Research Topics
| Cesar G FragaSummaryAffiliation: Universidad de Buenos Aires Country: Argentina Publications
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Detail Information
Publications
Iron toxicity and antioxidant nutrientsCesar G Fraga
Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
Toxicology 180:23-32. 2002..It can be concluded that the ingestion of antioxidant rich foods may prevent or delay primary and secondary effects associated with iron overload-related diseases...
Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer playersCesar G Fraga
Fisicoquímica PRALIB, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
Clin Dev Immunol 12:11-7. 2005..The presence of significant quantities of flavanols in FCMC is likely to have been one of the contributing factors to these results...
Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signalingCesar G Fraga
Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
Free Radic Biol Med 51:813-23. 2011....- Inhibition of angiotensin converting enzyme activity by flavanol-rich foodsLucas Actis-Goretta
Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina, , 1113 Buenos Aires, Argentina
J Agric Food Chem 54:229-34. 2006..The occurrence of such inhibition in vivo needs to be determined, although is supported by the association between the consumption of flavanol-rich foods and reductions in blood pressure observed in several experimental models... - Ultrastructural evidence of increased tolerance of hibernating myocardium to cardioplegic ischemia-reperfusion injuryJose Milei
Instituto de Investigaciones Cardiológicas ININCA, Department of Medicine, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
J Am Coll Cardiol 43:2329-36. 2004..The goal of this study was to investigate the effects of ischemia-reperfusion on myocardial ultrastructure in patients with and without hibernating myocardium... - Flavonoids and metabolic syndromeMonica Galleano
Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
Ann N Y Acad Sci 1259:87-94. 2012..Consequently, extensive basic and clinical research is warranted to assess the final relevance of flavonoids for MS... - Hypertension, nitric oxide, oxidants, and dietary plant polyphenolsMonica Galleano
Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956 C1113AAD, Buenos Aires, Argentina
Curr Pharm Biotechnol 11:837-48. 2010.... - Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibitionJavier I Ottaviani
Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
Biochimie 88:359-65. 2006..ACE inhibition by procyanidins in vivo might provide a mechanism to explain the benefits of flavonoid consumption on cardiovascular diseases... - Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidinsLucas Actis-Goretta
Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Juni;n 956, 1113, Buenos Aires, Argentina
FEBS Lett 555:597-600. 2003..As ACE is a membrane protein, the interaction of flavanols and procyanidins with the enzyme could be related to the number of hydroxyl groups on the procyanidins, which determine their capacity to be adsorbed on the membrane surface... - Cardiac mitochondrial function and tissue remodelling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive ratsBarbara Piotrkowski
Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
Free Radic Res 43:390-9. 2009..In summary, enalapril at a non-antihypertensive dose prevented cardiac hypertrophy and modifies parameters of cardiac mitochondrial dysfunction in SHR... - Basic biochemical mechanisms behind the health benefits of polyphenolsCesar G Fraga
Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
Mol Aspects Med 31:435-45. 2010.... - TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cellsAlejandra G Erlejman
IQUIFIB Department of Biological Chemistry UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
Arch Biochem Biophys 476:186-95. 2008.... - (-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cellsSandra V Verstraeten
Department of Biological Chemistry, IQUIFIB CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
Free Radic Res 42:864-72. 2008..These results indicate that EC and related oligomers, assayed at physiologically achievable concentrations, can modulate [Ca(2+)](i) and then prevent cell oxidation and other Ca(2+)-regulated events... - Influence of flavan-3-ols and procyanidins on UVC-mediated formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in isolated DNAJavier I Ottaviani
, , Universidad de Buenos Aires, , Buenos Aires, Argentina
Arch Biochem Biophys 406:203-8. 2002..Both epimerism and degree of oligomerization are important determinants of the antioxidant activity of flavan-3-ols and procyanidins... - Mitochondrial function and nitric oxide metabolism are modified by enalapril treatment in rat kidneyBarbara Piotrkowski
Physical Chemistry PRALIB, Univ of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
Am J Physiol Regul Integr Comp Physiol 292:R1494-501. 2007..These findings may clarify the role of NO in the interactions between RAS and mitochondrial metabolism and can help to unravel the mechanisms involved in renal protection by RAS inhibitors... - The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: a hypothesis including the participation of mitochondria in agingElena M V de Cavanagh
Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
Front Biosci 12:1049-62. 2007.... - Concerted action of the renin-angiotensin system, mitochondria, and antioxidant defenses in agingElena M V de Cavanagh
Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
Mol Aspects Med 25:27-36. 2004.... - Antioxidant actions of flavonoids: thermodynamic and kinetic analysisMonica Galleano
Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
Arch Biochem Biophys 501:23-30. 2010..The final mechanisms mediating the antioxidant actions of flavonoid will be determined by their actual concentration in the tissue under consideration... - Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damageAlejandra G Erlejman
IQUIFIB-Department of Biological Chemistry (UBA-CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
Free Radic Biol Med 41:1247-56. 2006..At the gastrointestinal tract, large procyanidins may exert beneficial effects in pathologies such us inflammatory diseases, alterations in intestinal barrier permeability, and cancer... - The regular supplementation with an antioxidant mixture decreases oxidative stress in healthy humans. Gender effectLucas Actis-Goretta
, , Universidad de Buenos Aires, 1113-Buenos Aires, Argentina
Clin Chim Acta 349:97-103. 2004.... - Cocoa, chocolate, and cardiovascular diseaseMonica Galleano
Physical Chemistry Program of Free Radicals in Biochemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Argentina
J Cardiovasc Pharmacol 54:483-90. 2009..This review will summarize the most recent research on the cardiovascular effects of cocoa flavanols and related compounds... - Blood pressure-lowering effect of dietary (-)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levelsMaría C Litterio
Physical Chemistry IBIMOL, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
Free Radic Biol Med 53:1894-902. 2012.... - Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusionJose Milei
Instituto de Investigaciones Cardiológicas Alberto C Taquini UBA Conicet, Buenos Aires, Argentina
Cardiovasc Res 73:710-9. 2007..Thus, we wanted to ascertain whether the relationship between oxidant formation and development of myocardial injury also translates to the situation of patients subjected to cardioplegic arrest... - Flavonoid-membrane interactions: a protective role of flavonoids at the membrane surface?Patricia I Oteiza
Department of Biological Chemistry, IQUIFIB UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
Clin Dev Immunol 12:19-25. 2005..We suggest that interactions of polyphenols at the surface of bilayers through hydrogen bonding, can act to reduce the access of deleterious molecules (i.e. oxidants), thus protecting the structure and function of membranes... - Polyphenols and red wine as peroxynitrite scavengers: a chemiluminescent assaySilvia Alvarez
Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
Ann N Y Acad Sci 957:271-3. 2002..The quickness and reliability of this assay makes it particularly suitable for a large-scale screening of watery food extracts... - Cocoa flavanols: effects on vascular nitric oxide and blood pressureCesar G Fraga
Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
J Clin Biochem Nutr 48:63-7. 2011..In this paper we present data supporting the hypothesis that flavanols could define superoxide anion production and then, establish optimal nitric oxide levels and blood pressure... - Enalapril and losartan attenuate mitochondrial dysfunction in aged ratsElena M V de Cavanagh
Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
FASEB J 17:1096-8. 2003..An association with oxidative stress modulation is suggested... - Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoaRoberta R Holt
Department of Nutrition, University of California, Davis 95616-8669, USA
Am J Clin Nutr 76:798-804. 2002..92 +/- 0.60 micro mol/L, and 0.16 +/- 0.03 micro mol/L, respectively). CONCLUSION: Dimeric procyanidins can be detected in human plasma as early as 30 min after the consumption of a flavanol-rich food such as cocoa... - Cocoa, diabetes, and hypertension: should we eat more chocolate?Cesar G Fraga
Am J Clin Nutr 81:541-2. 2005 - Trace elements and human healthCesar G Fraga
Mol Aspects Med 26:233-4. 2005 - Plant polyphenols: how to translate their in vitro antioxidant actions to in vivo conditionsCesar G Fraga
Department of Nutrition, One Shields Avenue, Davis, CA 95616, USA
IUBMB Life 59:308-15. 2007.... - Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetesElena M V de Cavanagh
Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
Am J Physiol Heart Circ Physiol 294:H456-65. 2008..In conclusion, AT(1) blockade protects kidney mitochondria and kidney structure in streptozotocin-induced diabetes independently of blood pressure and glycemia...