Cesar G Fraga

Summary

Affiliation: Universidad de Buenos Aires
Country: Argentina

Publications

  1. ncbi request reprint Iron toxicity and antioxidant nutrients
    Cesar G Fraga
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Toxicology 180:23-32. 2002
  2. doi request reprint In vitro measurements and interpretation of total antioxidant capacity
    Cesar G Fraga
    Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires Institute of Molecular Biochemistry and Medicine IBIMOL, National Council of Scientific and Technological Research CONICET, Buenos Aires, Argentina Department of Nutrition, University of California at Davis, Davis, CA 95616, USA Electronic address
    Biochim Biophys Acta 1840:931-4. 2014
  3. doi request reprint Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signaling
    Cesar G Fraga
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
    Free Radic Biol Med 51:813-23. 2011
  4. pmc Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players
    Cesar G Fraga
    Fisicoquímica PRALIB, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Clin Dev Immunol 12:11-7. 2005
  5. ncbi request reprint Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells
    Gerardo G MacKenzie
    Departamento de Quimica Biologica, Instituto de Quimica y Fisicoquimica Biologicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina
    FASEB J 18:167-9. 2004
  6. ncbi request reprint Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes
    Elena M V de Cavanagh
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 294:H456-65. 2008
  7. doi request reprint Blood pressure-lowering effect of dietary (-)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levels
    María C Litterio
    Physical Chemistry IBIMOL, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
    Free Radic Biol Med 53:1894-902. 2012
  8. doi request reprint Large procyanidins prevent bile-acid-induced oxidant production and membrane-initiated ERK1/2, p38, and Akt activation in Caco-2 cells
    Mathieu Da Silva
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Free Radic Biol Med 52:151-9. 2012
  9. ncbi request reprint Inhibition of angiotensin converting enzyme activity by flavanol-rich foods
    Lucas Actis-Goretta
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina, Junin 956, 1113 Buenos Aires, Argentina
    J Agric Food Chem 54:229-34. 2006
  10. ncbi request reprint Antioxidant and membrane effects of procyanidin dimers and trimers isolated from peanut and cocoa
    Sandra V Verstraeten
    IQUIFIB Department of Biological Chemistry UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    J Agric Food Chem 53:5041-8. 2005

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Iron toxicity and antioxidant nutrients
    Cesar G Fraga
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Toxicology 180:23-32. 2002
    ..It can be concluded that the ingestion of antioxidant rich foods may prevent or delay primary and secondary effects associated with iron overload-related diseases...
  2. doi request reprint In vitro measurements and interpretation of total antioxidant capacity
    Cesar G Fraga
    Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires Institute of Molecular Biochemistry and Medicine IBIMOL, National Council of Scientific and Technological Research CONICET, Buenos Aires, Argentina Department of Nutrition, University of California at Davis, Davis, CA 95616, USA Electronic address
    Biochim Biophys Acta 1840:931-4. 2014
    ..A large amount of research has been published using TAC. However, it remains unclear which is the significance of these investigations for understanding the biological importance of free radical reactions...
  3. doi request reprint Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signaling
    Cesar G Fraga
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
    Free Radic Biol Med 51:813-23. 2011
    ....
  4. pmc Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players
    Cesar G Fraga
    Fisicoquímica PRALIB, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Clin Dev Immunol 12:11-7. 2005
    ..The presence of significant quantities of flavanols in FCMC is likely to have been one of the contributing factors to these results...
  5. ncbi request reprint Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells
    Gerardo G MacKenzie
    Departamento de Quimica Biologica, Instituto de Quimica y Fisicoquimica Biologicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina
    FASEB J 18:167-9. 2004
    ..A model is presented for possible interactions between DP-B and NF-kappaB proteins, which could lead to the inhibition of NF-kappaB binding to kappaB sites...
  6. ncbi request reprint Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes
    Elena M V de Cavanagh
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 294:H456-65. 2008
    ..In conclusion, AT(1) blockade protects kidney mitochondria and kidney structure in streptozotocin-induced diabetes independently of blood pressure and glycemia...
  7. doi request reprint Blood pressure-lowering effect of dietary (-)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levels
    María C Litterio
    Physical Chemistry IBIMOL, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
    Free Radic Biol Med 53:1894-902. 2012
    ....
  8. doi request reprint Large procyanidins prevent bile-acid-induced oxidant production and membrane-initiated ERK1/2, p38, and Akt activation in Caco-2 cells
    Mathieu Da Silva
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Free Radic Biol Med 52:151-9. 2012
    ..The capacity of large procyanidins to interact with the cell membrane and prevent those cell membrane-associated events can in part explain the beneficial effects of procyanidins on CRC...
  9. ncbi request reprint Inhibition of angiotensin converting enzyme activity by flavanol-rich foods
    Lucas Actis-Goretta
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina, Junin 956, 1113 Buenos Aires, Argentina
    J Agric Food Chem 54:229-34. 2006
    ..The occurrence of such inhibition in vivo needs to be determined, although is supported by the association between the consumption of flavanol-rich foods and reductions in blood pressure observed in several experimental models...
  10. ncbi request reprint Antioxidant and membrane effects of procyanidin dimers and trimers isolated from peanut and cocoa
    Sandra V Verstraeten
    IQUIFIB Department of Biological Chemistry UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    J Agric Food Chem 53:5041-8. 2005
    ..As a consequence of this interaction, they can provide protection against the attack of oxidants and other molecules that challenge the integrity of the bilayer...
  11. ncbi request reprint Ultrastructural evidence of increased tolerance of hibernating myocardium to cardioplegic ischemia-reperfusion injury
    Jose Milei
    Instituto de Investigaciones Cardiológicas ININCA, Department of Medicine, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    J Am Coll Cardiol 43:2329-36. 2004
    ..The goal of this study was to investigate the effects of ischemia-reperfusion on myocardial ultrastructure in patients with and without hibernating myocardium...
  12. ncbi request reprint Membrane effects of cocoa procyanidins in liposomes and Jurkat T cells
    Sandra V Verstraeten
    IQUIFIB Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Biol Res 37:293-300. 2004
    ..Together, these results support the hypothesis that procyanidins could interact with the polar headgroup of lipids, increasing membrane fluidity and also, preventing the access of molecules that could affect membrane integrity...
  13. ncbi request reprint Flavan-3-ols and procyanidins protect liposomes against lipid oxidation and disruption of the bilayer structure
    Sandra V Verstraeten
    IQUIFIB Department of Biological Chemistry UBA CONICET, University of Buenos Aires, Buenos Aires, Argentina
    Free Radic Biol Med 34:84-92. 2003
    ..Thus, flavanols and procyanidins can potentially reduce oxidative modifications of membranes by restraining the access of oxidants to the bilayer and the propagation of lipid oxidation in the hydrophobic membrane matrix...
  14. doi request reprint Cardiac mitochondrial function and tissue remodelling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats
    Barbara Piotrkowski
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
    Free Radic Res 43:390-9. 2009
    ..In summary, enalapril at a non-antihypertensive dose prevented cardiac hypertrophy and modifies parameters of cardiac mitochondrial dysfunction in SHR...
  15. doi request reprint Flavonoids and metabolic syndrome
    Monica Galleano
    Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Ann N Y Acad Sci 1259:87-94. 2012
    ..Consequently, extensive basic and clinical research is warranted to assess the final relevance of flavonoids for MS...
  16. ncbi request reprint Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition
    Javier I Ottaviani
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Biochimie 88:359-65. 2006
    ..ACE inhibition by procyanidins in vivo might provide a mechanism to explain the benefits of flavonoid consumption on cardiovascular diseases...
  17. ncbi request reprint Hypertension, nitric oxide, oxidants, and dietary plant polyphenols
    Monica Galleano
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956 C1113AAD, Buenos Aires, Argentina
    Curr Pharm Biotechnol 11:837-48. 2010
    ....
  18. doi request reprint (-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells
    Sandra V Verstraeten
    Department of Biological Chemistry, IQUIFIB CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Free Radic Res 42:864-72. 2008
    ..These results indicate that EC and related oligomers, assayed at physiologically achievable concentrations, can modulate [Ca(2+)](i) and then prevent cell oxidation and other Ca(2+)-regulated events...
  19. ncbi request reprint Comparative study on the antioxidant capacity of wines and other plant-derived beverages
    Lucas Actis-Goretta
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Ann N Y Acad Sci 957:279-83. 2002
    ..Further studies of absorption and metabolism of the active compounds will judge the physiological relevance of these results for human health...
  20. ncbi request reprint Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins
    Lucas Actis-Goretta
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Juni n 956, 1113, Buenos Aires, Argentina
    FEBS Lett 555:597-600. 2003
    ..As ACE is a membrane protein, the interaction of flavanols and procyanidins with the enzyme could be related to the number of hydroxyl groups on the procyanidins, which determine their capacity to be adsorbed on the membrane surface...
  21. ncbi request reprint Assessing the antioxidant capacity in the hydrophilic and lipophilic domains: study of a sample of Argentine wines
    Silvina B Lotito
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Ann N Y Acad Sci 957:284-7. 2002
    ..The antioxidant capacity of the white wines was significantly lower, as evaluated by all the assays. Significant correlations were found for phenolics and catechin content with the antioxidant capacity of the studied wines...
  22. doi request reprint Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding
    Gerardo G MacKenzie
    Department of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Biochem Pharmacol 78:1252-62. 2009
    ..The results support the concept that B-type dimeric procyanidins can provide anti-inflammatory benefits due to their ability to reduce NF-kappaB binding to the DNA...
  23. doi request reprint TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells
    Alejandra G Erlejman
    IQUIFIB Department of Biological Chemistry UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Arch Biochem Biophys 476:186-95. 2008
    ....
  24. doi request reprint Basic biochemical mechanisms behind the health benefits of polyphenols
    Cesar G Fraga
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
    Mol Aspects Med 31:435-45. 2010
    ....
  25. doi request reprint (-)-Epicatechin reduces blood pressure and improves vasorelaxation in spontaneously hypertensive rats by NO-mediated mechanism
    Monica Galleano
    Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires Institute of Biochemistry and Molecular Medicine, National Council of Scientific and Technological Research CONICET, Buenos Aires, Argentina
    IUBMB Life 65:710-5. 2013
    ..These results give further support to the concept that (-)-epicatechin can modulate BP in hypertension by increasing NO levels in the vasculature...
  26. ncbi request reprint Plant polyphenols: how to translate their in vitro antioxidant actions to in vivo conditions
    Cesar G Fraga
    Department of Nutrition, One Shields Avenue, Davis, CA 95616, USA
    IUBMB Life 59:308-15. 2007
    ....
  27. doi request reprint Antioxidant actions of flavonoids: thermodynamic and kinetic analysis
    Monica Galleano
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
    Arch Biochem Biophys 501:23-30. 2010
    ..The final mechanisms mediating the antioxidant actions of flavonoid will be determined by their actual concentration in the tissue under consideration...
  28. ncbi request reprint Concerted action of the renin-angiotensin system, mitochondria, and antioxidant defenses in aging
    Elena M V de Cavanagh
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    Mol Aspects Med 25:27-36. 2004
    ....
  29. ncbi request reprint Mitochondrial function and nitric oxide metabolism are modified by enalapril treatment in rat kidney
    Barbara Piotrkowski
    Physical Chemistry PRALIB, Univ of Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    Am J Physiol Regul Integr Comp Physiol 292:R1494-501. 2007
    ..These findings may clarify the role of NO in the interactions between RAS and mitochondrial metabolism and can help to unravel the mechanisms involved in renal protection by RAS inhibitors...
  30. ncbi request reprint The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: a hypothesis including the participation of mitochondria in aging
    Elena M V de Cavanagh
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Front Biosci 12:1049-62. 2007
    ....
  31. ncbi request reprint Influence of flavan-3-ols and procyanidins on UVC-mediated formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in isolated DNA
    Javier I Ottaviani
    Fisicoquímica PRALIB, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, Buenos Aires, Argentina
    Arch Biochem Biophys 406:203-8. 2002
    ..Both epimerism and degree of oligomerization are important determinants of the antioxidant activity of flavan-3-ols and procyanidins...
  32. doi request reprint Procyanidins can interact with Caco-2 cell membrane lipid rafts: involvement of cholesterol
    Sandra V Verstraeten
    Department of Biological Chemistry and IQUIFIB UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Biochim Biophys Acta 1828:2646-53. 2013
    ..Procyanidin-lipid raft interactions can in part explain the capacity of large procyanidins to modulate cell physiology. ..
  33. pmc Cocoa, chocolate, and cardiovascular disease
    Monica Galleano
    Physical Chemistry Program of Free Radicals in Biochemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Argentina
    J Cardiovasc Pharmacol 54:483-90. 2009
    ..This review will summarize the most recent research on the cardiovascular effects of cocoa flavanols and related compounds...
  34. ncbi request reprint The regular supplementation with an antioxidant mixture decreases oxidative stress in healthy humans. Gender effect
    Lucas Actis-Goretta
    Fisicoquímica PRALIB CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina
    Clin Chim Acta 349:97-103. 2004
    ..We evaluated if the regular supplementation with an antioxidant mixture modified oxidative stress parameters in healthy humans...
  35. ncbi request reprint Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damage
    Alejandra G Erlejman
    IQUIFIB Department of Biological Chemistry UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Free Radic Biol Med 41:1247-56. 2006
    ..At the gastrointestinal tract, large procyanidins may exert beneficial effects in pathologies such us inflammatory diseases, alterations in intestinal barrier permeability, and cancer...
  36. pmc Flavonoid-membrane interactions: a protective role of flavonoids at the membrane surface?
    Patricia I Oteiza
    Department of Biological Chemistry, IQUIFIB UBA CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Clin Dev Immunol 12:19-25. 2005
    ..We suggest that interactions of polyphenols at the surface of bilayers through hydrogen bonding, can act to reduce the access of deleterious molecules (i.e. oxidants), thus protecting the structure and function of membranes...
  37. ncbi request reprint Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusion
    Jose Milei
    Instituto de Investigaciones Cardiológicas Alberto C Taquini UBA Conicet, Buenos Aires, Argentina
    Cardiovasc Res 73:710-9. 2007
    ..Thus, we wanted to ascertain whether the relationship between oxidant formation and development of myocardial injury also translates to the situation of patients subjected to cardioplegic arrest...
  38. doi request reprint Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells
    Gerardo G MacKenzie
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Int J Cancer 123:56-65. 2008
    ..The above findings provide a mechanistic rationale for the potential use of curcumin as a therapeutic agent for patients with HL...
  39. ncbi request reprint Polyphenols and red wine as peroxynitrite scavengers: a chemiluminescent assay
    Silvia Alvarez
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Ann N Y Acad Sci 957:271-3. 2002
    ..The quickness and reliability of this assay makes it particularly suitable for a large-scale screening of watery food extracts...
  40. pmc Cocoa flavanols: effects on vascular nitric oxide and blood pressure
    Cesar G Fraga
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
    J Clin Biochem Nutr 48:63-7. 2011
    ..In this paper we present data supporting the hypothesis that flavanols could define superoxide anion production and then, establish optimal nitric oxide levels and blood pressure...
  41. ncbi request reprint Relevance, essentiality and toxicity of trace elements in human health
    Cesar G Fraga
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Mol Aspects Med 26:235-44. 2005
    ..The dietary reference intakes provided by national regulatory agencies are guides to define intake, supplementation and toxicity of Mn, Fe, Cu, Zn, and Se, as well other elements considered micronutrients for humans...
  42. ncbi request reprint Enalapril and losartan attenuate mitochondrial dysfunction in aged rats
    Elena M V de Cavanagh
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    FASEB J 17:1096-8. 2003
    ..An association with oxidative stress modulation is suggested...
  43. ncbi request reprint Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa
    Roberta R Holt
    Department of Nutrition, University of California, Davis 95616 8669, USA
    Am J Clin Nutr 76:798-804. 2002
    ....
  44. ncbi request reprint Trace elements and human health
    Cesar G Fraga
    Mol Aspects Med 26:233-4. 2005
  45. ncbi request reprint Cocoa, diabetes, and hypertension: should we eat more chocolate?
    Cesar G Fraga
    Am J Clin Nutr 81:541-2. 2005