Mario D Galigniana
Affiliation: Universidad de Buenos Aires
Leonardi D, Anselmino N, Brandani J, Jaworski F, Paez A, Mazaira G, et al
. Heme Oxygenase 1 Impairs Glucocorticoid Receptor Activity in Prostate Cancer. Int J Mol Sci. 2019;20: pubmed publisher
..We did not observe HO-1 staining in tumor cells, but high HO-1 reactivity was detected in tumor infiltrating macrophages. Our results suggest an association and crossed modulation between HO-1 and GR pathways. ..
Erlejman A, Lagadari M, Harris D, Cox M, Galigniana M. Molecular chaperone activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52. Curr Protein Pept Sci. 2014;15:205-15 pubmed
..In this article we review the most relevant features of these two immunophilins and their potential as pharmacologic targets. ..
Galigniana N, Ballmer L, Toneatto J, Erlejman A, Lagadari M, Galigniana M. Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51. J Neurochem. 2012;122:4-18 pubmed publisher
..In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response. ..
Erlejman A, Lagadari M, Toneatto J, Piwien Pilipuk G, Galigniana M. Regulatory role of the 90-kDa-heat-shock protein (Hsp90) and associated factors on gene expression. Biochim Biophys Acta. 2014;1839:71-87 pubmed publisher
..In this article, we discuss some aspects of the regulatory action of Hsp90 on transcriptional regulation and how this effect could have impacted genetic assimilation mechanism in some organisms. ..