diego A Golombek
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
    Front Biosci 8:s285-93. 2003
    ..These mechanisms lead to expression of specific clock genes which eventually set the phase of the clock and of clock-controlled circadian rhythms...
  9. doi request reprint Physiology of circadian entrainment
    Diego A Golombek
    Laboratory of Chronobiology, Department of Science and Technology, University of Quilmes Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Quilmes, Argentina
    Physiol Rev 90:1063-102. 2010
    ..Finally, we describe and analyze clock gene expression and its importance in entrainment mechanisms, as well as circadian disorders or retinal diseases related to entrainment deficits, including experimental and clinical treatments...
  10. ncbi request reprint [Sleep is rhythm (and the rhythm, rhythm is)]
    Diego A Golombek
    Universidad Nacional de Quilmes CONICET, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
    Vertex 18:283-7. 2007
    ....
  11. ncbi request reprint Nerve growth factor-induced circadian phase shifts and MAP kinase activation in the hamster suprachiasmatic nuclei
    Gastón A Pizzio
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, R S Peña 180, 1876 Bernal, Buenos Aires, Argentina
    Eur J Neurosci 22:665-71. 2005
    ..These results suggest that NGF, acting through MAPK activation, plays a role in photic entrainment of the mammalian circadian clock...
  12. doi request reprint Paying the circadian toll: the circadian response to LPS injection is dependent on the Toll-like receptor 4
    Natalia Paladino
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
    J Neuroimmunol 225:62-7. 2010
    ..In conclusion, we show that LPS-induced circadian responses are mediated by TLR4...
  13. ncbi request reprint Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei
    Patricia V Agostino
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal 1876, Buenos Aires, Argentina
    Neurochem Int 44:617-25. 2004
    ....
  14. pmc Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules
    Patricia V Agostino
    Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, 1876 Buenos Aires, Argentina
    Proc Natl Acad Sci U S A 104:9834-9. 2007
    ..These results suggest that sildenafil may be useful for treatment of circadian adaptation to environmental changes, including transmeridian eastbound flight schedules...
  15. doi request reprint Circadian entrainment to light-dark cycles involves extracellular nitric oxide communication within the suprachiasmatic nuclei
    Santiago A Plano
    Department of Science and Technology, Laboratory of Chronobiology, National University of Quilmes CONICET, Buenos Aires, Argentina
    Eur J Neurosci 31:876-82. 2010
    ..e. the time for light-induced phase advances). These findings demonstrate the role of extracellular NO communication within the SCN in the steady-state synchronization to LD cycles...
  16. ncbi request reprint Circadian heme oxygenase activity in the hamster suprachiasmatic nuclei
    María Fernanda Rubio
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, R S Peña 180, Bernal, 1876 Buenos Aires, Argentina
    Neurosci Lett 353:9-12. 2003
    ..HO inhibition by Zn-protoporphyrin did not affect light-induced phase shifts in vivo, suggesting that the enzyme is not necessary for light input to the clock...
  17. doi request reprint Effect of experimental glaucoma on the non-image forming visual system
    Nuria de Zavalía
    Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Departamento de Bioquimica Humana, Facultad de Medicina CEFyBO, Universidad de Buenos Aires CONICET, Paraguay, Buenos Aires, Argentina
    J Neurochem 117:904-14. 2011
    ..These results indicate the glaucoma induced significant alterations in the non-image forming visual system...
  18. ncbi request reprint Suprachiasmatic astrocytes as an interface for immune-circadian signalling
    María Juliana Leone
    Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
    J Neurosci Res 84:1521-7. 2006
    ..These results suggest that the glial cells of the SCN can mediate input signals to the mouse circadian system coming from the immune system via NF-kappaB signaling...
  19. doi request reprint Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
    Marcelo E Katz
    Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
    Pharmacol Biochem Behav 90:763-8. 2008
    ....
  20. ncbi request reprint Circadian responses to endotoxin treatment in mice
    Luciano Marpegan
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, R S Peña 180, 1876 Bernal, Buenos Aires, Argentina
    J Neuroimmunol 160:102-9. 2005
    ..At CT 15, LPS induced c-Fos expression in the dorsal area of the suprachiasmatic nuclei (SCN). Our results suggest that the activation of the immune system should be considered an entraining signal for the murine circadian clock...
  21. doi request reprint Role of proinflammatory cytokines on lipopolysaccharide-induced phase shifts in locomotor activity circadian rhythm
    M Juliana Leone
    Laboratorio de Cronobiologia, Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
    Chronobiol Int 29:715-23. 2012
    ....
  22. doi request reprint Diurnal variation in endotoxin-induced mortality in mice: correlation with proinflammatory factors
    Luciano Marpegan
    Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
    Chronobiol Int 26:1430-42. 2009
    ....
  23. doi request reprint Circadian variations of prostaglandin E2 and F2 alpha release in the golden hamster retina
    Nuria de Zavalía
    Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Departamento de Bioquimica Humana, Facultad de Medicina CEFyBO, Universidad de Buenos Aires CONICET, Buenos Aires, Argentina
    J Neurochem 112:972-9. 2010
    ..Thus, the present results suggest that the prostaglandin/COX-1 system could be a retinal clock output or part of the retinal clock mechanism...
  24. doi request reprint Casein kinase-1-epsilon (CK1epsilon) and circadian photic responses in hamsters
    Patricia V Agostino
    Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
    Chronobiol Int 26:126-33. 2009
    ..We now demonstrate that the mutation results in a heightened sensitivity to light, suggesting that CK1epsilon also regulates the photic entrainment pathway...
  25. ncbi request reprint Photic regulation of map kinase phosphatases MKP1/2 and MKP3 in the hamster suprachiasmatic nuclei
    Gastón A Pizzio
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Sáenz Peña 352 Bernal, B1876BXD, Buenos Aires, Argentina
    J Mol Neurosci 34:187-92. 2008
    ..These results show a different perspective on MAPKs in the SCN, which includes its regulation by a complex net of phosphatases...
  26. ncbi request reprint Circadian and pharmacological regulation of casein kinase I in the hamster suprachiasmatic nucleus
    Patricia V Agostino
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
    J Genet 87:467-71. 2008
    ....
  27. doi request reprint Circadian rhythms in metabolic variables in Caenorhabditis elegans
    María Laura Migliori
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina National Research Council CONICET, Argentina
    Physiol Behav 103:315-20. 2011
    ..elegans metabolic variables vary daily. In summary, our results will allow us to take full advantage of this widely used animal model (including research in genetics, ageing and developmental biology) for studies in Chronobiology...
  28. ncbi request reprint Circadian and photic regulation of ERK, JNK and p38 in the hamster SCN
    Gastón A Pizzio
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal B1876BXD Pcia de Buenos Aires, Buenos Aires, Argentina
    Neuroreport 14:1417-9. 2003
    ..Light pulses during the subjective night induce rapid activation of the three enzymes, suggesting that the three MAP kinases might be implicated in mammalian photic entrainment...
  29. doi request reprint Forced desynchronization of activity rhythms in a model of chronic jet lag in mice
    Leandro P Casiraghi
    Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Quilmes, Argentina
    J Biol Rhythms 27:59-69. 2012
    ....
  30. ncbi request reprint An automated tracking system for Caenorhabditis elegans locomotor behavior and circadian studies application
    Sergio H Simonetta
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, National Research Council CONICET, R S Peña 352, B1876BXD Bernal, Buenos Aires, Argentina
    J Neurosci Methods 161:273-80. 2007
    ..44 h period (52% of significantly rhythmic animals) in LD, and a 23.1+/-0.40 h period (37.5% of significantly rhythmic animals) under DD. The system is automateable using microcontrollers, of low-cost construction and highly reproducible...
  31. doi request reprint Circadian stress tolerance in adult Caenorhabditis elegans
    Sergio H Simonetta
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque S Peña 352, 1876, Bernal, Pcia de Buenos Aires, Argentina
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:821-8. 2008
    ..This work demonstrates for the first time that in the adult nematode, C. elegans stress responses vary daily, and provides evidence of an underlying rhythmic gene expression that governs these behaviors...
  32. pmc Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-α
    José M Duhart
    Laboratorio de Cronobiologia, Universidad Nacional de Quilmes Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, 1876 Bernal, Buenos Aires, Argentina
    J Immunol 191:4656-64. 2013
    ..These findings suggest a role for astroglial cells in the alteration of circadian timing by immune activation. ..
  33. doi request reprint Daily variation in melatonin synthesis and arylalkylamine N-acetyltransferase activity in the nematode Caenorhabditis elegans
    María L Migliori
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, National Research Council CONICET, Buenos Aires, Argentina
    J Pineal Res 53:38-46. 2012
    ..elegans. In summary, this study takes additional advantage of an extremely useful invertebrate model system, which has only recently been exploited for circadian studies...
  34. ncbi request reprint Extracellular nitric oxide signaling in the hamster biological clock
    Santiago A Plano
    Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 352, Bernal B1876BXD, Buenos Aires, Argentina
    FEBS Lett 581:5500-4. 2007
    ..These results suggest that NO may act as an intercellular messenger in the SCN, mediating light-induced phase advances...
  35. ncbi request reprint Ghrelin effects on the circadian system of mice
    Paola C Yannielli
    Universidad Nacional de Quilmes Consejo Nacional de Investigaciones Científicas y Técnicas, Bernal, 1876 Buenos Aires, Argentina
    J Neurosci 27:2890-5. 2007
    ....
  36. doi request reprint Circadian modulation of interval timing in mice
    Patricia V Agostino
    Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
    Brain Res 1370:154-63. 2011
    ..Taken together, our results indicate that short-time estimation is modulated by the circadian clock...
  37. doi request reprint Circadian variation in Pseudomonas fluorescens (CHA0)-mediated paralysis of Caenorhabditis elegans
    Andres Romanowski
    Laboratory of Chronobiology, Dept of Science and Technology, National University of Quilmes, Buenos Aires, Argentina
    Microb Pathog 50:23-30. 2011
    ..The innate immune response to P. fluorescens CHA0 might depend on the stress response pathway of C. elegans. The fact that the tolerance varies daily gives further proof of an underlying clock that governs cyclic behavior in C. elegans...
  38. doi request reprint N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
    Fernando M Baidanoff
    Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Bernal, Argentina
    J Neurochem 129:60-71. 2014
    ..Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances...
  39. doi request reprint Minutes, days and years: molecular interactions among different scales of biological timing
    Diego A Golombek
    Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Roque Saenz Pena 352, Bernal, Buenos Aires B1876BXD, Argentina
    Philos Trans R Soc Lond B Biol Sci 369:20120465. 2014
    ....
  40. pmc Unwinding the molecular basis of interval and circadian timing
    Patricia V Agostino
    Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes Buenos Aires, Argentina
    Front Integr Neurosci 5:64. 2011
    ..While there is currently no common neurochemical substrate for timing mechanisms in the brain, circadian modulation of interval timing suggests an interaction of different frequencies in cerebral temporal processes...
  41. ncbi request reprint Diurnal variation in the proconvulsant effect of 3-mercaptopropionic acid and the anticonvulsant effect of androsterone in the Syrian hamster
    Gabriela Naum
    CEI Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, R S Peña 180, Bernal 1876, Pcia de Buenos Aires, Argentina
    Life Sci 71:91-8. 2002
    ..These results support the importance of temporal regulation of GABAergic modulation in the central nervous system...
  42. ncbi request reprint Constitutive activation of the ERK-MAPK pathway in the suprachiasmatic nuclei inhibits circadian resetting
    Ernesto C Hainich
    Departamento de Ciencia y Tecnología Universidad Nacional de Quilmes CONICET, R S Peña 180, 1876 Bernal Buenos Aires, Argentina
    FEBS Lett 580:6665-8. 2006
    ..Therefore, circadian regulation of the ERK pathway is not essential for the normal mechanism of the biological clock, but it is fundamental as an interface with environmental entrainment by light...
  43. ncbi request reprint The circadian system of Trypanosoma cruzi-infected mice
    Tomas Fernandez Alfonso
    Weill Medical College of Cornell University, New York, New York, USA
    Chronobiol Int 20:49-64. 2003
    ..We conclude that the main effect of T. cruzi infection on the circadian system is an impairment of the motor output from the clock toward controlled rhythms, together with an effect on circadian visual sensitivity...
  44. doi request reprint Blunting of circadian rhythms and increased acrophase variability in sleep-time hypertensive subjects
    Santiago Perez-Lloret
    Physiology Department, School of Medicine, University of Buenos Aires, Argentina
    Chronobiol Int 25:99-113. 2008
    ..Altogether, the findings suggest a disorganization of the BP circadian rhythm in sleep-time hypertensives that results in reduced 24 h rhythm amplitude and integrity that could be related to cardiovascular risk...